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1. 发明申请

WO0215846A3 ANTI-RANK LIGAND MONOCLONAL ANTIBODIES USEFUL IN TREATMENT OF RANK LIGAND MEDIATED DISORDERS 审中-公开
标题翻译：抗RANK配体单克隆抗体可用于治疗RANK LIGAND介导的疾病
公开(公告)号：WO0215846A3
公开(公告)日：2004-07-01
申请号：PCT/US0126161
申请日：2001-08-21
申请人： SMITHKLINE BEECHAM CORP , SWEET RAYMOND W , SMITHKLINE BEECHAM PLC , TORNETTA MARK A , TRUNEH ALEMSEGED , WATTAM TREVOR A
发明人： SWEET RAYMOND W , TORNETTA MARK A , TRUNEH ALEMSEGED , WATTAM TREVOR A
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P1/04 , A61P3/10 , A61P17/06 , A61P19/02 , A61P19/08 , A61P19/10 , A61P25/28 , A61P29/00 , A61P43/00 , C07K16/18 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/13 , C12N15/19 , C12N15/28 , C12P21/08 , C07H21/04 , C07K16/24
CPC分类号： C07K16/2875 , A61K2039/505 , C07K2317/56 , C07K2317/565
摘要： Chimeric, humanized and other RANK-L MAbs, derived from high affinity neutralizing MAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
摘要翻译：提供衍生自高亲和力中和MAB的嵌合，人源化和其它RANK-L MAb，含有其的药物组合物，治疗方法和诊断。

2. 发明申请

WO0232463A9 METHODS OF TREATING CANCERS BY STIMULATING DENDRITIC CELLS OR LYMPHOMAS WITH CERTAIN TNF MOLECULES 审中-公开
标题翻译：通过用某些TNF分子刺激树突状细胞或淋巴瘤治疗癌症的方法
公开(公告)号：WO0232463A9
公开(公告)日：2002-12-12
申请号：PCT/US0132302
申请日：2001-10-18
申请人： SMITHKLINE BEECHAM CORP , COSTELLO REGIS T , MOREL YANNIS , OLIVE DANIEL , SWEET RAYMOND W , TRUNEH ALEMSEGED
发明人： COSTELLO REGIS T , MOREL YANNIS , OLIVE DANIEL , SWEET RAYMOND W , TRUNEH ALEMSEGED
IPC分类号： A61K38/17 , C07K14/525 , A61K48/00 , A61K35/00 , A61K38/00 , C12N15/63
CPC分类号： A61K38/1709 , A61K2039/5156 , A61K2039/53 , C07K14/525
摘要： Novel methods for treating cancers comprising improving tumor immunospecificity through stimulating dendritic cells and lymphomas with certain TNF molecules, such as LIGHT.
摘要翻译：治疗癌症的新方法包括通过用某些TNF分子如LIGHT刺激树突细胞和淋巴瘤来提高肿瘤免疫特异性。

3. 发明申请

WO9747732A3 HEXAMERIC FUSION PROTEINS AND USES THEREFOR 审中-公开
标题翻译： HEXAMERIC融合蛋白及其用途
公开(公告)号：WO9747732A3
公开(公告)日：1998-01-29
申请号：PCT/US9712599
申请日：1997-06-13
申请人： SMITHKLINE BEECHAM CORP , CHAIKIN MARGERY ANN , LYN SALLY DOREEN PATRICIA , SWEET RAYMOND WHITNEY , TRUNEH ALEMSEGED
发明人： CHAIKIN MARGERY ANN , LYN SALLY DOREEN PATRICIA , SWEET RAYMOND WHITNEY , TRUNEH ALEMSEGED
IPC分类号： G01N33/50 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , C07K1/04 , C07K14/705 , C07K16/28 , C07K16/46 , C07K19/00 , C12N15/09 , C12N15/62 , C12Q1/68 , G01N33/15 , C12N
CPC分类号： C12N15/62 , A61K39/00 , C07K14/70521 , C07K16/2818 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32
摘要： A hexameric fusion protein containing a dimeric binding protein provided with a tailpiece from an IgA antibody is described. This fusion protein is useful in therapeutics and vaccines, but is particularly well suited for applications for which the binding protein from which it is derived is unsatisfactory because of low binding affinity or for applications where multivalency is desired. These applications include diagnostics, binding assays and screening assays.

4. 发明申请

WO2004098524A2 LIPID PLATINUM COMPLEXES AND METHODS OF USE THEREOF 审中-公开
标题翻译： LIPID PLATINUM复合物及其使用方法
公开(公告)号：WO2004098524A2
公开(公告)日：2004-11-18
申请号：PCT/US2004013727
申请日：2004-05-03
申请人： ARONEX PHARMACERUTICALS INC , DZIEWISZEK KRZYSZTOF J , TRUNEH ALEMSEGED
发明人： DZIEWISZEK KRZYSZTOF J , TRUNEH ALEMSEGED
IPC分类号： A61K20060101 , A61K9/127 , C07F15/00 , A61K
CPC分类号： C07F15/0093 , A61K9/127
摘要： This invention provides novel lipid platinum complexes, liposomally encapsulated lipid platinum complexes, pharmaceutical compositions comprising a lipid platinum complex, and methods for treating cancer using a lipid platinum complex. Kits comprising a unit dosage form of a compound or composition of the invention are also provided.
摘要翻译：本发明提供新颖的脂质铂络合物，脂质体包封的脂质铂络合物，包含脂质铂络合物的药物组合物，以及使用脂质铂复合物治疗癌症的方法。还提供了包含本发明化合物或组合物的单位剂型的试剂盒。

5. 发明申请

WO2008145754A3 LIGANDS OF HVEM FOR TREATING HEMATOLOGIC MALIGNANCIES AND AUTOIMMUNE DISEASES 审中-公开
标题翻译：用于治疗血液恶性疾病和自发性疾病的HVEM系统
公开(公告)号：WO2008145754A3
公开(公告)日：2009-07-30
申请号：PCT/EP2008056756
申请日：2008-06-02
申请人： INST NAT SANTE RECH MED , UNIV AIX MARSEILLE II , OLIVE DANIEL , TRUNEH ALEMSEGED , PASERO CHRISTINE
发明人： OLIVE DANIEL , TRUNEH ALEMSEGED , PASERO CHRISTINE
IPC分类号： A61K39/395 , A61P35/02 , A61P37/06 , C07K14/705 , C07K16/28
CPC分类号： C07K16/2878 , A61K38/191 , A61K39/39558 , C07K14/70575 , C07K2317/73 , C07K2317/75 , A61K2300/00
摘要： The present invention relates to ligands of HVEM for the treatment of hematologic malignancies, in particular Chronic lymphocytic leukaemia, and for the treatment of autoimmune diseases.
摘要翻译：本发明涉及用于治疗血液恶性肿瘤，特别是慢性淋巴细胞性白血病和用于治疗自身免疫性疾病的HVEM的配体。

6. 发明申请

WO2006084248A3 COMPOSITIONS COMPRISING A PLATINUM COMPLEX, LIPID, AND SURFACTANT 审中-公开
标题翻译：包含铂复合物，脂质和表面活性剂的组合物
公开(公告)号：WO2006084248A3
公开(公告)日：2006-12-07
申请号：PCT/US2006004152
申请日：2006-02-06
申请人： ANTIGENICS INC , TRUNEH ALEMSEGED , DZIEWISZEK KRZYSZTOF , LUI GUI
发明人： TRUNEH ALEMSEGED , DZIEWISZEK KRZYSZTOF , LUI GUI
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K9/19
摘要： Disclosed are compositions comprising a lipid, a surfactant, and a platinum complex having the formula II: Pt R K9/ \ K7 (II) wherein R6 and R7 each independently represent a leaving group; wherein R8 and R9 are each amines substituted by a group selected from a substituted or unsubstituted alkyl, -aryl, -arylalkyl, heteroalkyl, heterocyclyl, heteroaryl, heteroarylalkyl, -alkenyl, -cycloalkyl, or -cycloalkenyl groups having between 4 and 20 carbon atoms; or R8 and R9 are linked together as represented by formula (Ha): (Ha) and wherein said lipid is capable of forming a liposome. The compositions of the invention are more stable (e.g., resistant to solids formation) than are conventional liposomal platinum compositions which do not contain a surfactant. Also disclosed are methods for making the compositions and the use of the compositions for treating or preventing cancer.
摘要翻译：公开了包含脂质，表面活性剂和具有式II的铂络合物的组合物：其中R 6和R 7各自独立地表示离去基团; 其中R8和R9各自被选自取代或未取代的烷基，芳基， - 芳基烷基，杂烷基，杂环基，杂芳基，杂芳基烷基， - 烯基， - 环烷基或具有4-20个碳原子的 - 环烯基 ; 或者R 8和R 9连接在一起，如式（IIa）所示：（IIa），并且其中所述脂质能够形成脂质体。本发明的组合物比不含表面活性剂的常规脂质体铂组合物更稳定（例如耐固体形成）。还公开了制备组合物和组合物用于治疗或预防癌症的方法。

7. 发明申请

WO2005028496A3 VACCINE FOR TREATMENT AND PREVENTION OF HERPES SIMPLEX VIRUS INFECTION 审中-公开
标题翻译：用于治疗和预防疱疹病毒感染的疫苗
公开(公告)号：WO2005028496A3
公开(公告)日：2005-10-06
申请号：PCT/US2004029908
申请日：2004-09-13
申请人： ANTIGENICS INC , TRUNEH ALEMSEGED , LEVEY DANIEL L , MO XIAOYAN , LECLAIR KENNETH P , KASHI RAMESH S , LIU CHUANLIANG
发明人： TRUNEH ALEMSEGED , LEVEY DANIEL L , MO XIAOYAN , LECLAIR KENNETH P , KASHI RAMESH S , LIU CHUANLIANG
IPC分类号： A61K39/00 , A61K39/12 , A61K39/245 , C07K20060101 , C07K14/035
CPC分类号： A61K39/245 , A61K36/185 , A61K39/00 , A61K39/12 , A61K39/39 , A61K39/395 , A61K45/06 , A61K2039/555 , A61K2039/55566 , A61K2039/55577 , A61K2039/55583 , C07K14/005 , C12N2710/16622 , C12N2710/16634 , C12N2710/16671
摘要： The present invention relates to methods and compositions for the prevention and treatment of herpes virus infections. The invention provides antigenic peptides, and pharmaceutical compositions comprising complexes of antigenic peptides and adjuvants that can activate an immune response against herpes viruses. The invention also provides methods of making the antigenic peptides and complexes of antigenic peptides and adjuvants. Methods of use of the pharmaceutical compositions are also provided.
摘要翻译：本发明涉及用于预防和治疗疱疹病毒感染的方法和组合物。本发明提供抗原肽，以及药物组合物，其包含能够激活针对疱疹病毒的免疫应答的抗原肽和佐剂的复合物。本发明还提供了制备抗原肽和抗原肽和佐剂的复合物的方法。还提供了药物组合物的使用方法。

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