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1. 发明申请

WO2017087684A1 RELIABILITY ASSESSABLE SYSTEMS FOR ACTUATING HYDRAULICALLY ACTUATED DEVICES AND RELATED METHODS 审中-公开
标题翻译：用于致动液压致动装置的可靠性评估系统及相关方法
公开(公告)号：WO2017087684A1
公开(公告)日：2017-05-26
申请号：PCT/US2016/062551
申请日：2016-11-17
申请人： TRANSOCEAN INNOVATION LABS LTD , LEACH, Andrew , BOIKE, Matthew , FAIRFAX, Stephen
发明人： LEACH, Andrew , BOIKE, Matthew , FAIRFAX, Stephen
IPC分类号： F15B1/033 , E21B33/03 , E21B33/035 , E21B33/038 , E21B33/064 , F15B1/00
CPC分类号： E21B33/0355 , E21B33/064 , F15B1/033 , F15B1/04 , F15B11/08 , F15B2201/411 , F15B2201/51 , F15B2211/205
摘要： Some of the present systems include a hydraulic power storage system having an accumulator configured to supply pressurized hydraulic fluid to a hydraulically actuated device to actuate the hydraulically actuated device and a drain in fluid communication with the accumulator and including a valve that is actuatable to drain hydraulic fluid from the hydraulic power storage system such that an internal pressure of the accumulator is reduced and a flow restrictor configured to reduce a flow rate of hydraulic fluid through the valve, a hydraulic pump configured to pressurize the accumulator, a pressure sensor configured to capture data indicative of the internal pressure of the accumulator, and a processor configured to actuate the hydraulic pump to increase the internal pressure of the accumulator if the internal pressure of the accumulator, as indicated in data captured by the pressure sensor, falls below a threshold pressure.
摘要翻译：本系统中的一些包括液压动力储存系统，该液压动力储存系统具有配置成向液压致动装置供应加压液压流体以致动液压致动装置的蓄能器以及与蓄能器流体连通并包括可致动以从液压动力储存系统排出液压流体以使得储存器的内部压力降低的阀以及构造成减小通过阀的液压流体的流速的限流器;液压泵，其构造成对储存器，被配置为捕获指示蓄积器的内部压力的数据的压力传感器以及被配置为如果蓄积器的内部压力如由压力捕获的数据所指示的那样致动液压泵以增加蓄积器的内部压力传感器低于阈值压力。

2. 发明申请

WO2018048867A1 SYSTEMS AND METHODS FOR ACTUATING HYDRAULICALLY-ACTUATED DEVICES 审中-公开
公开(公告)号：WO2018048867A1
公开(公告)日：2018-03-15
申请号：PCT/US2017/050227
申请日：2017-09-06
申请人： TRANSOCEAN INNOVATION LABS LTD , LEACH, Andrew , BOIKE, Matthew
发明人： LEACH, Andrew , BOIKE, Matthew
IPC分类号： E21B33/064 , E21B33/06 , E21B34/16 , E21B21/10 , E21B33/0355 , E21B33/038 , E21B33/061 , E21B34/02 , E21B34/085 , F15B1/022 , F15B1/033 , F15B19/005 , F15B20/00 , F15B2013/0409 , F15B2201/411 , F15B2201/51 , F15B2211/205 , F15B2211/212 , F15B2211/30575 , F15B2211/327 , F15B2211/625 , F15B2211/6306 , F15B2211/6309 , F15B2211/6313 , F15B2211/632 , F15B2211/6336 , F15B2211/6343 , F15B2211/857 , F15B2211/87
摘要： This disclosure includes systems and methods for actuating hydraulically-actuated devices.

3. 发明申请

WO2017210308A1 METHODS FOR ASSESSING THE RELIABILITY OF HYDRAULICALLY-ACTUATED DEVICES AND RELATED SYSTEMS 审中-公开
标题翻译：用于评估液压驱动装置和相关系统的可靠性的方法
公开(公告)号：WO2017210308A1
公开(公告)日：2017-12-07
申请号：PCT/US2017/035234
申请日：2017-05-31
申请人： TRANSOCEAN INNOVATION LABS LTD , LEACH, Andrew , PEREIRA, Luis, Rafael , BOIKE, Matthew
发明人： LEACH, Andrew , PEREIRA, Luis, Rafael , BOIKE, Matthew
IPC分类号： F15B19/00 , E21B33/035 , E21B33/06 , E21B33/064 , E21B34/16 , F15B1/033
摘要： This disclosure includes methods for testing hydraulically-actuated devices and related systems. Some hydraulically-actuated devices have a housing defining an interior volume and a piston disposed within the interior volume and dividing the interior volume into a first chamber and a second chamber, where the piston is movable relative to the housing between a maximum first position and a maximum second position in response to pressure differentials between the first and second chambers. Some methods include: (1) moving the piston to the first position by varying pressure within at least one of the first and second chambers such that pressure within the second chamber is higher than pressure within the first chamber; and (2) while the piston remains in the first position: (a) reducing pressure within the second chamber and/or increasing pressure within the first chamber; and (b) increasing pressure within the second chamber and/or decreasing pressure within the first chamber.
摘要翻译：本公开包括用于测试液压致动装置和相关系统的方法。一些液压致动装置具有限定内部容积的壳体和设置在内部容积内并将内部容积分成第一腔室和第二腔室的活塞，其中活塞可相对于壳体在最大第一位置和最大第一位置之间移动响应于第一和第二腔室之间的压差的最大第二位置。一些方法包括：（1）通过改变第一和第二腔室中的至少一个腔室内的压力使活塞移动到第一位置，使得第二腔室内的压力高于第一腔室内的压力; （2）当活塞保持在第一位置时：（a）减小第二室内的压力和/或增加第一室内的压力; 和（b）增加第二室内的压力和/或减小第一室内的压力。

4. 发明申请

WO2011121350A1 4 -AMINO -7,8- DIHYDROPYRIMIDO [5, 4 - F] [1, 4] OXAZEPIN- 5 ( 6H) - ONE BASED DGAT1 INHIBITORS 审中-公开
标题翻译： 4-氨基-7,8-二氢嘧啶并[5,4-F] [1,4]奥沙伯-5（6H） - 一种基于DGAT1的抑制剂
公开(公告)号：WO2011121350A1
公开(公告)日：2011-10-06
申请号：PCT/GB2011/050648
申请日：2011-03-30
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , BIRCH, Alan, Martin , GOLDBERG, Frederick, Woolf , LEACH, Andrew
发明人： BIRCH, Alan, Martin , GOLDBERG, Frederick, Woolf , LEACH, Andrew
IPC分类号： C07D498/04 , A61K31/553 , A61P3/04 , A61P3/10
CPC分类号： C07D498/04
摘要： DGAT-1 inhibitor compounds of formula (I), pharmaceutically-acceptable salts and pro- drugs thereof are described, together with pharmaceutical compositions, processes for making them and their use in treating, for example, diabetes and obesity wherein, R 1 , R 2 , R 3 , R 4 , X 2 , q, Y 1 , Y 2 , n, Q and Z are as defined in the description.
摘要翻译：与药物组合物一起描述式（I）的DGAT-1抑制剂化合物，其药学上可接受的盐和前体药物，其制备方法及其用于治疗例如糖尿病和肥胖症，其中R1，R2， R3，R4，X2，q，Y1，Y2，n，Q和Z如说明书中所定义。

5. 发明申请

WO2009130496A1 SUBSTITUTED PYRIMIDIN-5-CARBOXAMIDES 281 审中-公开
标题翻译：取代的吡咯烷-5-羧酰胺281
公开(公告)号：WO2009130496A1
公开(公告)日：2009-10-29
申请号：PCT/GB2009/050392
申请日：2009-04-20
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , GILL, Adrian, Liam , LEACH, Andrew , PACKER, Martin , SCOTT, James, Stewart , SÖRME, Pernilla , SWALES, John, Gibbin , WHITTAMORE, Paul, Robert, Owen
发明人： GILL, Adrian, Liam , LEACH, Andrew , PACKER, Martin , SCOTT, James, Stewart , SÖRME, Pernilla , SWALES, John, Gibbin , WHITTAMORE, Paul, Robert, Owen
IPC分类号： C07D239/28 , C07D239/38 , C07D239/42 , C07D239/47 , C07D239/48 , C07D239/58 , C07D401/14 , C07D403/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D417/04 , C07D239/557 , A61K31/506 , A61P3/10
CPC分类号： C07D239/42 , C07D239/28 , C07D239/38 , C07D239/47 , C07D239/48 , C07D239/557 , C07D239/58 , C07D401/14 , C07D403/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D417/04
摘要： A compound of formula (I) and pharmaceutically-acceptable salts thereof wherein the variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are also described.
摘要翻译：式（I）化合物及其药学上可接受的盐，其中可变基团定义在其内; 还描述了其在抑制11βHSD1中的用途，其制备方法和包含它们的药物组合物。

6. 发明申请

WO2007085833A2 PYRIMIDINE DERIVATIVES 审中-公开
标题翻译：嘧啶衍生物
公开(公告)号：WO2007085833A2
公开(公告)日：2007-08-02
申请号：PCT/GB2007/000251
申请日：2007-01-25
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , KETTLE, Jason, Grant , READ, Jon , LEACH, Andrew , BARLAAM, Bernard, Christophe , DUCRAY, Richard , LAMBERT-VAN DER BREMPT, Christine, Marie Paul
发明人： KETTLE, Jason, Grant , READ, Jon , LEACH, Andrew , BARLAAM, Bernard, Christophe , DUCRAY, Richard , LAMBERT-VAN DER BREMPT, Christine, Marie Paul
CPC分类号： C07D239/48 , C07D403/12 , C07D405/12 , C07D413/12
摘要： The invention concerns benzamide compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R 1 , ring A, n, R 3 , and R 4 are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to the inhibition of EphB4, and/or EphA2 and/or Src kinases.
摘要翻译：本发明涉及式（I）的苯甲酰胺化合物或其药学上可接受的盐，其中R 1，环A，n，R 3， R 4和R 4如说明书中所定义。本发明还涉及制备这些化合物的方法，含有它们的药物组合物及其在制备用作抗增殖剂的药物中的用途，所述药物用于预防或治疗对抑制敏感的肿瘤或其他增殖性病症 EphB4和/或EphA2和/或Src激酶。

7. 发明申请

WO2017077297A2 A SHOCK ABSORBING HORSESHOE 审中-公开
标题翻译：减震马蹄
公开(公告)号：WO2017077297A2
公开(公告)日：2017-05-11
申请号：PCT/GB2016/053403
申请日：2016-11-02
申请人： LEACH, Andrew
发明人： LEACH, Andrew
IPC分类号： A01L1/00 , A01L5/00 , A01L7/02
CPC分类号： A01L1/00 , A01L5/00 , A01L7/02
摘要： A Shock Absorbing Horseshoe A shock absorbing horseshoe having a shock absorbing layer/zone of lattice form. The size of the walls and/or interstices of the lattice structure can be varied to vary the compressibility of the shock adsorbing layer. The shoe includes a relatively inflexible member that may be metallic. The inflexible member is arranged to sit nearest most the hoof. The shoe may also include a tread layer for contact with the ground, the tread layer and shock absorbing layer being formed from a single integral piece using a 3D printing process. The inflexible member may be formed of two parts positioned on either side of the frog and joined, and possibly inset within a relatively flexible material.
摘要翻译：减震马蹄具有减震层/格子形状区域的减震马蹄。格子结构的壁和/或空隙的尺寸可以变化，以改变震动吸收层的可压缩性。鞋包括可以是金属的相对非柔性构件。柔性构件被布置成最靠近蹄最近坐。鞋还可以包括用于与地面接触的胎面层，胎面层和减震层使用3D印刷工艺由单个整体件形成。非柔性构件可以由位于青蛙两侧的两个部分形成并且可以嵌入相对柔性的材料中。

8. 发明申请

WO2011049520A1 ADAMANTYL IMINOCARBONYL-SUBSTITUTED PYRIMIDINES AS INHIBITORS OF 1 1 BETAHSD1 审中-公开
标题翻译：作为1 1 BETAHSD1的抑制剂的亚氨基羰基取代的吡咯烷
公开(公告)号：WO2011049520A1
公开(公告)日：2011-04-28
申请号：PCT/SE2010/051127
申请日：2010-10-19
申请人： ASTRAZENECA AB , BENNETT, Stuart Norman, Lile , GOLDBERG, Frederick Woolf , LEACH, Andrew , SÖRME, Pernilla , WHITTAMORE, Paul Robert Owen
发明人： BENNETT, Stuart Norman, Lile , GOLDBERG, Frederick Woolf , LEACH, Andrew , SÖRME, Pernilla , WHITTAMORE, Paul Robert Owen
IPC分类号： C07D405/12 , A61K31/505 , A61K31/506 , A61P3/00 , C07D239/42 , C07D401/12 , C07D403/12 , C07D409/12
CPC分类号： C07D405/12 , C07D239/42 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12
摘要： A compound of formula (I): and pharmaceutically acceptable salts thereof wherein the variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are also described.
摘要翻译：式（I）的化合物及其药学上可接受的盐，其中所述可变基团定义在其内; 还描述了其在抑制11βHSD1中的用途，其制备方法和包含它们的药物组合物。

9. 发明申请

WO2011030139A1 4- (PYRIMIDIN-2-YL) -PIPERAZINE AND 4- (PYRIMIDIN-2-YL) -PIPERIDINE DERIVATIVES AS GPR119 MODULATORS 审中-公开
标题翻译： 4-（PYRIMIDIN-2-YL） - 哌嗪和4-（吡咯烷-2-基） - 哌啶衍生物作为GPR119调节剂
公开(公告)号：WO2011030139A1
公开(公告)日：2011-03-17
申请号：PCT/GB2010/051483
申请日：2010-09-07
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , BIRCH, Alan, Martin , BROO, Dan, Anders , BUTLIN, Roger, John , CLARKE, David, Stephen , DAVIDSSON, Ojvind, Percy , DE LA MOTTE, Hanna , JOHANSSON, Kjell, Erik , LEACH, Andrew , MACFAUL, Philip, Alexander , O'DONNELL, Charles, John , SCOTT, James, Stewart , WHITTAMORE, Paul, Robert, Owen
发明人： BIRCH, Alan, Martin , BROO, Dan, Anders , BUTLIN, Roger, John , CLARKE, David, Stephen , DAVIDSSON, Ojvind, Percy , DE LA MOTTE, Hanna , JOHANSSON, Kjell, Erik , LEACH, Andrew , MACFAUL, Philip, Alexander , O'DONNELL, Charles, John , SCOTT, James, Stewart , WHITTAMORE, Paul, Robert, Owen
IPC分类号： C07D239/47 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , A61K31/506 , A61P3/04 , A61P3/10
CPC分类号： C07D239/47 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D471/08 , C07D487/08
摘要： A compound of formula (I) or a pharmaceutically acceptable salt thereof, processes for preparing such compounds, their use as GPR119 modulators, methods for their therapeutic use, particularly in the treatment of obesity and diabetes mellitus, and pharmaceutical compositions containing them.
摘要翻译：式（I）化合物或其药学上可接受的盐，制备此类化合物的方法，其用作GPR119调节剂，其治疗用途的方法，特别是治疗肥胖症和糖尿病，以及含有它们的药物组合物。

10. 发明申请

WO2008075109A1 SUBSTITUTED PIPERIDINES HAVING PROTEIN KINASE INHIBITING ACTIVITY 审中-公开
标题翻译：具有蛋白激酶抑制活性的替代哌啶
公开(公告)号：WO2008075109A1
公开(公告)日：2008-06-26
申请号：PCT/GB2007/050776
申请日：2007-12-20
申请人： ASTEX THERAPEUTICS LIMITED , THE INSTITUTE OF CANCER RESEARCH:ROYAL CANCER HOSPITAL , CANCER RESEARCH TECHNOLOGY LIMITED , ASTRAZENECA AB , WOODHEAD, Steven, John , FREDERICKSON, Martyn , HAMLETT, Christopher , WOODHEAD, Andrew, James , VERDONK, Marinus, Leendert , SORE, Hannah, Fiona , WALKER, David, Winter , BLURTON, Peter , COLLINS, Ian , CHEUNG, Kwai, Ming , CALDWELL, John , DA FONSECA MCHARDY, Tatiana, Faria , LUKE, Richard, William, Arthur , MATUSIAK, Zbigniew, Stanley , LEACH, Andrew , MORRIS, Jeffrey, James
发明人： WOODHEAD, Steven, John , FREDERICKSON, Martyn , HAMLETT, Christopher , WOODHEAD, Andrew, James , VERDONK, Marinus, Leendert , SORE, Hannah, Fiona , WALKER, David, Winter , BLURTON, Peter , COLLINS, Ian , CHEUNG, Kwai, Ming , CALDWELL, John , DA FONSECA MCHARDY, Tatiana, Faria , LUKE, Richard, William, Arthur , MATUSIAK, Zbigniew, Stanley , LEACH, Andrew , MORRIS, Jeffrey, James
IPC分类号： C07D471/04 , C07D473/34 , C07D487/04 , C07D519/00 , A61K31/437 , A61K31/52 , A61P35/00
CPC分类号： C07D487/04 , C07D471/04 , C07D473/34 , C07D519/00
摘要： The invention provides PKA and PKB kinase-inhibiting compounds of the formula (I); or salts, solvates, tautomers or N-oxides thereof, wherein E is a five membered heteroaryl ring containing 1, 2, 3 or 4 heteroatoms selected from O, N and S provided that no more than 1 heteroatom may be other than N; q and r are each is 0 or 1; provided that q+r is 1 or 2; T is N or a group CR 5 ; J 1 -J 2 is N=C(R 6 ), (R 7 )C=N, (R 8 )N- C(O), (R 8 ) 2 C-C(O), N=N or (R 7 )C=C(R 6 ); Q 3 is a bond or a saturated C 1-3 hydrocarbon linker group optionally substituted by fluorine and hydroxy; G is NR 2 R 3 , CN or OH; m and n are each 0 or 1, provided that m+n is 1 or 2, and provided also that m or n are each 0 when the adjacent ring member of ring E is S or O; R 1a and R 1b are the same or different and each is hydrogen or a substituent R 10 ; or R 1a and R 1b together with the carbon atoms or heteroatoms to which they are attached form a 5 or 6-membered aryl or heteroaryl ring, wherein the aryl or heteroaryl rings are optionally substituted by one or more substituents R 10 ; and R 2 , R 3 , R 4 , R 5 , R 7 , R 6 , R 8 , and R 10 are as defined in the claims.
摘要翻译：本发明提供了式（I）的PKA和PKB激酶抑制化合物; 或其盐，溶剂合物，互变异构体或N-氧化物，其中E是含有1,2,3或4个选自O，N和S的杂原子的五元杂芳基环，条件是不超过1个杂原子可以不是N; q和r各自为0或1; q + r为1或2; T是N或CR 5; J 1是N = C（R 6），（R 7）C = N，（R 8）N C（O），（R 8）2 CC（O），N = N或（R 0 > 7 ）C = C（R ^{6 ）; Q 3是任选被氟和羟基取代的键或饱和C 1-3烃连接基团; G是NR 2 R 3，CN或OH; m和n各自为0或1，条件是m + n为1或2，并且当环E的相邻环构件为S或O时，m或n各自为0; R 1a和R 1b相同或不同，各自为氢或取代基R 10; 或R 1a和R 1b与它们所连接的碳原子或杂原子一起形成5或6元芳基或杂芳基环，其中芳基或杂芳基环任选地被一个或多个取代基R 10取代; R 2，R 3，R 4，R 5，R 7， R 6，R 8和R 10如权利要求中所定义。}

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