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1. 发明申请

WO2014197599A1 PEG-PROM MEDIATED SURFACE EXPRESSION OF AVIDIN/STREPTAVIDIN 审中-公开
标题翻译： PEG-PROM介导的AVIDIN / STREPTAVIDIN表面表达
公开(公告)号：WO2014197599A1
公开(公告)日：2014-12-11
申请号：PCT/US2014/040913
申请日：2014-06-04
申请人： THE JOHNS HOPKINS UNIVERSITY , VIRGINIA COMMONWEALTH UNIVERSITY
发明人： FISHER, Paul, B. , DAS, Swadesh, K. , MENEZES, Mitchell, E. , SARKAR, Devanand , POMPER, Marting, G.
IPC分类号： C12N15/64
CPC分类号： C12N15/85 , A61K38/164 , A61K38/1703 , A61K38/20 , A61K41/0028 , A61K48/00 , A61K48/0058 , A61K48/0075 , A61K49/00 , A61N7/00 , A61N2007/0039 , B82Y5/00 , B82Y15/00 , C07K14/36 , C07K14/465 , C07K14/47 , C07K14/54 , C07K2319/02 , C07K2319/03 , C07K2319/035 , C12N7/00 , C12N15/625 , C12N15/64 , C12N15/86 , C12N2710/10043 , C12N2710/10343 , C12N2799/02 , C12N2799/022 , C12N2800/22 , C12N2810/855 , C12N2830/002 , C12N2830/008 , G01N33/50 , G01N33/574
摘要： The presently disclosed subject matter relates to compositions and methods directed to cancer theranostic nucleic acid constructs that permit simultaneous cancer- specific viral replication, expression of a diagnostic gene product, and expression of a therapeutic gene.
摘要翻译：目前公开的主题涉及可以同时进行癌症特异性病毒复制，诊断基因产物的表达和治疗性基因表达的癌症主要核酸构建体的组合物和方法。

2. 发明申请

WO2014197598A2 TRIPARTITE CANCER THERANOSTIC NUCLEIC ACID CONSTRUCTS 审中-公开
标题翻译：三磷酸核苷酸核酸结构
公开(公告)号：WO2014197598A2
公开(公告)日：2014-12-11
申请号：PCT/US2014/040912
申请日：2014-06-04
申请人： THE JOHNS HOPKINS UNIVERSITY , VIRGINIA COMMONWEALTH UNIVERSITY
发明人： FISHER, Paul, B. , DAS, Swadesh, K. , MENEZES, Mitchell E. , SARKAR, Devanand , POMPER, Martin, G.
IPC分类号： A61K51/06
CPC分类号： A61K48/0058 , A61K9/0019 , A61K38/20 , A61K41/0028 , A61K41/0033 , A61K49/0013 , A61K49/0045 , A61K49/0054 , A61K51/00 , A61K51/0491 , C12N7/00 , C12N15/86 , C12N15/87 , C12N2710/10043 , C12N2710/10343 , C12N2710/16143 , C12N2710/16171 , C12N2830/008 , C12Q1/6897
摘要： The presently disclosed subject matter relates to compositions and methods directed to tripartite cancer theranostic nucleic acid constructs that permit simultaneous cancer-specific viral replication, expression of a diagnostic gene product, and expression of a therapeutic gene.
摘要翻译：目前公开的主题涉及针对允许同时进行癌症特异性病毒复制，诊断基因产物的表达和治疗基因表达的三方癌症核糖核酸构建体的组合物和方法。

3. 发明申请

WO2022155312A1 METHODS AND COMPOSITIONS FOR TWO-STAGE MICROBUBBLE DELIVERY OF ACTIVE AGENTS 审中-公开
公开(公告)号：WO2022155312A1
公开(公告)日：2022-07-21
申请号：PCT/US2022/012285
申请日：2022-01-13
申请人： VIRGINIA COMMONWEALTH UNIVERSITY
发明人： FISHER, Paul, B. , EMDAD, Luni , BHOOPATHI, Praveen , PRADHAN, Anjan, K. , DAS, Swadesh, K. , KLIBANOV, Alexander, L.
IPC分类号： A61B8/08 , A61N7/00 , C12N15/85 , C07K14/47 , C12N15/86
摘要： In various aspects, the present disclosure provides methods, compositions, and kits for treating a target tissue with one or more active agents. In embodiments, delivering an active agent to a target tissue comprises administration of microbubbles and ultrasound.

4. 发明申请

WO2019147623A3 MDA-7/IL SECRETORY VARIANTS AND METHODS OF USE 审中-公开
公开(公告)号：WO2019147623A3
公开(公告)日：2019-08-01
申请号：PCT/US2019/014686
申请日：2019-01-23
申请人： VIRGINIA COMMONWEALTH UNIVERSITY , FISHER, Paul, B. , MENEZES, Mitchell, E. , BHOOPATHI, Praveen , DAS, Swadesh, K. , EMDAD, Luni , SARKAR, Devanand , PRADHAN, Anjan, K. , WANG, Xiang-yang
发明人： FISHER, Paul, B. , MENEZES, Mitchell, E. , BHOOPATHI, Praveen , DAS, Swadesh, K. , EMDAD, Luni , SARKAR, Devanand , PRADHAN, Anjan, K. , WANG, Xiang-yang
IPC分类号： A61K38/17 , A61K39/395 , A61K48/00 , C07H21/04 , C07K14/82 , C07K16/30
摘要： In various aspects, the present disclosure provides polynucleotides encoding a fusion protein, as well as vectors, cells, and compositions comprising the same. In embodiments, the fusion protein includes an insulin signal peptide and an MDA-7/IL-24 protein. Methods of using the polynucleotides, vectors, cells, and compositions, such as in the treatment or prevention of cancer, are also provided.

5. 发明申请

WO2019084401A1 COMPOSITIONS COMPRISING MDA-7/IL-24 PROTEIN AND METHODS OF USE 审中-公开
公开(公告)号：WO2019084401A1
公开(公告)日：2019-05-02
申请号：PCT/US2018/057708
申请日：2018-10-26
申请人： VIRGINIA COMMONWEALTH UNIVERSITY
发明人： FISHER, Paul, B. , PRADHAN, Anjan, K. , DAS, Swadesh, K. , EMDAD, Luni
IPC分类号： A61K35/12 , A61K38/20 , C07K14/54 , C12N5/10
摘要： In various aspects, the present disclosure provides methods of preventing metastasis to bone in a subject with cancer, as well as compositions and kits for use in the same. In various aspects, the present disclosure provides methods of treating bone metastasis in a subject with cancer, as well as compositions and kits for use in the same. In embodiments, compositions comprise an MDA-7/IL-24 protein.

6. 发明申请

WO2019147623A2 MDA-7/IL SECRETORY VARIANTS AND METHODS OF USE 审中-公开
公开(公告)号：WO2019147623A2
公开(公告)日：2019-08-01
申请号：PCT/US2019/014686
申请日：2019-01-23
申请人： VIRGINIA COMMONWEALTH UNIVERSITY , FISHER, Paul, B. , MENEZES, Mitchell, E. , BHOOPATHI, Praveen , DAS, Swadesh, K. , EMDAD, Luni , SARKAR, Devanand , PRADHAN, Anjan, K. , WANG, Xiang-yang
发明人： FISHER, Paul, B. , MENEZES, Mitchell, E. , BHOOPATHI, Praveen , DAS, Swadesh, K. , EMDAD, Luni , SARKAR, Devanand , PRADHAN, Anjan, K. , WANG, Xiang-yang
IPC分类号： A61K48/00
摘要： In various aspects, the present disclosure provides polynucleotides encoding a fusion protein, as well as vectors, cells, and compositions comprising the same. In embodiments, the fusion protein includes an insulin signal peptide and an MDA-7/IL-24 protein. Methods of using the polynucleotides, vectors, cells, and compositions, such as in the treatment or prevention of cancer, are also provided.

7. 发明申请

WO2017173101A1 COMBINATION THERAPY FOR NEUROBLASTOMA USING MDA-7/IL-24 WITH THERAPEUTIC AGENTS 审中-公开
标题翻译：用MDA-7 / IL-24与治疗药物联合治疗神经母细胞瘤
公开(公告)号：WO2017173101A1
公开(公告)日：2017-10-05
申请号：PCT/US2017/025056
申请日：2017-03-30
申请人： VIRGINIA COMMONWEALTH UNIVERSITY
发明人： FISHER, Paul, B. , BHOOPATHI, Praveen , EMDAD, Luni , DAS, Swadesh, K. , SARKAR, Devanand
IPC分类号： A61K38/20 , A61K48/00 , A61P35/00 , C07K14/54 , C12N15/86
摘要： This invention discloses methods of treating neuroblastoma using Ad.5/3- CTV . In one embodiment, the present invention provides a method of treating neuroblastoma in a subject using Ad.5/3- CTV . In another embodiment, the present invention provides a method of inhibiting the growth of a neuroblastoma tumor using Ad.5/3- CTV . In one embodiment, the present invention provides a method of inhibiting the growth of a neuroblastoma cell using Ad.5/3- CTV . In yet another embodiment, the present invention provides a method of inducing apoptosis or toxic autophagy in a neuroblastoma cell using Ad.5/3- CTV . In one embodiment, the present invention provides a method of maintaining remission of neuroblastoma in a subject which has been treated for neuroblastoma. In one embodiment, the methods described herein further comprise a step of administering to the subject or cell a therapeutic agent selected from the group consisting of poly[IC]-PEI, doxorubicin, and any other therapeutic agents that promote toxic autophagy and/or apoptosis.
摘要翻译：本发明公开了使用Ad.5 / 3-CTV治疗神经母细胞瘤的方法。在一个实施方案中，本发明提供了使用Ad.5 / 3-CTV治疗受试者中神经母细胞瘤的方法。在另一个实施方案中，本发明提供了使用Ad.5 / 3-CTV抑制成神经细胞瘤肿瘤生长的方法。在一个实施方案中，本发明提供了使用Ad.5 / 3-CTV抑制成神经细胞瘤细胞生长的方法。在又一个实施方案中，本发明提供了使用Ad.5 / 3-CTV诱导成神经细胞瘤细胞凋亡或毒性自噬的方法。在一个实施方案中，本发明提供了维持已经治疗神经母细胞瘤的受试者中成神经细胞瘤缓解的方法。在一个实施方案中，本文所述的方法还包括向受试者或细胞施用选自聚[IC] -PEI，多柔比星和任何其它促进毒性自噬和/或细胞凋亡的治疗剂的治疗剂的步骤

8. 发明申请

WO2017120439A1 A METHOD OF MODULATING SURVIVAL AND STEMNESS OF CANCER STEM CELLS BY MDA-9/SYNTENIN (SDCBP) 审中-公开
标题翻译： MDA-9 / SYNTENIN（SDCBP）调节癌干细胞存活和健侧的方法
公开(公告)号：WO2017120439A1
公开(公告)日：2017-07-13
申请号：PCT/US2017/012486
申请日：2017-01-06
申请人： VIRGINIA COMMONWEALTH UNIVERSITY , FISHER, Paul , TALUKDAR, Sarmistha , EMDAD, Luni , DAS, Swadesh, K.
发明人： FISHER, Paul , TALUKDAR, Sarmistha , EMDAD, Luni , DAS, Swadesh, K.
IPC分类号： A61P35/00 , C12N5/095 , C12Q1/00
CPC分类号： G01N33/57492 , C12N5/0693 , G01N33/5073
摘要： This invention discloses a method of modulating the survival and stemness of cancer stem cells (CSCs) by modulating the expression of MDA-9/Syntenin (SDCBP), which regulates multiple stemness genes, and controls survival of CSCs by activating the pathways, including without limitation NOTCH1. In one embodiment, the stemness genes that can be regulated by modulating expression or activity of MDA-9/Syntenin (SDCBP) includes, but are not limited to, ALDH1A1, AXL, CD44, DDR1, ID1, ITGB1, c-myc, Nanog, NOTCH, Oct4/POU5F1, Sox2 , and STAT3. The invention also discloses a method of decreasing/inhibiting CSCs's tumorigenicity and a method of increasing survival of a subject with cancer by suppression of mda -9. This invention provides a method of inhibiting the growth of a cancer, and a method of determining the metastatic or angiogenic potential of a cancer. This invention further provides a method of screening for a candidate compound that modulate the expression or activities of MDA-9/Syntenin (SDCBP).
摘要翻译：本发明公开了通过调节调节多干症基因的MDA-9 / Syntenin（SDCBP）的表达来调节癌症干细胞（CSC）的存活和干细胞的方法， CSCs通过激活途径，包括但不限于NOTCH1。在一个实施方案中，可通过调节MDA-9 / Syntenin（SDCBP）的表达或活性来调节的茎干基因包括但不限于ALDH1A1，AXL，CD44，DDR1，ID1，ITGB1，c- myc，Nanog，NOTCH，Oct4 / POU5F1，Sox2和STAT3。本发明还公开了降低/抑制CSC致瘤性的方法和通过抑制mda-9增加患有癌症的受试者的存活的方法。本发明提供了抑制癌症生长的方法，以及确定癌症的转移或血管生成潜力的方法。本发明还提供了筛选调节MDA-9 / Syntenin（SDCBP）表达或活性的候选化合物的方法。

9. 发明申请

WO2014209553A1 USE OF A TRUNCATED CCN1 PROMOTER FOR CANCER DIAGNOSTICS, THERAPEUTICS AND THERANOSTICS 审中-公开
标题翻译：用于癌症诊断，治疗和治疗的CCN1促性腺激素的使用
公开(公告)号：WO2014209553A1
公开(公告)日：2014-12-31
申请号：PCT/US2014/040796
申请日：2014-06-04
申请人： VIRGINIA COMMONWEALTH UNIVERSITY
发明人： FISHER, Paul, B. , DAS, Swadesh, K. , DASH, Rupesh , SARKAR, Devanand , SARKAR, Siddik , WINDLE, Jolene
IPC分类号： A01K67/027
CPC分类号： A61K48/0058 , A01K67/0275 , A01K2207/12 , A01K2217/052 , A01K2217/206 , A01K2227/105 , A01K2267/0331 , A01K2267/0393 , A61K35/761 , A61K49/0008 , A61K49/005 , C12N15/86 , C12N2015/8536 , C12N2015/8572 , C12N2710/10332 , C12N2830/008 , C12N2830/34
摘要： Recombinant vectors in which expression of one or more elements (e.g. genes required for viral replication, detectable imaging agents, therapeutic agents, etc.) is driven by a truncated CCN 1 cancer selective promoter ( tCCN1 -Prom) are provided, as are cells and transgenic animals that contain such vectors. The vectors are used in cancer therapy and/or diagnostics, and the transgenic mice are used to monitor cancer progression, e.g. in screening assays.
摘要翻译：提供其中一种或多种元件的表达（例如病毒复制所需的基因，可检测的成像剂，治疗剂等）由截短的CCN 1癌选择性启动子（tCCN1-Prom）驱动的重组载体，细胞和含有这些载体的转基因动物。这些载体用于癌症治疗和/或诊断，并且转基因小鼠用于监测癌症进展。在筛选试验中。

10. 发明申请

WO2014197586A1 MDA-9/SYNTENIN PROMOTER TO IMAGE AND TREAT METASTATIC CANCER CELLS 审中-公开
标题翻译： MDA-9 / SYNTENIN促进剂到图像和TREAT分子癌细胞
公开(公告)号：WO2014197586A1
公开(公告)日：2014-12-11
申请号：PCT/US2014/040898
申请日：2014-06-04
申请人： VIRGINIA COMMONWEALTH UNIVERSITY
发明人： FISHER, Paul, B. , DAS, Swadesh, K. , MENEZES, Michelle, D. , SARKAR, Devanand
IPC分类号： G01N33/48
CPC分类号： C12N15/86 , A61K49/0008 , C07K14/47 , C12N15/85 , C12N15/8509 , C12N2710/10331 , C12N2710/10345 , C12N2830/008 , C12N2830/85 , G01N33/5088 , G01N33/57492
摘要： Recombinant vectors in which expression of one or more elements (e.g. genes required for viral replication, detectable imaging agents, therapeutic agents, etc.) is driven by an mda-9/syntenin ( mda -9) cancer selective promoter are provided, as are cells and transgenic animals that contain such vectors. The vectors are used in cancer therapy and/or diagnostics, especially to visualize (image) and treat metastasis (including in rapid in vitro assays), and the transgenic mice are used to monitor cancer progression and/or the efficacy of candidate therapeutic agents in screening assays.
摘要翻译：提供其中一种或多种元件的表达（例如病毒复制所需的基因，可检测的成像剂，治疗剂等）由mda-9 / syntenin（mda-9）癌选择性启动子驱动的重组载体，如细胞和含有这些载体的转基因动物。这些载体用于癌症治疗和/或诊断，特别是可视化（图像）和治疗转移（包括快速体外测定），并且转基因小鼠用于监测候选治疗剂的癌症进展和/或功效筛选试验。

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