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1. 发明申请

WO2009059023A2 PREPARATION OF PRECISELY CONTROLLED THIN FILM NANOCOMPOSITE OF CARBON NANOTUBES AND BIOMATERIALS 审中-公开
标题翻译：碳纳米管和生物材料的精细控制薄膜纳米复合材料的制备
公开(公告)号：WO2009059023A2
公开(公告)日：2009-05-07
申请号：PCT/US2008081819
申请日：2008-10-30
申请人： UNIV AUBURN , DAVIS VIRGINIA A , SIMONIAN ALEKSANDR L , NEPAL DHRITI , BALASUBRAMANIAN SHANKAR
发明人： DAVIS VIRGINIA A , SIMONIAN ALEKSANDR L , NEPAL DHRITI , BALASUBRAMANIAN SHANKAR
CPC分类号： B82Y5/00 , A01N37/46 , A01N57/16 , Y10T428/265 , A01N25/10 , A01N25/34 , A01N2300/00
摘要： Disclosed are nanocomposite materials comprising multiple layers of biomolecules bound to aligned carbon nanotubes. The thickness of each of the layers may be precisely controlled using a layer-by-layer assembly technique.
摘要翻译：公开了纳米复合材料，其包含结合到对准的碳纳米管的多层生物分子。可以使用逐层组装技术来精确地控制每个层的厚度。

2. 发明申请

WO02061126A3 THE PREPARATION OF POLYNUCLEOTIDE ARRAYS 审中-公开
标题翻译：多核苷酸阵列的制备
公开(公告)号：WO02061126A3
公开(公告)日：2003-02-06
申请号：PCT/GB0200438
申请日：2002-01-30
申请人： SOLEXA LTD , BARNES COLIN , BALASUBRAMANIAN SHANKAR , KLENERMAN DAVID , OSBORNE MARK ALLEN
发明人： BARNES COLIN , BALASUBRAMANIAN SHANKAR , KLENERMAN DAVID , OSBORNE MARK ALLEN
IPC分类号： G01N33/53 , B01J19/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B40/06 , G01N33/566 , G01N37/00
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00497 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , C12Q2525/301 , C40B40/06 , C12Q2565/507 , C12Q2565/107 , C12Q2525/197 , C12Q2565/619
摘要： A device comprising an array of molecules immobilised on a solid surface is disclosed, wherein the array has a high density of relatively short molecules and relatively long polynucleotides immobilised on the surface of a solid support, wherein the polynucleotides are at a density that permits individual resolution of those parts thereof that extend beyond the relatively short molecules.
摘要翻译：公开了一种包含固定在固体表面上的分子阵列的装置，其中所述阵列具有固定在固体支持物表面上的相对较短分子的高密度和相对长的多核苷酸，其中所述多核苷酸处于允许单独分辨的密度的那些部分延伸超过相对短的分子。

3. 发明申请

WO2012106384A3 NANO/MICROSCALE VEHICLES FOR CAPTURE AND ISOLATION OF TARGET BIOMOLECULES AND LIVING ORGANISMS 审中-公开
标题翻译：用于捕获和分离靶生物分子和生命体的纳米/微米级车辆
公开(公告)号：WO2012106384A3
公开(公告)日：2012-11-08
申请号：PCT/US2012023410
申请日：2012-01-31
申请人： UNIV CALIFORNIA , WANG JOSEPH , BALASUBRAMANIAN SHANKAR , KAGAN DANIEL , CAMPUZANO-RUIZ SUSANA
发明人： WANG JOSEPH , BALASUBRAMANIAN SHANKAR , KAGAN DANIEL , CAMPUZANO-RUIZ SUSANA
IPC分类号： G01N33/53 , C12Q1/68 , G01N33/543
CPC分类号： C12Q1/6806 , B01D15/3885 , B01J20/22 , B01J20/32 , B01J2220/4812 , C12M1/268 , C12Q1/6834 , G01N1/10 , G01N33/54313 , G01N33/5436 , G01N33/54393 , G01N33/544
摘要： Techniques, systems, devices and materials are disclosed for capturing, isolating and transporting target biomolecules and living organisms. In one aspect, a device includes a tube structured to include a large opening and a small opening that are on opposite ends of the tube, and a tube body connecting the openings and having a cross section spatially reducing in size from the large opening to the small opening, in which the tube includes a layered wall including an inner layer having a catalyst material that is reactive with a fuel fluid to produce bubbles exiting the tube from the large opening to propel the tube to move in the fuel fluid and an external layer formed of a material capable of being functionalized, and a molecular layer functionalized onto the external layer of the tube and structured to attach to a targeted molecule in the fuel fluid.
摘要翻译：公开了捕获，分离和运输目标生物分子和活生物体的技术，系统，装置和材料。在一个方面，一种装置包括管，所述管构造成包括在所述管的相对端部上的大开口和小开口以及连接所述开口并且具有从所述大开口到所述大开口在空间上尺寸减小的横截面的管体小开口，其中管包括分层壁，所述分层壁包括具有催化剂材料的内层，所述催化剂材料与燃料流体反应以产生从所述大开口离开所述管的气泡以推动所述管在所述燃料流体中移动，并且外层由能够官能化的材料形成，以及分子层功能化到管的外层上并构造成附着到燃料流体中的目标分子。

4. 发明申请

WO2011031463A3 NANOMOTOR-BASED PATTERNING OF SURFACE MICROSTRUCTURES 审中-公开
标题翻译：基于纳米电极的表面微结构的图案
公开(公告)号：WO2011031463A3
公开(公告)日：2011-08-04
申请号：PCT/US2010046558
申请日：2010-08-24
申请人： UNIV CALIFORNIA , WANG JOSEPH , MANESH KALAYIL MANIAN , BALASUBRAMANIAN SHANKAR
发明人： WANG JOSEPH , MANESH KALAYIL MANIAN , BALASUBRAMANIAN SHANKAR
IPC分类号： B82B3/00 , B82B1/00
CPC分类号： B82B3/00 , B05D1/18 , B05D3/10 , B05D3/107 , B05D5/00 , B05D2202/00 , B05D2350/60 , B05D2401/00 , B82Y30/00 , B82Y40/00
摘要： Among other things, methods, systems and apparatus are described for implementing nanomotor-based micro- and nanofabrication. In one aspect, a method of fabricating nanoobjects comprises functionalizing a nanomotor with a reagent. The method also includes controlling a movement of the functionalized nanomotor in a solution containing material to react with the reagent to induce a localized deposition or precipitation of a product onto a surface of a substrate or etching of the substrate.
摘要翻译：其中，描述了用于实现基于纳米电机的微和纳米制造的方法，系统和装置。在一个方面，制造纳米对象的方法包括用试剂官能化纳米电动机。该方法还包括控制官能化纳米电动机在含有材料的溶液中与所述试剂反应以使产物局部沉积或沉淀到衬底的表面上或蚀刻衬底的运动。

5. 发明申请

WO02061127A3 ARRAYED POLYNUCLEOTIDES AND THEIR USE IN GENOME ANALYSIS 审中-公开
标题翻译：阵列多核苷酸及其在基因组分析中的应用
公开(公告)号：WO02061127A3
公开(公告)日：2003-07-24
申请号：PCT/GB0200439
申请日：2002-01-30
申请人： SOLEXA LTD , BARNES COLIN , BALASUBRAMANIAN SHANKAR , KLENERMAN DAVID
发明人： BARNES COLIN , BALASUBRAMANIAN SHANKAR , KLENERMAN DAVID
IPC分类号： G01N33/53 , B01J19/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B40/06 , G01N33/566 , G01N37/00
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00497 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , C12Q2525/301 , C40B40/06 , C12Q2565/507 , C12Q2565/107 , C12Q2525/197 , C12Q2565/619
摘要： A method for determining a single nucleotide polymorphism present in a genome, comprises the steps of: (i) immobilising fragments of said genome onto the surface of a solid support to form an array of polynucleotide molecules capable of interrogation, wherein the array allows the molecules to be individually resolved by optical microscopy, and wherein each molecule is immobilised by covalent bonding to the surface, other than at part of each molecule that can be interrogated; (ii) identifying nucleotides at selected positions in the genome; and (iii) comparing the results of step (ii) with a known consensus sequence, and identifying any differences between the consensus sequence and said genome.
摘要翻译：确定存在于基因组中的单核苷酸多态性的方法包括以下步骤：（i）将所述基因组的片段固定在固体支持物的表面上以形成能够询问的多核苷酸分子阵列，其中该阵列允许分子通过光学显微镜单独解析，并且其中每个分子通过共价键合固定在表面上，而不是每个可被询问的分子的部分; （ii）鉴定基因组中选定位置的核苷酸; 和（iii）将步骤（ii）的结果与已知的共有序列比较，并鉴定共有序列和所述基因组之间的任何差异。

6. 发明申请

WO2011120048A3 NANOMOTORS AND MOTION-BASED DETECTION OF BIOMOLECULAR INTERACTIONS 审中-公开
标题翻译： NANOMOTORS和基于运动的生物分子相互作用的检测
公开(公告)号：WO2011120048A3
公开(公告)日：2012-02-23
申请号：PCT/US2011030211
申请日：2011-03-28
申请人： UNIV CALIFORNIA , WANG JOSEPH , WU JIE , BALASUBRAMANIAN SHANKAR , KAGAN DANIEL , MANESH KAKAYIL MANIAN
发明人： WANG JOSEPH , WU JIE , BALASUBRAMANIAN SHANKAR , KAGAN DANIEL , MANESH KAKAYIL MANIAN
IPC分类号： G01N33/53 , C12Q1/68 , G01N33/58
CPC分类号： C12Q1/6886 , B82Y15/00 , C07K17/14 , C12N15/115 , C12Q1/6816 , G01N33/557 , G01N33/558 , G01N33/587 , Y10S977/726 , Y10S977/773 , Y10S977/92 , C12Q2563/113 , C12Q2563/155
摘要： Techniques and systems are disclosed for detecting biomolecular interactions based on the motion of nanomotors. In one aspect, a method of detecting biomolecular interactions based on a motion of a nanomachine includes functionalizing a nanomachine with a capture probe adapted to interact with biological targets; and detecting a presence of the biological targets in an environment based on a motion of the nanomachine.
摘要翻译：公开了用于基于纳米电动机的运动来检测生物分子相互作用的技术和系统。在一个方面，基于纳米机械的运动来检测生物分子相互作用的方法包括用适于与生物靶相互作用的捕获探针对纳米机械进行功能化; 以及基于所述纳米机械的运动在环境中检测所述生物学目标的存在。

7. 发明申请

WO0123610A3 POLYNUCLEOTIDE SEQUENCING 审中-公开
标题翻译：多核苷酸序列
公开(公告)号：WO0123610A3
公开(公告)日：2001-10-11
申请号：PCT/GB0003734
申请日：2000-09-29
申请人： SOLEXA LTD , BALASUBRAMANIAN SHANKAR
发明人： BALASUBRAMANIAN SHANKAR
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q1/6823 , C12Q2521/319
摘要： A method for sequencing polynucleotides involves sequential addition of detectably labelled bases. A labelled base is incorporated by a polymerase onto a nascent strand, and, after detection, the polymerase is induced to replace the terminal labelled base with a corresponding unlabelled base, thereby permitting further sequencing to occur. The exonuclease activity of many polymerase enzymes is used, to remove the terminal base.
摘要翻译：用于测序多核苷酸的方法涉及顺序添加可检测地标记的碱基。标记的碱基通过聚合酶掺入到新生链上，并且在检测后，诱导聚合酶用相应的未标记的碱替代末端标记的碱基，从而允许进一步测序。使用许多聚合酶的外切核酸酶活性来除去末端碱基。

8. 发明申请

WO9848048A2 DNA MUTATION MAPPING BY MULTIPLE ENERGY TRANSFER INTERACTIONS 审中-公开
标题翻译：通过多种能量转移相互作用的DNA复制映射
公开(公告)号：WO9848048A2
公开(公告)日：1998-10-29
申请号：PCT/GB9801138
申请日：1998-04-20
申请人： UNIV CAMBRIDGE TECH , BALASUBRAMANIAN SHANKAR
发明人： BALASUBRAMANIAN SHANKAR
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6818
摘要： A method for determining the presence and location of a mismatch in a target sequence using Fluorescence Resonance Energy Transfer (FRET). The method comprises contacting the target sequence with at least three labelled oligonucleotide probes capable of hybridising to the natural sequence, in juxtaposition. The central probe is labelled with a donor fluorophore and the probe either side of this is labelled with a distinct acceptor fluorophore. Hybridisation to the target sequence results in resonance between the donor fluorophore and the acceptor fluorophores. A mismatch present in the target sequence will disrupt hybridisation to that region, resulting in a significant alteration to the resonance signal.
摘要翻译：使用荧光共振能量转移（FRET）确定目标序列失配的存在和位置的方法。该方法包括使目标序列与能与天然序列杂交的至少三个标记的寡核苷酸探针并列并入。中心探针用供体荧光团标记，其两侧的探针用不同的受体荧光团标记。与靶序列的杂交导致供体荧光团和受体荧光团之间的共振。靶序列中存在的失配将破坏与该区域的杂交，导致对共振信号的显着改变。

9. 发明申请

WO2013017853A3 METHODS FOR DETECTION OF NUCLEOTIDE MODIFICATION 审中-公开
标题翻译：检测核苷酸修饰的方法
公开(公告)号：WO2013017853A3
公开(公告)日：2013-04-18
申请号：PCT/GB2012051819
申请日：2012-07-27
申请人： CAMBRIDGE EPIGENETIX LTD , BOOTH MICHAEL JOHN , BALASUBRAMANIAN SHANKAR
发明人： BOOTH MICHAEL JOHN , BALASUBRAMANIAN SHANKAR
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C01G55/002 , C07H1/00 , C07H21/02 , C07H21/04 , C12Q1/6806 , C12Q1/6827 , C12Q2600/154 , C12Q2523/115 , C12Q2523/125
摘要： This invention relates to the identification of modified cytosine residues, such as 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC) to be distinguished from cytosine (C) in a sample nucleotide sequence. Methods may comprise oxidising or reducing a first portion of polynucleotides which comprise the sample nucleotide sequence; treating the oxidised or reduced first portion and a second portion of polynucleotides with bisulfite; sequencing the polynucleotides in the first and second portions of the population following steps ii) and iii) to produce first and second nucleotide sequences, respectively and; identifying the residue in the first and second nucleotide sequences which corresponds to a cytosine residue in the sample nucleotide sequence. These methods may be useful, for example in the analysis of genomic DNA and/or of RNA.
摘要翻译：本发明涉及在样品核苷酸序列中鉴定与胞嘧啶（C）区别的修饰胞嘧啶残基，例如5-甲基胞嘧啶（5mC），5-羟甲基胞嘧啶（5hmC）和5-甲酰胞嘧啶（5fC）。方法可以包括氧化或还原包含样品核苷酸序列的第一部分多核苷酸; 用亚硫酸氢盐处理氧化或还原的第一部分和第二部分多核苷酸; 在步骤ii）和iii）之后对群体的第一和第二部分中的多核苷酸进行测序以分别产生第一和第二核苷酸序列; 鉴定第一和第二核苷酸序列中对应于样品核苷酸序列中胞嘧啶残基的残基。这些方法可能是有用的，例如在分析基因组DNA和/或RNA时。

10. 发明申请

WO03048387A3 LABELLED NUCLEOTIDES 审中-公开
标题翻译：标签核心
公开(公告)号：WO03048387A3
公开(公告)日：2003-10-16
申请号：PCT/GB0205474
申请日：2002-12-04
申请人： SOLEXA LTD , BALASUBRAMANIAN SHANKAR , BARNES COLIN , LIU XIAOHAI , SWERDLOW HAROLD
发明人： BALASUBRAMANIAN SHANKAR , BARNES COLIN , LIU XIAOHAI , SWERDLOW HAROLD
IPC分类号： G01N33/53 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H21/04 , C12N15/09 , G01N33/533 , G01N33/566 , C12Q1/68
CPC分类号： C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12Q1/6869 , C12Q2525/186 , C12Q2535/113 , C12Q2525/197
摘要： Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
摘要翻译：公开了通过可切割连接基团与可检测标记物连接的核苷和核苷酸。

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