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1. 发明申请

WO2007025164A3 HYDROGEL BALLOON PROSTHESIS FOR NUCLEUS PULPOSUS 审中-公开
标题翻译：氢化球藻对核仁的影响
公开(公告)号：WO2007025164A3
公开(公告)日：2007-12-06
申请号：PCT/US2006033276
申请日：2006-08-25
申请人： SYNTHES USA , SYNTHES GMBH , MARCOLONGO MICHELE S , LOWMAN ANTHONY M , CLEMOW ALASTAIR J T , KEANE MICHAEL F , VRESILOVIC EDWARD
发明人： MARCOLONGO MICHELE S , LOWMAN ANTHONY M , CLEMOW ALASTAIR J T , KEANE MICHAEL F , VRESILOVIC EDWARD
IPC分类号： A61L27/52 , A61F2/44
CPC分类号： A61L27/52 , A61F2/30767 , A61F2/441 , A61F2002/444
摘要： A prosthesis for replacing or supplementing a nucleus pulposus of an intervertebral disk is an expandable container having flexible walls, the container being adapted to be inserted into a central cavity of an intervertebral disk through a narrow cannula, and the flexible walls are made from a biocompatible hydrogel. A preferred hydrogel is a cryogel formed from an aqueous solution of poly(vinyl alcohol) and poly(vinyl pyrrolidone). The prosthesis may be prepared by dip-coating a mandrel with an aqueous solution of a hydrogel-forming polymer or mixture of such polymers, gelling the coated solution by chilling, and subjecting the gelled coating to a series of repeated freeze-thaw treatments. In use, the prosthesis is inserted into a central cavity of an intervertebral disk and filled with biocompatible material, e.g., a biocompatible liquid, a biocompatible polymer, and a biocompatible hydrogel, particularly a thermogelling hydrogel.
摘要翻译：用于替换或补充椎间盘髓核的假体是具有柔性壁的可扩张容器，该容器适于通过狭窄的插管插入到椎间盘的中心空腔中，并且柔性壁由生物相容性水凝胶。优选的水凝胶是由聚（乙烯醇）和聚（乙烯基吡咯烷酮）的水溶液形成的冷冻凝胶。假体可以通过用形成水凝胶的聚合物或这种聚合物的混合物的水溶液浸渍心轴来制备，通过冷却使涂覆的溶液凝胶化，并使凝胶涂层进行一系列重复的冻融处理。在使用中，将假体插入到椎间盘的中心空腔中，并填充有生物相容性材料，例如生物相容性液体，生物相容性聚合物和生物相容性水凝胶，特别是热胶凝水凝胶。

2. 发明申请

WO2008106582A3 TENSION FIXATION SYSTEM 审中-公开
标题翻译：张力固定系统
公开(公告)号：WO2008106582A3
公开(公告)日：2009-12-30
申请号：PCT/US2008055246
申请日：2008-02-28
申请人： MASS MODULAR SPINE SYSTEM , SNYDER BRIAN D , VRESILOVIC EDWARD J JR , MEHTA HEMAL P , MULLER JOHN A
发明人： SNYDER BRIAN D , VRESILOVIC EDWARD J JR , MEHTA HEMAL P , MULLER JOHN A
IPC分类号： A61B17/70
CPC分类号： A61B17/7032 , A61B17/7037 , A61B17/7038
摘要： The present invention provides an apparatus and method for fixation of a bone anchor to a structural member used for spinal fixation, whereby spinal deformity can be corrected and mechanical stability of the spine is provided so that load is carried fully or partially through the structural member. This invention provides fixation of a bone anchor to a structural member through tensile loading of a component of the fixation mechanism. This invention is widely adaptable to a variety of bone anchors and structural members. This invention allows reduction of spine deformity resulting from varied spinal disease through the fixation mechanism alone without the need for added reduction instrumentation systems. This invention equally provides a fixation mechanism for fixation of a bone anchor to the structural member of a spine fixation system in the absence of deformity.
摘要翻译：本发明提供了一种用于将骨锚定固定到用于脊柱固定的结构构件的装置和方法，由此可以校正脊柱畸形并提供脊柱的机械稳定性，使得负载被完全地或部分地穿过结构构件。本发明通过拉伸加载固定机构的部件来提供将骨锚固定到结构构件上。本发明广泛适用于各种骨锚和结构构件。本发明允许通过单独的固定机构减少由不同的脊柱疾病引起的脊柱畸形，而不需要附加的还原仪器系统。本发明同样提供了一种用于在不存在畸形的情况下将骨锚定固定到脊椎固定系统的结构构件的固定机构。

3. 发明申请

WO2008008458A2 MODULAR SPINAL FIXATION SYSTEM 审中-公开
标题翻译：模块化脊柱固定系统
公开(公告)号：WO2008008458A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/015931
申请日：2007-07-13
申请人： MASS MODULAR SPINE SYSTEM , SNYDER, Brian, D. , VRESILOVIC, Edward, J., Jr. , MEHTA, Hemal, P. , MULLER, John, A.
IPC分类号： A61B17/58
CPC分类号： A61B17/7001 , A61B17/7032 , A61B17/7037
摘要： A spinal fixation system having a modular construction to allow universal application to varying spine anatomy and load requirements of individual vertebral attachment members, while reducing requirements for large inventories to optimize spinal fixation. Modularity allows the individual attachment members, once attached optimally to bone, to be attached to a variety of interconnecting structural members optimized for load carrying capacity.
摘要翻译：脊柱固定系统具有模块化结构，以允许通用应用于改变脊柱附件的各种脊柱解剖结构和负载要求，同时减少大量库存以优化脊柱固定的要求。模块化允许一旦最佳地附接到骨头上的各个附接构件被附接到针对承载能力优化的各种互连结构构件。

4. 发明申请

WO2006105190A2 METHOD AND APPARATUS FOR IMPLANTING A HYDROGEL PROSTHESIS FOR A NUCLEUS PULPOSUS 审中-公开
标题翻译：用于植入NUCLEUS PULPOSUS的水凝胶预处理方法和装置
公开(公告)号：WO2006105190A2
公开(公告)日：2006-10-05
申请号：PCT/US2006/011454
申请日：2006-03-29
申请人： SYNTHES INC. , VRESILOVIC, Edward , KEANE, Michael, F. , SCHAER, Thomas, P. , ARTHUR, Amy , SINGHATAT, Wamis
发明人： VRESILOVIC, Edward , KEANE, Michael, F. , SCHAER, Thomas, P. , ARTHUR, Amy , SINGHATAT, Wamis
IPC分类号： A61F2/46 , A61F2/44
CPC分类号： A61F2/4657 , A61B2090/064 , A61F2/4611 , A61F2002/30075 , A61F2002/3009 , A61F2002/30235 , A61F2002/30581 , A61F2002/30617 , A61F2002/444 , A61F2002/4627 , A61F2002/4663 , A61F2002/4677 , A61F2002/4693 , A61F2002/4694 , A61F2210/0061 , A61F2230/0069 , A61F2250/0091 , A61F2250/0097
摘要： An instrument for inserting an elongated hydrogel prosthesis into an intervertebral disc includes an insertion cannula that is inserted through the annulus fibrosus of an intervertebral disc to provide access to the nucleus region of the disc, an elongated hydrogel prosthesis packaged within a tubular container adapted to be coupled to a proximal end of the insertion cannula, and a source of fluid pressure adapted to be coupled to a proximal end of the tubular container. Auxiliary instruments for use in convenient insertion of the insertion cannula through the nucleus pulposus and providing for a complete and controlled passage of the hydrogel prosthesis through the insertion cannula are provided in a kit with the insertion cannula. A sizing apparatus for determining the volume of prosthesis to be inserted includes a catheter or cannula capable of being inserted through the insertion cannula into the nucleus region of the intervertebral disc and having at its distal end a balloon capable of being inflated within the intervertebral disc with a measurable volume of a fluid in order to determine the amount of hydrogel prosthesis to be injected.
摘要翻译：用于将细长水凝胶假体插入椎间盘的器械包括插入插入穿过椎间盘纤维环的插入套管，以提供进入椎间盘的细胞核区域的细长水凝胶假体，耦合到插入套管的近端，以及适于联接到管状容器的近端的流体源的源。用于通过髓核方便地插入插入插管并且通过插入套管提供水凝胶假体的完整和受控通道的辅助仪器在具有插入套管的套件中提供。用于确定要插入的假体的体积的定径装置包括导管或套管，其能够穿过插入插管插入到椎间盘的细胞核区域中，并且在其远端具有能够在椎间盘内膨胀的气囊，可测量体积的流体，以确定待注射的水凝胶假体的量。

5. 发明申请

WO2005113032A3 REPLACEMENT OF NUCLEUS PULPOSUS USING A HYDROGEL 审中-公开
公开(公告)号：WO2005113032A3
公开(公告)日：2005-12-01
申请号：PCT/US2005/018028
申请日：2005-05-23
申请人： SYNTHES INC. , VRESILOVIC, Edward , KEANE, Michael, F. , CLEMOW, Alastair, J.T. , SMITH, Nigel, G.
发明人： VRESILOVIC, Edward , KEANE, Michael, F. , CLEMOW, Alastair, J.T. , SMITH, Nigel, G.
IPC分类号： A61L27/52 , A61F2/44
摘要： A nucleus pulposus of an intervertebral disc is supplemented or replaced by an elongated, physiologically fully hydrated hydrogel prosthesis inserted into the central region of an intervertebral disc, where it can fold upon itself to form a prosthesis body within the central region of the annulus fibrosus. The hydrogel prosthesis may have expanded portions that assist in preventing expulsion of the prosthesis through the insertion aperture. An instrument for inserting the prosthesis has a cutter for severing the elongated prosthesis within the central region of the intervertebral disc after a sufficient amount has been implanted.

6. 发明申请

WO2005113032A2 REPLACEMENT OR SUPPLEMENTATION OF A NUCLEUS PULPOSUS USING A HYDROGEL 审中-公开
标题翻译：使用HYDROGEL替代或补充核桃浆
公开(公告)号：WO2005113032A2
公开(公告)日：2005-12-01
申请号：PCT/US2005018028
申请日：2005-05-23
申请人： SYNTHES INC , VRESILOVIC EDWARD , KEANE MICHAEL F , CLEMOW ALASTAIR J T , SMITH NIGEL G
发明人： VRESILOVIC EDWARD , KEANE MICHAEL F , CLEMOW ALASTAIR J T , SMITH NIGEL G
IPC分类号： A61B17/34 , A61F2/00 , A61F2/44 , A61F2/46 , A61L27/00 , A61L27/52
CPC分类号： A61F2/442 , A61B17/3468 , A61B17/3472 , A61F2/4611 , A61F2002/3008 , A61F2002/30242 , A61F2002/444 , A61F2002/4495 , A61F2002/4627 , A61F2230/0071 , A61F2250/0098 , A61L27/00 , A61L27/52
摘要： A nucleus pulposus of an intervertebral disc is supplemented or replaced by an elongated, physiologically fully hydrated hydrogel prosthesis inserted into the central region of an intervertebral disc, where it can fold upon itself to form a prosthesis body within the central region of the annulus fibrosus. The hydrogel prosthesis may have expanded portions that assist in preventing expulsion of the prosthesis through the insertion aperture. An instrument for inserting the prosthesis has a cutter for severing the elongated prosthesis within the central region of the intervertebral disc after a sufficient amount has been implanted.
摘要翻译：椎间盘的髓核由插入到椎间盘的中心区域中的细长的，生理上完全水合的水凝胶假体补充或代替，其中它可以折叠在其上以在纤维环的中心区域内形成假体。水凝胶假体可以具有有助于防止假体通过插入孔排出的扩张部分。用于插入假体的器具具有切割器，用于在已经植入足够数量之后切断椎间盘中心区域内的细长假体。

7. 发明申请

WO2008008458A3 MODULAR SPINAL FIXATION SYSTEM 审中-公开
标题翻译：模块化脊柱固定系统
公开(公告)号：WO2008008458A3
公开(公告)日：2008-10-09
申请号：PCT/US2007015931
申请日：2007-07-13
申请人： MASS MODULAR SPINE SYSTEM , SNYDER BRIAN D , VRESILOVIC EDWARD J JR , MEHTA HEMAL P , MULLER JOHN A
IPC分类号： A61B17/70
CPC分类号： A61B17/7001 , A61B17/7032 , A61B17/7037
摘要： A spinal fixation system having a modular construction to allow universal application to varying spine anatomy and load requirements of individual vertebral attachment members, while reducing requirements for large inventories to optimize spinal fixation. Modularity allows the individual attachment members, once attached optimally to bone, to be attached to a variety of interconnecting structural members optimized for load carrying capacity.
摘要翻译：具有模块化构造的脊柱固定系统允许通用于各种椎骨附件的不同脊柱解剖结构和负载要求，同时减少对大型库存的需求以优化脊柱固定。模块化允许单独的附接构件一旦最佳地附接到骨头，就附接到优化用于承载能力的各种互连结构构件。

8. 发明申请

WO2008106582A2 TENSION FIXATION SYSTEM 审中-公开
标题翻译：张力固定系统
公开(公告)号：WO2008106582A2
公开(公告)日：2008-09-04
申请号：PCT/US2008/055246
申请日：2008-02-28
申请人： MASS MODULAR SPINE SYSTEM , SNYDER, Brian, D. , VRESILOVIC, Edward, J. JR. , MEHTA, Hemal, P. , MULLER, John, A.
发明人： SNYDER, Brian, D. , VRESILOVIC, Edward, J. JR. , MEHTA, Hemal, P. , MULLER, John, A.
IPC分类号： A61B17/70
CPC分类号： A61B17/7032 , A61B17/7037 , A61B17/7038
摘要： The present invention provides an apparatus and method for fixation of a bone anchor to a structural member used for spinal fixation, whereby spinal deformity can be corrected and mechanical stability of the spine is provided so that load is carried fully or partially through the structural member. This invention provides fixation of a bone anchor to a structural member through tensile loading of a component of the fixation mechanism. This invention is widely adaptable to a variety of bone anchors and structural members. This invention allows reduction of spine deformity resulting from varied spinal disease through the fixation mechanism alone without the need for added reduction instrumentation systems. This invention equally provides a fixation mechanism for fixation of a bone anchor to the structural member of a spine fixation system in the absence of deformity.
摘要翻译：本发明提供了一种用于将骨锚定固定到用于脊柱固定的结构构件的装置和方法，由此可以校正脊柱畸形并提供脊柱的机械稳定性，使得负载被完全地或部分地穿过结构构件。本发明通过拉伸加载固定机构的部件来提供将骨锚固定到结构构件上。本发明广泛适用于各种骨锚和结构构件。本发明允许通过单独的固定机构减少由不同的脊柱疾病引起的脊柱畸形，而不需要附加的还原仪器系统。本发明同样提供了一种用于在不存在畸形的情况下将骨锚定固定到脊椎固定系统的结构构件的固定机构。

9. 发明申请

WO2006105190A3 METHOD AND APPARATUS FOR IMPLANTING A HYDROGEL PROSTHESIS FOR A NUCLEUS PULPOSUS 审中-公开
标题翻译：用于植入NUCLEUS PULPOSUS的水凝胶预处理方法和装置
公开(公告)号：WO2006105190A3
公开(公告)日：2007-05-24
申请号：PCT/US2006011454
申请日：2006-03-29
申请人： SYNTHES USA , SYNTHES GMBH , VRESILOVIC EDWARD , KEANE MICHAEL F , SCHAER THOMAS P , ARTHUR AMY , SINGHATAT WAMIS
发明人： VRESILOVIC EDWARD , KEANE MICHAEL F , SCHAER THOMAS P , ARTHUR AMY , SINGHATAT WAMIS
IPC分类号： A61F2/46 , A61F2/44
CPC分类号： A61F2/4657 , A61B2090/064 , A61F2/4611 , A61F2002/30075 , A61F2002/3009 , A61F2002/30235 , A61F2002/30581 , A61F2002/30617 , A61F2002/444 , A61F2002/4627 , A61F2002/4663 , A61F2002/4677 , A61F2002/4693 , A61F2002/4694 , A61F2210/0061 , A61F2230/0069 , A61F2250/0091 , A61F2250/0097
摘要： An instrument (100) for inserting an elongated hydrogel prosthesis into an intervertebral disc includes an insertion cannula (200) that is inserted through the annulus fibrosus of an intervertebral disc to provide access to the nucleus region of the disc, an elongated hydrogel prosthesis packaged within a tubular container (300) adapted to be coupled to a proximal end of the insertion cannula, and a source of fluid pressure (400) adapted to be coupled to a proximal end of the tubular container. Auxiliary instruments for use in convenient insertion of the insertion cannula through the nucleus pulposus and providing for a complete and controlled passage of the hydrogel prosthesis through the insertion cannula are provided in a kit with the insertion cannula. A sizing apparatus (700) for determining the volume of prosthesis to be inserted includes a catheter or cannula (702) capable of being inserted through the insertion cannula into the nucleus region of the intervertebral disc and having at its distal end a balloon (704) capable of being inflated within the intervertebral disc with a measurable volume of a fluid in order to determine the amount of hydrogel prosthesis to be injected.
摘要翻译：用于将细长水凝胶假体插入椎间盘的器械（100）包括插入穿过椎间盘纤维环的插入套管（200），以提供通向椎间盘的细胞核区域的通路，适于联接到所述插入套管的近端的管状容器（300）以及适于联接到所述管状容器的近端的流体压力源（400）。用于通过髓核方便地插入插入插管并且通过插入套管提供水凝胶假体的完整和受控通道的辅助仪器在具有插入套管的套件中提供。用于确定待插入的假体的体积的定径装置（700）包括能够穿过插入插管插入椎间盘的核区域中的导管或套管（702），并且在其远端处具有气囊（704）能够在具有可测量体积的流体的椎间盘内充气，以便确定待注射的水凝胶假体的量。

10. 发明申请

WO2011057286A1 COMPOSITIONS AND METHODS FOR TREATING A DISORDER OR DEFECT IN SOFT TISSUE 审中-公开
标题翻译：用于治疗疾病或软组织缺陷的组合物和方法
公开(公告)号：WO2011057286A1
公开(公告)日：2011-05-12
申请号：PCT/US2010/056064
申请日：2010-11-09
申请人： DREXEL UNIVERSITY , MARCOLONGO, Michele , VRESILOVIC, Edward , JACKSON, Benjamin , SARKAR, Sumona , SCHAUER, Caroline
发明人： VRESILOVIC, Edward , JACKSON, Benjamin , SARKAR, Sumona , SCHAUER, Caroline
IPC分类号： C08B37/00
CPC分类号： C08L5/08 , C08B37/003 , C08B37/0063 , C08B37/0069 , C08B37/0072 , C08B37/0075 , C08G81/00 , C08L5/00 , C08L5/10
摘要： The present invention encompasses methods and compositions for generating a biomimetic proteoglycan. The invention includes methods of treating a disease, disorder, or condition of soft tissue using a biomimetic proteoglycan.
摘要翻译：本发明包括用于产生仿生蛋白多糖的方法和组合物。本发明包括使用仿生蛋白多糖来治疗软组织的疾病，病症或状况的方法。

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