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    • 5. 发明申请
    • MESH POUCHES FOR IMPLANTABLE MEDICAL DEVICES
    • WO2008127411A1
    • 2008-10-23
    • PCT/US2007/083843
    • 2007-11-06
    • TYRX PHARMA, INC.BUEVICH, FatimaMOSES, ArikhaDO, FrankMCJAMES, WilliamEDELMAN, WillamDIAMOND, MasonPULAPURA, SatishTIMOTHY, Shari
    • BUEVICH, FatimaMOSES, ArikhaDO, FrankMCJAMES, WilliamEDELMAN, WillamDIAMOND, MasonPULAPURA, SatishTIMOTHY, Shari
    • A61B19/00
    • A61F2/0063A61F2210/0004A61L31/048A61L31/10A61L31/146A61L31/16A61L2300/00A61N1/375A61N1/3968C08L23/12C08L67/04
    • Biodegradable polymer-coated surgical meshes formed into pouches are described for use with cardiac rhythm management devices (CRMs) and other implantable medical devices. Such meshes are formed into a receptacle, e.g., a pouch or other covering, capable of encasing, surrounding and/or holding the cardiac rhythm management device or other implantable medical device for the purpose of securing it in position, inhibiting or reducing bacterial growth, providing pain relief and/or inhibiting scarring or fibrosis on or around the CRM or other implantable medical device. Preferred embodiments include surgical mesh pouches coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The pouches of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use, and, optionally, include one or more drugs in the polymer matrix of the coating to provide prophylactic effects and/or alleviate side effects or complications associated with the surgery or implantation of the CRM or other implantable medical device.
    • 描述形成袋的可生物降解的聚合物涂覆的手术网与心律管理装置(CRM)和其他可植入医疗装置一起使用。 这样的网状物形成为能够包围,围绕和/或保持心律管理装置或其它可植入医疗装置的容器,例如袋或其它覆盖物,以确保其在适当位置,抑制或减少细菌生长, 在CRM或其他可植入医疗设备上或周围提供疼痛缓解和/或抑制瘢痕形成或纤维化。 优选的实施方案包括涂覆有一种或多种可生物降解的聚合物的手术网袋,其可以通过涂覆网的细丝或纤维来暂时固定那些丝或纤维的接触点和/或通过增加网的刚度而充当硬化剂 至少是其原始刚度的1.1倍。 本发明的小袋还可以缓解与其植入,插入或手术使用相关的各种术后并发症,并且任选地在包衣的聚合物基质中包括一种或多种药物以提供预防效果和/或缓解侧 与手术或植入CRM或其他可植入医疗器械相关的影响或并发症。