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1. 发明申请

WO2011112893A9 COMPOSITIONS FOR AMELIORATING CELL PROLIFERATIVE DISORDERS AND METHODS OF MAKING AND USING THEM 审中-公开
标题翻译：用于改善细胞增殖性疾病的组合物及其制备和使用它们的方法
公开(公告)号：WO2011112893A9
公开(公告)日：2011-11-10
申请号：PCT/US2011028029
申请日：2011-03-11
申请人： UNIV CALIFORNIA , GERWICK WILLIAM H , TIDGEWELL KEVIN , VALERIOTE FRED
发明人： GERWICK WILLIAM H , TIDGEWELL KEVIN , VALERIOTE FRED
IPC分类号： A61K31/427 , A61K9/08 , A61K9/20 , A61K31/426 , A61P25/00 , A61P29/00
CPC分类号： C07D513/18 , C07D513/08
摘要： In alternative embodiments, the invention provides apratoxin F and apratoxin G compounds, which include apratoxin F and apratoxin G stereoisomers, derivatives and analogs compositions and methods. In alternative embodiments, the invention provides pharmaceutical compositions and formulations comprising apratoxin F (compound 6 of Figure 1) and apratoxin G (compound 7 of Figure 1) and their stereoisomers, derivatives and analogs. In alternative embodiments, pharmaceutical compositions and formulations of the invention are administered in an amount sufficient to treat, prevent and/or ameliorate a disease or condition that can be ameliorated by decreasing or inhibiting cell growth, e.g., pathological, uncontrolled or unwanted cell growth, e.g., a cancer or a metastases, or any disease or condition (e.g., allergy) or infection having a hyperproliferative cell growth component.
摘要翻译：在替代实施方案中，本发明提供了包括阿曲毒素F和阿曲毒素G立体异构体，衍生物和类似物组合物和方法的阿曲毒素F和阿曲毒素G化合物。在替代实施方案中，本发明提供了药物组合物和制剂，其包含阿曲毒素F（图1的化合物6）和阿曲毒素G（图1的化合物7）及其立体异构体，衍生物和类似物。在替代实施方案中，本发明的药物组合物和制剂以足以治疗，预防和/或改善可通过减少或抑制细胞生长而改善的疾病或病症的量施用，例如病理学，不受控制或不期望的细胞生长，例如癌症或转移瘤，或任何疾病或病症（例如过敏）或具有过度增殖细胞生长成分的感染。

2. 发明申请

WO2011112893A3 COMPOSITIONS FOR AMELIORATING CELL PROLIFERATIVE DISORDERS AND METHODS OF MAKING AND USING THEM 审中-公开
标题翻译：用于改善细胞增殖性疾病的组合物及其制备和使用它们的方法
公开(公告)号：WO2011112893A3
公开(公告)日：2012-03-15
申请号：PCT/US2011028029
申请日：2011-03-11
申请人： UNIV CALIFORNIA , GERWICK WILLIAM H , TIDGEWELL KEVIN , VALERIOTE FRED
发明人： GERWICK WILLIAM H , TIDGEWELL KEVIN , VALERIOTE FRED
IPC分类号： A61K31/427 , A61K9/08 , A61K9/20 , A61K31/426 , A61P25/00 , A61P29/00
CPC分类号： C07D513/18 , C07D513/08
摘要： In alternative embodiments, the invention provides apratoxin F and apratoxin G compounds, which include apratoxin F and apratoxin G stereoisomers, derivatives and analogs compositions and methods. In alternative embodiments, the invention provides pharmaceutical compositions and formulations comprising apratoxin F (compound 6 of Figure 1) and apratoxin G (compound 7 of Figure 1) and their stereoisomers, derivatives and analogs. In alternative embodiments, pharmaceutical compositions and formulations of the invention are administered in an amount sufficient to treat, prevent and/or ameliorate a disease or condition that can be ameliorated by decreasing or inhibiting cell growth, e.g., pathological, uncontrolled or unwanted cell growth, e.g., a cancer or a metastases, or any disease or condition (e.g., allergy) or infection having a hyperproliferative cell growth component.
摘要翻译：在替代实施方案中，本发明提供了包括阿曲毒素F和阿曲毒素G立体异构体，衍生物和类似物组合物和方法的阿曲毒素F和阿曲毒素G化合物。在替代实施方案中，本发明提供药物组合物和制剂，其包含阿曲马毒素F（图1的化合物6）和阿曲毒素G（图1的化合物7）及其立体异构体，衍生物和类似物。在替代实施方案中，本发明的药物组合物和制剂以足以治疗，预防和/或改善可以通过减少或抑制细胞生长（例如病理，不受控制或不期望的细胞生长）而改善的疾病或病症的量施用，例如癌症或转移瘤，或任何疾病或病症（例如过敏）或具有过度增殖细胞生长成分的感染。

3. 发明申请

WO2011153502A3 ANTI-INFLAMMATORY AND QUORUM SENSING INHIBITION COMPOUNDS AND METHODS OF MAKING AND USING THEM 审中-公开
标题翻译：抗炎和感应抑制化合物及其制备和使用方法
公开(公告)号：WO2011153502A3
公开(公告)日：2012-04-19
申请号：PCT/US2011039175
申请日：2011-06-03
申请人： UNIV CALIFORNIA , GERWICK WILLIAM H , GERWICK LENA , CHOI HUYKJAE , VILLA FRANCISCO A , SMITH JENNIFER , ROWLEY DAVID C , UNIV RHODE ISLAND RES FOUNDATION
发明人： GERWICK WILLIAM H , GERWICK LENA , CHOI HUYKJAE , VILLA FRANCISCO A , SMITH JENNIFER , ROWLEY DAVID C
IPC分类号： C07D307/33 , A61K31/19 , A61K31/22 , A61K31/341 , A61P25/00 , A61P29/00 , A61P31/04 , C07C57/54 , C07C69/653
CPC分类号： C07D307/33 , A61F2310/0097 , A61K8/14 , A61K8/37 , A61K8/42 , A61K8/4973 , A61K8/69 , A61K9/0019 , A61K9/127 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/202 , A61L2300/404 , A61L2300/41 , A61Q11/00 , C07C57/52 , C07C57/54 , C07C69/732 , C07C233/15
摘要： The invention provides novel compositions based on a structure designated as "Honaucin A", including Honaucin A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used as bacterial quorumsensing inhibitors. Accordingly, in alternative embodiments the compositions of the invention are used as anti-bacterial agents.
摘要翻译：本发明提供了基于称为“Honaucin A”的结构的新型组合物，包括Honaucin A变体和类似物，以及包含它们的药物组合物，脂质体和纳米颗粒，以及制备和使用它们的方法。在一个实施方案中，这些Honaucin A化合物及其变体和类似物用于改善（包括治疗或预防）炎症。在一个实施方案中，这些Honaucin A化合物及其变体和类似物用于改善（包括治疗或预防）炎症。在一个实施方案中，这些Honaucin A化合物及其变体和类似物用作细菌麻醉抑制剂。因此，在替代实施方案中，本发明的组合物用作抗细菌剂。

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