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1. 发明申请

WO2008098377A1 SERPINE1 POLYMORPHISMS ARE PREDICTIVE OF RESPONSE TO ACTIVATED PROTEIN C ADMINISTRATION AND RISK OF DEATH 审中-公开
标题翻译： SERPINE1多态性对于激活的蛋白C的应答预防和死亡风险的预测
公开(公告)号：WO2008098377A1
公开(公告)日：2008-08-21
申请号：PCT/CA2008/000305
申请日：2008-02-18
申请人： THE UNIVERSITY OF BRITISH COLUMBIA , SIRIUS GENOMICS INC. , WALLEY, Keith, R. , RUSSELL, James, A. , SIDDIQUI, Asim, Sarosh , GORDON, Anthony , WILLIAMS, Mark, D. , MACIAS, William, Louis , CLOSE KIRKWOOD, Sandra
发明人： WALLEY, Keith, R. , RUSSELL, James, A. , SIDDIQUI, Asim, Sarosh , GORDON, Anthony , WILLIAMS, Mark, D. , MACIAS, William, Louis , CLOSE KIRKWOOD, Sandra
IPC分类号： C40B40/06 , A61K38/48 , A61K45/00 , A61P29/00 , C07H21/00 , C12N15/10 , C12N15/12 , C12N15/57 , C12Q1/68 , C07K14/81 , C12N9/64
CPC分类号： C12Q1/6883 , A61K38/4866 , C07K14/8121 , C12N9/6464 , C12Q2600/106 , C12Q2600/156 , C12Y304/21069 , C40B40/06 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/473 , Y02A50/478
摘要： Methods, oligonucleotides arrays etc. for treating inflammatory conditions and of predicting subject outcome based on polymorphisms in SERPINE1 and/or PROC, alone or in combination, wherein the method of treatment includes administering to the subject an anti- inflammatory agent or an anti-coagulant agent, wherein said subject is determined to have an improved response genotype or combination.
摘要翻译：用于治疗炎性病症的方法，寡核苷酸阵列等，以及基于SERPINE1和/或PROC单独或组合的多态性预测受试者结局的方法，其中所述治疗方法包括向受试者施用抗炎剂或抗凝血剂其中所述受试者被确定为具有改善的应答基因型或组合。

2. 发明申请

WO2009033282A1 MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14 (MAP3K14) POLYMORPHISMS AS INDICATORS OF SUBJECT OUTCOME IN CRITICALLY 111 SUBJECTS 审中-公开
标题翻译：作为主要指标的致突变蛋白激酶蛋白激酶激酶14（MAP3K14）多态性作为临界指标
公开(公告)号：WO2009033282A1
公开(公告)日：2009-03-19
申请号：PCT/CA2008/001612
申请日：2008-09-10
申请人： THE UNIVERSITY OF BRITISH COLUMBIA , SIRIUS GENOMICS INC. , WALLEY, Keith, R. , RUSSEL, James, A. , MOODER, Karen, Patricia
发明人： WALLEY, Keith, R. , RUSSEL, James, A. , MOODER, Karen, Patricia
IPC分类号： A61K39/395 , A61K31/573 , A61K38/17 , A61K45/00 , A61P29/00 , C12Q1/68 , C07K14/525 , C07K14/715 , C12N15/54 , C12N9/12
CPC分类号： A61K31/573 , A61K45/06 , C12N9/1205 , C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172 , A61K2300/00
摘要： The present application provides methods, uses, commercial packages, and kits for obtaining a prognosis for a subject having or at risk of developing an inflammatory condition and for identifying subjects having a greater benefit from treatment with an anti-inflammatory agent or an anti-coagulant agent. The method generally includes determining the genotype at position rs7222094 or a polymorphic site in linkage disequilibrium thereto for a subject for a polymorphisms in the these genes. The application also provides for methods of identifying potential subjects having an inflammatory condition who are more likely to benefit from treatment with an anti-inflammatory agent or anti-coagulant agent and to recover from the inflammatory condition. The invention also provides for methods of treating such subjects with an anti-inflammatory agent or anti-coagulant agent based on the subject's genotype.
摘要翻译：本申请提供了用于获得具有或具有发展炎性病症风险的受试者的预后的方法，用途，商业包装和试剂盒，并且用于鉴定具有抗炎剂或抗凝剂治疗更大益处的受试者剂。该方法通常包括确定rs7222094位置的基因型或连锁不平衡的多态性位点，用于受试者中这些基因的多态性。本申请还提供了鉴定具有炎症状况的潜在受试者的方法，所述炎症病症更可能受益于用抗炎剂或抗凝血剂治疗并从炎性病症中恢复。本发明还提供了基于受试者的基因型用抗炎剂或抗凝血剂治疗这些受试者的方法。

3. 发明申请

WO2003100090A2 PROTEIN C POLYMORPHISMS USEFUL AS AN INDICATOR OF PATIENT OUTCOME 审中-公开
标题翻译：蛋白C多态性作为患者观察指标有用
公开(公告)号：WO2003100090A2
公开(公告)日：2003-12-04
申请号：PCT/CA2003/000751
申请日：2003-05-28
申请人： THE UNIVERSITY OF BRITISH COLUMBIA , RUSSELL, James, A. , WALLEY, Keith, R.
发明人： RUSSELL, James, A. , WALLEY, Keith, R.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156
摘要： The invention provides methods and kits for obtaining a prognosis for a patient having or at risk of developing an inflammatory condition. The method generally comprises determining a protein C promoter genotype of a patient for a polymorphism in the protein C promoter region of the patient, comparing the determined genotype with known genotypes for the polymorphism that correspond with the ability of the patient to recover from the inflammatory condition and identifying patients based on their prognosis. The invention also provides for methods of identifying other polymorphisms that correspond with the ability of the patient to recover from the inflammatory condition.
摘要翻译：本发明提供了用于获得具有或具有发展炎性病症风险的患者的预后的方法和试剂盒。该方法通常包括确定患者的蛋白C启动子基因型，用于患者的蛋白C启动子区域中的多态性，将确定的基因型与已知基因型与多态性相比较，其与患者从炎性病症恢复的能力相对应并根据患者的预后鉴别患者。本发明还提供了鉴定与患者从炎性病症恢复的能力相对应的其他多态性的方法。

4. 发明申请

WO2003100090A3 PROTEIN C POLYMORPHISMS 审中-公开
公开(公告)号：WO2003100090A3
公开(公告)日：2003-12-04
申请号：PCT/CA2003/000751
申请日：2003-05-28
申请人： THE UNIVERSITY OF BRITISH COLUMBIA , RUSSELL, James, A. , WALLEY, Keith, R.
发明人： RUSSELL, James, A. , WALLEY, Keith, R.
IPC分类号： C12Q1/68
摘要： The invention provides methods and kits for obtaining a prognosis for a patient having or at risk of developing an inflammatory condition. The method generally comprises determining a protein C promoter genotype of a patient for a polymorphism in the protein C promoter region of the patient, comparing the determined genotype with known genotypes for the polymorphism that correspond with the ability of the patient to recover from the inflammatory condition and identifying patients based on their prognosis. The invention also provides for methods of identifying other polymorphisms that correspond with the ability of the patient to recover from the inflammatory condition.

5. 发明申请

WO2007079592A1 PROTEIN C PATHWAY ASSOCIATED POLYMORPHISMS AS RESPONSE PREDICTORS TO ACTIVATED PROTEIN C OR PROTEIN C LIKE COMPOUND ADMINISTRATION 审中-公开
标题翻译：蛋白C途径相关多态性作为反应蛋白C或蛋白C的化合物类似化合物的施用
公开(公告)号：WO2007079592A1
公开(公告)日：2007-07-19
申请号：PCT/CA2007/000054
申请日：2007-01-12
申请人： THE UNIVERSITY OF BRITISH COLUMBIA , RUSSELL, James, A. , WALLEY, Keith, R.
发明人： RUSSELL, James, A. , WALLEY, Keith, R.
IPC分类号： C40B40/06 , A61K38/36 , A61K38/48 , A61P29/00 , A61P31/00 , A61P7/02 , C07H21/04 , C12Q1/00 , C12Q1/68 , C07K14/47 , C07K14/745 , C12N15/12 , C12N15/57 , C12N9/64
CPC分类号： A61K38/4866 , C12N9/6464 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , C12Y304/21069 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/473 , Y02A50/478 , Y10T436/143333
摘要： The invention provides methods, nucleic acids, compositions and kits for predicting a subject's response to treatment with activated protein C or protein C like compound to identify subjects having a greater benefit from treatment with activated protein C. The method generally comprises determining a protein C pathway associated gene polymorphism genotype(s) of a subject for one or more polymorphisms in the these genes, comparing the determined genotype with known genotypes for the polymorphism that correspond with an improved response polymorphism to identify potential subjects having an inflammatory condition who are more likely to benefit from treatment with activated protein C or protein C like compound and subsequent to treatment recover from the inflammatory condition. The invention also provides for methods of treating such subjects with an anti-inflammatory agent or anti-coagulant agent based on the subject's genotype.
摘要翻译：本发明提供了用于预测受试者对用活化蛋白C或蛋白C类化合物治疗的反应的方法，核酸，组合物和试剂盒，以鉴定受活化蛋白C治疗具有更大益处的受试者。该方法通常包括测定蛋白C途径将这些基因中的一个或多个多态性的受试者的相关基因多态性基因型进行比较，将确定的基因型与已知基因型进行比较，所述多态性与改善的应答多态性相对应，以鉴定具有更可能发生炎症的潜在受试者受益于用活化蛋白C或蛋白C类化合物治疗，随后治疗从炎症状态恢复。本发明还提供了基于受试者的基因型用抗炎剂或抗凝血剂治疗这些受试者的方法。

6. 发明申请

WO2006136033A1 COAGULATION FACTOR III POLYMORPHISMS ASSOCIATED WITH PREDICTION OF SUBJECT OUTCOME AND RESPONSE TO THERAPY 审中-公开
标题翻译：凝血因子III多态性与预测受试者的预后和治疗反应
公开(公告)号：WO2006136033A1
公开(公告)日：2006-12-28
申请号：PCT/CA2006/001058
申请日：2006-06-23
申请人： THE UNIVERSITY OF BRITISH COLUMBIA , RUSSELL, James, A. , WALLEY, Keith, R.
发明人： RUSSELL, James, A. , WALLEY, Keith, R.
IPC分类号： C12Q1/68 , A61K45/00 , A61P29/00 , A61P7/02 , C40B40/06 , G01N33/50 , C07H21/00 , C12N15/57
CPC分类号： C07K14/745 , C07K14/70596 , C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172
摘要： ABSTRACT The invention provides methods and kits for obtaining a prognosis for a subject having or at risk of developing an inflammatory condition or hypertension. The method generally comprises determining a coagulation factor III genotype(s) of a subject for one or more SNPs, comparing the determined genotype with known genotypes for the polymorphism that correspond with the ability of the subject to recover from the inflammatory condition and identifying subjects based on their prognosis. The invention also provides for methods of identifying potential subjects having an inflammatory condition who are more likely to benefit from treatment with an anti-inflammatory agent or anti-coagulant agent and subsequent to treatment recover from the inflammatory condition. The invention also provides for methods of treating such subjects with an anti-inflammatory agent or anti-coagulant agent based on the subject's genotype.
摘要翻译：摘要本发明提供了获得具有或有发展为炎性病症或高血压危险的受试者的预后的方法和试剂盒。该方法通常包括确定一个或多个SNP的受试者的凝血因子III基因型，将确定的基因型与已知基因型与多态性相对应，所述多态性与受试者从炎性病症恢复的能力相符合并鉴定受试者对他们的预后。本发明还提供了鉴定潜在受试者的方法，所述潜在受试者具有更可能受益于用抗炎剂或抗凝血剂治疗并且随后治疗从炎症状态恢复的炎性病症。本发明还提供了基于受试者的基因型用抗炎剂或抗凝血剂治疗这些受试者的方法。

7. 发明申请

WO2005085274A1 TOLL-LIKE RECEPTOR 2 (TLR-2) HAPLOTYPES PREDICT OUTCOME OF PATIENTS 审中-公开
标题翻译： TOLL-LIKE RECEPTOR 2（TLR-2）HAPLOTYPES PREDICT OUTCOME OF PATIENTS
公开(公告)号：WO2005085274A1
公开(公告)日：2005-09-15
申请号：PCT/CA2005/000357
申请日：2005-03-04
申请人： THE UNIVERSITY OF BRITISH COLUMBIA , RUSSELL, James, A. , WALLEY, Keith, R.
发明人： RUSSELL, James, A. , WALLEY, Keith, R.
IPC分类号： C07H21/00
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172
摘要： The invention provides methods and kits for obtaining a prognosis for a subject having or at risk of developing an inflammatory condition and or a gram positive infection. The method generally includes determining a toll-like receptor 2 (TLR-2) risk genotype of a subject for one or more SNPs, comparing the determined genotype with known genotypes for the polymorphism that correspond with the ability of the subject to recover from the inflammatory condition and identifying subjects based on their prognosis.
摘要翻译：本发明提供用于获得具有或具有发展为炎性病症和/或革兰氏阳性感染风险的受试者的预后的方法和试剂盒。所述方法通常包括确定一个或多个SNP的受试者的toll样受体2（TLR-2）风险基因型，将确定的基因型与已知基因型与已知基因型的多态性相对应，所述多态性与受试者从炎症中恢复的能力相对应条件和根据其预后鉴定受试者。

8. 发明申请

WO2005085273A1 THROMBOMODULIN (THBD) HAPLOTYPES PREDICT OUTCOME OF PATIENTS 审中-公开
标题翻译：血小板计数（THBD）HAPLOTYPES预测患者的成果
公开(公告)号：WO2005085273A1
公开(公告)日：2005-09-15
申请号：PCT/CA2005/000356
申请日：2005-03-04
申请人： THE UNIVERSITY OF BRITISH COLUMBIA , RUSSELL, James, A. , WALLEY, Keith, R.
发明人： RUSSELL, James, A. , WALLEY, Keith, R.
IPC分类号： C07H21/00
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172
摘要： The invention provides methods and kits for obtaining a prognosis for a subject having or at risk of developing an inflammatory condition. The method generally comprises determining a thrombomodulin genotype(s) of a subject for one or more SNPs, comparing the determined genotype with known genotypes for the polymorphism that correspond with the ability of the subject to recover from the inflammatory condition and identifying subjects based on their prognosis.
摘要翻译：本发明提供了用于获得具有或具有发展炎性病症风险的受试者的预后的方法和试剂盒。该方法通常包括确定一个或多个SNP的受试者的血栓调节蛋白基因型，将确定的基因型与已知基因型与多态性的已知基因型进行比较，所述基因型与受试者从炎性病症恢复的能力相对应，并基于它们鉴别受试者预后。

9. 发明申请

WO2007140625A1 INTERFERON GAMMA POLYMORPHISMS AS INDICATORS OF SUBJECT OUTCOME IN CRITICALLY ILL SUBJECTS 审中-公开
标题翻译：作为主要观察指标的干扰素多态性
公开(公告)号：WO2007140625A1
公开(公告)日：2007-12-13
申请号：PCT/CA2007/001042
申请日：2007-06-11
申请人： THE UNIVERSITY OF BRITISH COLUMBIA , WALLEY, Keith, R. , RUSSELL, James, A. , WATTANATHUM, Anan
发明人： WALLEY, Keith, R. , RUSSELL, James, A. , WATTANATHUM, Anan
IPC分类号： C40B40/06 , A61K38/48 , A61P29/00 , C12Q1/68 , C40B40/14
CPC分类号： C12Q1/6883 , A61K38/4866 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/473 , Y02A50/478
摘要： The invention provides methods, nucleic acids, compositions and kits for predicting a subject's outcome with an inflammatory condition and a subject's response to treatment with activated protein C or protein C like compound to identify subjects having a greater benefit from treatment with activated protein C. The method generally comprises determining a interferon gamma (IFNG) gene polymorphism genotype(s) of a subject for one or more polymorphisms in the IFNG gene or associated sequence, comparing the determined genotype with known genotypes for the polymorphism that correspond with an improved response polymorphism to identify potential subjects having an inflammatory condition who are more likely to benefit from treatment with activated protein C or protein C like compound and subsequent to treatment recover from the inflammatory condition. The invention also provides for methods of treating such subjects with an anti-inflammatory agent or anti-coagulant agent based on the subject's genotype.
摘要翻译：本发明提供了用活性蛋白C或蛋白C类化合物治疗炎症状况和受试者对治疗反应的方法，核酸，组合物和试剂盒，用于预测受试者的结局，以鉴定用活化蛋白C治疗具有更大益处的受试者。方法通常包括确定受试者在IFNG基因或相关序列中的一个或多个多态性的干扰素γ（IFNG）基因多态性基因型，将确定的基因型与已知基因型与对应于改良的应答多态性的多态性进行比较，鉴定具有更有可能受到活化蛋白C或蛋白C类化合物治疗并随后治疗的炎症状况的潜在受试者从炎症状态恢复。本发明还提供了基于受试者的基因型用抗炎剂或抗凝血剂治疗这些受试者的方法。

10. 发明申请

WO2005087789A1 PROTEIN C AND ENDOTHELIAL PROTEIN C RECEPTOR POLYMORPHISMS AS INDICATORS OF SUBJECT OUTCOME 审中-公开
标题翻译：蛋白C和内皮蛋白C受体多态性作为主要观察指标
公开(公告)号：WO2005087789A1
公开(公告)日：2005-09-22
申请号：PCT/CA2005/000409
申请日：2005-03-18
申请人： THE UNIVERSITY OF BRITISH COLUMBIA , RUSSELL, James, A. , WALLEY, Keith, R.
发明人： RUSSELL, James, A. , WALLEY, Keith, R.
IPC分类号： C07H21/00
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172
摘要： The invention provides methods and kits for obtaining a prognosis for a subject having or at risk of developing an inflammatory condition and for identifying subjects having a greater benefit from treatment with an anti-inflammatory agent or an anti-coagulant agent. The method generally comprises determining a protein C and/or EPCR genotype(s) of a subject for a polymorphisms in the these genes, comparing the determined genotype with known genotypes for the polymorphism that correspond with the ability of the subject to recover from the inflammatory condition and identifying subjects based on their prognosis. The invention also provides for methods of identifying potential subjects having an inflammatory condition who are more likely to benefit from treatment with an anti-inflammatory agent or anti-coagulant agent and subsequent to treatment recover from the inflammatory condition. The invention also provides for methods of treating such subjects with an anti-inflammatory agent or anti-coagulant agent based on the subject's genotype.
摘要翻译：本发明提供了用于获得具有或处于发展炎症状态的风险的受试者的预后以及用于通过用抗炎剂或抗凝血剂治疗具有更大益处的受试者来获得预后的方法和试剂盒。该方法通常包括确定受试者的蛋白质C和/或EPCR基因型，用于这些基因中的多态性，将确定的基因型与已知基因型与多态性相对应的受试者从炎症中恢复的能力进行比较条件和根据其预后鉴定受试者。本发明还提供了鉴定潜在受试者的方法，所述潜在受试者具有更可能受益于用抗炎剂或抗凝血剂治疗并且随后治疗从炎症状态恢复的炎症状况。本发明还提供了基于受试者的基因型用抗炎剂或抗凝血剂治疗这些受试者的方法。

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