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1. 发明申请

WO2008024302A8 COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS 审中-公开
标题翻译：用于治疗增生性疾病的化合物
公开(公告)号：WO2008024302A8
公开(公告)日：2008-05-08
申请号：PCT/US2007018362
申请日：2007-08-20
申请人： SYNTA PHARMACEUTICALS CORP , SUN LIJUN , KOYA KEIZO , CHEN SHOUJUN , DEMKO ZACHARY , XIA ZHI-QIANG
发明人： SUN LIJUN , KOYA KEIZO , CHEN SHOUJUN , DEMKO ZACHARY , XIA ZHI-QIANG
IPC分类号： C07D213/86 , A61K31/16 , A61K31/165 , C07C243/24 , C07C327/00 , C07D207/416 , C07D231/08 , C07D237/04 , C07D277/50 , C07D303/48 , C07D307/66 , C07D307/68 , C07D309/30 , C07D333/36 , C07D333/38
CPC分类号： C07C327/56 , C07C243/24 , C07C255/56 , C07C255/58 , C07C337/02 , C07C337/06 , C07C2601/02 , C07C2601/14 , C07D207/34 , C07D213/81 , C07D213/86 , C07D231/08 , C07D237/04 , C07D277/50 , C07D303/48 , C07D307/66 , C07D307/68 , C07D309/38 , C07D333/36 , C07D333/38
摘要： Disclosed are compounds and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also, disclosed are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier.
摘要翻译：公开了使用本发明化合物治疗患有增殖性疾病如癌症的受试者的化合物和方法，以及用于治疗响应于Hsp70诱导和/或自然杀伤诱导的病症的方法。此外，公开了包含本发明化合物和药学上可接受的载体的药物组合物。

2. 发明申请

WO2008033494A2 PURIFICATION OF BIS(THIOHYDRAZIDE AMIDES) 审中-公开
标题翻译： BIS（THOHOHDRAZIDE AMIDES）的纯化
公开(公告)号：WO2008033494A2
公开(公告)日：2008-03-20
申请号：PCT/US2007019987
申请日：2007-09-14
申请人： SYNTA PHARMACEUTICALS CORP , CHEN SHOUJUN , XIA ZHI-QIANG , KOSTIK ELENA , KOYA KEIZO , SUN LIJUN
发明人： CHEN SHOUJUN , XIA ZHI-QIANG , KOSTIK ELENA , KOYA KEIZO , SUN LIJUN
CPC分类号： C07C327/56
摘要： Disclosed herein are methods of purifying a bis(thio-hydrazide amides) compounds of structural formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 7 , R 8 , Z, and Y are defined herein.
摘要翻译：本文公开了纯化结构式（I）的双（硫代酰肼酰胺）化合物的方法，其中R 1，R 2，R 3， R 4，R 4，R 7，R 8，Z和Y在本文中定义。

3. 发明申请

WO2008024302A2 COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS 审中-公开
公开(公告)号：WO2008024302A2
公开(公告)日：2008-02-28
申请号：PCT/US2007018362
申请日：2007-08-20
申请人： SYNTA PHARMACEUTICAL CORP , SUN LIJUN , KOYA KEIZO , CHEN SHOUJUN , DEMKO ZACHARY , XIA ZHI-QIANG
发明人： SUN LIJUN , KOYA KEIZO , CHEN SHOUJUN , DEMKO ZACHARY , XIA ZHI-QIANG
IPC分类号： C07D213/86 , A61K31/16 , A61K31/165 , C07C243/24 , C07C327/00 , C07D207/416 , C07D231/08 , C07D237/04 , C07D277/50 , C07D303/48 , C07D307/66 , C07D307/68 , C07D309/30 , C07D333/36 , C07D333/38
CPC分类号： C07C327/56 , C07C243/24 , C07C255/56 , C07C255/58 , C07C337/02 , C07C337/06 , C07C2601/02 , C07C2601/14 , C07D207/34 , C07D213/81 , C07D213/86 , C07D231/08 , C07D237/04 , C07D277/50 , C07D303/48 , C07D307/66 , C07D307/68 , C07D309/38 , C07D333/36 , C07D333/38
摘要： Disclosed are compounds and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also, disclosed are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier.

4. 发明申请

WO2004024727A3 SYNTHESIS OF INDOLIZINES 审中-公开
标题翻译：吲哚类化合物的合成
公开(公告)号：WO2004024727A3
公开(公告)日：2004-06-03
申请号：PCT/US0328252
申请日：2003-09-10
申请人： SYNTA PHARMACEUTICALS CORP , SUN LIJUN , KOYA KEIZO , XIA ZHI-QIANG , PRZEWLOKA TERESA , ZHANG SHIJIE , ONO MITSUNORI
发明人： SUN LIJUN , KOYA KEIZO , XIA ZHI-QIANG , PRZEWLOKA TERESA , ZHANG SHIJIE , ONO MITSUNORI
IPC分类号： A61P35/00 , C07D471/04 , A61K31/404
CPC分类号： C07D471/04
摘要： Disclosed are methods of preparing substituted indolizines represented by the following formula: comprising reacting a substrate represented by the following formula: with either the cyclization reagent of the following formula: or, a reagent prepared by reacting the compound represented the formula below with an alkylating agent: The variables in the above formulas are defined herein.
摘要翻译：公开了由下式表示的制备取代中氮茚的方法：包括使由下式表示的底物与下式的环化试剂反应：或通过使下式表示的化合物与烷基化剂：上述公式中的变量在此定义。

5. 发明申请

WO2005025507A3 DIHYDROPYRIDINE COMPOUNDS FOR TREATING OR PREVENTING METABOLIC DISORDERS 审中-公开
标题翻译：用于治疗或预防代谢障碍的二氢吡啶化合物
公开(公告)号：WO2005025507A3
公开(公告)日：2005-09-29
申请号：PCT/US2004029636
申请日：2004-09-10
申请人： SYNTA PHAMACEUTICALS CORP , ONO MITSUNORI , WADA YUMIKO , SUN LIJUN , CHEN SHOUJUN , PRZEWLOKA TERESA , ZHANG SHIJIE , BORELLA CHRISTOPHER , KOYA KEIZO , FOLEY KEVIN , XIA ZHI-QIANG , LI HAO , ZHOU DAN
发明人： ONO MITSUNORI , WADA YUMIKO , SUN LIJUN , CHEN SHOUJUN , PRZEWLOKA TERESA , ZHANG SHIJIE , BORELLA CHRISTOPHER , KOYA KEIZO , FOLEY KEVIN , XIA ZHI-QIANG , LI HAO , ZHOU DAN
IPC分类号： A61K31/47 , A61K31/4741 , A61K31/4743 , A61K31/4745 , C07D215/54 , C07D221/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D471/02 , C07D491/02 , C07D491/04 , C07D498/02 , A61K31/4709 , C07D215/20
CPC分类号： C04B35/632 , C07D215/54 , C07D221/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D491/04
摘要： This invention relates to dihydropyridine compounds of formula: (I) or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein A2, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, and m are defined herein, and compositions comprising such compounds. The invention also relates to methods of preventing or treating metabolic disorders, such as diabetes mellitus, and conditions and complications associated with diabetes mellitus, comprising administering to a subject in need thereof a compound of formula (I) or a composition comprising such a compound. The invention further relates to kits comprising a compound of formula (I).
摘要翻译：本发明涉及式（I）的二氢吡啶化合物或其药学上可接受的盐，溶剂合物，包合物或前药，其中A2，R12，R13，R14，R15，R16，R17，R18，R19，R20，R21，和m在本文中定义，组合物包含这些化合物。本发明还涉及预防或治疗诸如糖尿病的代谢疾病以及与糖尿病有关的病症和并发症的方法，其包括向有需要的受试者施用式（I）化合物或包含这种化合物的组合物。本发明还涉及包含式（I）化合物的试剂盒。

6. 发明申请

WO2010065512A3 COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS 审中-公开
标题翻译：用于治疗增生性疾病的化合物
公开(公告)号：WO2010065512A3
公开(公告)日：2010-07-29
申请号：PCT/US2009066211
申请日：2009-12-01
申请人： SYNTA PHARMACEUTICALS CORP , JIANG JUN , KOWALCZYK-PRZEWLOKA TERESA , SCHWEIZER STEFAN M , XIA ZHI-QIANG , CHEN SHOUJUN , BORELLA CHRISTOPHER , SUN LIJUN
发明人： JIANG JUN , KOWALCZYK-PRZEWLOKA TERESA , SCHWEIZER STEFAN M , XIA ZHI-QIANG , CHEN SHOUJUN , BORELLA CHRISTOPHER , SUN LIJUN
IPC分类号： C07C327/56 , A61K31/175 , A61K31/36 , A61K31/40 , A61K31/421 , A61K31/426 , A61K31/4402 , A61P35/00 , C07D213/86 , C07D263/34 , C07D277/56 , C07D295/16 , C07D317/62
CPC分类号： C07D295/195 , C07C327/56 , C07C333/12 , C07C335/40 , C07C337/02 , C07C337/06 , C07C2601/02 , C07C2601/04 , C07D211/72 , C07D213/86 , C07D213/87 , C07D241/24 , C07D277/56 , C07D295/155 , C07D307/68 , C07D317/68 , C07D333/38 , C07D333/68
摘要： The present invention is directed to compounds represented by structural formula (I), or a pharmaceutically acceptable salt or a transition metal chelate, coordinate or complex thereof or a transition metal chelate, coordinate or complex of a deprotonated form of the compound. Pharmaceutical composition and method of use for these compounds are also included.
摘要翻译：本发明涉及由结构式（I）表示的化合物或其药学上可接受的盐或过渡金属螯合物，其配位体或络合物或过渡金属螯合物，化合物去质子化形式的配位体或络合物。也包括这些化合物的药物组合物和使用方法。

7. 发明申请

WO2006065842A3 5,6,7,8-TETRAHYDROQUINOLINES AND RELATED COMPOUNDS AND USES THEREOF 审中-公开
标题翻译： 5,6,7,8-四氢喹啉和相关化合物及其用途
公开(公告)号：WO2006065842A3
公开(公告)日：2007-02-22
申请号：PCT/US2005045136
申请日：2005-12-13
申请人： SYNTA PHARMACEUTICALS CORP , BORELLA CHRISTOPHER , FOLEY KEVIN , SUN LIJUN , CHIMMANAMADA DINESH U , LI HAO , XIA ZHI-QIANG , VO NHA HUU , BOHNERT GARY , CHEN SHOUJUN , WU YAMING
发明人： BORELLA CHRISTOPHER , FOLEY KEVIN , SUN LIJUN , CHIMMANAMADA DINESH U , LI HAO , XIA ZHI-QIANG , VO NHA HUU , BOHNERT GARY , CHEN SHOUJUN , WU YAMING
IPC分类号： C07D215/54 , A61K31/47
CPC分类号： C07D215/38 , C07D215/20 , C07D215/24 , C07D215/54 , C07D219/06 , C07D221/20 , C07D401/04 , C07D401/06 , C07D405/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D471/04 , C07D491/04
摘要： This invention relates to substituted 5,6,7,8-tetrahydroquinoline compounds, substituted dihydropyridine compounds, and substituted tricyclic compounds. The invention also relates to methods of preventing or treating metabolic disorders, such as diabetes mellitus, and conditions and complications associated with diabetes mellitus, comprising administering to a subject in need thereof a compound of the invention or a composition comprising such a compound. The invention further relates to methods of treating inflammatory bowel disease, comprising administering to a subject in need thereof a compound of the invention or a composition comprising such a compound.
摘要翻译：本发明涉及取代的5,6,7,8-四氢喹啉化合物，取代的二氢吡啶化合物和取代的三环化合物。本发明还涉及预防或治疗诸如糖尿病的代谢疾病以及与糖尿病相关的病症和并发症的方法，其包括向有需要的受试者施用本发明的化合物或包含这种化合物的组合物。本发明进一步涉及治疗炎症性肠病的方法，包括向有需要的受试者施用本发明化合物或包含这种化合物的组合物。

8. 发明申请

WO03022280A3 3-GLYOXLYLAMIDEINDOLES FOR TREATING CANCER 审中-公开
标题翻译：用于治疗癌症的3-甘油酰胺醇
公开(公告)号：WO03022280A3
公开(公告)日：2003-05-22
申请号：PCT/US0227513
申请日：2002-08-28
申请人： SBR PHARMACEUTICALS CORP , KOYA KEIZO , SUN LIJUN , ONO MITSUNORI , LIANG GUIQING , JAMES DAVID , LI HAO , XIA ZHI-QIANG
发明人： KOYA KEIZO , SUN LIJUN , ONO MITSUNORI , LIANG GUIQING , JAMES DAVID , LI HAO , XIA ZHI-QIANG
IPC分类号： A61K31/405 , A61K31/4155 , A61K31/4196 , A61K31/422 , A61K31/423 , A61K31/425 , A61K31/433 , A61K31/4439 , A61K31/4709 , A61P35/00 , C07D209/12 , C07D209/14 , C07D209/18 , C07D401/12 , C07D403/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D521/00 , A61K31/47 , A61K31/40 , A61K31/41 , A61K31/42 , A61K31/44
CPC分类号： C07D249/08 , C07D209/12 , C07D209/18 , C07D231/12 , C07D233/56 , C07D401/12 , C07D403/12 , C07D405/14 , C07D413/12 , C07D417/12
摘要： Disclosed is an anti-cancer compound represented by Structural Formula (I). The variables in Structural Formula (I) are described herein. Also disclosed is a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound represented by Structural Formula (I) (preferablyan effective amount). Also disclosed is a method of treating a subject with cancer by administering to the subject an effective amount of a compound represented by Structural Formula (I).
摘要翻译：公开了由结构式（I）表示的抗癌化合物。本文描述了结构式（I）中的变量。还公开了包含药学上可接受的载体或稀释剂和由结构式（I）表示的化合物（优选有效量）的药物组合物。还公开了通过向受试者施用有效量的由结构式（I）表示的化合物来治疗患有癌症的受试者的方法。

9. 发明申请

WO2007089904A3 PYRIDYLPHENYL COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES 审中-公开
标题翻译：用于炎症和免疫相关用途的吡啶基苯酚化合物
公开(公告)号：WO2007089904A3
公开(公告)日：2008-01-03
申请号：PCT/US2007002790
申请日：2007-01-31
申请人： SYNTA PHARMACEUTICALS CORP , JIANG JUN , XIA ZHI-QIANG , ZHANG JUNYI , BOHNERT GARY , CHEN SHOUJUN , XIE YU
发明人： JIANG JUN , XIA ZHI-QIANG , ZHANG JUNYI , BOHNERT GARY , CHEN SHOUJUN , XIE YU
IPC分类号： C07D213/44 , A61K31/44
CPC分类号： C07D417/14 , C07D211/70 , C07D211/72 , C07D213/72 , C07D213/75 , C07D213/81 , C07D401/12 , C07D405/10 , C07D409/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/12
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein Y, L, X 1 , X 2 , Z, R 3 , R 4 , and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
摘要翻译：本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂合物，包合物或前药，其中Y，L，X 1，X 2，，Z，R 3，R 4和n如本文所定义。这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症，过敏性疾病和免疫疾病。

10. 发明申请

WO2006124736A3 SYNTHESIS OF BIS(THIO-HYDRAZIDE AMIDE) SALTS 审中-公开
标题翻译： BIS（THIO-HYDRAZIDE AMATE）SALTS的合成
公开(公告)号：WO2006124736A3
公开(公告)日：2007-03-29
申请号：PCT/US2006018653
申请日：2006-05-11
申请人： SYNTA PHARMACEUTICALS CORP , CHEN SHOUJUN , XIA ZHI-QIANG
发明人： CHEN SHOUJUN , XIA ZHI-QIANG
IPC分类号： C07C327/56
CPC分类号： C07C327/56 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14
摘要： A method of preparing a bis(thio-hydrazide amide) disalt includes the steps of combining a neutral bis(thio-hydrazide amide), an organic solvent and a base to form a bis(thio-hydrazide amide) solution; and combining the solution and methyl tert-butyl ether, thereby precipitating a disalt of the bis(thio-hydrazide amide). In some embodiments, a method of preparing a bis(thio-hydrazide amide) disalt includes the steps of combining a neutral bis(thio-hydrazide amide) and an organic solvent selected from methanol, ethanol, acetone, and methyl ethyl ketone to make a mixture; adding at least two equivalents of a base selected from sodium hydroxide, potassium hydroxide, sodium methoxide, potassium methoxide, sodium ethoxide and potassium ethoxide to the mixture, thereby forming a solution; and combining the solution and methyl tert-bvtyl ether to precipitate the disalt of the bis(thio-hydrazide amide). The disclosed methods do not require lyophylization and the solvents used in the process can be more readily removed to low levels consistent with pharmaceutically acceptable preparation.
摘要翻译：制备双（硫代 - 酰肼酰胺）二盐的方法包括将中性双（硫代酰肼）酰胺，有机溶剂和碱组合以形成双（硫代 - 酰肼酰胺）溶液的步骤; 并将该溶液与甲基叔丁基醚混合，从而沉淀出双（硫代 - 酰肼）酰胺的残留物。在一些实施方案中，制备双（硫代 - 酰肼酰胺）二盐的方法包括将中性双（硫代酰肼）酰胺和选自甲醇，乙醇，丙酮和甲基乙基酮的有机溶剂合并以制备混合物; 向混合物中加入至少两当量的选自氢氧化钠，氢氧化钾，甲醇钠，甲醇钾，乙醇钠和乙醇钾的碱，从而形成溶液; 并将该溶液与甲基叔丁基醚混合以沉淀双（硫代 - 酰肼）酰胺的混合物。所公开的方法不需要冻干，并且可以更容易地将该方法中使用的溶剂除去至与药学上可接受的制剂一致的低水平。

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