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1. 发明申请

WO0215846A3 ANTI-RANK LIGAND MONOCLONAL ANTIBODIES USEFUL IN TREATMENT OF RANK LIGAND MEDIATED DISORDERS 审中-公开
标题翻译：抗RANK配体单克隆抗体可用于治疗RANK LIGAND介导的疾病
公开(公告)号：WO0215846A3
公开(公告)日：2004-07-01
申请号：PCT/US0126161
申请日：2001-08-21
申请人： SMITHKLINE BEECHAM CORP , SWEET RAYMOND W , SMITHKLINE BEECHAM PLC , TORNETTA MARK A , TRUNEH ALEMSEGED , WATTAM TREVOR A
发明人： SWEET RAYMOND W , TORNETTA MARK A , TRUNEH ALEMSEGED , WATTAM TREVOR A
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P1/04 , A61P3/10 , A61P17/06 , A61P19/02 , A61P19/08 , A61P19/10 , A61P25/28 , A61P29/00 , A61P43/00 , C07K16/18 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/13 , C12N15/19 , C12N15/28 , C12P21/08 , C07H21/04 , C07K16/24
CPC分类号： C07K16/2875 , A61K2039/505 , C07K2317/56 , C07K2317/565
摘要： Chimeric, humanized and other RANK-L MAbs, derived from high affinity neutralizing MAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
摘要翻译：提供衍生自高亲和力中和MAB的嵌合，人源化和其它RANK-L MAb，含有其的药物组合物，治疗方法和诊断。

2. 发明申请

WO0232463A9 METHODS OF TREATING CANCERS BY STIMULATING DENDRITIC CELLS OR LYMPHOMAS WITH CERTAIN TNF MOLECULES 审中-公开
标题翻译：通过用某些TNF分子刺激树突状细胞或淋巴瘤治疗癌症的方法
公开(公告)号：WO0232463A9
公开(公告)日：2002-12-12
申请号：PCT/US0132302
申请日：2001-10-18
申请人： SMITHKLINE BEECHAM CORP , COSTELLO REGIS T , MOREL YANNIS , OLIVE DANIEL , SWEET RAYMOND W , TRUNEH ALEMSEGED
发明人： COSTELLO REGIS T , MOREL YANNIS , OLIVE DANIEL , SWEET RAYMOND W , TRUNEH ALEMSEGED
IPC分类号： A61K38/17 , C07K14/525 , A61K48/00 , A61K35/00 , A61K38/00 , C12N15/63
CPC分类号： A61K38/1709 , A61K2039/5156 , A61K2039/53 , C07K14/525
摘要： Novel methods for treating cancers comprising improving tumor immunospecificity through stimulating dendritic cells and lymphomas with certain TNF molecules, such as LIGHT.
摘要翻译：治疗癌症的新方法包括通过用某些TNF分子如LIGHT刺激树突细胞和淋巴瘤来提高肿瘤免疫特异性。

3. 发明申请

WO2004108748A3 GROWTH ARREST SPECIFIC GENE 6 PEPTIDES, ANTIBODIES, COMPOSITIONS, METHODS AND USES 审中-公开
标题翻译：生长特异性基因6肽，抗体，组合物，方法和用途
公开(公告)号：WO2004108748A3
公开(公告)日：2007-02-22
申请号：PCT/US0329909
申请日：2003-09-24
申请人： DOW KENNETH CENTOCOR INC , YANG JING , HEAVNER GEORGE , JORDAN ROBERT , SWEET RAYMOND W
发明人： YANG JING , HEAVNER GEORGE , JORDAN ROBERT , SWEET RAYMOND W
IPC分类号： C12P21/00 , C07K20060101 , C07K14/745 , C07K16/18
CPC分类号： C07K14/745 , C07K16/18 , C07K2317/21 , C07K2317/56 , C07K2317/76
摘要： The present invention provides novel proteins and peptides from the receptor binding region of human Growth Arrest Specific Gene 6 (Gas6) and antibodies, including specified portions or variants, specific for at least one such Gas6 peptide or fragment thereof. The aforesaid peptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDRgrafted anti-Gas6 antibodies. The invention also provides for the nucleic acids encoding such peptides and anti-Gas6 antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, including therapeutic formulations, administration and devices. Fifteen novel peptide sequences from the Gas6 G domain that are implicated in Gas6 interactions with its receptors are identified, isolated, and synthesized so as to allow generation of anti-Gas6 antibodies. The peptide sequences include three ESTs that encompass regions predicted to contribute to receptor binding or that can raise anti-Gas6 antibodies. This invention provides for such antibodies to be used in modulating or treating at least one Gas6-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, thromboembolic disease, ischemic disease, venous thromboembolism, arterial or venous thrombosis, pulmonary embolism, restenosis, diabetic angiopathy and allograft atherosclerosis.
摘要翻译：本发明提供了来自人生长抑制特异性基因6（Gas6）的受体结合区的新型蛋白质和肽，以及对至少一种这样的Gas6肽或其片段特异的包括特定部分或变体的抗体。上述肽可用于产生人，灵长类动物，啮齿动物，哺乳动物，嵌合，人源化和/或移植的抗Gas6抗体。本发明还提供了编码这些肽和抗Gas6抗体的核酸，互补核酸，载体，宿主细胞，以及制备和使用它们的方法，包括治疗制剂，给药和装置。识别，分离和合成来自Gas6G结构域的15个新的肽序列，其与其受体相关的Gas6相互作用，以便产生抗Gas6抗体。肽序列包括三个EST，其包含预期有助于受体结合的区域或可产生抗Gas6抗体。本发明提供这样的抗体用于调节或治疗细胞，组织，器官，动物或患者中的至少一种Gas6相关疾病。这些疾病可以包括但不限于血栓栓塞性疾病，缺血性疾病，静脉血栓栓塞，动脉或静脉血栓形成，肺栓塞，再狭窄，糖尿病性血管病和同种异体移植动脉粥样硬化。

4. 发明申请

WO2006119115A2 ANTI-IL-6 ANTIBODIES, COMPOSITIONS, METHODS AND USES 审中-公开
标题翻译：抗IL-6抗体，组合物，方法和用途
公开(公告)号：WO2006119115A2
公开(公告)日：2006-11-09
申请号：PCT/US2006016457
申请日：2006-04-28
申请人： CENTOCOR INC , APPLIED MOLECULAR EVOLUTION , CHEN YAN , GARDNER DEBRA , KNIGHT DAVID M , LARK MICHAEL W , LIANG BAILIN , SHEALY DAVID J , SONG XIAO-YU R , STOJANOVIC-SUSULIC VEDRANA , SWEET RAYMOND W , TAM SUSAN H , WU SHENG-JIUN , YANG JING , MARQUIS DAVID MATTHEW , SMITH ERIC MICHAEL , VASSEROT ALAIN PHILIPPE
发明人： CHEN YAN , GARDNER DEBRA , KNIGHT DAVID M , LARK MICHAEL W , LIANG BAILIN , SHEALY DAVID J , SONG XIAO-YU R , STOJANOVIC-SUSULIC VEDRANA , SWEET RAYMOND W , TAM SUSAN H , WU SHENG-JIUN , YANG JING , MARQUIS DAVID MATTHEW , SMITH ERIC MICHAEL , VASSEROT ALAIN PHILIPPE
IPC分类号： A61K39/395 , C07H21/04 , C07K16/24
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译：抗IL-6抗体，包括编码至少一种抗IL-6抗体，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用方法在诊断和/或治疗组合物中的应用，方法和设备。

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