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1. 发明申请

WO2009008933A2 OPTOACOUSTIC MONITORING OF MULTIPLE PARAMETERS 审中-公开
标题翻译：多参数光声监测
公开(公告)号：WO2009008933A2
公开(公告)日：2009-01-15
申请号：PCT/US2008/004732
申请日：2008-04-11
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , PROUGH, Donald, S. , ESENALIEV, Rinat, O. , DEYO, Donald , PETROV, Yuriy, Y. , PETROV, Irina, Y.
发明人： PROUGH, Donald, S. , ESENALIEV, Rinat, O. , DEYO, Donald , PETROV, Yuriy, Y. , PETROV, Irina, Y.
IPC分类号： G01N21/17 , A61B5/145
CPC分类号： A61B5/14542 , A61B5/0095 , A61B5/412 , A61B5/7239
摘要： An optoacoustic technique for absolute, accurate, continuous, and real-time measurement of a variety of important diagnostic variables is disclosed, where the variables include: (1) noninvasive measurements of circulating blood volume (BV) and cardiac output (CO); (2) calculation from the measured variables of cardiac index (CI) and systemic oxygen delivery (DO2); (3) concentrations of hemoglobin derivatives (e.g., carboxyhemoglobin [HbCO], reduced hemoglobin [Hb], oxygenated hemoglobin [HbOxy], and methemoglobin [HbMet]), total hemoglobin concentration [THb], concentrations of lactate, myoglobin, cholesterol, body pigments, and exogenous dyes; (4) content in tissues of water, fat, protein, calcium, and blood; as well as density of hard and soft tissues; and (5) accurate noninvasive measurement of blood pressure (or vascular pressure) in arteries, arterioles, veins, capillaries, using occlusion-induced changes in optoacoustic signal induced in blood circulating in the vessels. The optoacoustic technique can be used for single measurement, continuous measurement, or continuous monitoring of these variables.
摘要翻译：本发明公开了一种用于绝对，精确，连续和实时测量各种重要诊断变量的光声技术，其中变量包括：（1）循环血量的无创测量（BV）和心输出量（CO）; （2）从心脏指数（CI）和全身氧输送（DO2）的测量变量计算; （3）血红蛋白衍生物（例如碳氧血红蛋白[HbCO]，还原血红蛋白[Hb]，氧合血红蛋白[HbOxy]和高铁血红蛋白[HbMet]），总血红蛋白浓度[THb]，乳酸盐，肌红蛋白，胆固醇，颜料和外源染料; （4）在水，脂肪，蛋白质，钙和血液的组织中的含量; 以及硬组织和软组织的密度; 和（5）使用血管中血液循环中诱导的光声信号中的阻塞引起的变化来精确无创地测量动脉，小动脉，静脉，毛细血管中的血压（或血管压力）。光声技术可用于单次测量，连续测量或持续监测这些变量。

2. 发明申请

WO2004096082A2 NONINVASIVE BLOOD ANALYSIS BY OPTICAL PROBING OF THE VEINS UNDER THE TONGUE 审中-公开
标题翻译：通过在TONGUE下的视觉光学检测的非血液血液分析
公开(公告)号：WO2004096082A2
公开(公告)日：2004-11-11
申请号：PCT/US2004/012758
申请日：2004-04-26
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , ESENALIEV, Rinat, O. , PROUGH, Donald S.
发明人： ESENALIEV, Rinat, O. , PROUGH, Donald S.
IPC分类号： A61F
CPC分类号： A61B5/0068 , A61B5/0066 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/682
摘要： A method for analysis of blood components or parameters is disclosed where a probe having an excitation outlet and a response inlet is placed in proximity to or in contact with a tissue of an underside of a patient's tongue over a big vein in the tongue so that an excitation signal exits the outlet, produces a response which enters the inlet for detection and analysis.
摘要翻译：公开了一种用于分析血液成分或参数的方法，其中具有激发出口（116）和反应入口（118）的探针（102）被放置在患者舌头的下侧的组织附近或与其接触舌头中的大静脉（108），使得激发信号离开出口，产生进入入口以进行检测和分析的响应。

3. 发明申请

WO2012149519A1 METHODS AND APPARATUS FOR OPTOACOUSTIC GUIDANCE AND CONFIRMATION OF PLACEMENT OF INDWELLING MEDICAL APPARATUS 审中-公开
标题翻译：光学指导方法和装置及确定医疗器械放置
公开(公告)号：WO2012149519A1
公开(公告)日：2012-11-01
申请号：PCT/US2012/035756
申请日：2012-04-30
申请人： BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM , PROUGH, Donald, S. , ESENALIEV, Rinat, O. , PETROV, Yuriy , PETROV, Irene
发明人： PROUGH, Donald, S. , ESENALIEV, Rinat, O. , PETROV, Yuriy , PETROV, Irene
IPC分类号： A61B18/18 , A61B5/05 , A61B8/00
CPC分类号： A61B5/061 , A61B1/0676 , A61B1/07 , A61B5/0095 , A61B5/06 , A61B2505/05 , A61M16/0411 , A61M16/0434 , A61M16/0488 , A61M2205/3375 , A61M2205/502 , A61M2205/581 , A61M2205/583
摘要： Medical apparatus are disclosed for optoacoustic monitoring of an indwelling unit of the apparatus, where the indwelling unit includes one or more optical components capable of directing pulsed light into an overlying tissue. The apparatus also include one or more acoustic components in contact with an exterior surface of the tissue to detect induced pressure waves producing an acoustic output analyzed with an optoacoustic unit to monitor and confirm proper placement of the indwelling unit. Methods for using the apparatus are also disclosed.
摘要翻译：公开了用于设备的留置单元的光声监测的医疗设备，其中留置单元包括能够将脉冲光引导到上覆组织中的一个或多个光学部件。该装置还包括与组织的外表面接触的一个或多个声学部件，以检测产生用光声单元分析的声输出的感应压力波，以监测和确认留置单元的正确放置。还公开了使用该装置的方法。

4. 发明申请

WO2018067876A3 NANOPULSE LIGHT THERAPY 审中-公开
公开(公告)号：WO2018067876A3
公开(公告)日：2018-04-12
申请号：PCT/US2017/055423
申请日：2017-10-05
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , ESENALIEV, Rinat, O. , MICCI, Maria-Adelaide , PROUGH, Donald, S.
发明人： ESENALIEV, Rinat, O. , MICCI, Maria-Adelaide , PROUGH, Donald, S.
IPC分类号： A61B18/20 , A61N7/00
摘要： Provided herein are noninvasive stimulation methods and apparatus for the treatment of injury to tissues using a novel pulsed laser system that combines the benefits of near-infrared laser light and optoacoustic waves. In certain embodiments, short, high-energy laser light pulses generate low intensity ultrasound waves that travel deep into brain tissues to stimulate neural function and treat neurological dysfunctions. In certain embodiments, a patient interface is provided wherein optoacoustic waves are produced by a plurality of optical absorbers overlying all of a plurality of optical fibers while in other embodiments optoacoustic waves are generated both inside the tissue and outside the tissue via a plurality of optical absorbers overlying some but not all of the optical fibers thus enabling an option of varying proportions of optoacoustic waves generated inside and outside of tissue.

5. 发明申请

WO2018067876A2 NANOPULSE LIGHT THERAPY 审中-公开
标题翻译： NANOPULSE光疗法
公开(公告)号：WO2018067876A2
公开(公告)日：2018-04-12
申请号：PCT/US2017/055423
申请日：2017-10-05
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , ESENALIEV, Rinat, O. , MICCI, Maria-Adelaide , PROUGH, Donald, S.
发明人： ESENALIEV, Rinat, O. , MICCI, Maria-Adelaide , PROUGH, Donald, S.
IPC分类号： A61N5/067
CPC分类号： A61N7/00 , A61B18/26 , A61B2018/266 , A61N2007/0026
摘要： Provided herein are noninvasive stimulation methods and apparatus for the treatment of injury to tissues using a novel pulsed laser system that combines the benefits of near-infrared laser light and optoacoustic waves. In certain embodiments, short, high-energy laser light pulses generate low intensity ultrasound waves that travel deep into brain tissues to stimulate neural function and treat neurological dysfunctions. In certain embodiments, a patient interface is provided wherein optoacoustic waves are produced by a plurality of optical absorbers overlying all of a plurality of optical fibers while in other embodiments optoacoustic waves are generated both inside the tissue and outside the tissue via a plurality of optical absorbers overlying some but not all of the optical fibers thus enabling an option of varying proportions of optoacoustic waves generated inside and outside of tissue.
摘要翻译：本文提供了使用结合了近红外激光和光声波的益处的新型脉冲激光系统来治疗组织损伤的非侵入性刺激方法和装置。在某些实施方式中，短的高能量激光脉冲产生深度进入脑组织以刺激神经功能并治疗神经功能障碍的低强度超声波。在某些实施例中，提供患者界面，其中通过覆盖所有多根光纤的多个光学吸收器产生光声波，而在其他实施例中，在组织内和组织外部经由多个光学吸收器产生光声波覆盖一些但不是全部的光纤，从而使得可以选择不同比例的组织内外产生的光声波。

6. 发明申请

WO2018049415A1 ULTRASOUND-GUIDED OPTOACOUSTIC MONITORING OF OXYGEN SATURATION 审中-公开
标题翻译：超声波导向氧饱和度的光声监测
公开(公告)号：WO2018049415A1
公开(公告)日：2018-03-15
申请号：PCT/US2017/051217
申请日：2017-09-12
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , PROUGH, Donald, S. , KINSKY, Michael, P. , ESENALIEV, Rinat, O. , PETROV, Irene, Y. , PETROV, Yuri
发明人： PROUGH, Donald, S. , KINSKY, Michael, P. , ESENALIEV, Rinat, O. , PETROV, Irene, Y. , PETROV, Yuri
IPC分类号： A61B1/06 , A61B5/00 , A61B5/145 , A61B8/00 , G01H9/00 , G01N21/17
摘要： Apparatus and methods are described for ultrasound guided optoacoustic monitoring to provide diagnostic information for many clinical applications blood oxygenation in blood vessels and in tissues including for early diagnosis and management of circulatory shock (including that induced by hemorrhage). In certain embodiments provided herein, methods and apparatus for optoacoustics for measurement of blood oxygenation in the innominate vein are provided.
摘要翻译：描述了用于超声引导的光声监测的设备和方法，以提供用于血管和组织中血氧合的许多临床应用的诊断信息，包括用于循环性休克（包括由出血诱发的）的早期诊断和处理，。在本文提供的某些实施方式中，提供了用于测量无名静脉中血液氧合的光声学的方法和设备。

7. 发明申请

WO1997027801A1 LASER OPTO-ACOUSTIC IMAGING SYSTEM 审中-公开
标题翻译：激光OPO-ACOUSTIC成像系统
公开(公告)号：WO1997027801A1
公开(公告)日：1997-08-07
申请号：PCT/US1997001815
申请日：1997-01-31
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
发明人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , ORAEVSKY, Alexander, A. , JACQUES, Steven, L. , ESENALIEV, Rinat, O.
IPC分类号： A61B05/00
CPC分类号： G01N21/1702 , A61B5/0095 , A61B5/1459 , A61B8/08 , A61B2017/00128 , A61F9/008 , A61F2009/00851 , A61F2009/00897 , A61K49/225
摘要： The present invention provides a system and principles of laser photo-acoustic imaging and tomography. The basis for laser photo-acoustic tomography is the time resolved detection of laser induced transient stress waves, selectively generated in absorbing tissues of diagnostic interest. Such a technique allows to visualize absorbed light distribution in turbid biological tissues irradiated by short laser pulses. Laser photo-acoustic tomography can be used for detection of tissue pathological changes that result in increased concentration of various tissue chromophore such as hemoglobin or development of enhanced micro-circulation in diseased tissue. The invented technology combines the advantages of pulsed laser excitation with time resolved detection of acoustic transients. The invented technology can be used for determination of optical heterogeneities in biological tissues. These heterogeneities include blood vessels, tissue layers, abnormal tissues and damaged tissues with further reconstruction of 3D tomographic images of human organs or portions thereof.
摘要翻译：本发明提供了激光光声成像和层析成像的系统和原理。激光光声层析成像的基础是激光诱发瞬态应激波的时间分辨检测，在诊断感兴趣的吸收组织中有选择性地产生。这种技术允许可视化由短激光脉冲照射的混浊生物组织中的吸收光分布。激光光声层析成像可用于组织病理学变化的检测，导致各种组织发色团的浓度增加，如血红蛋白或病变组织中增强的微循环的发展。本发明的技术将脉冲激光激发的优点与声学瞬态的时间分辨检测相结合。本发明技术可用于确定生物组织中的光学异质性。这些异质性包括血管，组织层，异常组织和受损组织，进一步重建人体器官或其部分的3D断层图像。

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