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1. 发明申请

WO2012122029A3 NANOPORE DEVICE FOR REVERSIBLE ION AND MOLECULE SENSING OR MIGRATION 审中-公开
标题翻译：用于可逆离子和分子感测或移动的纳米设备
公开(公告)号：WO2012122029A3
公开(公告)日：2012-11-22
申请号：PCT/US2012027531
申请日：2012-03-02
申请人： UNIV CALIFORNIA , POURMAND NADER , VILOZNY BOAZ , ACTIS PAOLO , SEGER R ADAM , SINGARAM BAKTHAN
发明人： POURMAND NADER , VILOZNY BOAZ , ACTIS PAOLO , SEGER R ADAM , SINGARAM BAKTHAN
IPC分类号： G01N27/26 , G01N27/49 , G01N35/00
CPC分类号： G01N27/44791 , B01L3/021 , B01L3/50273 , B01L2300/0896 , B82Y35/00 , G01N33/48721 , G01Q60/44
摘要： Disclosed are methods and devices for detection of ion migration and binding, utilizing a nanopipette adapted for use in an electrochemical sensing circuit. The nanopipette may be functionalized on its interior bore with metal chelators for binding and sensing metal ions or other specific binding molecules such as boronic acid for binding and sensing glucose. Such a functionalized nanopipette is comprised in an electrical sensor that detects when the nanopipette selectively and reversibly binds ions or small molecules. Also disclosed is a nanoreactor, comprising a nanopipette, for controlling precipitation in aqueous solutions by voltage-directed ion migration, wherein ions may be directed out of the interior bore by a repulsing charge in the bore.
摘要翻译：公开了用于检测离子迁移和结合的方法和装置，利用适用于电化学感测电路的纳米管。纳米胶管可以在其内孔上用金属螯合剂进行官能化，用于结合和感测金属离子或其它特异性结合分子例如硼酸用于结合和感测葡萄糖。这种功能化的纳米移液管包含在电传感器中，该传感器检测纳米管片何时选择性地和可逆地结合离子或小分子。还公开了一种纳米反应器，其包括用于通过电压导向离子迁移控制水溶液中的沉淀的纳米滴管，其中离子可以通过孔中的排斥电荷引出到内孔内。

2. 发明申请

WO2013012452A3 NANOPIPETTE APPARATUS FOR MANIPULATING CELLS 审中-公开
标题翻译：用于操作细胞的纳米技术装置
公开(公告)号：WO2013012452A3
公开(公告)日：2013-04-25
申请号：PCT/US2012026781
申请日：2012-02-27
申请人： UNIV CALIFORNIA , SEGER R ADAM , ACTIS PAOLO , VILOZNY BOAZ , POURMAND NADER
发明人： SEGER R ADAM , ACTIS PAOLO , VILOZNY BOAZ , POURMAND NADER
IPC分类号： C12M1/42 , C12N13/00
CPC分类号： B82Y5/00 , B01J2219/00371 , B01L3/502715 , B01L3/50273 , B01L2300/0645 , B82Y15/00 , G01N33/48728 , G01Q60/44
摘要： Disclosed herein are methods and systems for controlled ejection of desired material onto surfaces including single cells using nanopipettes, as well as ejection and into cells. Some systems are directed to a method and system comprising nanopipettes combined with an xyz controller for depositing a user defined pattern on an arbitrary substrate for the purpose of controlled cell adhesion and growth. Alternate embodiments are directed to a method and system comprising nanopipettes combined with an xyz controller and electronic control of a voltage differential in a bore of the nanopipette electroosmotically injecting material into a cell in a high-throughput manner and with minimal damage to the cell. Yet other embodiments are directed to method and system comprising functionalized nanopipettes combined with scanning ion conductance microscopy for studying molecular interactions and detection of biomolecules inside a single living cell.
摘要翻译：本文公开了用于将所需材料控制喷射到表面上的方法和系统，包括使用纳米移液管的单个细胞，以及喷射和进入细胞。一些系统涉及一种方法和系统，其包括与xyz控制器组合的纳米移液器，用于将用户定义的图案沉积在任意基底上，以便控制细胞粘附和生长。替代实施例涉及一种方法和系统，其包括与xyz控制器组合的纳米移液器，并且以高通量方式以高通量方式电动地将材料的孔中的电压差电子控制到电池中并以最小的细胞损伤来电子控制。其他实施方案涉及包括与扫描离子电导显微镜结合的功能化纳米小片剂用于研究单个活细胞内的分子相互作用和生物分子的检测的方法和系统。

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