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1. 发明申请

WO2009089526A3 BIOADHESIVE HYDROGELS 审中-公开
公开(公告)号：WO2009089526A3
公开(公告)日：2010-05-27
申请号：PCT/US2009030731
申请日：2009-01-12
申请人： SYNTHES USA LLC , SYNTHES GMBH , UNIV DREXEL , KITA KRISTIN B , SMITH NIGEL G , LOWMAN ANTHONY M , FUSSELL GARLAND W
发明人： KITA KRISTIN B , SMITH NIGEL G , LOWMAN ANTHONY M , FUSSELL GARLAND W
IPC分类号： A61L24/04
CPC分类号： A61L24/043 , A61L2430/38
摘要： A method of forming and the resulting bioadhesive hydrogel composition for repairing or supplementing a nucleus pulposus of an intervertebral disc comprises at least a first component, a second component and a third component, wherein the first component, the second component and the third component are crosslinked. The first component comprises an amine-containing polymer component at a concentration from about 0.1% weight by weight to about 13.65% weight by weight. The second component comprises a hydrophilic polymer or pre-polymer component at a concentration from about 3% weight by weight to about 35% weight by weight. The third component comprises an aldehyde component at a concentration from about 0.1% weight by weight to about 30% weight by weight. A method of repairing or supplementing a nucleus pulposus of an intervertebral disc comprises implanting the bioadhesive hydrogel composition in a patient.
摘要翻译：一种形成方法和所得到的用于修复或补充椎间盘髓核的生物粘附性水凝胶组合物包括至少第一组分，第二组分和第三组分，其中第一组分，第二组分和第三组分是交联的。第一组分包含浓度为约0.1重量％至约13.65重量％的含胺聚合物组分。第二组分包含浓度为约3重量％至约35重量％的亲水性聚合物或预聚物组分。第三组分包含浓度为约0.1重量％至约30重量％浓度的醛组分。修复或补充椎间盘的髓核的方法包括将生物粘附性水凝胶组合物植入患者体内。

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