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1. 发明申请

WO2009008933A2 OPTOACOUSTIC MONITORING OF MULTIPLE PARAMETERS 审中-公开
标题翻译：多参数光声监测
公开(公告)号：WO2009008933A2
公开(公告)日：2009-01-15
申请号：PCT/US2008/004732
申请日：2008-04-11
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , PROUGH, Donald, S. , ESENALIEV, Rinat, O. , DEYO, Donald , PETROV, Yuriy, Y. , PETROV, Irina, Y.
发明人： PROUGH, Donald, S. , ESENALIEV, Rinat, O. , DEYO, Donald , PETROV, Yuriy, Y. , PETROV, Irina, Y.
IPC分类号： G01N21/17 , A61B5/145
CPC分类号： A61B5/14542 , A61B5/0095 , A61B5/412 , A61B5/7239
摘要： An optoacoustic technique for absolute, accurate, continuous, and real-time measurement of a variety of important diagnostic variables is disclosed, where the variables include: (1) noninvasive measurements of circulating blood volume (BV) and cardiac output (CO); (2) calculation from the measured variables of cardiac index (CI) and systemic oxygen delivery (DO2); (3) concentrations of hemoglobin derivatives (e.g., carboxyhemoglobin [HbCO], reduced hemoglobin [Hb], oxygenated hemoglobin [HbOxy], and methemoglobin [HbMet]), total hemoglobin concentration [THb], concentrations of lactate, myoglobin, cholesterol, body pigments, and exogenous dyes; (4) content in tissues of water, fat, protein, calcium, and blood; as well as density of hard and soft tissues; and (5) accurate noninvasive measurement of blood pressure (or vascular pressure) in arteries, arterioles, veins, capillaries, using occlusion-induced changes in optoacoustic signal induced in blood circulating in the vessels. The optoacoustic technique can be used for single measurement, continuous measurement, or continuous monitoring of these variables.
摘要翻译：本发明公开了一种用于绝对，精确，连续和实时测量各种重要诊断变量的光声技术，其中变量包括：（1）循环血量的无创测量（BV）和心输出量（CO）; （2）从心脏指数（CI）和全身氧输送（DO2）的测量变量计算; （3）血红蛋白衍生物（例如碳氧血红蛋白[HbCO]，还原血红蛋白[Hb]，氧合血红蛋白[HbOxy]和高铁血红蛋白[HbMet]），总血红蛋白浓度[THb]，乳酸盐，肌红蛋白，胆固醇，颜料和外源染料; （4）在水，脂肪，蛋白质，钙和血液的组织中的含量; 以及硬组织和软组织的密度; 和（5）使用血管中血液循环中诱导的光声信号中的阻塞引起的变化来精确无创地测量动脉，小动脉，静脉，毛细血管中的血压（或血管压力）。光声技术可用于单次测量，连续测量或持续监测这些变量。

2. 发明申请

WO2009008933A3 OPTOACOUSTIC MONITORING OF MULTIPLE PARAMETERS 审中-公开
标题翻译：多参数光学监测
公开(公告)号：WO2009008933A3
公开(公告)日：2009-04-16
申请号：PCT/US2008004732
申请日：2008-04-11
申请人： UNIV TEXAS , PROUGH DONALD S , ESENALIEV RINAT O , DEYO DONALD , PETROV YURIY Y , PETROV IRINA Y
发明人： PROUGH DONALD S , ESENALIEV RINAT O , DEYO DONALD , PETROV YURIY Y , PETROV IRINA Y
IPC分类号： A61B5/00
CPC分类号： A61B5/14542 , A61B5/0095 , A61B5/412 , A61B5/7239
摘要： An optoacoustic technique for absolute, accurate, continuous, and real-time measurement of a variety of important diagnostic variables is disclosed, where the variables include: (1) noninvasive measurements of circulating blood volume (BV) and cardiac output (CO); (2) calculation from the measured variables of cardiac index (CI) and systemic oxygen delivery (DO2); (3) concentrations of hemoglobin derivatives (e.g., carboxyhemoglobin [HbCO], reduced hemoglobin [Hb], oxygenated hemoglobin [HbOxy], and methemoglobin [HbMet]), total hemoglobin concentration [THb], concentrations of lactate, myoglobin, cholesterol, body pigments, and exogenous dyes; (4) content in tissues of water, fat, protein, calcium, and blood; as well as density of hard and soft tissues; and (5) accurate noninvasive measurement of blood pressure (or vascular pressure) in arteries, arterioles, veins, capillaries, using occlusion-induced changes in optoacoustic signal induced in blood circulating in the vessels. The optoacoustic technique can be used for single measurement, continuous measurement, or continuous monitoring of these variables.
摘要翻译：公开了用于绝对，准确，连续和实时测量各种重要诊断变量的光声技术，其中变量包括：（1）循环血液体积（BV）和心输出量（CO）的无创测量; （2）从心脏指数（CI）和全身氧气输送（DO2）的测量变量计算; （3）血红蛋白衍生物（例如，碳氧血红蛋白[HbCO]，血红蛋白降低[Hb]，氧合血红蛋白[HbOxy]和高铁血红蛋白[HbMet]）的浓度，总血红蛋白浓度[THb]，乳酸盐，肌红蛋白，胆固醇，体内浓度颜料和外源染料; （4）水，脂肪，蛋白质，钙和血液组织中的含量; 以及硬组织和软组织的密度; 和（5）使用血管中循环血液中诱导的光声信号的闭塞诱发的变化，准确地无创地测量动脉，小动脉，静脉，毛细血管中的血压（或血管压力）。光声技术可用于单次测量，连续测量或连续监测这些变量。

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