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    • 1. 发明申请
    • BIOMARKERS FOR GOSSYPOL CHEMOTHERAPY AND METHODS OF TREATING DISEASE
    • 生物标记物治疗疾病和治疗疾病的方法
    • WO2011017145A2
    • 2011-02-10
    • PCT/US2010/043477
    • 2010-07-28
    • THE REGENTS OF THE UNIVERSITY OF MICHIGANWANG, ShaomengJIANG, FengLONG, JiantingBAI, Longchuan
    • WANG, ShaomengJIANG, FengLONG, JiantingBAI, Longchuan
    • C12Q1/68G01N33/68G01N33/574G01N33/15
    • G01N33/57434C12Q1/6886C12Q2600/106C12Q2600/158G01N2800/52
    • The present invention provides a biomarker for selecting a patient for treatment with gossypol, wherein the biomarker comprises an elevated expression level of c-Myc, Mcl-1, or combination thereof, relative to the normal expression level of c-Myc, Mcl-1, or combination thereof. The present invention also provides methods for targeting patients for treatment with gossypol, wherein the patient has a disease, condition, or disorder that overexpresses c-Myc, Mcl-1, or combination thereof. The present invention also provides methods for treating or ameliorating a disease, condition, or disorder in a patient comprising determining the expression level of c-Myc, Mcl-1, or combination thereof in the patient and administering gossypol to the patient. In certain embodiments of the invention, the disease is cancer, and the cancer cells show elevated expression levels of c-Myc compared to non-cancerous cells. The invention also provides methods for overcoming Mcl-1-mediated chemoresistance comprising administering gossypol to a patient in need thereof.
    • 本发明提供了一种用于选择用棉酚处理的患者的生物标志物,其中相对于c-Myc,Mcl-1的正常表达水平,生物标志物包括c-Myc,Mcl-1或其组合的升高的表达水平 ,或其组合。 本发明还提供了靶向患者用棉酚治疗的方法,其中患者具有过表达c-Myc,Mcl-1或其组合的疾病,病症或病症。 本发明还提供了用于治疗或改善患者疾病,病症或障碍的方法,包括确定患者中c-Myc,Mcl-1或其组合的表达水平,并向患者施用棉酚。 在本发明的某些实施方案中,该疾病是癌症,与非癌细胞相比,癌细胞表现出c-Myc的升高的表达水平。 本发明还提供克服Mcl-1介导的化学耐药性的方法,包括向有需要的患者施用棉酚。
    • 5. 发明申请
    • POWER CONTROL FOR CHANNEL SOUNDING
    • 信道探测的功率控制
    • WO2018081472A1
    • 2018-05-03
    • PCT/US2017/058608
    • 2017-10-26
    • LI, QinghuaJIANG, FengAMIZUR, YuvalSEGEV, JonathanSTACEY, Robert J.
    • LI, QinghuaJIANG, FengAMIZUR, YuvalSEGEV, JonathanSTACEY, Robert J.
    • H04W52/24H04W52/52H04W52/32
    • H04W52/325H04B17/318H04W52/242H04W52/54
    • Disclosed are methods, systems, devices, and computer readable storage medium to manage a received signal strength of sounding frames at a receiving device. If the received signal strengths vary, an automatic gain control parameter may be more highly influenced by those frames having higher received signal strength. A trigger frame indicates a transmission power of the trigger frame, and a target received signal strength at an access point transmitting the trigger frame. Receiving stations may determine a transmit power for a sounding frame based on the trigger frame. For example, a path loss between the access point and receiving station may be determined based on the transmit power and the received power of the trigger frame. A transmit power for the sounding frame may then be determined, in some aspects, by adding the path loss and the target RSSI value.
    • 公开了用于管理接收设备处的探测帧的接收信号强度的方法,系统,设备和计算机可读存储介质。 如果接收信号强度变化,则自动增益控制参数可能受到具有较高接收信号强度的那些帧的影响更大。 触发帧指示触发帧的发送功率以及发送触发帧的接入点处的目标接收信号强度。 接收站可以基于触发帧来确定探测帧的发射功率。 例如,接入点和接收站之间的路径损耗可以基于发送功率和触发帧的接收功率来确定。 然后可以在一些方面通过添加路径损耗和目标RSSI值来确定用于探测帧的发射功率。