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1. 发明申请

WO2012054905A2 APPARATUS, METHODS, AND COMPOSITIONS FOR ENDODONTIC TREATMENTS 审中-公开
标题翻译：装置，方法和组合物用于内切治疗
公开(公告)号：WO2012054905A2
公开(公告)日：2012-04-26
申请号：PCT/US2011/057401
申请日：2011-10-21
申请人： SONENDO, INC. , BERGHEIM, Bjarne , KHAKPOUR, Mehrzad , PHAM, Michele , GHARIB, Morteza , TEBBS, Richard, S.
发明人： BERGHEIM, Bjarne , KHAKPOUR, Mehrzad , PHAM, Michele , GHARIB, Morteza , TEBBS, Richard, S.
IPC分类号： A61C5/02 , C12N15/85
CPC分类号： A61C5/44 , A61C5/40 , A61C5/50 , A61C17/20
摘要： Examples of apparatus, methods, and compositions for endodontic treatments are described. The apparatus can include a fluid platform configured to substantially retain fluid in a tooth chamber during treatment. The fluid platform can help maintain fluid circulation in the tooth chamber as fluid flows into and out of the tooth chamber. The apparatus can also include a pressure wave generator configured to generate acoustic waves that can be used for cleaning root canals and tooth surfaces in the tooth chamber. Examples of pressure wave generators include a liquid jet, an electromagnetic energy delivery device, and an ultrasonic device. The fluid can include antiseptic or antibacterial solutions to assist in tooth cleaning. The fluid may be degassed to have a reduced dissolved gas content (compared to non- degassed fluids used in endodontic treatments), which may improve the effectiveness of the pressure wave generation or the cleaning.
摘要翻译：描述了用于牙髓治疗的装置，方法和组合物的实例。该装置可以包括流体平台，该流体平台构造成在处理期间基本上将流体保持在齿室中。当流体流入和流出齿室时，流体平台可帮助保持在齿室中的流体循环。该装置还可以包括压力波发生器，该压力波发生器被配置为产生可用于清洁牙槽中的根管和齿表面的声波。压力波发生器的实例包括液体射流，电磁能量输送装置和超声装置。流体可以包括消毒或抗菌溶液以帮助牙齿清洁。流体可以被脱气以具有降低的溶解气体含量（与用于牙髓治疗中的非脱气流体相比），这可以提高压力波产生或清洁的有效性。

2. 发明申请

WO2011060327A1 LIQUID JET APPARATUS AND METHODS FOR DENTAL TREATMENTS 审中-公开
标题翻译：液体喷射装置和牙科治疗方法
公开(公告)号：WO2011060327A1
公开(公告)日：2011-05-19
申请号：PCT/US2010/056620
申请日：2010-11-12
申请人： DENTATEK CORPORATION , BERGHEIM, Bjarne , GHARIB, Morteza , KHAKPOUR, Mehrzad , PHAM, Michele , TEBBS, Richard, S.
发明人： BERGHEIM, Bjarne , GHARIB, Morteza , KHAKPOUR, Mehrzad , PHAM, Michele , TEBBS, Richard, S.
IPC分类号： A61C5/02
CPC分类号： A61C5/62 , A61C5/40 , A61C17/02 , A61C17/028
摘要： Systems and methods for using a liquid jet apparatus for dental treatments are disclosed. In one implementation, the liquid jet apparatus may include a handpiece configured to deliver a high velocity liquid jet to a desired location in the mouth of a patient. The handpiece may include a positioning member having a channel through or along which the jet can propagate. The positioning member may have a distal end portion configured to be at least partially disposed in a pulp cavity, canal space, or opening in the tooth under treatment. During operation, the jet may impact an impingement surface of the distal end portion of the positioning member and be deflected as a spray through one or more openings in the distal end portion. The liquid jet apparatus may be used for root canal treatments.
摘要翻译：公开了用于牙科治疗的液体喷射装置的系统和方法。在一个实施方案中，液体喷射装置可以包括构造成将高速液体射流输送到患者口腔中的期望位置的手持件。手持件可以包括定位构件，该定位构件具有通过喷射器可以传播的通道。定位构件可以具有远端部分，其构造成至少部分地设置在纸浆腔，运河空间或处理的牙齿中的开口处。在操作期间，射流可以冲击定位构件的远端部分的冲击表面，并且通过远端部分中的一个或多个开口作为喷射而偏转。液体喷射装置可用于根管治疗。

3. 发明申请

WO2008092125A2 APPARATUS AND METHODS FOR MONITORING A TOOTH 审中-公开
标题翻译：用于监测牙齿的装置和方法
公开(公告)号：WO2008092125A2
公开(公告)日：2008-07-31
申请号：PCT/US2008/052122
申请日：2008-01-25
申请人： DENTATEK CORPORATION , GHARIB, Morteza , ADAMS, Joshua , BERGHEIM, Bjarne , PIOTROWSKI, Adam, E.
发明人： GHARIB, Morteza , ADAMS, Joshua , BERGHEIM, Bjarne , PIOTROWSKI, Adam, E.
IPC分类号： A61C17/032
CPC分类号： A61B5/4547 , A61B5/113 , A61B8/08 , A61C5/40 , A61C19/04 , A61C19/042
摘要： Apparatus and methods for monitoring a tooth may include sensing acoustic energy propagating from regions (such as a root canal system) in and/or near a tooth. The apparatus and methods may be used with root canal cleaning treatments to determine the efficacy of the treatment and/or to reduce risk of post- treatment complications. An acoustic source (e.g., an acoustic transducer and/or a high-speed liquid jet) may be used to transmit energy into a tooth and/or regions near a tooth. An acoustic receiver may be used to detect acoustic signatures of acoustic events (e.g., acoustic echoes and/or acoustic cavitation) occurring in the tooth. The acoustic signatures may be used, for example, to determine the progress of a root canal cleaning treatment and/or the presence or movement of material toward a periapical region of the tooth. Apparatus and methods for monitoring a tooth may include detecting impact of a first jet on a tooth and actuating a second jet in response to detection of the impact.
摘要翻译：用于监测牙齿的装置和方法可包括感测从牙齿中和/或牙齿附近的区域（例如根管系统）传播的声能。该设备和方法可与根管清洁治疗一起使用以确定治疗的功效和/或降低治疗后并发症的风险。可以使用声源（例如声学换能器和/或高速液体喷射器）将能量传输到牙齿附近的牙齿和/或区域。可以使用声学接收器来检测在牙齿中发生的声学事件（例如声学回声和/或声学空化）的声学标记。例如，可以使用声学特征来确定根管清洁处理的进展和/或材料朝向牙齿的根尖区域的存在或运动。用于监测牙齿的装置和方法可以包括检测第一射流对牙齿的冲击并且响应于检测到冲击而致动第二射流。

4. 发明申请

WO2007124038A2 APPARATUS AND METHODS FOR TREATING ROOT CANALS OF TEETH 审中-公开
标题翻译：用于处理牙根的装置和方法
公开(公告)号：WO2007124038A2
公开(公告)日：2007-11-01
申请号：PCT/US2007/009633
申请日：2007-04-19
申请人： DENTATEK CORPORATION , GHARIB, Morteza , ADAMS, Joshua , HARS, Erik , BERGHEIM, Bjarne , STOCKS, Karl , DOHERTY, Lance
发明人： GHARIB, Morteza , ADAMS, Joshua , HARS, Erik , BERGHEIM, Bjarne , STOCKS, Karl , DOHERTY, Lance
IPC分类号： A61C5/02
CPC分类号： A61C17/02 , A61C5/40 , A61C5/50 , A61C17/0202 , A61C17/16
摘要： Apparatus and methods for endodontic treatment of teeth provide effective cleaning of organic material (such as pulp and diseased tissue) from the root canal system. In an embodiment, a compressor system generates high pressure liquid (e.g., water) that flows through an orifice to produce a high-velocity collimated jet of liquid. The high-velocity jet is directed toward a surface of a tooth, for example, an exposed dentinal surface, and impingement of the jet onto the surface generates an acoustic wave that propagates throughout the tooth. The acoustic wave effectively detaches organic material from dentinal surfaces and tubules. The detached organic material is flushed from the root canal system by the liquid jet and/or by additional irrigation.
摘要翻译：用于牙齿治疗牙齿的装置和方法提供了从根管系统有效清洁有机材料（例如纸浆和病变组织）。在一个实施例中，压缩机系统产生流过孔口的高压液体（例如水），以产生高速准直的液体射流。高速射流被引导到牙齿的表面，例如暴露的牙质表面，并且喷射到表面上的冲击产生在整个齿上传播的声波。声波有效地从牙本质表面和小管分离有机材料。分离的有机材料通过液体喷射从根管系统冲洗和/或通过额外的灌溉冲洗。

5. 发明申请

WO2008092101A3 METHODS AND SYSTEMS FOR REDUCING PARAVALVULAR LEAKAGE IN HEART VALVES 审中-公开
公开(公告)号：WO2008092101A3
公开(公告)日：2008-07-31
申请号：PCT/US2008/052088
申请日：2008-01-25
申请人： 3F THERAPEUTICS, INC. , BERGHEIM, Bjarne , TOOMES, Chris , NITZ, Marc , LEE, Tracey , QUIJANO, Roldolfo C. , ELIZONDO, David R.
发明人： BERGHEIM, Bjarne , TOOMES, Chris , NITZ, Marc , LEE, Tracey , QUIJANO, Roldolfo C. , ELIZONDO, David R.
IPC分类号： A61F2/24
摘要： A replacement valve comprises a valve body having an inflow end, an outflow end, and a valve support structure, and a valve cuff surrounding the inflow end of the valve body. The valve support structure surrounds the valve body, and the valve cuff is coupled to the valve support structure. The valve cuff includes a skirt portion and at least one flange coupled to and protruding from the skirt portion, the at least one flange forming a seal around the inflow end of the valve body.

6. 发明申请

WO2008010817A1 MINIMALLY INVASIVE VALVE REPLACEMENT SYSTEM 审中-公开
标题翻译：微型入门阀更换系统
公开(公告)号：WO2008010817A1
公开(公告)日：2008-01-24
申请号：PCT/US2006/032485
申请日：2006-08-18
申请人： 3F THERAPEUTICS, INC. , ARTOF, Jason , BERGHEIM, Bjarne , NITZ, Marc, R. , DUMONTELLE, Jeff
发明人： ARTOF, Jason , BERGHEIM, Bjarne , NITZ, Marc, R. , DUMONTELLE, Jeff
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61B5/0066 , A61B5/0084 , A61B5/0086 , A61B8/12 , A61B8/445 , A61F2/2415 , A61F2/243 , A61F2/2433 , A61F2/2439 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2230/0054
摘要： Methods and systems for minimally invasive replacement of a valve. The system includes a collapsible valve and anchoring structure. The valve assembly comprises a valve and anchoring structure for the valve, dimensioned to fit substantially within the valve sinus.
摘要翻译：用于微创更换瓣膜的方法和系统。该系统包括可折叠阀和锚定结构。阀组件包括用于阀的阀和锚固结构，其尺寸被设计成基本上配合在阀窦内。

7. 发明申请

WO2007016187A2 METHODS AND SYSTEMS FOR CARDIAC VALVE DELIVERY 审中-公开
标题翻译：用于心脏瓣膜递送的方法和系统
公开(公告)号：WO2007016187A2
公开(公告)日：2007-02-08
申请号：PCT/US2006/029080
申请日：2006-07-26
申请人： 3F THERAPEUTICS, INC. , BERGHEIM, Bjarne , CUEVAS, Walter , DUMONTELLE, Jeff
发明人： BERGHEIM, Bjarne , CUEVAS, Walter , DUMONTELLE, Jeff
IPC分类号： A61F2/24 , A61F2/01
CPC分类号： A61F2/2427 , A61F2/013 , A61F2/2418 , A61F2/2433 , A61F2/91 , A61F2002/018 , A61F2230/0006 , A61F2230/001 , A61F2230/0065 , A61F2230/0067 , A61F2230/0069 , A61F2230/008 , A61F2250/0039
摘要： The present invention provides systems and methods for the repair, removal, and/or replacement of heart valves. The methods comprise introducing a delivery system into the heart, wherein a prosthesis is disposed on the delivery member attached to the delivery system, advancing the prosthesis to the target site, and disengaging the prosthesis from the delivery member at the target site for implantation. The present invention also provides implant systems for delivering a prosthesis to a target site in or near the heart. In one embodiment of the present invention, the implant system comprises a delivery system, an access system, and a prosthesis.
摘要翻译：本发明提供了用于修复，移除和/或替换心脏瓣膜的系统和方法。该方法包括将输送系统引入心脏，其中假体设置在连接至输送系统的输送构件上，将假体推进至目标部位，并使假体与目标部位处的输送构件分离以进行植入。本发明还提供了用于将假体递送到心脏内或附近的目标部位的植入系统。在本发明的一个实施例中，植入系统包括输送系统，进入系统和假体。

8. 发明申请

WO2006031648A2 METHOD AND ASSEMBLY FOR DISTAL EMBOLIC PROTECTION 审中-公开
标题翻译：用于远端保护的方法和装配
公开(公告)号：WO2006031648A2
公开(公告)日：2006-03-23
申请号：PCT/US2005/032164
申请日：2005-09-07
申请人： 3F THERAPEUTICS, INC. , BERGHEIM, Bjarne
发明人： BERGHEIM, Bjarne
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2/24 , A61F2002/018 , A61F2230/0006 , A61F2230/0008 , A61F2230/0067 , A61F2250/0003
摘要： Methods and assemblies are described for capturing embolic material in a blood vessel or other body cavity during cardiovascular or valve replacement and repair surgery, wherein access is provided through the apical area of the patient’s heart. The distal embolic protection assembly generally comprises a sleeve having a lumen, an actuating member having proximal and distal ends, wherein the actuating member is movably disposed within the lumen, and a filter assembly coupled to the distal end of the actuating member. The filter assembly generally comprises a porous bag having an open proximal end, a collapsible and expandable frame that is coupled to the open proximal end of the porous bag, and at least one support spine disposed at least a part of the longitudinal axis of the porous bag, and at least one support spine disposed at least a part of the longitudinal axis of the porous bag. The porous bag is configured such that it permits blood to perfuse freely while capturing embolic material and other debris.
摘要翻译：描述了用于在心血管或瓣膜置换和修复手术期间在血管或其他体腔中捕获栓塞材料的方法和组件，其中通过患者心脏的顶端区域提供通路。远侧栓塞保护组件通常包括具有内腔的套筒，具有近端和远端的致动构件，其中致动构件可移动地设置在内腔内，以及联接到致动构件的远端的过滤器组件。过滤器组件通常包括多孔袋，其具有敞开的近端，可折叠和可扩张的框架，其联接到多孔袋的开口近端，以及至少一个支撑脊，其设置在多孔袋的纵向轴线的至少一部分上袋和至少一个支撑脊柱，其设置在多孔袋的纵向轴线的至少一部分上。多孔袋配置成允许血液自动灌注，同时捕获栓塞物质和其他碎屑。

9. 发明申请

WO2005104957A2 METHOD AND SYSTEM FOR CARDIAC VALVE DELIVERY 审中-公开
标题翻译：用于心脏瓣膜输送的方法和系统
公开(公告)号：WO2005104957A2
公开(公告)日：2005-11-10
申请号：PCT/US2005/013901
申请日：2005-04-22
申请人： 3F THERAPEUTICS, INC. , BERGHEIM, Bjarne
发明人： BERGHEIM, Bjarne
IPC分类号： A61B17/00
CPC分类号： A61F2/2427 , A61B8/12 , A61B8/445 , A61B17/04 , A61B17/068 , A61B17/3468 , A61B2017/00243 , A61B2017/00247 , A61B2017/22097 , A61B2018/00392 , A61F2/01 , A61F2/2412 , A61F2/2433 , A61F2230/0006
摘要： The invention provides methods and systems for introducing a delivery device in the heart at or near the apex of the heart, wherein the delivery device includes a prosthesis, advancing the prosthesis to the target site, and disengaging the prosthesis from the delivery device at the target site for implantation. Specifically, the present invention provides valve replacement systems for delivering a replacement heart valve to a target site in or near a heart. The valve replacement system comprises a trocar or other suitable device to penetrate the heart at or near the apex of the heart, a delivery member that is movably disposed within the trocar, and a replacement cardiac valve disposed on the delivery member. The delivery member may further comprise mechanical or inflatable expanding members to facilitate implantation of the prosthetic valve at the target site.
摘要翻译：本发明提供了用于在心脏顶点或其附近的心脏中引入输送装置的方法和系统，其中所述输送装置包括假体，将所述假体推进到所述目标部位，以及使所述假体与所述输送装置脱离所述靶植入部位。具体地，本发明提供了用于将替换心脏瓣膜递送到心脏内或附近的靶部位的瓣膜置换系统。瓣膜置换系统包括套管针或其它合适的装置，以在心脏顶点处或附近穿透心脏，可移动地设置在套管针内的输送构件和设置在输送构件上的置换心脏瓣膜。输送构件还可以包括机械的或可膨胀的膨胀构件，以便于在目标位置植入人造瓣膜。

10. 发明申请

WO2005102015A3 IMPLANTABLE PROSTHETIC VALVE 审中-公开
公开(公告)号：WO2005102015A3
公开(公告)日：2005-11-03
申请号：PCT/US2005/013746
申请日：2005-04-22
申请人： 3F THERAPEUTICS, INC. , BERGHEIM, Bjarne , DUMONTELLE, Jeffrey , MYERS, Keith
发明人： BERGHEIM, Bjarne , DUMONTELLE, Jeffrey , MYERS, Keith
IPC分类号： A61F2/24 , A61M25/00
摘要： A valve prostheses (12, 15) adapted to be initially crimped in a narrow configuration suitable for catheterization through body ducts to a target location and adapated to be deployed by exerting substantially radial forces from within by means of a deployment device to a deployed state in the target location.

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