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1. 发明申请

WO1997013251A1 GATED RECORDING OF HOLOGRAMS USING RARE-EARTH DOPED FERROELECTRIC MATERIALS 审中-公开
标题翻译：使用稀土掺杂的电解材料进行埋藏记录
公开(公告)号：WO1997013251A1
公开(公告)日：1997-04-10
申请号：PCT/US1996015816
申请日：1996-10-02
申请人： SRI INTERNATIONAL , IBM CORPORATION , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： SRI INTERNATIONAL , IBM CORPORATION , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , BAI, Yu, Sheng , KACHRU, Ravinder , HESSELINK, Lambertus , MACFARLANE, Roger, M.
IPC分类号： G11C13/04
CPC分类号： B82Y10/00 , G11B7/0065 , G11B7/243 , G11B7/2433 , G11C13/042
摘要： Rare earth doped ferroelectric materials are disclosed as reversible holographic recording medium (25) for use in two-photon recording systems. Such rare earth elements provide long-lived electronic states intermediate the ferroelectric material's valence and conduction bands. In some cases, these rare earth intermediate states have a sufficiently long life that low-power continuous wave ("cw") lasers (1) can be used to record interference patterns on them. Thus, two-photon holographic recording systems are also disclosed which do not require high-power, short pulse length, mode-locked or Q-switched lasers. Rather, the disclosed holographic recording systems employ cw lasers such as diode lasers. The rare earth dopants include praseodymium, neodymium, dysprosium, holmium, erbium, and thulium. These dopants provide ions having 4f excited states that give rise to absorptions in the near infra-red and visible spectral regions and typically have lifetimes on the order of 0.1 to 1 milliseconds. The disclosed two-photon holographic recording systems provide for absorption of a first photon which excites electrons of a holographic recording medium to a rare-earth intermediate state. Thereafter, upon absorption of a second photon, the electrons are promoted to the medium's conduction band where they are arranged according to the interference pattern provided by the recording system.
摘要翻译：稀土掺杂的铁电材料被公开为用于双光子记录系统的可逆全息记录介质（25）。这种稀土元素在铁电材料的价带和导带之间提供长寿命的电子态。在某些情况下，这些稀土中间体具有足够长的寿命，可以使用低功率连续波（“cw”）激光器（1）来记录干涉图案。因此，还公开了不需要大功率，短脉冲长度，锁模或Q开关激光器的双光子全息记录系统。相反，所公开的全息记录系统采用诸如二极管激光器之类的cw激光器。稀土掺杂剂包括镨，钕，镝，钬，铒和。。这些掺杂剂提供具有4f激发态的离子，其在近红外和可见光谱区域中产生吸收，并且通常具有0.1至1毫秒量级的寿命。所公开的双光子全息记录系统提供了将全息记录介质的电子激发到稀土中间状态的第一光子的吸收。此后，在吸收第二光子时，电子被提升到介质的导带，它们根据由记录系统提供的干涉图案排列。

2. 发明申请

WO1996037630A1 OLIGONUCLEOTIDE SIZING USING CLEAVABLE PRIMERS 审中-公开
标题翻译：使用可拆卸的PRIMERS的OLIGONUCLEOTIDE SIZING
公开(公告)号：WO1996037630A1
公开(公告)日：1996-11-28
申请号：PCT/US1996006116
申请日：1996-04-30
申请人： SRI INTERNATIONAL
发明人： SRI INTERNATIONAL , MONFORTE, Joseph, Albert , BECKER, Christopher, Hank , SHALER, Thomas, Andrew , POLLART, Daniel, Joseph
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6853 , C12Q1/6816 , C12Q1/6858 , C12Q1/6869 , C12Q1/6872 , Y02A50/54 , Y10T436/255 , C12Q2563/167 , C12Q2525/131 , C12Q2533/101 , C12Q2565/518 , C12Q2521/301 , C12Q2565/627 , C12Q2523/319
摘要： The present invention provides modified oligonucleotide primers designed to incorporate a cleavable moiety so that a (3') portion of the primer (linked to an extension product) can be released from an upstream (5') portion of the primer. Upon selective cleavage of the cleavable site, primer extension products that contain about five or fewer base pairs of the primer sequence are released, to provide more useful sizing and sequence information per fragment than extension products containing the entire primer.
摘要翻译：本发明提供设计成掺入可切割部分的修饰的寡核苷酸引物，使得引物（连接于延伸产物）的（3'）部分可以从引物的上游（5'）部分释放。在可切割位点的选择性切割时，释放含有约5个或更少碱基对引物序列的引物延伸产物，以提供比包含整个引物的扩增产物更多的有用的上浆和序列信息。

3. 发明申请

WO1996022514A3 METHOD AND APPARATUS FOR SPEECH RECOGNITION ADAPTED TO AN INDIVIDUAL SPEAKER 审中-公开
公开(公告)号：WO1996022514A3
公开(公告)日：1996-07-25
申请号：PCT/US1996000762
申请日：1996-01-19
申请人： SRI INTERNATIONAL
发明人： SRI INTERNATIONAL , DIGALAKIS, Vassilios , NEUMEYER, Leonardo , RTISCHEV, Dimitry
IPC分类号： G10L05/06

4. 发明申请

WO1996021639A1 ORGANIC LIQUID ELECTROLYTES AND PLASTICIZERS 审中-公开
标题翻译：有机液体电解质和增塑剂
公开(公告)号：WO1996021639A1
公开(公告)日：1996-07-18
申请号：PCT/US1996000183
申请日：1996-01-04
申请人： SRI INTERNATIONAL
发明人： SRI INTERNATIONAL , VENTURA, Susanna, C. , NARANG, Subhash, C. , HUM, Georgina , LIU, Peikang , RANGANATHAN, Prema , SUN, Luying
IPC分类号： C07C69/96
CPC分类号： H01M10/052 , C07C69/96 , C07D317/36 , C07D323/00 , H01B1/122 , H01M6/164 , H01M6/168 , H01M6/22 , H01M10/0565 , H01M2300/0085
摘要： Novel liquid electrolyte plasticizers having enhanced ambient temperature conductivity are provided. These plasticizers have general structures (1), (2) and (3), in which R , R , R , R , R , R , alpha , beta , gamma , l, p and q are as defined herein. Also provided are conductive compositions containing these novel plasticizers, particularly film compositions, and batteries formulated with such compositions.
摘要翻译：提供了具有增强的环境温度导电性的新型液体电解质增塑剂。这些增塑剂具有通式结构（1），（2）和（3），其中R a，R b，R c，R e，R f，R i，，β，γ，l，p和q如本文所定义。还提供了含有这些新型增塑剂，特别是膜组合物的导电组合物和用这种组合物配制的电池。

5. 发明申请

WO1994026806A1 PRECERAMIC SILICON POLYMERS 审中-公开
标题翻译：先导硅聚合物
公开(公告)号：WO1994026806A1
公开(公告)日：1994-11-24
申请号：PCT/US1994005466
申请日：1994-05-17
申请人： SRI INTERNATIONAL
发明人： SRI INTERNATIONAL , BLUM, Yigal , McDERMOTT, Gregory, A.
IPC分类号： C08G77/62
CPC分类号： C08G77/62 , C08G77/38 , C08G77/60
摘要： Novel methods for the preparation of polymers useful as precursors to ceramic materials by catalytic activation of Si-H bonds are disclosed. The methods comprise reacting, in the presence of a catalyst effective to activate Si-H bonds, Si-N bonds, or both, and/or a reactive solvent, a polymer in the form of a polysilane, polysilazane, polysiloxane or polycarbosilane with a reactant having the structural formula R-X-H, wherein X is NR' or O, R is H, organic, silyl, siloxyl, silazanyl or carboxilyl and may contain at least one additional X-H group, and R' is H, amino, silyl or silazanyl, to produce a modified polymer containing at least one Si-X bond. Polymers produced by these methods are also disclosed.
摘要翻译：公开了通过催化活化Si-H键制备可用作陶瓷材料前体的聚合物的新方法。所述方法包括在有效活化Si-H键，Si-N键或两者的催化剂和/或反应性溶剂的存在下，将聚硅烷，聚硅氮烷，聚硅氧烷或聚碳硅烷形式的聚合物与具有结构式RXH的反应物，其中X是NR'或O，R是H，有机，甲硅烷基，甲硅烷氧基，硅氮烷基或羧酰基，并且可以含有至少一个另外的XH基团，R'是H，氨基，甲硅烷基或硅氮烷基，以产生含有至少一个Si-X键的改性聚合物。还公开了通过这些方法制备的聚合物。

6. 发明申请

WO1994020207A1 EXOTHERMIC PROCESS WITH POROUS MEANS TO CONTROL REACTION RATE AND EXOTHERMIC HEAT 审中-公开
标题翻译：具有多孔手段控制反应速率和超热能的多功能工艺
公开(公告)号：WO1994020207A1
公开(公告)日：1994-09-15
申请号：PCT/US1994002342
申请日：1994-03-02
申请人： SRI INTERNATIONAL
发明人： SRI INTERNATIONAL , ASHER, William, J. , ROBERTS, Daryl, L. , JONES, Jerry, L. , GOTTSCHLICH, Douglas, E.
IPC分类号： B01J10/00
CPC分类号： B01D67/0088 , B01D63/061 , B01D67/0041 , B01D69/02 , B01D71/02 , B01D2323/08 , B01J8/009 , B01J8/06 , B01J8/067 , B01J10/007 , B01J12/007 , B01J14/005 , B01J19/2425 , B01J19/2475 , B01J2208/00008 , B01J2208/00265 , B01J2208/0053 , B01J2208/00548 , B01J2208/00575 , Y02P20/582
摘要： An exothermic process for forming a product which may be in a liquid phase is disclosed wherein a first reactant (3), preferably a liquid reactant, is directly fed into a reaction zone (10) containing mixing elements (12, 58) and which comprises a first compartment (10) of a reactor (2, 40). A second reactant, which is maintained at a higher pressure, is fed into a second compartment (20) of the reactor (2, 40) separated from the first compartment (10) by a porous wall (32, 52). The second reactant (4) passes through this porous wall (32, 52) into the reaction zone to react with the first reactant (3). The process thereby controls rates of the reactions and the exothermic heats generated by the reactions. Pulsatile flow in one or both reaction compartments improves mixing. An evaporator for a portion of the production improves product quality and permits higher reaction temperatures in the reactor.
摘要翻译：公开了用于形成可能处于液相的产物的放热方法，其中将第一反应物（3），优选液体反应物直接进料到含有混合元件（12,58）的反应区（10）中，其包含反应器（2,40）的第一隔室（10）。保持在较高压力的第二反应物通过多孔壁（32,52）进料到与第一隔室（10）分离的反应器（2,40）的第二隔室（20）中。第二反应物（4）通过该多孔壁（32,52）进入反应区以与第一反应物（3）反应。该方法由此控制由反应产生的反应速率和放热。一个或两个反应室中的脉动流改善混合。用于部分生产的蒸发器提高了产品质量并允许反应器中的较高反应温度。

7. 发明申请

WO1993012234A1 ANTIVIRAL REAGENTS BASED ON RNA-BINDING PROTEINS 审中-公开
标题翻译：基于RNA结合蛋白的抗病毒试剂
公开(公告)号：WO1993012234A1
公开(公告)日：1993-06-24
申请号：PCT/US1992010770
申请日：1992-12-11
申请人： SRI INTERNATIONAL
发明人： SRI INTERNATIONAL , JAYASENA, Sumedha, D. , JOHNSTON, Brian, H.
IPC分类号： C12N15/49
CPC分类号： A61K31/70 , A61K38/00 , C07K14/005 , C12N9/16 , C12N9/22 , C12N15/113 , C12N2310/15 , C12N2310/321 , C12N2310/3511 , C12N2740/16322 , C12Q1/6839
摘要： The present invention describes the generation of site-directed RNA cleaving agents. These agents consist of RNA-binding proteins, or polypeptides derived thereof, which are modified to contain a moiety capable of cleaving RNA backbones. Alternatively, the agents are oligonucleotides having nuclease resistant backbones to which a moiety capable of cleaving RNA backbones has been attached. The present invention also describes a method of cleaving target RNA substrates using the cleaving agents described herein. Further, the invention describes a method for inhibiting RNA virus expression in infected cells.
摘要翻译：本发明描述了定点RNA切割剂的产生。这些试剂由RNA结合蛋白或其衍生的多肽组成，其被修饰以含有能够切割RNA主链的部分。或者，试剂是具有核酸酶抗性骨架的寡核苷酸，其上附着能够切割RNA主链的部分。本发明还描述了使用本文所述的切割剂来切割靶RNA底物的方法。此外，本发明描述了抑制感染细胞中RNA病毒表达的方法。

8. 发明申请

WO1992022575A1 M-PROTEIN PEPTIDES OF INFLUENZA VIRUS AS ANTIVIRAL AGENTS 审中-公开
标题翻译：流感病毒的M蛋白肽作为抗病毒剂
公开(公告)号：WO1992022575A1
公开(公告)日：1992-12-23
申请号：PCT/US1992005186
申请日：1992-06-17
申请人： SRI INTERNATIONAL , NEW YORK MEDICAL COLLEGE
发明人： SRI INTERNATIONAL , NEW YORK MEDICAL COLLEGE , JUDD, Amrit, K. , BUCHER, Doris, J.
IPC分类号： C07K07/10
CPC分类号： C07K14/005 , A61K38/00 , C12N2760/16122 , C12N2760/16222
摘要： Peptides substantially corresponding to the 148-162 region of type A influenza M protein and additionally containing at least one amino acid in the 163-166 region are disclosed to have high activity as influenza transcription inhibitors and thus as antiviral agents against influenza virus and other RNA viruses. The modification of these peptides by incorporation into liposomes or by addition of long-chain alkylamino acids is also shown as in the use of all such materials in antiviral drug formulations.
摘要翻译：公开了基本上对应于A型流感M蛋白的148-162区域并且另外在163-166区域中含有至少一个氨基酸的肽作为流感转录抑制剂具有高活性，因此作为抗流感病毒和其它RNA的抗病毒剂病毒。通过掺入脂质体或通过加入长链烷基氨基酸对这些肽的修饰也显示为在抗病毒药物制剂中使用所有这些材料。

9. 发明申请

WO1992021696A1 HYDROXYAZIDO DERIVATIVES AND RELATED COMPOUNDS AS RENIN INHIBITORS 审中-公开
标题翻译：羟肟酸衍生物和相关化合物作为RININ抑制剂
公开(公告)号：WO1992021696A1
公开(公告)日：1992-12-10
申请号：PCT/US1992003893
申请日：1992-05-06
申请人： SRI INTERNATIONAL
发明人： SRI INTERNATIONAL , ALMQUIST, Ronald, G. , NAKAZATO, Atsuro
IPC分类号： C07K05/06
CPC分类号： C07D233/64 , A61K38/00 , C07K5/06078
摘要： Novel compounds useful as renin inhibitors are provided. The compounds are hydroxyazido derivatives having structural formula (1), wherein the substituents R1 through R7 are as defined herein. Analogs of these compounds which are ketoazido derivatives are also provided. Additionally disclosed are methods for using the novel compounds to treat hypertension, and pharmaceutical compositions containing the compounds. Of particular interest are formulations for oral administration.

10. 发明申请

WO1992006037A1 CARBONATE-FREE INORGANIC NITRATES OR OXIDES AND PROCESS THEREOF 审中-公开
标题翻译：无碳酸的无机氮化物或氧化物及其过程
公开(公告)号：WO1992006037A1
公开(公告)日：1992-04-16
申请号：PCT/US1991007183
申请日：1991-09-30
申请人： SRI INTERNATIONAL
发明人： SRI INTERNATIONAL , GUSMAN, Michael , TONG, Gilbert , SANJURJO, Angel , JOHNSON, Sylvia, M. , LAMOREAUX, Robert
IPC分类号： C01B21/48
CPC分类号： C01B21/48 , C01B13/18 , C01B33/26 , C01G3/006 , C01G23/006 , C01P2002/34 , C01P2002/72 , Y10S505/725 , Y10S505/734 , Y10S505/737 , Y10S505/78
摘要： The present invention relates to an improved process to produce an essentially carbon-free nitrate of an alkali metal, alkaline earth metal, transition metal, lanthanide metal, actinide metal, metal, or mixtures thereof, which process comprises: contacting an anhydrous composition of an alkali metal, alkaline earth metal, transition metal, lanthanide metal, actinide metal, or mixtures thereof substituted with an organic or an inorganic carbon-containing substitute with flowing nitrogen dioxide, dinitrogen tetroxide or mixtures thereof at a temperature of between about 40 to 150 °C under anhydrous conditions for a time and at a pressure effective to form the nitrate of the alkaline metal, alkaline earth metal, transition metal, lanthanide metal, actinide metal, or mixtures thereof, essentially free of any carbon containing contaminant. Materials produced by this improved process are useful as electrical superconductors, e.g. YBa2Cu3O7, or as high performance advanced materials, e.g. BaTiO3 or bariumaluminosilicate.

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