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1. 发明申请

WO2005113032A2 REPLACEMENT OR SUPPLEMENTATION OF A NUCLEUS PULPOSUS USING A HYDROGEL 审中-公开
标题翻译：使用HYDROGEL替代或补充核桃浆
公开(公告)号：WO2005113032A2
公开(公告)日：2005-12-01
申请号：PCT/US2005018028
申请日：2005-05-23
申请人： SYNTHES INC , VRESILOVIC EDWARD , KEANE MICHAEL F , CLEMOW ALASTAIR J T , SMITH NIGEL G
发明人： VRESILOVIC EDWARD , KEANE MICHAEL F , CLEMOW ALASTAIR J T , SMITH NIGEL G
IPC分类号： A61B17/34 , A61F2/00 , A61F2/44 , A61F2/46 , A61L27/00 , A61L27/52
CPC分类号： A61F2/442 , A61B17/3468 , A61B17/3472 , A61F2/4611 , A61F2002/3008 , A61F2002/30242 , A61F2002/444 , A61F2002/4495 , A61F2002/4627 , A61F2230/0071 , A61F2250/0098 , A61L27/00 , A61L27/52
摘要： A nucleus pulposus of an intervertebral disc is supplemented or replaced by an elongated, physiologically fully hydrated hydrogel prosthesis inserted into the central region of an intervertebral disc, where it can fold upon itself to form a prosthesis body within the central region of the annulus fibrosus. The hydrogel prosthesis may have expanded portions that assist in preventing expulsion of the prosthesis through the insertion aperture. An instrument for inserting the prosthesis has a cutter for severing the elongated prosthesis within the central region of the intervertebral disc after a sufficient amount has been implanted.
摘要翻译：椎间盘的髓核由插入到椎间盘的中心区域中的细长的，生理上完全水合的水凝胶假体补充或代替，其中它可以折叠在其上以在纤维环的中心区域内形成假体。水凝胶假体可以具有有助于防止假体通过插入孔排出的扩张部分。用于插入假体的器具具有切割器，用于在已经植入足够数量之后切断椎间盘中心区域内的细长假体。

2. 发明申请

WO2009079507A3 CROSSLINKED HYDROGELS 审中-公开
标题翻译：交联水晶
公开(公告)号：WO2009079507A3
公开(公告)日：2010-04-22
申请号：PCT/US2008086997
申请日：2008-12-16
申请人： SYNTHES USA , SYNTHES GMBH , UNIV DREXEL , KITA KRISTIN , SMITH NIGEL G , LOWMAN ANTHONY M , FUSSELL GARLAND W , KEANE MICHAEL F
发明人： KITA KRISTIN , SMITH NIGEL G , LOWMAN ANTHONY M , FUSSELL GARLAND W , KEANE MICHAEL F
IPC分类号： A61L27/16
CPC分类号： A61L27/16
摘要： The present invention preferably provides for a method of forming and the resulting solid polymer gel composition comprising polyethylene imine and at least one hydrogen bonding polymer. The composition has a greater viscosity than either of the polyethylene imine or the hydrogen bonding polymer alone and is injectable immediately after mixing of the polyethylene imine and the at least one hydrogen bonding polymer. A method of tissue repair may include mixing about 9.25% (w/w) to about 13.65% (w/w) polyethylene imine and about 18.02% (w/w) to about 26.62% (w/w) polyvinyl alcohol to form an injectable composition; injecting the injectable composition into a cavity within a human body; and allowing the composition to solidify in situ. A kit may include a multi-barrel syringe at least one barrel is loaded with polyethylene imine and at least another barrel is loaded with at least one hydrogen bonding polymer.
摘要翻译：本发明优选提供一种形成方法和所得到的固体聚合物凝胶组合物，其包含聚乙烯亚胺和至少一种氢键聚合物。该组合物比单独的聚乙烯亚胺或氢键聚合物具有更大的粘度，并且在聚乙烯亚胺和至少一种氢键聚合物混合后立即进行注射。组织修复的方法可包括混合约9.25％（w / w）至约13.65％（w / w）的聚乙烯亚胺和约18.02％（w / w）至约26.62％（w / w）的聚乙烯醇，形成可注射组合物将可注射组合物注射到人体内的空腔中; 并使组合物原位固化。套件可以包括多桶注射器，至少一个桶装有聚乙烯亚胺，并且至少另一个筒装有至少一个氢键聚合物。

3. 发明申请

WO2009089526A3 BIOADHESIVE HYDROGELS 审中-公开
公开(公告)号：WO2009089526A3
公开(公告)日：2010-05-27
申请号：PCT/US2009030731
申请日：2009-01-12
申请人： SYNTHES USA LLC , SYNTHES GMBH , UNIV DREXEL , KITA KRISTIN B , SMITH NIGEL G , LOWMAN ANTHONY M , FUSSELL GARLAND W
发明人： KITA KRISTIN B , SMITH NIGEL G , LOWMAN ANTHONY M , FUSSELL GARLAND W
IPC分类号： A61L24/04
CPC分类号： A61L24/043 , A61L2430/38
摘要： A method of forming and the resulting bioadhesive hydrogel composition for repairing or supplementing a nucleus pulposus of an intervertebral disc comprises at least a first component, a second component and a third component, wherein the first component, the second component and the third component are crosslinked. The first component comprises an amine-containing polymer component at a concentration from about 0.1% weight by weight to about 13.65% weight by weight. The second component comprises a hydrophilic polymer or pre-polymer component at a concentration from about 3% weight by weight to about 35% weight by weight. The third component comprises an aldehyde component at a concentration from about 0.1% weight by weight to about 30% weight by weight. A method of repairing or supplementing a nucleus pulposus of an intervertebral disc comprises implanting the bioadhesive hydrogel composition in a patient.
摘要翻译：一种形成方法和所得到的用于修复或补充椎间盘髓核的生物粘附性水凝胶组合物包括至少第一组分，第二组分和第三组分，其中第一组分，第二组分和第三组分是交联的。第一组分包含浓度为约0.1重量％至约13.65重量％的含胺聚合物组分。第二组分包含浓度为约3重量％至约35重量％的亲水性聚合物或预聚物组分。第三组分包含浓度为约0.1重量％至约30重量％浓度的醛组分。修复或补充椎间盘的髓核的方法包括将生物粘附性水凝胶组合物植入患者体内。

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