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1. 发明申请

WO2012106011A1 LEAFLET SUTURING TO COMMISSURE POINT FOR PROSTHETIC HEART VALVE 审中-公开
标题翻译： LEAFLUR FOR TO COMMISSURE POINT FOR PROSTHETIC HEART VALVE
公开(公告)号：WO2012106011A1
公开(公告)日：2012-08-09
申请号：PCT/US2011/048967
申请日：2011-08-24
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC. D/B/A ST. JUDE MEDICAL, CARDIOVASCULAR DIVISION , ALKHATIB, Yousef, F. , BRAIDO, Peter, Nicholas
发明人： ALKHATIB, Yousef, F. , BRAIDO, Peter, Nicholas
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2427 , A61F2/2436 , A61F2/95 , A61F2002/9517 , A61F2002/9534 , A61F2220/0075 , A61F2230/0013 , A61F2250/0039
摘要： A collapsible prosthetic heart valve (100) includes a collapsible and expandable stent (102) and a collapsible and expandable valve assembly (104). The stent has a proximal end and a distal end. A plurality of commissure points (116) is disposed on the stent. The valve assembly is disposed within the stent and includes a plurality of leaflets (108). Each leaflet has a free edge (505). An end portion (724a, 724b) of the free edge of each leaflet is folded and sutured (730a, 730b) to a corresponding one of the plurality of the commissure points.
摘要翻译：可折叠假体心脏瓣膜（100）包括可折叠和可扩张的支架（102）和可折叠和可膨胀的阀组件（104）。支架具有近端和远端。多个连合点（116）设置在支架上。瓣膜组件设置在支架内并且包括多个传单（108）。每个小叶都有一个自由边（505）。每个小叶的自由边缘的端部（724a，724b）折叠并缝合（730a，730b）到多个连合点中的相应的一个。

2. 发明申请

WO2012027487A3 REPOSITIONING OF PROSTHETIC HEART VALVE AND DEPLOYMENT 审中-公开
公开(公告)号：WO2012027487A3
公开(公告)日：2012-03-01
申请号：PCT/US2011/048989
申请日：2011-08-24
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC. D/B/A ST. JUDE MEDICAL, CARDIOVASCULAR DIVISION , ALKHATIB, Yousef, F. , BRAIDO, Peter, Nicholas
发明人： ALKHATIB, Yousef, F. , BRAIDO, Peter, Nicholas
IPC分类号： A61F2/24
摘要： A collapsible prosthetic heart valve (200) includes a stent (202) and a valve assembly (204). The stent (202) has an annulus section (240) with a relatively small cross-section, and an aortic section (242) with a relatively large cross-section. The valve assembly (204), including a cuff (206) and a plurality of leaflets (208), is secured to the stent (202) in the annulus section (240) such that the valve assembly (204) can be entirely deployed in the native valve annulus and function as intended while at least a portion of the aortic section (242) is held by the delivery device (1010) in a manner that allows for resheathing. The configuration of the prosthetic valve (200) is such that the valve leaflets (208) can fully coapt and the valve (200) can function properly even when the stent (202) and/or valve assembly (204) become distorted upon deployment or use.

3. 发明申请

WO2012106010A2 BLUNT ENDED STENT FOR PROSTHETIC HEART VALE 审中-公开
公开(公告)号：WO2012106010A2
公开(公告)日：2012-08-09
申请号：PCT/US2011/048963
申请日：2011-08-24
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIDVISION, INC. D/B/A ST. JUDE MEDICAL, CARDIOVASCULAR DIVISION , ALKHATIB, Yousef, F. , BRAIDO, Peter, Nicholas , BENSON, Thomas, M.
发明人： ALKHATIB, Yousef, F. , BRAIDO, Peter, Nicholas , BENSON, Thomas, M.
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2002/9517 , A61F2002/9534 , A61F2220/0075 , A61F2230/0013 , A61F2250/0039
摘要： A collapsible prosthetic heart valve (100) includes a stent (102) and a valve assembly (104). The stent has a proximal end and a distal end and includes a plurality of struts (114). The struts have free ends (615, 625) configured to inhibit tissue penetration. The valve assembly, including a plurality of leaflets (108), is disposed within the stent.
摘要翻译：可折叠假体心脏瓣膜（100）包括支架（102）和阀组件（104）。支架具有近端和远端，并且包括多个支柱（114）。支柱具有配置成抑制组织穿透的自由端（615,625）。包括多个小叶（108）的瓣膜组件设置在支架内。

4. 发明申请

WO2020257381A1 GUIDEWIRE FOR TAVR PROCEDURE 审中-公开
公开(公告)号：WO2020257381A1
公开(公告)日：2020-12-24
申请号：PCT/US2020/038320
申请日：2020-06-18
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC. , ALKHATIB, Yousef, F. , MORRISSEY, Michael, Shane , REIMER, Jay , VIETMEIER, Kristopher, Henry , NESS, Peter, J.
发明人： ALKHATIB, Yousef, F. , MORRISSEY, Michael, Shane , REIMER, Jay , VIETMEIER, Kristopher, Henry , NESS, Peter, J.
IPC分类号： A61M25/09 , A61F2/2436 , A61F2/9517 , A61M2025/09075 , A61M2025/09141 , A61M2025/09175
摘要： A guidewire is configured for insertion into a heart of a patient during a procedure such as a transcatheter aortic valve replacement procedure. The guidewire includes a proximal end and a distal end portion. The distal end portion includes a leading section (520), a loop structure (510) at a terminal distal end of the guidewire, and a transition section extending between the leading section and the loop structure. In the absence of applied forces, the leading section is not tangential to the loop structure. With such a configuration, the guidewire may avoid contact with the ventricular septum of the heart when the loop structure is seated within the left ventricle, which may mitigate potential interference with conduction pathways in the ventricular septum, which may in turn mitigate the need for a pacemaker.

5. 发明申请

WO2010098857A1 STENT FEATURES FOR COLLAPSIBLE PROSTHETIC HEART VALVES 审中-公开
标题翻译：可靠的前置心脏瓣膜的特点
公开(公告)号：WO2010098857A1
公开(公告)日：2010-09-02
申请号：PCT/US2010/000561
申请日：2010-02-25
申请人： ST. JUDE MEDICAL, INC. , BRAIDO, Peter, N. , ALKHATIB, Yousef, F. , BENSON, Thomas, A. , CHALEKIAN, Aaron, J. , KHOUENGBOUA, Ott , NEUMAN, Julia, A.
发明人： BRAIDO, Peter, N. , ALKHATIB, Yousef, F. , BENSON, Thomas, A. , CHALEKIAN, Aaron, J. , KHOUENGBOUA, Ott , NEUMAN, Julia, A.
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/915 , A61F2002/91575 , A61F2220/0075 , A61F2230/0054 , A61F2230/0067 , A61F2230/008
摘要： A prosthetic heart valve includes a stent (700) having an expanded condition and a collapsed condition. The stent includes a plurality of distal cells (702), a plurality of proximal cells (706), a plurality of support struts (704) coupling the proximal cells to the distal cells, and at least one support post (708) connected to a plurality of proximal cells. The proximal cells are longitudinally spaced apart from the distal cells. Various strut configurations and connections of the struts to the proximal cells and of the proximal cells to the support post improve stent flexibility and reduce stress in the valve leaflets.
摘要翻译：假体心脏瓣膜包括具有扩张状态和折叠状态的支架（700）。支架包括多个远端细胞（702），多个近端细胞（706），将近端细胞耦合到远端细胞的多个支撑支柱（704）以及连接到远端细胞的至少一个支撑柱多个近端细胞。近端细胞与远端细胞纵向间隔开。支柱结构和连接到近端细胞和近端细胞到支撑柱的各种支柱构型和连接可改善支架的灵活性并减少瓣膜小叶中的压力。

6. 发明申请

WO2009149405A1 BALLOON BIFURCATED LUMEN TREATMENT 审中-公开
标题翻译：气球分离式乳液治疗
公开(公告)号：WO2009149405A1
公开(公告)日：2009-12-10
申请号：PCT/US2009/046490
申请日：2009-06-05
申请人： BOSTON SCIENTIFIC SCIMED, INC. , NODDIN, Richard, A. , QUILLIN, Dan , HORN, Daniel, J. , XIONG, Ying , GOODIN, Richard , TRAN, The, Thomas, Trinh , ALKHATIB, Yousef, F. , HOFF, Steve , DUNN, Richard , HOLMAN, Thomas , TEGELS, Zachary, J.
发明人： NODDIN, Richard, A. , QUILLIN, Dan , HORN, Daniel, J. , XIONG, Ying , GOODIN, Richard , TRAN, The, Thomas, Trinh , ALKHATIB, Yousef, F. , HOFF, Steve , DUNN, Richard , HOLMAN, Thomas , TEGELS, Zachary, J.
IPC分类号： A61F2/84
CPC分类号： A61F2/954 , A61F2/856 , A61F2/958 , A61F2250/0036 , A61M25/1027
摘要： Balloon systems for treating bifurcated lumens include desirable burst and folding characteristics. In some cases, the balloon systems can be formed by varying the wall thickness of a balloon parison.
摘要翻译：用于治疗分叉腔的气球系统包括所需的爆裂和折叠特性。在一些情况下，球囊系统可以通过改变气球型坯的壁厚来形成。

7. 发明申请

WO2010009399A1 TWISTING BIFURCATION DELIVERY SYSTEM 审中-公开
公开(公告)号：WO2010009399A1
公开(公告)日：2010-01-21
申请号：PCT/US2009/050998
申请日：2009-07-17
申请人： BOSTON SCIENTIFIC SCIMED, INC. , ALKHATIB, Yousef, F.
发明人： ALKHATIB, Yousef, F.
IPC分类号： A61M25/00 , A61M25/10 , A61F2/84
CPC分类号： A61M25/0054 , A61F2/856 , A61F2/954 , A61F2/958 , A61M25/0013 , A61M25/10 , A61M25/1006 , A61M2025/0004 , A61M2025/1045
摘要： A catheter assembly (10) includes a catheter shaft (15) having a proximal portion and a distal portion, the catheter shaft having a torsionally weakened region (50) at the distal portion, the torsionally weakened region including one or more portions (52) that are recessed from an outer surface of the catheter shaft. The assembly also includes a primary guidewire lumen defined in the catheter shaft and sized to receive a primary guidewire, and an inflatable member (70) positioned at the distal portion of the catheter shaft.
摘要翻译：导管组件（10）包括具有近端部分和远端部分的导管轴（15），所述导管轴在所述远侧部分处具有扭转弱化区域（50），所述扭转减弱区域包括一个或多个部分（52）其从导管轴的外表面凹陷。组件还包括限定在导管轴中并且尺寸设计成容纳主导丝的主要导丝腔，以及定位在导管轴的远端部分处的可膨胀构件（70）。

8. 发明申请

WO2009091509A1 DELIVERY AND RETRIEVAL SYSTEMS FOR COLLAPSIBLE/EXPANDABLE PROSTHETIC HEART VALVES 审中-公开
标题翻译：可拆卸/可扩展的心脏瓣膜输送和检测系统
公开(公告)号：WO2009091509A1
公开(公告)日：2009-07-23
申请号：PCT/US2009/000104
申请日：2009-01-08
申请人： ST. JUDE MEDICAL, INC. , ALKHATIB, Yousef, F.
发明人： ALKHATIB, Yousef, F.
IPC分类号： A61F2/24 , A61F2/84
CPC分类号： A61F2/2436 , A61F2/2418 , A61F2/2427 , A61F2/2439 , A61F2002/9511
摘要： A system for delivering a collapsible and re-expandable prosthetic heart valve into a patient includes a valve support structure (140) around which the valve (10) is disposed in a collapsed condition. A sheath structure (110) surrounds the collapsed valve, but can be moved relative to the valve to uncover it for expansion at the desired implant site in the patient. The sheath structure may be variously mounted and moved to deploy the valve in various ways. For example, the sheath structure may include multiple parts, each of which can be moved separately to separately deploy various parts of the valve. The apparatus may have other aspects, such as the ability to reverse deployment of the valve, the ability to pass other instrumentation through the valve delivery apparatus, the ability to be smoothly withdrawn from the patient after deployment of the valve, etc.
摘要翻译：用于将可折叠和可再膨胀的假体心脏瓣膜递送到患者中的系统包括阀支撑结构（140），阀（10）围绕该阀支撑结构设置在折叠状态。护套结构（110）围绕塌缩的瓣膜，但是可以相对于瓣膜移动以露出，以便在患者的期望的植入部位处展开。护套结构可以以各种方式进行各种安装和移动以展开阀。例如，护套结构可以包括多个部件，每个部件可以单独移动以分开地部署阀的各个部件。该装置可以具有其他方面，例如逆向部署阀的能力，通过其他仪器通过阀输送装置的能力，在部署阀之后能够平稳地从患者撤出的能力等。

9. 发明申请

WO2009029199A1 PROSTHETIC AORTIC HEART VALVES 审中-公开
标题翻译：先天性心脏瓣膜
公开(公告)号：WO2009029199A1
公开(公告)日：2009-03-05
申请号：PCT/US2008/009950
申请日：2008-08-21
申请人： ST. JUDE MEDICAL, INC. , ALKHATIB, Yousef, F.
发明人： ALKHATIB, Yousef, F.
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2445 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2230/0076
摘要： A prosthetic aortic valve includes an annular, annulus inflow portion that is designed to reside in or near the patient's native aortic valve annulus, and an annular, aortic outflow portion that is designed to reside in the patient's aorta downstream from at least a portion of the valsalva sinus. The annulus inflow portion and the aortic outflow portion are connected to one another by a plurality of connecting struts that are confined to regions near the commissures of the patient's native aortic valve. The connecting struts are designed to bulge out into the valsalva sinus to help anchor the prosthetic valve in place. The valve is circumferentially collapsible to a relatively small diameter for less-invasive delivery into the patient. The valve circumferentially expands to a larger operational diameter when deployed at the implant site.
摘要翻译：假体主动脉瓣包括环形环形流入部分，其被设计为驻留在患者的天然主动脉瓣膜环内或附近，以及环形主动脉流出部分，其被设计为驻留在患者主动脉中的至少一部分 valsalva窦。环形流入部分和主动脉流出部分通过多个连接支柱彼此连接，所述多个连接支柱被限制在患者天然主动脉瓣的连合处附近的区域。连接支柱被设计成凸出到瓦尔萨瓦窦中，以帮助将假肢瓣锚定到位。瓣膜周向可折叠到相对较小的直径，用于较少侵入性地输送到患者体内。当部署在植入部位时，阀周向地膨胀到更大的操作直径。

10. 发明申请

WO2008150529A1 PROSTHETIC HEART VALVES 审中-公开
标题翻译：先天性心脏瓣膜
公开(公告)号：WO2008150529A1
公开(公告)日：2008-12-11
申请号：PCT/US2008/007015
申请日：2008-06-04
申请人： ST. JUDE MEDICAL, INC. , BRAIDO, Peter N. , ALKHATIB, Yousef, F.
发明人： BRAIDO, Peter N. , ALKHATIB, Yousef, F.
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2210/0076 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2230/008 , A61L27/3604 , A61L27/54
摘要： A prosthetic heart valve (10) (e.g., a prosthetic aortic valve) is designed to be somewhat circumf erentially collapsible and then re-expandable. The collapsed condition may be used for less invasive delivery of the valve into a patient. When the valve reaches the implant site in the patient, it re-expands to normal operating size, and also to engage surrounding tissue of the patient. The valve includes a stent portion (200) and a ring portion (100) that is substantially concentric with the stent portion but downstream from the stent portion in the direction of blood flow through the implanted valve. When the valve is implanted, the stent portion engages the patient's tissue at or near the native valve annulus, while the ring portion engages tissue downstream from the native valve site (e.g., the aorta).
摘要翻译：假体心脏瓣膜（10）（例如，假体主动脉瓣）被设计成在某种程度上是可折叠的并且然后再膨胀。折叠状态可以用于将瓣膜侵入性较差的患者。当阀门到达病人的植入部位时，它会重新扩大到正常的操作大小，并且还可以接合病人的周围组织。所述阀包括支架部分（200）和环状部分（100），所述支架部分（100）与所述支架部分大致同心，但在所述支架部分的下游沿着通过所述植入瓣膜的血流方向。当植入瓣膜时，支架部分在天然瓣膜环处或附近接合患者组织，而环部分接合自然瓣膜部位（例如，主动脉）下游的组织。

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