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1. 发明申请

WO2011061330A9 USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS 审中-公开
标题翻译： USE生理学冷却或物质的含有这种物质的
公开(公告)号：WO2011061330A9
公开(公告)日：2012-01-05
申请号：PCT/EP2010067936
申请日：2010-11-22
申请人： SYMRISE AG , BASF SE , SURBURG HORST , BACKES MICHAEL , OERTLING HEIKO , MACHINEK ARNOLD , LOGES HUBERT , SIMCHEN ULRIKE , SUBKOWSKI THOMAS , BOLLSCHEILER CLAUS , WITTENBERG JENZ , SIEGEL WOLFGANG
发明人： SURBURG HORST , BACKES MICHAEL , OERTLING HEIKO , MACHINEK ARNOLD , LOGES HUBERT , SIMCHEN ULRIKE , SUBKOWSKI THOMAS , BOLLSCHEILER CLAUS , WITTENBERG JENZ , SIEGEL WOLFGANG
IPC分类号： C09D5/16 , A23L1/226 , A61K31/165 , A61K31/167 , A61K31/36 , A61K31/426 , A61K31/4402 , A61K31/443 , A61K31/4741 , A61K31/4743 , A61K31/506 , A61K31/513 , C07C233/11 , C07C235/36 , C07C235/38 , C07D213/75
CPC分类号： C07D495/20 , A23G3/36 , A23G4/06 , A23L2/52 , A23L27/2054 , A23L33/10 , A23V2002/00 , A24B13/00 , A24D1/002 , A61K8/49 , A61K8/4953 , A61K31/165 , A61K31/167 , A61K31/36 , A61K31/426 , A61K31/4375 , A61K31/438 , A61K31/4402 , A61K31/443 , A61K31/4741 , A61K31/4743 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K2800/10 , A61K2800/244 , A61K2800/78 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/004 , C07C233/11 , C07C235/36 , C07C235/38 , C07C2601/14 , C07D213/75 , C07D317/60 , C07D401/04 , C07D405/12 , C07D491/147 , C07D495/22 , C09D5/1625 , D06M15/03 , D06M15/07 , D06M16/00
摘要： The invention relates to a TRPM8 modulator for achieving a cooling effect on skin or mucous membrane.
摘要翻译：本发明涉及一种调制器TRPM8用于获得对皮肤或粘膜的冷却效果。

3. 发明申请

WO2010149798A4 USE OF POLYOLS FOR ENHANCING THE COOLING EFFECT OF A COOLING SUBSTANCE AND COOLING MIXTURES HAVING AN ENHANCED COOLING EFFECT 审中-公开
标题翻译：用于增强冷却物质的冷却效果和具有增强冷却效果的冷却混合物的使用
公开(公告)号：WO2010149798A4
公开(公告)日：2011-12-29
申请号：PCT/EP2010066272
申请日：2010-10-27
申请人： SYMRISE AG , KUEPER THOMAS , OERTLING HEIKO , LANGE SABINE
发明人： KUEPER THOMAS , OERTLING HEIKO , LANGE SABINE
IPC分类号： A61Q19/00 , A61K8/34 , A61K8/42
CPC分类号： A61K8/345 , A61K8/42 , A61K2800/244 , A61Q5/00 , A61Q19/00
摘要： The invention relates to a use of one, two, three or more certain polyols for enhancing the cooling effect of a cooling substance. It further relates to a cooling mixture comprising a cooling effect enhancing polyol and a cooling substance consisting of one or more physiologically cooling compounds and optionally further compounds having a further enhancing effect on the cooling effect of the substance, too. Moreover the invention relates to a method for producing a corresponding cooling mixture and a method for generating an enhanced cooling effect of a cooling substance on the skin or a mucous membrane.
摘要翻译：本发明涉及一种，两种，三种或更多种某些多元醇用于增强冷却物质的冷却效果的用途。此外，还涉及包含冷却效果增强多元醇的冷却混合物和由一种或多种生理冷却化合物组成的冷却物质，以及任选地对物质的冷却效果具有进一步增强作用的其它化合物。此外，本发明涉及一种生产相应的冷却混合物的方法和一种产生冷却物质在皮肤或粘膜上的增强的冷却效果的方法。

4. 发明申请

WO2010122178A3 CYCLOHEXYL CARBAMATE COMPOUNDS AS SKIN AND/OR HAIR LIGHTENING ACTIVES 审中-公开
标题翻译： CYCLOHEXYL CARBAMATE化合物作为皮肤和/或头发照明活动
公开(公告)号：WO2010122178A3
公开(公告)日：2011-04-14
申请号：PCT/EP2010057115
申请日：2010-05-25
申请人： SYMRISE AG , VIELHABER GABRIELE , OERTLING HEIKO , TITZE NICOLE , GOEMANN CLAUDIA , BRODHAGE RAHIM
发明人： VIELHABER GABRIELE , OERTLING HEIKO , TITZE NICOLE , GOEMANN CLAUDIA , BRODHAGE RAHIM
IPC分类号： A61K8/42 , A61Q5/08 , A61Q19/02 , C08B37/00
CPC分类号： A61K8/44 , A61K8/40 , A61K8/42 , A61K8/445 , A61K31/27 , A61K45/06 , A61Q17/04 , A61Q19/02 , C08L5/00
摘要： The present invention relates to the cosmetic, dermatological or therapeutic use of certain cyclohexyl carbamate compounds of formula (I) given below, preferably as skin and/or hair lightening (whitening) actives. The invention further relates to compositions and cosmetic, dermatological or therapeutic products comprising one or more compounds of formula (I) suitable for lightening human skin and/or hair and corresponding methods. The invention further relates to compounds of formula (I) as a drug, their use for the preparation of a pharmaceutical composition for lightening human skin and/or hair and to novel compounds of formula (I) wherein A denotes wherein X, Y and Z independently of one another denote hydrogen, C1-C4-alkyl or C2-C4-alkenyl, wherein optionally two of the radicals X, Y and Z are covalently bonded to one another under formation of a bicyclic ring system, in such a bicyclic ring system two of the radicals X, Y and Z together preferably form a radical having 1 to 4 carbon atoms, preferably a hydrocarbon radical having 1 to 3 carbon atoms, B denotes NR1R2, wherein R1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R1 and R2 are covalently bonded to one another, preferably so that B is a 3 to 8 membered ring.
摘要翻译：本发明涉及以下给出的某些式（I）环己基氨基甲酸酯化合物的化妆品，皮肤病学或治疗用途，优选作为皮肤和/或发白（增白）活性物质。本发明还涉及包含一种或多种适合于减轻人类皮肤和/或头发的相应方法的式（I）化合物的组合物和化妆品，皮肤病学或治疗产品。本发明还涉及作为药物的式（I）化合物，其用于制备用于减轻人类皮肤和/或头发的药物组合物的用途和新的式（I）化合物，其中A表示其中X，Y和Z 彼此独立地表示氢，C 1 -C 4 - 烷基或C 2 -C 4 - 烯基，其中任选地，两个基团X，Y和Z彼此共价键合形成双环体系，在这种双环体系中两个基团X，Y和Z一起优选形成具有1至4个碳原子的基团，优选具有1至3个碳原子的烃基，B表示NR1R2，其中R1表示氢或具有1至14个碳原子的有机基团 R 2表示碳原子数为1〜14的有机基团，且R 1和R 2中任选具有共价键，优选为B为3〜8元环。

5. 发明申请

WO2010149798A3 USE OF POLYOLS FOR ENHANCING THE COOLING EFFECT OF A COOLING SUBSTANCE AND COOLING MIXTURES HAVING AN ENHANCED COOLING EFFECT 审中-公开
标题翻译：多元醇用于增强冷却物质和具有增强的冷却效果的冷却混合物的冷却效果
公开(公告)号：WO2010149798A3
公开(公告)日：2011-04-14
申请号：PCT/EP2010066272
申请日：2010-10-27
申请人： SYMRISE AG , KUEPER THOMAS , OERTLING HEIKO , LANGE SABINE
发明人： KUEPER THOMAS , OERTLING HEIKO , LANGE SABINE
IPC分类号： A61Q19/00 , A61K8/34 , A61K8/42
CPC分类号： A61K8/345 , A61K8/42 , A61K2800/244 , A61Q5/00 , A61Q19/00
摘要： The invention relates to a use of one, two, three or more certain polyols for enhancing the cooling effect of a cooling substance. It further relates to a cooling mixture comprising a cooling effect enhancing polyol and a cooling substance consisting of one or more physiologically cooling compounds and optionally further compounds having a further enhancing effect on the cooling effect of the substance, too. Moreover the invention relates to a method for producing a corresponding cooling mixture and a method for generating an enhanced cooling effect of a cooling substance on the skin or a mucous membrane.
摘要翻译：本发明涉及一种，两种，三种或更多种特定多元醇用于增强冷却物质的冷却效果的用途。本发明还涉及冷却混合物，其包含冷却效果增强多元醇和由一种或多种生理学冷却化合物组成的冷却物质以及任选地还具有对物质的冷却效应进一步增强作用的其它化合物。此外，本发明涉及用于制备相应的冷却混合物的方法以及用于在皮肤或粘膜上产生冷却物质的增强的冷却效果的方法。

6. 发明申请

WO2010097479A3 CYCLOHEXYL CARBAMATE COMPOUNDS AS ACTIVE ANTI-CELLULITE INGREDIENTS 审中-公开
标题翻译： CYCLOHEXYL碳酸酯化合物作为活性抗细胞成分
公开(公告)号：WO2010097479A3
公开(公告)日：2011-04-14
申请号：PCT/EP2010057112
申请日：2010-05-25
申请人： SYMRISE AG , MEYER IMKE , OERTLING HEIKO , HILLEBRAND NADINE , GOEMANN CLAUDIA , BRODHAGE RAHIM
发明人： MEYER IMKE , OERTLING HEIKO , HILLEBRAND NADINE , GOEMANN CLAUDIA , BRODHAGE RAHIM
IPC分类号： A61K8/42 , A61Q19/06
CPC分类号： A61K8/44 , A61K31/00 , A61K31/27 , A61Q19/06
摘要： The present invention relates to the cosmetic, dermatological or therapeutic use of certain cyclohexyl carbamate compounds of formula (I) given below, preferably as anti-cellulite actives. The invention further relates to compositions and cosmetic, dermatological or therapeutic products comprising such compounds of formula (I), which are preferably suitable for the prophylaxis (prevention) and cosmetic treatment (combating) of cellulite in human beings, corresponding methods and novel compounds of formula (I) wherein A denotes (II), wherein X, Y and Z independently of one another denote hydrogen, C1-C4-alkyl or C2-C4-alkenyl, wherein optionally two of the radicals X, Y and Z are covalently bonded to one another under formation of a bicyclic ring system, in such a bicyclic ring system two of the radicals X, Y and Z together preferably form a radical having 1 to 4 carbon atoms, preferably a hydrocarbon radical having 1 to 3 carbon atoms, B denotes NR1R2, wherein R1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R1 and R2 are covalently bonded to one another, preferably so that B is a 3 to 8 membered ring.
摘要翻译：本发明涉及以下给出的某些式（I）环己基氨基甲酸酯化合物的化妆品，皮肤病学或治疗用途，优选作为抗脂肪团活性物质。本发明还涉及包含这样的式（I）化合物的组合物和化妆品，皮肤病学或治疗产品，其优选适用于预防（预防）和化妆品处理（抗击）人体中的脂肪团，相应的方法和新的化合物式（I）其中A表示（II），其中X，Y和Z彼此独立地表示氢，C1-C4-烷基或C2-C4-烯基，其中任选地两个基团X，Y和Z共价键合在这样的双环体系中，基团X，Y和Z中的两个一起优选形成具有1至4个碳原子的基团，优选地具有1至3个碳原子的烃基，B 表示NR 1 R 2，其中R 1表示氢或具有1至14个碳原子的有机基团，R 2表示具有1至14个碳原子的有机基团，并且其中任选地R 1和R 2彼此共价键合，优选为该B为3至8元环。

7. 发明申请

WO2010097480A3 MENTHYL CARBAMATE COMPOUNDS AS SKIN AND/OR HAIR LIGHTENING ACTIVES 审中-公开
标题翻译： MENTHYL CARBAMATE化合物作为皮肤和/或头发照明活动
公开(公告)号：WO2010097480A3
公开(公告)日：2011-04-14
申请号：PCT/EP2010057119
申请日：2010-05-25
申请人： SYMRISE AG , VIELHABER GABRIELE , OERTLING HEIKO , SCHAPER KARIN , GOEMANN CLAUDIA , BRODHAGE RAHIM
发明人： VIELHABER GABRIELE , OERTLING HEIKO , SCHAPER KARIN , GOEMANN CLAUDIA , BRODHAGE RAHIM
IPC分类号： A61K8/42 , A61Q5/08 , A61Q19/02
CPC分类号： A61K8/40 , A61K8/44 , A61K8/4973 , A61K31/325 , A61Q5/00 , A61Q5/08 , A61Q17/00 , A61Q19/02
摘要： The present invention relates to the cosmetic, dermatological or pharmaceutical (therapeutic) use of compounds of formula (I) or a cosmetically acceptable salt of a compound of formula (I) or a mixture containing two or more of these compounds or the salts thereof, wherein R1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R1 and R2 are covalently bonded to one another, preferably so that a 3 to 8 membered ring is formed, for the lightening of skin and/or hair. The invention further relates to compositions and cosmetic, dermatological or pharmaceutical preparations (compositions) comprising one or more compounds of formula (I) suitable for lightening human skin and/or hair and corresponding methods. The invention further relates to compounds of formula (I) as a drug, their use for the preparation of a pharmaceutical composition for lightening human skin and/or hair and to certain novel compounds of formula (I).
摘要翻译：本发明涉及式（I）化合物或式（I）化合物的化妆品可接受的盐的化妆品，皮肤病学或药学（治疗）用途或包含这些化合物或其盐中的两种或更多种的混合物，其中R1表示氢或具有1至14个碳原子的有机基团，R2表示具有1至14个碳原子的有机基团，并且其中任选地R 1和R 2彼此共价键合，优选使得3至8元环为形成，用于减轻皮肤和/或头发。本发明还涉及包含一种或多种适合于减轻人类皮肤和/或头发的相应方法的式（I）化合物的组合物和化妆品，皮肤病学或药物制剂（组合物）。本发明还涉及作为药物的式（I）化合物，其用于制备用于减轻人类皮肤和/或毛发的药物组合物和某些新的式（I）化合物的用途。

8. 发明申请

WO2010089421A3 MENTHYL CARBAMATE COMPOUNDS AS ACTIVE ANTI-CELLULITE INGREDIENTS 审中-公开
标题翻译：戊烯碳酸酯化合物作为活性抗细胞成分
公开(公告)号：WO2010089421A3
公开(公告)日：2011-04-14
申请号：PCT/EP2010057117
申请日：2010-05-25
申请人： SYMRISE AG , MEYER IMKE , OERTLING HEIKO , HILLEBRAND NADINE , GOEMANN CLAUDIA , BRODHAGE RAHIM
发明人： MEYER IMKE , OERTLING HEIKO , HILLEBRAND NADINE , GOEMANN CLAUDIA , BRODHAGE RAHIM
IPC分类号： A61K8/42 , A61Q19/06
CPC分类号： A61K8/42 , A61K8/4973 , A61Q19/06 , C07C271/34 , C07C271/36 , C07C271/38 , C07C2601/14 , C07D307/14 , C07D317/58
摘要： The present invention relates to the cosmetic, dermatological or therapeutic use of certain menthyl carbamate compounds of formula (I) given below, preferably as anti-cellulite actives. The invention further relates to compositions and cosmetic, dermatological or therapeutic products comprising such compounds of formula (I), which are preferably suitable for the prophylaxis (prevention) and cosmetic treatment (combating) of cellulite in human beings, corresponding methods and to certain novel compounds of formula (I) wherein R1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R1 and R2 are covalently bonded to one another, preferably so that a 3 to 8 membered ring is formed.
摘要翻译：本发明涉及以下给出的某些式（I）的薄荷基氨基甲酸酯化合物的化妆品，皮肤病学或治疗用途，优选作为抗脂肪团活性成分。本发明还涉及包含这样的式（I）化合物的组合物和化妆品，皮肤病学或治疗产品，其优选适用于预防（预防）和化妆品处理（抗击）人体中的脂肪团，相应的方法和某些新颖的其中R 1表示氢或具有1至14个碳原子的有机基团的式（I）化合物，R 2表示具有1至14个碳原子的有机基团，并且其中任选地R 1和R 2彼此共价键合，优选使得形成3〜8元环。

9. 发明申请

WO2009087242A3 COMPOSITIONS COMPRISING TRANS-TERT-BUTYL CYCLOHEXANOL AS SKIN IRRITATION-REDUCING AGENT 审中-公开
标题翻译：包含转铁蛋白胆固醇的组合物作为皮肤刺激减少剂
公开(公告)号：WO2009087242A3
公开(公告)日：2010-02-25
申请号：PCT/EP2009054336
申请日：2009-04-09
申请人： SYMRISE GMBH & CO KG , VIELHABER GABRIELE , OERTLING HEIKO , GOEMANN CLAUDIA , PFEIFFER ANTJE , KROHN MICHAEL , ZINKE HOLGER
发明人： VIELHABER GABRIELE , OERTLING HEIKO , GOEMANN CLAUDIA , PFEIFFER ANTJE , KROHN MICHAEL , ZINKE HOLGER
IPC分类号： A61K31/045 , A61K8/34 , A61K45/06 , A61P17/00 , A61P17/16 , A61Q19/00
CPC分类号： A61K8/34 , A23C9/1307 , A23C11/103 , A23L2/02 , A23L2/39 , A23L33/10 , A61K8/0216 , A61K8/0229 , A61K31/045 , A61K45/06 , A61K2800/75 , A61K2800/874 , A61K2800/92 , A61Q5/02 , A61Q11/00 , A61Q15/00 , A61Q17/04 , A61Q19/004 , A61Q19/005 , A61Q19/02 , A61Q19/04 , A61K2300/00
摘要： The present invention primarily relates to the use of trans-tert-butyl cyclohexanol as skin irritation-reducing agent as well as compositions (formulations) having a skin irritation- reducing action comprising trans-tert-butyl cyclohexanol as skin irritation-reducing agent.
摘要翻译：本发明主要涉及使用反式叔丁基环己醇作为皮肤刺激性还原剂，以及具有皮肤刺激 - 还原作用的组合物（制剂），其包含反式叔丁基环己醇作为皮肤刺激性还原剂。

10. 发明申请

WO2013171018A3 MIXTURES HAVING IMPROVED COOLING EFFECT 审中-公开
标题翻译：融合了改进的冷却效果
公开(公告)号：WO2013171018A3
公开(公告)日：2014-04-10
申请号：PCT/EP2013058118
申请日：2013-04-18
申请人： SYMRISE AG
发明人： LAGES RITA , LOGES HUBERT , MACHINEK ARNOLD , NEUENDORFF GABRIELE , DILK ERICH , OERTLING HEIKO
IPC分类号： A23L27/00 , A61K8/34 , A23L27/20 , A61K8/33 , A61K31/015 , A61Q11/00 , A61Q13/00 , A61Q19/00
CPC分类号： A23L27/204 , A23G3/36 , A23G3/38 , A23G4/06 , A23G9/32 , A23L1/22091 , A23L27/86 , A23L27/88 , A23V2002/00 , A61K8/33 , A61K8/34 , A61K31/045 , A61K31/11 , A61K2800/244 , A61Q11/00 , A61Q19/00
摘要： The invention relates to mixtures which contain (a) at least one phenylalkenal of formula (I) wherein R1 and R2 independently represent hydrogen, a methyl or phenyl group, R3 represents hydrogen, a phenyl group, alkenyl group or a linear or branched alkyl group with 1 to 5 carbon atoms, and the broken double lines independently represent a single bond or a double bond, and (b) at least one physiological cooling agent.
摘要翻译：是含有（a）至少一种Phenylalkenal式（I），其中R1和R2独立地为氢，表示甲基或苯基的，R3是氢，苯基，链烯基或直链或支链烷基具有提议的混合物为1至5个碳原子，虚线双线独立地表示单键或双键，和（b）至少一种生理清凉剂。

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