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1. 发明申请

WO2007025164A3 HYDROGEL BALLOON PROSTHESIS FOR NUCLEUS PULPOSUS 审中-公开
标题翻译：氢化球藻对核仁的影响
公开(公告)号：WO2007025164A3
公开(公告)日：2007-12-06
申请号：PCT/US2006033276
申请日：2006-08-25
申请人： SYNTHES USA , SYNTHES GMBH , MARCOLONGO MICHELE S , LOWMAN ANTHONY M , CLEMOW ALASTAIR J T , KEANE MICHAEL F , VRESILOVIC EDWARD
发明人： MARCOLONGO MICHELE S , LOWMAN ANTHONY M , CLEMOW ALASTAIR J T , KEANE MICHAEL F , VRESILOVIC EDWARD
IPC分类号： A61L27/52 , A61F2/44
CPC分类号： A61L27/52 , A61F2/30767 , A61F2/441 , A61F2002/444
摘要： A prosthesis for replacing or supplementing a nucleus pulposus of an intervertebral disk is an expandable container having flexible walls, the container being adapted to be inserted into a central cavity of an intervertebral disk through a narrow cannula, and the flexible walls are made from a biocompatible hydrogel. A preferred hydrogel is a cryogel formed from an aqueous solution of poly(vinyl alcohol) and poly(vinyl pyrrolidone). The prosthesis may be prepared by dip-coating a mandrel with an aqueous solution of a hydrogel-forming polymer or mixture of such polymers, gelling the coated solution by chilling, and subjecting the gelled coating to a series of repeated freeze-thaw treatments. In use, the prosthesis is inserted into a central cavity of an intervertebral disk and filled with biocompatible material, e.g., a biocompatible liquid, a biocompatible polymer, and a biocompatible hydrogel, particularly a thermogelling hydrogel.
摘要翻译：用于替换或补充椎间盘髓核的假体是具有柔性壁的可扩张容器，该容器适于通过狭窄的插管插入到椎间盘的中心空腔中，并且柔性壁由生物相容性水凝胶。优选的水凝胶是由聚（乙烯醇）和聚（乙烯基吡咯烷酮）的水溶液形成的冷冻凝胶。假体可以通过用形成水凝胶的聚合物或这种聚合物的混合物的水溶液浸渍心轴来制备，通过冷却使涂覆的溶液凝胶化，并使凝胶涂层进行一系列重复的冻融处理。在使用中，将假体插入到椎间盘的中心空腔中，并填充有生物相容性材料，例如生物相容性液体，生物相容性聚合物和生物相容性水凝胶，特别是热胶凝水凝胶。

2. 发明申请

WO2005113032A2 REPLACEMENT OR SUPPLEMENTATION OF A NUCLEUS PULPOSUS USING A HYDROGEL 审中-公开
标题翻译：使用HYDROGEL替代或补充核桃浆
公开(公告)号：WO2005113032A2
公开(公告)日：2005-12-01
申请号：PCT/US2005018028
申请日：2005-05-23
申请人： SYNTHES INC , VRESILOVIC EDWARD , KEANE MICHAEL F , CLEMOW ALASTAIR J T , SMITH NIGEL G
发明人： VRESILOVIC EDWARD , KEANE MICHAEL F , CLEMOW ALASTAIR J T , SMITH NIGEL G
IPC分类号： A61B17/34 , A61F2/00 , A61F2/44 , A61F2/46 , A61L27/00 , A61L27/52
CPC分类号： A61F2/442 , A61B17/3468 , A61B17/3472 , A61F2/4611 , A61F2002/3008 , A61F2002/30242 , A61F2002/444 , A61F2002/4495 , A61F2002/4627 , A61F2230/0071 , A61F2250/0098 , A61L27/00 , A61L27/52
摘要： A nucleus pulposus of an intervertebral disc is supplemented or replaced by an elongated, physiologically fully hydrated hydrogel prosthesis inserted into the central region of an intervertebral disc, where it can fold upon itself to form a prosthesis body within the central region of the annulus fibrosus. The hydrogel prosthesis may have expanded portions that assist in preventing expulsion of the prosthesis through the insertion aperture. An instrument for inserting the prosthesis has a cutter for severing the elongated prosthesis within the central region of the intervertebral disc after a sufficient amount has been implanted.
摘要翻译：椎间盘的髓核由插入到椎间盘的中心区域中的细长的，生理上完全水合的水凝胶假体补充或代替，其中它可以折叠在其上以在纤维环的中心区域内形成假体。水凝胶假体可以具有有助于防止假体通过插入孔排出的扩张部分。用于插入假体的器具具有切割器，用于在已经植入足够数量之后切断椎间盘中心区域内的细长假体。

3. 发明申请

WO2009079507A3 CROSSLINKED HYDROGELS 审中-公开
标题翻译：交联水晶
公开(公告)号：WO2009079507A3
公开(公告)日：2010-04-22
申请号：PCT/US2008086997
申请日：2008-12-16
申请人： SYNTHES USA , SYNTHES GMBH , UNIV DREXEL , KITA KRISTIN , SMITH NIGEL G , LOWMAN ANTHONY M , FUSSELL GARLAND W , KEANE MICHAEL F
发明人： KITA KRISTIN , SMITH NIGEL G , LOWMAN ANTHONY M , FUSSELL GARLAND W , KEANE MICHAEL F
IPC分类号： A61L27/16
CPC分类号： A61L27/16
摘要： The present invention preferably provides for a method of forming and the resulting solid polymer gel composition comprising polyethylene imine and at least one hydrogen bonding polymer. The composition has a greater viscosity than either of the polyethylene imine or the hydrogen bonding polymer alone and is injectable immediately after mixing of the polyethylene imine and the at least one hydrogen bonding polymer. A method of tissue repair may include mixing about 9.25% (w/w) to about 13.65% (w/w) polyethylene imine and about 18.02% (w/w) to about 26.62% (w/w) polyvinyl alcohol to form an injectable composition; injecting the injectable composition into a cavity within a human body; and allowing the composition to solidify in situ. A kit may include a multi-barrel syringe at least one barrel is loaded with polyethylene imine and at least another barrel is loaded with at least one hydrogen bonding polymer.
摘要翻译：本发明优选提供一种形成方法和所得到的固体聚合物凝胶组合物，其包含聚乙烯亚胺和至少一种氢键聚合物。该组合物比单独的聚乙烯亚胺或氢键聚合物具有更大的粘度，并且在聚乙烯亚胺和至少一种氢键聚合物混合后立即进行注射。组织修复的方法可包括混合约9.25％（w / w）至约13.65％（w / w）的聚乙烯亚胺和约18.02％（w / w）至约26.62％（w / w）的聚乙烯醇，形成可注射组合物将可注射组合物注射到人体内的空腔中; 并使组合物原位固化。套件可以包括多桶注射器，至少一个桶装有聚乙烯亚胺，并且至少另一个筒装有至少一个氢键聚合物。

4. 发明申请

WO2006105190A3 METHOD AND APPARATUS FOR IMPLANTING A HYDROGEL PROSTHESIS FOR A NUCLEUS PULPOSUS 审中-公开
标题翻译：用于植入NUCLEUS PULPOSUS的水凝胶预处理方法和装置
公开(公告)号：WO2006105190A3
公开(公告)日：2007-05-24
申请号：PCT/US2006011454
申请日：2006-03-29
申请人： SYNTHES USA , SYNTHES GMBH , VRESILOVIC EDWARD , KEANE MICHAEL F , SCHAER THOMAS P , ARTHUR AMY , SINGHATAT WAMIS
发明人： VRESILOVIC EDWARD , KEANE MICHAEL F , SCHAER THOMAS P , ARTHUR AMY , SINGHATAT WAMIS
IPC分类号： A61F2/46 , A61F2/44
CPC分类号： A61F2/4657 , A61B2090/064 , A61F2/4611 , A61F2002/30075 , A61F2002/3009 , A61F2002/30235 , A61F2002/30581 , A61F2002/30617 , A61F2002/444 , A61F2002/4627 , A61F2002/4663 , A61F2002/4677 , A61F2002/4693 , A61F2002/4694 , A61F2210/0061 , A61F2230/0069 , A61F2250/0091 , A61F2250/0097
摘要： An instrument (100) for inserting an elongated hydrogel prosthesis into an intervertebral disc includes an insertion cannula (200) that is inserted through the annulus fibrosus of an intervertebral disc to provide access to the nucleus region of the disc, an elongated hydrogel prosthesis packaged within a tubular container (300) adapted to be coupled to a proximal end of the insertion cannula, and a source of fluid pressure (400) adapted to be coupled to a proximal end of the tubular container. Auxiliary instruments for use in convenient insertion of the insertion cannula through the nucleus pulposus and providing for a complete and controlled passage of the hydrogel prosthesis through the insertion cannula are provided in a kit with the insertion cannula. A sizing apparatus (700) for determining the volume of prosthesis to be inserted includes a catheter or cannula (702) capable of being inserted through the insertion cannula into the nucleus region of the intervertebral disc and having at its distal end a balloon (704) capable of being inflated within the intervertebral disc with a measurable volume of a fluid in order to determine the amount of hydrogel prosthesis to be injected.
摘要翻译：用于将细长水凝胶假体插入椎间盘的器械（100）包括插入穿过椎间盘纤维环的插入套管（200），以提供通向椎间盘的细胞核区域的通路，适于联接到所述插入套管的近端的管状容器（300）以及适于联接到所述管状容器的近端的流体压力源（400）。用于通过髓核方便地插入插入插管并且通过插入套管提供水凝胶假体的完整和受控通道的辅助仪器在具有插入套管的套件中提供。用于确定待插入的假体的体积的定径装置（700）包括能够穿过插入插管插入椎间盘的核区域中的导管或套管（702），并且在其远端处具有气囊（704）能够在具有可测量体积的流体的椎间盘内充气，以便确定待注射的水凝胶假体的量。

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