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    • 1. 发明申请
    • COMPOSITIONS FOR AMELIORATING CELL PROLIFERATIVE DISORDERS AND METHODS OF MAKING AND USING THEM
    • 用于改善细胞增殖性疾病的组合物及其制备和使用它们的方法
    • WO2011112893A9
    • 2011-11-10
    • PCT/US2011028029
    • 2011-03-11
    • UNIV CALIFORNIAGERWICK WILLIAM HTIDGEWELL KEVINVALERIOTE FRED
    • GERWICK WILLIAM HTIDGEWELL KEVINVALERIOTE FRED
    • A61K31/427A61K9/08A61K9/20A61K31/426A61P25/00A61P29/00
    • C07D513/18C07D513/08
    • In alternative embodiments, the invention provides apratoxin F and apratoxin G compounds, which include apratoxin F and apratoxin G stereoisomers, derivatives and analogs compositions and methods. In alternative embodiments, the invention provides pharmaceutical compositions and formulations comprising apratoxin F (compound 6 of Figure 1) and apratoxin G (compound 7 of Figure 1) and their stereoisomers, derivatives and analogs. In alternative embodiments, pharmaceutical compositions and formulations of the invention are administered in an amount sufficient to treat, prevent and/or ameliorate a disease or condition that can be ameliorated by decreasing or inhibiting cell growth, e.g., pathological, uncontrolled or unwanted cell growth, e.g., a cancer or a metastases, or any disease or condition (e.g., allergy) or infection having a hyperproliferative cell growth component.
    • 在替代实施方案中,本发明提供了包括阿曲毒素F和阿曲毒素G立体异构体,衍生物和类似物组合物和方法的阿曲毒素F和阿曲毒素G化合物。 在替代实施方案中,本发明提供了药物组合物和制剂,其包含阿曲毒素F(图1的化合物6)和阿曲毒素G(图1的化合物7)及其立体异构体,衍生物和类似物。 在替代实施方案中,本发明的药物组合物和制剂以足以治疗,预防和/或改善可通过减少或抑制细胞生长而改善的疾病或病症的量施用,例如病理学,不受控制或不期望的细胞生长, 例如癌症或转移瘤,或任何疾病或病症(例如过敏)或具有过度增殖细胞生长成分的感染。
    • 2. 发明申请
    • COMPOSITIONS FOR AMELIORATING CELL PROLIFERATIVE DISORDERS AND METHODS OF MAKING AND USING THEM
    • 用于改善细胞增殖性疾病的组合物及其制备和使用它们的方法
    • WO2011112893A3
    • 2012-03-15
    • PCT/US2011028029
    • 2011-03-11
    • UNIV CALIFORNIAGERWICK WILLIAM HTIDGEWELL KEVINVALERIOTE FRED
    • GERWICK WILLIAM HTIDGEWELL KEVINVALERIOTE FRED
    • A61K31/427A61K9/08A61K9/20A61K31/426A61P25/00A61P29/00
    • C07D513/18C07D513/08
    • In alternative embodiments, the invention provides apratoxin F and apratoxin G compounds, which include apratoxin F and apratoxin G stereoisomers, derivatives and analogs compositions and methods. In alternative embodiments, the invention provides pharmaceutical compositions and formulations comprising apratoxin F (compound 6 of Figure 1) and apratoxin G (compound 7 of Figure 1) and their stereoisomers, derivatives and analogs. In alternative embodiments, pharmaceutical compositions and formulations of the invention are administered in an amount sufficient to treat, prevent and/or ameliorate a disease or condition that can be ameliorated by decreasing or inhibiting cell growth, e.g., pathological, uncontrolled or unwanted cell growth, e.g., a cancer or a metastases, or any disease or condition (e.g., allergy) or infection having a hyperproliferative cell growth component.
    • 在替代实施方案中,本发明提供了包括阿曲毒素F和阿曲毒素G立体异构体,衍生物和类似物组合物和方法的阿曲毒素F和阿曲毒素G化合物。 在替代实施方案中,本发明提供药物组合物和制剂,其包含阿曲马毒素F(图1的化合物6)和阿曲毒素G(图1的化合物7)及其立体异构体,衍生物和类似物。 在替代实施方案中,本发明的药物组合物和制剂以足以治疗,预防和/或改善可以通过减少或抑制细胞生长(例如病理,不受控制或不期望的细胞生长)而改善的疾病或病症的量施用, 例如癌症或转移瘤,或任何疾病或病症(例如过敏)或具有过度增殖细胞生长成分的感染。