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1. 发明申请

WO2007055822A3 PARYLENE VARIANTS AND METHODS OF SYNTHESIS AND USE 审中-公开
标题翻译： PARYLENE变体及其合成和使用方法
公开(公告)号：WO2007055822A3
公开(公告)日：2007-11-22
申请号：PCT/US2006038012
申请日：2006-09-28
申请人： SPECIALTY COATING SYSTEMS INC , HANEFELD PHILLIP , HORST SVEN , MEISE MARKUS , BOGNITZKI MICHAEL , GREINER ANDREAS , KUMAR RAKESH
发明人： HANEFELD PHILLIP , HORST SVEN , MEISE MARKUS , BOGNITZKI MICHAEL , GREINER ANDREAS , KUMAR RAKESH
IPC分类号： C07C1/00
CPC分类号： C07C22/08 , C07C17/269 , C07C17/35 , C07C17/354 , C07C2603/92 , C08G61/02 , C09D165/00 , Y10T428/12028
摘要： Fluorinated paracyclophane compounds are disclosed. These compounds can have a trifluorinated moiety and can be utilized as precursor dimer compounds to produce polymeric coatings comprising copolymers of trifluorinated paraxylylene.
摘要翻译：公开了氟化对环烷基化合物。这些化合物可以具有三氟化的部分并且可以用作前体二聚体化合物以制备包含三氟化对二甲苯的共聚物的聚合物涂层。

2. 发明申请

WO2007008607A3 NANOSCALE STRUCTURES AND METHODS OF PREPARATION 审中-公开
标题翻译：纳米结构和制备方法
公开(公告)号：WO2007008607A3
公开(公告)日：2009-05-07
申请号：PCT/US2006026356
申请日：2006-07-06
申请人： SPECIALTY COATING SYSTEMS INC , KUMAR RAKESH , SINGH BAWA , LEWIS BRIAN G , MARCZI MICHAEL T , HANFELD PHILLIP , KRIHA OLAF , GREINER ANDREAS
发明人： KUMAR RAKESH , SINGH BAWA , LEWIS BRIAN G , MARCZI MICHAEL T , HANFELD PHILLIP , KRIHA OLAF , GREINER ANDREAS
IPC分类号： B28B1/14 , B05D7/00 , B32B5/16 , B32B21/02
CPC分类号： D01D5/00 , B01J13/14 , D01F6/96 , D01F9/20
摘要： Structures in the nanoscale and mesoscale domain are provided. The structures may have a shell which can be comprised of a porous polymeric material such as parylene. The surfaces of the shell can further comprise pendant functional groups that can provide reactive or passive characteristics. A method of producing nanoscale structures utilizing a porous substrate is further disclosed.
摘要翻译：提供了纳米尺度和中尺度域中的结构。该结构可以具有可以由诸如聚对二甲苯的多孔聚合物材料构成的壳。壳体的表面可进一步包含可提供反应性或被动特性的侧链官能团。进一步公开了利用多孔基材制造纳米级结构的方法。

3. 发明申请

WO2007081554A2 FLUORINATED COATINGS 审中-公开
标题翻译：氟化涂料
公开(公告)号：WO2007081554A2
公开(公告)日：2007-07-19
申请号：PCT/US2006049333
申请日：2006-12-27
申请人： SPECIALTY COATING SYSTEMS INC , KUMAR RAKESH
发明人： KUMAR RAKESH
IPC分类号： B32B1/08
CPC分类号： C07C25/22 , A61L27/34 , A61L29/085 , A61L31/10 , B05D1/60 , C07C23/18 , C09D165/04 , H01L21/0212 , H01L21/02263 , H01L21/3127 , H05K3/284 , Y10T428/1393
摘要： Conformal coatings are disclosed. A fluorinated thin film, for example, is formed by vapor phase polymerization on a variety of sensitive surfaces that may include electronic and automotive sensors, biochips, implantable sensors and biomedical devices.
摘要翻译：公开了保形涂层。氟化薄膜例如通过气相聚合在各种敏感表面上形成，这些敏感表面可以包括电子和汽车传感器，生物芯片，可植入传感器和生物医学装置。

4. 发明申请

WO2008106286A3 PERFLUOROPARACYCLOPHANE AND METHODS OF SYNTHESIS AND USE THEREOF 审中-公开
标题翻译：全氟化合物及其合成方法及其用途
公开(公告)号：WO2008106286A3
公开(公告)日：2008-12-04
申请号：PCT/US2008053150
申请日：2008-02-06
申请人： SPECIALTY COATING SYSTEMS INC , DOLBIER WILLIAM R JR , XIE PUHUI , KUMAR RAKESH
发明人： DOLBIER WILLIAM R JR , XIE PUHUI , KUMAR RAKESH
IPC分类号： C07C17/269 , C07C25/18 , C08F114/18
CPC分类号： C07C17/392 , C07C17/269 , C08F14/18 , C07C25/22 , C08F2/04
摘要： A composition comprising perfluoro-[2,2]-paracyclophane dimer compound is disclosed. The synthesis reaction of the paracyclophane dimer from 1,4-bis(chlorodifluoromethane)-2,3,5,6-tetrafluorobenzene involves heating in the presence of a metal catalyst and a solvent. A perfluorinated paraxylylene coating formed from the perfluorinated paracyclophane dimer is also disclosed.
摘要翻译：公开了包含全氟 - [2,2] - 对环烷基二聚体化合物的组合物。来自1,4-双（氯二氟甲烷）-2,3,5,6-四氟苯的对环烷基二聚体的合成反应涉及在金属催化剂和溶剂的存在下加热。还公开了由全氟化对环烷基二聚体形成的全氟化对二甲苯涂层。

5. 发明申请

WO2012082337A3 COMBINATION 审中-公开
标题翻译：组合
公开(公告)号：WO2012082337A3
公开(公告)日：2013-12-27
申请号：PCT/US2011061985
申请日：2011-11-23
申请人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY LTD , KUMAR RAKESH , BARUCHEL SYLVAIN
发明人： KUMAR RAKESH , BARUCHEL SYLVAIN
IPC分类号： A61K31/47 , C07D231/56
CPC分类号： A61K31/506 , A61K31/4375 , A61K31/4745 , A61K2300/00
摘要： The present invention relates to methods of treating neuroblastoma, osteosarcoma, and rhabdomyosarcoma in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a neuroblastoma treatment method that includes administering 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide, or a pharmaceutically acceptable salt thereof, and (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7] indolizino [1,2-b]quinoline-3,14-(4H,12H)-dione, or a pharmaceutically acceptable salt thereof, to a human in need thereof.
摘要翻译：本发明涉及治疗人类的神经母细胞瘤，骨肉瘤和横纹肌肉瘤的方法以及用于这种治疗的药物组合。特别地，该方法涉及神经母细胞瘤治疗方法，其包括施用5 - [[4 - [（2,3-二甲基-2H-吲唑-6-基）甲基氨基] -2-嘧啶基]氨基] -2-甲基苯磺酰胺，或其药学上可接受的盐，和（S）-10 - [（二甲基氨基）甲基] -4-乙基-4,9-二羟基-1H-吡喃并[3'，4'：6,7]吲哚并[1,2 b]喹啉-3,14-（4H，12H） - 二酮或其药学上可接受的盐。

6. 发明申请

WO2012021877A3 METHOD AND SYSTEM FOR REVERSAL OF INTERACTIONS BETWEEN HYDROPHOBICALLY MODIFIED BIOPOLYMERS AND VESICLES OR CELL MEMBRANES 审中-公开
标题翻译：水解改性生物聚合物与VESICLES或细胞膜之间相互作用的方法和系统
公开(公告)号：WO2012021877A3
公开(公告)日：2012-06-28
申请号：PCT/US2011047694
申请日：2011-08-13
申请人： UNIV MARYLAND , DOWLING MATTHEW , KUMAR RAKESH , RAGHAVAN SRINIVASA R
发明人： DOWLING MATTHEW , KUMAR RAKESH , RAGHAVAN SRINIVASA R
IPC分类号： A61L15/22 , A61F13/00 , A61L15/28 , A61L15/42
CPC分类号： A61K31/724 , A61L15/28 , A61L15/42 , A61L26/0023 , A61L26/0061 , A61L26/0076 , A61L2300/232 , A61L2400/04
摘要： A method for reversing gelation of hydrophobically modified biopolymer attached to vesicle or cell membranes. The gelation of hydrophobically modified biopolymer attached to vesicles or cell membranes is reversed by application of a supramolecule, such as cyclodextrin, to the gelled composition. The supramolecule disrupts the interactions between the hydrophobically modified biopolymer and the vesicle or cell membrane, without affecting the structure of the membrane or the hydrophobically modified polymer to which the hydrophobic substituents are attached. A kit for treating wounds that includes a hydrophobically modified biopolymer and a supramolecule. The hydrophobically modified biopolymer is used to stop bleeding and the supramolecule is used to remove the hydrophobically modified biopolymer.
摘要翻译：疏水改性的生物聚合物与囊泡或细胞膜连接的凝胶化方法。连接到囊泡或细胞膜上的疏水改性的生物聚合物的凝胶化通过将超分子如环糊精施加到胶凝组合物来逆转。超分子破坏疏水改性生物聚合物与囊泡或细胞膜之间的相互作用，而不影响疏水性取代基所连接的膜或疏水改性聚合物的结构。用于治疗包含疏水改性生物聚合物和超分子的伤口的试剂盒。疏水改性的生物聚合物用于止血，超分子用于除去疏水改性的生物聚合物。

7. 发明申请

WO2010097811A4 MICROWAVE INDUCED SINGLE STEP GREEN SYNTHESIS OF SOME NOVEL 2-ARYL ALDEHYDES AND THEIR ANALOGUES 审中-公开
标题翻译：微波诱导的一些新型2-芳基醛及其类似物的单步合成
公开(公告)号：WO2010097811A4
公开(公告)日：2010-11-04
申请号：PCT/IN2010000110
申请日：2010-02-25
申请人： COUNCIL SCIENT IND RES , SINHA ARUN KUMAR , SHARMA ABHISHEK , KUMAR RAKESH , SHARMA NAINA
发明人： SINHA ARUN KUMAR , SHARMA ABHISHEK , KUMAR RAKESH , SHARMA NAINA
IPC分类号： C07C45/30 , C07C47/228 , C07C47/23 , C07C47/24 , C07C47/277 , C07C311/49 , C07D317/54
CPC分类号： C07C45/28 , C07C45/30 , C07C249/16 , C07C311/49 , C07D317/54 , C07C47/228 , C07C47/24 , C07C47/23 , C07C47/277
摘要： The present invention provides a process for the preparation of some novel 2-aryl and 2,2-diaryl aldehydes and analogues which are privileged intermediates for commercially important nonsteroidal anti-inflammatory drugs including naproxen, flurbiprofen and potent anticancer drug candidates, including phenstatin through a unique single step synthetic methodology utilizing easily available substrates in the form of aryl alkenes as well as environmentally benign aqueous reaction conditions in the form of solvents such as mixtures of water and DMSO or Dioxane and reagents N-bromosuccinimide, N- iodosuccinimide, N-cholorosuccinimide and phase transfer catalyst such as cetyltrimethyl ammonium bromide, N-hexyl ammonium chloride for a reaction time varying from 1min- 30min, depending upon microwave or conventional heating, without using expensive transition metal catalysts or lewis acids/bases with yield varying from 35-55 %, depending upon the solvent and substrate used. The developed method provides a clean and convenient alternative to access a diverse range of medicinally important 2-aryl and 2,2- diaryl aldehyde based scaffolds in lieu of the conventional multistep protocols employing expensive and hazardous transition metal catalysts and lewis acids/bases.
摘要翻译：本发明提供了制备一些新的2-芳基和2,2-二芳基醛和类似物的方法，所述醛和类似物是用于商业上重要的非甾体抗炎药，包括萘普生，氟比洛芬和有效的抗癌候选药物包括苯抑制素通过采用芳基烯烃形式的容易获得的底物以及溶剂形式的环境友好的水性反应条件，例如水和DMSO或二氧六环的混合物和试剂N-溴代琥珀酰亚胺，N-碘代琥珀酰亚胺，N-氯代琥珀酰亚胺和相转移催化剂如十六烷基三甲基溴化铵，N-己基氯化铵，反应时间从1分钟至30分钟不等，取决于微波或常规加热，而不使用昂贵的过渡金属催化剂或路易斯酸/碱，产率从35-55变化％，取决于所用的溶剂和基材。所开发的方法提供了一种干净而方便的替代方案，以取代使用昂贵且危险的过渡金属催化剂和路易斯酸/碱的常规多步骤方案的各种医学上重要的基于2-芳基和2,2-二芳基醛的支架。

8. 发明申请

WO2012129147A3 MANAGING POWER CONSUMPTION IN A MULTI-CORE PROCESSOR 审中-公开
标题翻译：在多核处理器中管理功耗
公开(公告)号：WO2012129147A3
公开(公告)日：2013-03-14
申请号：PCT/US2012029604
申请日：2012-03-19
申请人： INTEL CORP , FETZER ERIC , REIDLINGER REID J , SOLTIS DON , BOWHILL WILLIAM J , SHRIMALI SATISH , SISTLA KRISHNAKANTH , ROTEM EFRAIM , KUMAR RAKESH , GARG VIVEK , NAVEH ALON , SHARMA LOKESH
发明人： FETZER ERIC , REIDLINGER REID J , SOLTIS DON , BOWHILL WILLIAM J , SHRIMALI SATISH , SISTLA KRISHNAKANTH , ROTEM EFRAIM , KUMAR RAKESH , GARG VIVEK , NAVEH ALON , SHARMA LOKESH
IPC分类号： G06F1/32
CPC分类号： G06F1/3296 , G06F1/324 , Y02B60/1217 , Y02B60/1285 , Y02D10/126 , Y02D10/172 , Y02D50/20
摘要： A processor may include a core and an uncore area. The power consumed by the core area may be controlled by controlling the Cdyn of the processor such that the Cdyn is within an allowable Cdyn value irrespective of the application being processed by the core area. The power management technique includes measuring digital activity factor (DAF), monitoring architectural and data activity levels, and controlling power consumption by throttling the instructions based on the activity levels. As a result of throttling the instructions, throttling may be implemented in 3rd droop and thermal design point (TDP). Also, the idle power consumed by the uncore area while the core area is in deep power saving states may be reduced by varying the reference voltage VR and the VP provided to the uncore area. As a result, the idle power consumed by the uncore area may be reduced.
摘要翻译：处理器可以包括核心和无孔区域。可以通过控制处理器的Cdyn来控制核心区域消耗的功率，使得Cdyn处于可允许的Cdyn值内，而不管应用程序是否被核心区域处理。电源管理技术包括测量数字活动因素（DAF），监控架构和数据活动级别，以及通过基于活动级别来限制指令来控制功耗。作为节流指令的结果，节流可以在第3垂直和热设计点（TDP）中实现。此外，通过改变提供给无孔区域的参考电压VR和VP，可以减少核心区域处于深功率节省状态时由无孔区域消耗的空闲功率。结果，可以减少由无孔区域消耗的空闲功率。

9. 发明申请

WO2010113005A2 ONE POT MULTICOMPONENT SYNTHESIS OF SOME NOVEL HYDROXY STILBENE DERIVATIVES WITH ALPHA, BETA-CARBONYL CONJUGATION UNDER MICROWAVE IRRADIATION 审中-公开
标题翻译：一种具有ALPHA的新型羟基苯并苯衍生物的多糖合成，微波辐射下的碳纳米管结合
公开(公告)号：WO2010113005A2
公开(公告)日：2010-10-07
申请号：PCT/IB2010000675
申请日：2010-03-26
申请人： COUNCIL SCIENT IND RES , SHARMA ABHISHEK , SINHA ARUN KUMAR , KUMAR RAKESH , SHARMA NAINA
发明人： SHARMA ABHISHEK , SINHA ARUN KUMAR , KUMAR RAKESH , SHARMA NAINA
IPC分类号： C07C41/30
CPC分类号： A61K36/482 , C07D317/54 , C07D333/16
摘要： The present invention provides a method for the preparation of some novel commercially important multiconjugated 2- or 4-hydroxy substituted stilbenes including lithospermic acid based stilbene analogues possessing an a, ß-unsaturated carboxylic acid moiety i.e. (C6-C2-C6-C3 chain) with wide ranging applications as potent pharmcophores for diverse ailments including diabetes and cardiovascular disorders, besides finding usage in non-linear optical devices and optoelectronics etc. The method provides a unique one pot multicomponent approach wherein 3-4 step reaction sequences viz. condensation, decarboxylation and Heck coupling occur simultaneously either the need for decarboxylating/protection-deprotection agents or individual isolation of highly reactive intermediates which results in an enhanced yield of desired products and reduced reaction times. The present invention dispenses with the hitherto indispensable requirement for multistep approaches for a diverse range of hydroxy stilbene derivatives through a one pot muticomponent synthetic strategy.
摘要翻译：本发明提供一种制备一些新的商业上重要的多结合的2-或4-羟基取代的二苯乙烯的方法，包括具有α，β-不饱和羧酸部分的（例如（C 6 -C 2 -C 6 -C 3链）广泛的应用作为各种疾病（包括糖尿病和心血管疾病）的强大药剂，除了在非线性光学器件和光电子等中使用外，还提供了独特的一锅多组分方法，其中3-4步反应顺序即缩合，脱羧和Heck偶联同时发生脱羧/保护脱保护剂的需要或高反应中间体的单独分离，这导致所需产物的产率提高和反应时间缩短。本发明通过一锅多组分合成策略免除了对多种范围的羟基二苯乙烯衍生物的多步法的迄今不可或缺的要求。

10. 发明申请

WO2007013885A9 FLEXIBLE LAYER TRACKING WITH WEAK ONLINE APPEARANCE MODEL 审中-公开
标题翻译：柔性层跟踪与弱线性外观模型
公开(公告)号：WO2007013885A9
公开(公告)日：2007-03-29
申请号：PCT/US2005036585
申请日：2005-10-13
申请人： SARNOFF CORP , AGGARWAL MANOJ , SAWHNEY HARPREET , KUMAR RAKESH , SAMARASEKERA SUPUN
发明人： AGGARWAL MANOJ , SAWHNEY HARPREET , KUMAR RAKESH , SAMARASEKERA SUPUN
IPC分类号： B23K26/26
CPC分类号： G06T7/277 , G01S3/7864 , G06T7/251 , G06T2207/10016 , G06T2207/30196
摘要： Method for tracking an object recorded within a selected frame of a sequence of frames of video data, using a plurality of layers, where at least one object layer of the plurality of layers represents the object includes initializing layer ownership probabilities for pixels of the selected frame using a non-parametric motion model, estimating a set of motion parameters of the plurality of layers for the selected frame using a parametric maximization algorithm and tracking the object. The non-parametric motion model is optical flow and includes warping the mixing probabilities, the appearances of the plurality of layers, and the observed pixel data from the pixels of the preceding frame to the pixels of the selected frame to initialize the layer ownership probabilities for the pixels of the selected frame.
摘要翻译：用于使用多个层来跟踪记录在视频数据帧序列的所选帧内的对象的方法，其中多个层中的至少一个对象层表示对象包括初始化所选帧的像素的层所有权概率使用非参数运动模型，使用参数最大化算法估计所选择的帧的所述多个层的运动参数的集合并跟踪所述对象。非参数运动模型是光流，包括混合概率，多层的出现以及从前一帧的像素到所选帧的像素的观察像素数据的变形，以初始化层所有权概率所选帧的像素。

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