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1. 发明申请

WO1992001226A1 ANALYTICAL TEST DEVICE FOR SPECIFIC BINDING ASSAYS 审中-公开
标题翻译：用于特定绑定测试的分析测试装置
公开(公告)号：WO1992001226A1
公开(公告)日：1992-01-23
申请号：PCT/GB1991001079
申请日：1991-07-03
申请人： UNILEVER PLC , UNILEVER NV , CARR, Anthony, Hugh , MAY, Keith , MUNDILL, Paul, Henry, Charles , PRIOR, Michael, Evans
发明人： UNILEVER PLC , UNILEVER NV
IPC分类号： G01N33/558
CPC分类号： G01N33/558 , G01N33/525 , G01N33/54386
摘要： An analytical test device incorporates a porous membrane or filter through which an aqueous liquid must flow during the test, and a body comprising a microporous material of higher capillary suction force than the membrane or filter, in liquid-conductive contact with the membrane or filter, which acts as a "sink" to control the liquid flow path through the membrane or filter. Preferably the body comprises a clay or a molecular sieve material.
摘要翻译：分析测试装置包括多孔膜或过滤器，在测试期间水性液体必须通过该多孔膜或过滤器，并且包含与膜或过滤器的液体导电接触的具有比膜或过滤器更高的毛细吸力的微孔材料的主体，其作为“下沉”来控制通过膜或过滤器的液体流动路径。优选地，主体包括粘土或分子筛材料。

2. 发明申请

WO1990009592A1 SOLID-PHASE ANALYTICAL DEVICE 审中-公开
标题翻译：固相分析装置
公开(公告)号：WO1990009592A1
公开(公告)日：1990-08-23
申请号：PCT/GB1990000254
申请日：1990-02-16
申请人： UNILEVER PLC , UNILEVER NV , DAVIS, Paul, James , PRIOR, Michael, Evans , MAY, Keith
发明人： UNILEVER PLC , UNILEVER NV
IPC分类号： G01N33/558
CPC分类号： G01N33/558 , G01N33/76
摘要： An analytical test device incorporating a dry porous carrier to which a liquid sample, eg. urine, suspected of containing an analyte such as HCG or LH can be applied indirectly, the device also incorporating a labelled specific binding reagent which is freely mobile in the porous carrier when in the moist state, and an unlabelled specific binding reagent which is permanently immobilised in a detection zone on the carrier material, the labelled and unlabelled specific binding reagents being capable of participating in either a sandwich reaction or a competition reaction in the presente of the analyte, in which prior to the application to the device of a liquid sample suspected of containing the analyte, the labelled specific binding reagent is retained in the dry state in a macroporous body, e.g. of plastics material having a pore size of 10 microns or greater, through which the applied liquid sample must pass en route to the porous carrier material, the labelled specific binding reagent being freely soluble or dispersible in any liquid sample which enters the macroporous body.

3. 发明申请

WO1989003992A1 DEVICES AND METHODS FOR CHEMICAL TESTING 审中-公开
标题翻译：用于化学测试的装置和方法
公开(公告)号：WO1989003992A1
公开(公告)日：1989-05-05
申请号：PCT/GB1988000929
申请日：1988-10-28
申请人： UNILEVER PLC , UNILEVER NV , MAY, Keith , PRIOR, Michael, Evans
发明人： UNILEVER PLC , UNILEVER NV
IPC分类号： G01N33/52
CPC分类号： G01N33/54386 , G01N33/558
摘要： A chromatographic test device for detecting the presence of an analyte in a liquid sample and incorporating at least two liquid-conductive zones (3, 4) which form separate liquid flow paths which deliver separate liquid streams to a region (8) in the test device during the test procedure, wherein control of the relative liquid flows in the separate flow paths is achieved, at least in part, by ensuring that at least one of the liquid flow paths is enhanced or made and/or broken or restricted during the course of the test procedure. Preferably such control is achieved by incorporating a liquid-swellable material (11) which is arranged to swell by contact with liquid sample and/or reagent and thereby to make or break contact between two liquid-conductive zones.

4. 发明申请

WO1988008534A1 IMMUNOASSAYS AND DEVICES THEREFOR 审中-公开
标题翻译：免疫功能及其设备
公开(公告)号：WO1988008534A1
公开(公告)日：1988-11-03
申请号：PCT/GB1988000322
申请日：1988-04-26
申请人： UNILEVER PLC , UNILEVER NV , MAY, Keith , PRIOR, Michael, Evans , RICHARDS, Ian
发明人： UNILEVER PLC , UNILEVER NV
IPC分类号： G01N33/543
CPC分类号： G01N33/54366 , G01N30/90 , G01N33/54386 , G01N33/548 , G01N33/549 , G01N33/558 , G01N33/58 , G01N33/689 , G01N33/76 , G01N2800/368 , Y10S435/805 , Y10S435/81 , Y10S435/962 , Y10S435/969 , Y10S435/97 , Y10S435/975 , Y10S436/805 , Y10S436/81 , Y10S436/814 , Y10S436/817 , Y10S436/818 , Y10S436/906
摘要： An analytical test device useful for example in pregnancy testing, comprises a hollow casing (500) constructed of moisture-impervious solid material, such as plastics materials, containing a dry porous carrier (510) which communicates indirectly with the exterior of the casing via a bibulous sample receiving member (506) which protudes from the casing such that a liquid test sample can be applied to the receiving member and permeate therefrom to the porous carrier, the carrier containing in a first zone a labelled specific binding reagent is freely mobile within the porous carrier when in the moist state, and in a second zone spatially distinct from the first zone unlabelled specific binding reagent for the same analyte which unlabelled reagent is permanently immobilised on the carrier material and is therefore not mobile in the moist state, the two zones being arranged such that liquid sample applied to the porous carrier can permeate via the first zone into the second zone, and the device incorporating means, such as an aperture (508) in the casing, enabling the extent (if any) to whichthe labelled reagent becomes bound in the second zone to be observed. Preferably the device includes a removable cap for the protruding bibulous member.

5. 发明申请

WO1991001005A1 DETECTABLE PARTICLES 审中-公开
标题翻译：可检测颗粒
公开(公告)号：WO1991001005A1
公开(公告)日：1991-01-24
申请号：PCT/GB1990001039
申请日：1990-07-05
申请人： UNILEVER PLC , UNILEVER NV , BOSLEY, John, Anthony , DAVIDSON, Ian, William , MUNDILL, Paul, Henry, Charles , RICHARDS, Ian
发明人： UNILEVER PLC , UNILEVER NV
IPC分类号： G01N33/58
CPC分类号： G01N33/585
摘要： A reagent useful in immunoassays and the like comprises micro particles of latex (polystyrene) containing therein a water-insoluble fluorophore such as a laser dye, with the fluorophore being essentially absent from the particle surfaces. The particles can be sensitised with specific binding reagents such as antibodies. The fluorophore-containing particles exhibit constant fluorescent yield, and provide improved labels useful in sensitive quantitative assays.

6. 发明申请

WO1990012648A1 CONTAINER 审中-公开
标题翻译：集装箱
公开(公告)号：WO1990012648A1
公开(公告)日：1990-11-01
申请号：PCT/GB1990000569
申请日：1990-04-12
申请人： UNILEVER PLC , UNILEVER NV , CARR, Anthony, Hugh , DARNELL, Paul, Richard , DAVIDSON, Ian, William
发明人： UNILEVER PLC , UNILEVER NV
IPC分类号： B01L03/14
CPC分类号： B01L3/50825
摘要： A container or vessel useful in the preparation of bacterial extracts or similar analytical samples, constructed of resilient flexible plastics material and having a releasably engageable cap (3) incorporating a nozzle (8) through which liquid contents of the container may be expressed by squeezing the container, the cap being linked to the container by a double hinge comprising two strips (14a, 14b) of material which fold back upon themselves when the container is closed by the cap, the apices (18a, 18b) of the folded hinge strips together providing contact points upon which the capped end of the container may be rested on a horizontal surface such as a work bench.
摘要翻译：一种用于制备细菌提取物或类似分析样品的容器或容器，由挠性且有弹性的塑料材料制成，并具有结合有喷嘴（8）的可释放地接合的盖子（3），通过该盖子容器的液体含量可以通过容器的压缩来表示，盖子通过双铰链连接到容器，该双铰链具有当容器被盖关闭时自身折叠的两个材料条（14a，14b），顶点（18a，18b）将铰接条折叠在一起，提供接触点，容器的被覆盖的端部可以作为工作台搁置在水平表面上。

7. 发明申请

WO1984003303A1 MICROBIOLOGICAL TEST PROCESSES AND APPARATUS 审中-公开
标题翻译：微生物测试过程和设备
公开(公告)号：WO1984003303A1
公开(公告)日：1984-08-30
申请号：PCT/GB1984000060
申请日：1984-02-27
申请人： UNILEVER PLC , UNILEVER NV , CARR, Anthony, Hugh , JOBLING, Ian
发明人： UNILEVER PLC , UNILEVER NV
IPC分类号： C12Q01/04
CPC分类号： C12Q1/34 , C12Q1/04 , C12Q1/18 , C12Q2334/22 , C12Q2337/22 , G01N2415/00
摘要： Microbiological test processes and apparatus for identifying producers of penicillinase, in which a container for test incubation of a microorganism culture suspension with a cell density about 108 per ml is provided with penicillin, poor buffering and a fluorescent indicator, e.g. a coumarin such as 4-methyl-umbelliferone, in quantity sufficient to descriminate penicillinase producers and non-producers after incubation times over about one hour, e.g. up to 18 hours. The test can then be conveniently combined with antibiotic sensitivity testing, e.g. in different microtitre wells of the same microtitre plate.

8. 发明申请

WO1985005687A1 METHODS AND APPARATUS FOR CARRYING OUT CLINICAL, CHEMICAL AND BIOLOGICAL TESTING 审中-公开
标题翻译：进行临床，化学和生物试验的方法和装置
公开(公告)号：WO1985005687A1
公开(公告)日：1985-12-19
申请号：PCT/GB1985000239
申请日：1985-06-05
申请人： UNILEVER PLC , UNILEVER NV , PRIOR, Michael, Evans , DAWES, Clive, Christopher
发明人： UNILEVER PLC , UNILEVER NV
IPC分类号： G01N33/53
CPC分类号： G01N33/5304 , G01N33/54366
摘要： A method for carrying out a clinical, chemical or biological test, in which a macro-solid phase adsorbent test material is contacted with a sample and later washed or treated with a washing liquid, characterized in that the washing or reagent liquid treatment is carried out by (a) inserting the macro-solid phase test material into an apertured container in which there is located a compressible resilient porous liquid-retaining solid which contains washing or reagent liquid, (b) compressing the porous solid while the test material is in its inserted position to the extent necessary to wash or treat the surface of the test material, (c) releasing the compression to allow the porous solid to reabsorb substantially all the washing or treatment liquid, and (d) removing the washed or treated test solid substantially free of the washing or treatment liquid.

9. 发明申请

WO1982002818A1 A PROCESS AND APPARATUS FOR THE RECOVERY OF IMMUNOGLOBULINS 审中-公开
标题翻译：一种恢复免疫球蛋白的方法和装置
公开(公告)号：WO1982002818A1
公开(公告)日：1982-09-02
申请号：PCT/GB1982000060
申请日：1982-02-24
申请人： UNILEVER PLC , UNILEVER NV , GANI MOHAMED MUTWAHAR , MAY KEITH , PORTER PHILIP
发明人： UNILEVER PLC , UNILEVER NV
IPC分类号： A23J01/20
CPC分类号： A23C9/148 , A23J1/06 , A23J1/20 , B01J20/3092 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3274 , B01J2220/58 , C07K16/04 , C07K16/065 , C07K16/4283 , Y10S435/948 , Y10S530/808 , Y10S530/809 , Y10S530/83 , Y10S530/832
摘要： Procede et dispositif d'extraction d'immunoglobulines d'une purete et d'une efficacite elevees a partir du lait, dans lequel on fait passer le lait au travers d'une colonne immuno-adsorbante reutilisable comprenant un materiau de support insoluble auquel est lie un anticorps monoclonique a faible affinite specifique a une ou plusieurs immunoglobulines du lait sans etre specifiques a d'autres constituants comme du lait, l'anticorps lie les molecules d'immunoglobulines et apres l'extraction du residu du lait les molecules d'immunoglobulines sont liberees en eluant l'immuno-adsorbant. Le dispositif comprend de preference deux ou plusieurs colonnes immuno-adsorbantes disposees en parallele (206, 207), avec des moyens permettant d'eluer (226) chaque colonne et des moyens permettant de rincer (217) chaque colonne avant et apres l'elution.
摘要翻译： PCT No.PCT / GB82 / 00060 Sec。 371日期1982年9月22日 102（e）1982年9月22日PCT PCT 1982年2月24日PCT公布。出版物WO82 / 02818 日本1982年9月2日。一种用于从牛奶中回收高纯度和效力的免疫球蛋白的方法，其中使奶通过可重复使用的免疫吸附柱，其包含结合低亲和力单克隆抗体的不溶性载体材料特异于一种或多种牛奶免疫球蛋白，但不与乳的任何其它常见组分特异性，通过洗脱免疫吸附剂释放抗体结合免疫球蛋白分子。

10. 发明申请

WO1994002238A1 MAGNETIC STIRRING SYSTEM 审中-公开
标题翻译：磁力搅拌系统
公开(公告)号：WO1994002238A1
公开(公告)日：1994-02-03
申请号：PCT/GB1993001479
申请日：1993-07-14
申请人： UNILEVER PLC , UNILEVER N.V. , CARR, Anthony, Hugh
发明人： UNILEVER PLC , UNILEVER N.V.
IPC分类号： B01F13/08
CPC分类号： B01F13/0818
摘要： A magnetic stirrer wherein a relatively weakly magnetised disposable stirrer bar (14) inside a closed container (10), for example a stirrer bar moulded wholly of non-isotropic ferrite, is moved with a stirring action from outside the container by a relatively powerful magnetic driver (16), preferably consisting of a pair of permanent magnets (18, 20) of neodymium boron driven in rotation as an assembly.
摘要翻译：一种磁力搅拌器，其中在密封容器（10）内的相对弱磁化的一次性搅拌棒（14），例如完全由非各向同性铁素体成型的搅拌棒，通过相对强力的磁力从容器外部以搅拌作用移动驱动器（16），优选地由作为组件旋转驱动的钕硼的一对永磁体（18,20）组成。

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