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1. 发明申请

WO2012103059A2 BCL-2/BCL-XL INHIBITORS AND THERAPEUTIC METHODS USING THE SAME 审中-公开
标题翻译： BCL-2 / BCL-XL抑制剂和使用该抑制剂的治疗方法
公开(公告)号：WO2012103059A2
公开(公告)日：2012-08-02
申请号：PCT/US2012/022315
申请日：2012-01-24
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , WANG, Shaomeng , ZHOU, Haibin , CHEN, Jianfang , AGUILAR, Angelo , MEAGHER, Jennifer, Lynn , SUN, Duxin , YANG, Chao-Yie , LIU, Liu , BAI, Longchuan , MCEACHERM, Donna , STUCKEY, Jeanne , LI, Xiaoqin
发明人： WANG, Shaomeng , ZHOU, Haibin , CHEN, Jianfang , AGUILAR, Angelo , MEAGHER, Jennifer, Lynn , SUN, Duxin , YANG, Chao-Yie , LIU, Liu , BAI, Longchuan , MCEACHERM, Donna , STUCKEY, Jeanne , LI, Xiaoqin
IPC分类号： C07D403/10 , C07D403/14 , A61K31/496 , A61P35/00
CPC分类号： C07D239/28 , C07D207/34 , C07D231/12 , C07D233/28 , C07D233/56 , C07D261/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D471/04
摘要： Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed.
摘要翻译：公开了Bcl-2 / Bcl-xL的抑制剂和含有它们的组合物。也公开了使用Bcl-2 / Bcl-xL抑制剂治疗其中抑制Bcl-2 / Bcl-xL提供益处的疾病和病症的方法，如癌症。

2. 发明申请

WO2010077589A3 STAT3 INHIBITORS AND THERAPEUTIC METHODS USING THE SAME 审中-公开
标题翻译： STAT3抑制剂和使用它的治疗方法
公开(公告)号：WO2010077589A3
公开(公告)日：2010-10-21
申请号：PCT/US2009066932
申请日：2009-12-07
申请人： UNIV MICHIGAN OFFICE OF TECHNO , WANG SHAOMENG , CHEN JIANYONG , ZHAO YU-JUN , GOMEZ CINDY , BAI LONGCHUAN , NIKOLOVSKA-COLESKA ZANETA
发明人： WANG SHAOMENG , CHEN JIANYONG , ZHAO YU-JUN , GOMEZ CINDY , BAI LONGCHUAN , NIKOLOVSKA-COLESKA ZANETA
IPC分类号： C07D487/04 , A61K31/41 , A61P35/00 , C07D403/12
CPC分类号： C07D403/12 , A61K31/41 , C07D487/04
摘要： Inhibitors of STAT3 are disclosed. Methods of using the STAT3 inhibitors in the treatment of diseases and conditions wherein inhibition of STAT3 provides a benefit, like cancers, also are disclosed.
摘要翻译：公开了STAT3的抑制剂。也公开了使用STAT3抑制剂治疗其中抑制STAT3提供益处的疾病和病症的方法，如癌症。

3. 发明申请

WO2012103059A3 BCL-2/BCL-XL INHIBITORS AND THERAPEUTIC METHODS USING THE SAME 审中-公开
标题翻译： BCL-2 / BCL-XL抑制剂及其治疗方法
公开(公告)号：WO2012103059A3
公开(公告)日：2012-10-18
申请号：PCT/US2012022315
申请日：2012-01-24
申请人： UNIV MICHIGAN , WANG SHAOMENG , ZHOU HAIBIN , CHEN JIANFANG , AGUILAR ANGELO , MEAGHER JENNIFER LYNN , SUN DUXIN , YANG CHAO-YIE , LIU LIU , BAI LONGCHUAN , MCEACHERM DONNA , STUCKEY JEANNE , LI XIAOQIN
发明人： WANG SHAOMENG , ZHOU HAIBIN , CHEN JIANFANG , AGUILAR ANGELO , MEAGHER JENNIFER LYNN , SUN DUXIN , YANG CHAO-YIE , LIU LIU , BAI LONGCHUAN , MCEACHERM DONNA , STUCKEY JEANNE , LI XIAOQIN
IPC分类号： C07D403/10 , A61K31/496 , A61P35/00 , C07D403/14
CPC分类号： C07D239/28 , C07D207/34 , C07D231/12 , C07D233/28 , C07D233/56 , C07D261/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D471/04
摘要： Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed.
摘要翻译：公开了Bcl-2 / Bcl-xL的抑制剂及其组合物。还公开了使用Bcl-2 / Bcl-xL抑制剂治疗其中Bcl-2 / Bcl-xL的抑制提供益处的疾病和病症的方法，如癌症。

4. 发明申请

WO2011017145A3 BIOMARKERS FOR GOSSYPOL CHEMOTHERAPY AND METHODS OF TREATING DISEASE 审中-公开
标题翻译：紫杉醇化疗的生物标志物和治疗疾病的方法
公开(公告)号：WO2011017145A3
公开(公告)日：2011-06-30
申请号：PCT/US2010043477
申请日：2010-07-28
申请人： UNIV MICHIGAN , WANG SHAOMENG , JIANG FENG , LONG JIANTING , BAI LONGCHUAN
发明人： WANG SHAOMENG , JIANG FENG , LONG JIANTING , BAI LONGCHUAN
IPC分类号： C12Q1/68 , G01N33/15 , G01N33/574 , G01N33/68
CPC分类号： G01N33/57434 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N2800/52
摘要： The present invention provides a biomarker for selecting a patient for treatment with gossypol, wherein the biomarker comprises an elevated expression level of c-Myc, Mcl-1, or combination thereof, relative to the normal expression level of c-Myc, Mcl-1, or combination thereof. The present invention also provides methods for targeting patients for treatment with gossypol, wherein the patient has a disease, condition, or disorder that overexpresses c-Myc, Mcl-1, or combination thereof. The present invention also provides methods for treating or ameliorating a disease, condition, or disorder in a patient comprising determining the expression level of c-Myc, Mcl-1, or combination thereof in the patient and administering gossypol to the patient. In certain embodiments of the invention, the disease is cancer, and the cancer cells show elevated expression levels of c-Myc compared to non-cancerous cells. The invention also provides methods for overcoming Mcl-1-mediated chemoresistance comprising administering gossypol to a patient in need thereof.
摘要翻译：本发明提供了用于选择用棉酚治疗的患者的生物标志物，其中所述生物标志物包含相对于c-Myc，Mcl-1的正常表达水平升高的c-Myc，Mcl-1或其组合的表达水平，或其组合。本发明还提供了针对患有棉酚治疗的患者的方法，其中患者患有过表达c-Myc，Mcl-1或其组合的疾病，病症或病症。本发明还提供了用于治疗或改善患者中的疾病，病症或病症的方法，其包括测定患者中c-Myc，Mcl-1或其组合的表达水平并向患者施用棉酚。在本发明的某些实施方案中，疾病是癌症，并且与非癌细胞相比，癌细胞显示c-Myc的升高表达水平。本发明还提供了用于克服Mcl-1介导的化疗耐药性的方法，包括将棉酚给予有需要的患者。

5. 发明申请

WO2011017145A2 BIOMARKERS FOR GOSSYPOL CHEMOTHERAPY AND METHODS OF TREATING DISEASE 审中-公开
标题翻译：生物标记物治疗疾病和治疗疾病的方法
公开(公告)号：WO2011017145A2
公开(公告)日：2011-02-10
申请号：PCT/US2010/043477
申请日：2010-07-28
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , WANG, Shaomeng , JIANG, Feng , LONG, Jianting , BAI, Longchuan
发明人： WANG, Shaomeng , JIANG, Feng , LONG, Jianting , BAI, Longchuan
IPC分类号： C12Q1/68 , G01N33/68 , G01N33/574 , G01N33/15
CPC分类号： G01N33/57434 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N2800/52
摘要： The present invention provides a biomarker for selecting a patient for treatment with gossypol, wherein the biomarker comprises an elevated expression level of c-Myc, Mcl-1, or combination thereof, relative to the normal expression level of c-Myc, Mcl-1, or combination thereof. The present invention also provides methods for targeting patients for treatment with gossypol, wherein the patient has a disease, condition, or disorder that overexpresses c-Myc, Mcl-1, or combination thereof. The present invention also provides methods for treating or ameliorating a disease, condition, or disorder in a patient comprising determining the expression level of c-Myc, Mcl-1, or combination thereof in the patient and administering gossypol to the patient. In certain embodiments of the invention, the disease is cancer, and the cancer cells show elevated expression levels of c-Myc compared to non-cancerous cells. The invention also provides methods for overcoming Mcl-1-mediated chemoresistance comprising administering gossypol to a patient in need thereof.
摘要翻译：本发明提供了一种用于选择用棉酚处理的患者的生物标志物，其中相对于c-Myc，Mcl-1的正常表达水平，生物标志物包括c-Myc，Mcl-1或其组合的升高的表达水平，或其组合。本发明还提供了靶向患者用棉酚治疗的方法，其中患者具有过表达c-Myc，Mcl-1或其组合的疾病，病症或病症。本发明还提供了用于治疗或改善患者疾病，病症或障碍的方法，包括确定患者中c-Myc，Mcl-1或其组合的表达水平，并向患者施用棉酚。在本发明的某些实施方案中，该疾病是癌症，与非癌细胞相比，癌细胞表现出c-Myc的升高的表达水平。本发明还提供克服Mcl-1介导的化学耐药性的方法，包括向有需要的患者施用棉酚。

6. 发明申请

WO2010077589A2 STAT3 INHIBITORS AND THERAPEUTIC METHODS USING THE SAME 审中-公开
标题翻译： STAT3抑制剂和使用其的治疗方法
公开(公告)号：WO2010077589A2
公开(公告)日：2010-07-08
申请号：PCT/US2009/066932
申请日：2009-12-07
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN OFFICE OF TECHNOLOGY TRANSFER , WANG, Shaomeng , CHEN, Jianyong , ZHAO, Yu-jun , GOMEZ, Cindy , BAI, Longchuan , NIKOLOVSKA-COLESKA, Zaneta
发明人： WANG, Shaomeng , CHEN, Jianyong , ZHAO, Yu-jun , GOMEZ, Cindy , BAI, Longchuan , NIKOLOVSKA-COLESKA, Zaneta
IPC分类号： C07D487/04 , C07D403/12 , A61K31/41 , A61P35/00
CPC分类号： C07D403/12 , A61K31/41 , C07D487/04
摘要： Inhibitors of STAT3 are disclosed. Methods of using the STAT3 inhibitors in the treatment of diseases and conditions wherein inhibition of STAT3 provides a benefit, like cancers, also are disclosed.
摘要翻译：公开了STAT3的抑制剂。还公开了使用STAT3抑制剂治疗其中抑制STAT3提供益处的疾病和病症的方法，如癌症。

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