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1. 发明申请

WO2008124703A2 DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY 审中-公开
标题翻译：使用单一化学物质开发碳氢化合物IX的分子成像探针
公开(公告)号：WO2008124703A2
公开(公告)日：2008-10-16
申请号：PCT/US2008/059599
申请日：2008-04-07
申请人： SIEMENS MEDICAL SOLUTIONS USA, INC. , KOLB, Hartmuth C , WALSH, Joseph C. , KASI, Dhanalakshmi , MOCHARLA, Vani , WANG, Bing , GANGADHARMATH, Umesh B. , DUCLOS, Brian A. , CHEN, Kai , ZHANG, Wei , CHEN, Gang , PADGETT, Henry Clifton , KARIMI, Farhad , SCOTT, Peter J. H. , GAO, Zhiyong , LIANG, Qianwa , COLLIER, Thomas Lee , ZHAO, Tieming , XIA, Chunfang
发明人： KOLB, Hartmuth C , WALSH, Joseph C. , KASI, Dhanalakshmi , MOCHARLA, Vani , WANG, Bing , GANGADHARMATH, Umesh B. , DUCLOS, Brian A. , CHEN, Kai , ZHANG, Wei , CHEN, Gang , PADGETT, Henry Clifton , KARIMI, Farhad , SCOTT, Peter J. H. , GAO, Zhiyong , LIANG, Qianwa , COLLIER, Thomas Lee , ZHAO, Tieming , XIA, Chunfang
IPC分类号： C07D249/04 , C07D249/06 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D417/04 , C07D417/12 , C07D417/14 , A61P35/00 , A61K31/4192 , G01N33/532
CPC分类号： C07D417/04 , C07D249/04 , C07D249/06 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D417/12 , C07D417/14 , C12Q1/485 , G01N2500/04 , G01N2500/10
摘要： The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.
摘要翻译：本申请公开了使用点击化学法鉴定对碳酸酐酶IX（CA-IX）酶具有高结合亲和力的抑制剂的方法，并将其候选用作正电子发射断层摄影（PET）成像剂。

2. 发明申请

WO2009102498A1 NOVEL IMAGING AGENTS FOR DETECTING NEUROLOGICAL DYSFUNCTION 审中-公开
标题翻译：用于检测神经功能障碍的新型成像剂
公开(公告)号：WO2009102498A1
公开(公告)日：2009-08-20
申请号：PCT/US2009/000961
申请日：2009-02-17
申请人： SIEMENS MEDICAL SOLUTIONS USA, INC. , KOLB, Hartmuth C. , WALSH, Joseph C. , LIANG, Qianwa , DUCLOS, Brian A. , ZHANG, Wei , SCOTT, Peter J.h. , CHEN, Kai , GAO, Zhiyong , ZHAO, Tieming , MOCHARLA, Vani P. , KASI, Dhanalakshmi , CHEN, Gang , WANG, Eric , SINHA, Anjana , XIA, Chunfang , PADGETT, Henry Clifton , KARIMI, Farhad
发明人： KOLB, Hartmuth C. , WALSH, Joseph C. , LIANG, Qianwa , DUCLOS, Brian A. , ZHANG, Wei , SCOTT, Peter J.h. , CHEN, Kai , GAO, Zhiyong , ZHAO, Tieming , MOCHARLA, Vani P. , KASI, Dhanalakshmi , CHEN, Gang , WANG, Eric , SINHA, Anjana , XIA, Chunfang , PADGETT, Henry Clifton , KARIMI, Farhad
IPC分类号： C07B59/00
CPC分类号： C07B59/002
摘要： Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled flavones, coumarins, carbazoles, quinolinones, chromenones, imidazoles and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease
摘要翻译：本文公开了在哺乳动物中诊断阿尔茨海默病或其倾向的化合物和方法，所述方法包括向哺乳动物施用诊断有效量的放射性标记的化合物，其中所述化合物选自放射性标记的黄酮，香豆素，咔唑，喹啉酮，色烯酮，咪唑和三唑衍生物，使化合物分布到脑组织中，并使脑组织成像，其中与正常对照结合水平相比，化合物与脑组织的结合增加指示哺乳动物患有或有发生阿尔茨海默病的风险

3. 发明申请

WO2010011964A2 IMAGING AGENTS USEFUL FOR IDENTIFYING AD PATHOLOGY 审中-公开
标题翻译：成像代理有助于识别广泛的病理学
公开(公告)号：WO2010011964A2
公开(公告)日：2010-01-28
申请号：PCT/US2009/051748
申请日：2009-07-24
申请人： SIEMENS MEDICAL SOLUTIONS USA, INC. , KOLB, Hartmuth, C. , WALSH, Joseph, C. , ZHANG, Wei , GANGADHARMATH, Umesh B. , KASI, Dhanalakshmi , CHEN, Kai , SINHA, Anjana , WANG, Eric , CHEN, Gang , MOCHARLA, Vani, P. , SCOTT, Peter J.H. , PADGETT, Henry, Clifton , LIANG, Qianwa , GAO, Zhiyong , ZHAO, Tieming , XIA, Chunfang
发明人： KOLB, Hartmuth, C. , WALSH, Joseph, C. , ZHANG, Wei , GANGADHARMATH, Umesh B. , KASI, Dhanalakshmi , CHEN, Kai , SINHA, Anjana , WANG, Eric , CHEN, Gang , MOCHARLA, Vani, P. , SCOTT, Peter J.H. , PADGETT, Henry, Clifton , LIANG, Qianwa , GAO, Zhiyong , ZHAO, Tieming , XIA, Chunfang
IPC分类号： A61K51/04 , C07D498/14 , C07D513/04 , C07D513/14
CPC分类号： C07D417/14 , A61K51/0406 , A61K51/0453 , A61K51/0455 , A61K51/0459 , C07D277/64 , C07D277/68 , C07D417/04 , C07D471/04 , C07D498/14 , C07D513/04 , C07D513/14
摘要： Provided herein are compounds and compositions which comprise the formulae as disclosed herein, wherein the compound is an amyloid binding compound. An amyloid binding compound according to the invention may be administered to a patient in amounts suitable for in vivo imaging of amyloid deposits, and distinguish between neurological tissue with amyloid deposits and normal neurological tissue. Amyloid probes of the invention may be used to detect and quantitate amyloid deposits in diseases including, for example, Down's syndrome, familial Alzheimer's Disease. In another embodiment, the compounds may be used in the treatment or prophylaxis of neurodegenerative disorders.. Also provided herein are methods of allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing a neurodegenerative disease.
摘要翻译：本文提供了包含本文公开的式的化合物和组合物，其中所述化合物是淀粉样蛋白结合化合物。根据本发明的淀粉样蛋白结合化合物可以以适于淀粉样蛋白沉积物的体内成像的量施用于患者，并且可以区分具有淀粉样沉积物的神经组织和正常神经组织。本发明的淀粉样蛋白探针可用于检测和定量疾病中的淀粉样蛋白沉积物，包括例如唐氏综合症，家族性阿尔茨海默氏病。在另一个实施方案中，所述化合物可用于治疗或预防神经变性疾病。本文还提供了允许化合物分布于脑组织和成像脑组织的方法，其中化合物与脑组织与正常对照水平的结合相比表明哺乳动物患有或有发展为神经变性疾病的风险。

4. 发明申请

WO2009134405A3 SUBSTRATE BASED PET IMAGING AGENTS 审中-公开
公开(公告)号：WO2009134405A3
公开(公告)日：2009-11-05
申请号：PCT/US2009/002659
申请日：2009-04-30
申请人： SIEMENS MEDICAL SOLUTIONS USA, INC. , KOLB, Hartmuth, C. , WALSH, Joseph, C. , CHEN, Kai , GANGADHARMATH, Umesh, B. , CHEN, Gang , MOCHARLA, Vani, P. , KASI, Dhanalakshmi , SCOTT, Peter, J.H. , LIANG, Qianwa
发明人： KOLB, Hartmuth, C. , WALSH, Joseph, C. , CHEN, Kai , GANGADHARMATH, Umesh, B. , CHEN, Gang , MOCHARLA, Vani, P. , KASI, Dhanalakshmi , SCOTT, Peter, J.H. , LIANG, Qianwa
IPC分类号： A61K51/08 , A61P1/00
摘要： The present application is directed to radiolabeled imaging agents comprising a radiolabel, and a substrate, pharmaceutical compositions comprising radiolabeled imaging agents, and methods of using the radiolabeled imaging agents. The present application is further directed to methods of preparing the radiolabeled imaging agent. Such imaging agents can used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT)

5. 发明申请

WO2013028664A1 PSMA IMAGING AGENTS 审中-公开
标题翻译： PSMA成像代理
公开(公告)号：WO2013028664A1
公开(公告)日：2013-02-28
申请号：PCT/US2012/051674
申请日：2012-08-21
申请人： SIEMENS MEDICAL SOLUTIONS USA, INC. , WANG, Eric , KOLB, Hartmuth C. , SZARDENINGS, Anna Katrin , LIU, Changhui , WALSH, Joseph C. , CHEN, Gang , SINHA, Anjana , KASI, Dhanalakshmi , YU, Chul , GANGADHARMATH, Umesh B. , ZHANG, Wei , ZHAO, Tieming , MOCHARLA, Vani P.
发明人： WANG, Eric , KOLB, Hartmuth C. , SZARDENINGS, Anna Katrin , LIU, Changhui , WALSH, Joseph C. , CHEN, Gang , SINHA, Anjana , KASI, Dhanalakshmi , YU, Chul , GANGADHARMATH, Umesh B. , ZHANG, Wei , ZHAO, Tieming , MOCHARLA, Vani P.
IPC分类号： A61K51/08 , C07K5/02 , C07K5/06 , C07D223/16 , A61P35/00
CPC分类号： C07K5/0215 , A61K38/00 , A61K51/0453 , A61K51/088 , C07D207/16 , C07D209/48 , C07D213/81 , C07D213/82 , C07D233/78 , C07D233/96 , C07D239/60 , C07D249/04 , C07D249/06 , C07D251/30 , C07D263/34 , C07D277/56 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07K5/06026 , C07K5/06113
摘要： Compounds for targeting and agents for imaging, Prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.
摘要翻译：公开了靶向化合物和成像剂，前列腺特异性膜抗原（PSMA）。还公开了合成化合物和成像剂的方法以及PSMA成像方法。所公开的成像剂适用于PET和SPECT成像。

6. 发明申请

WO2009018175A2 CYCLIC AZAPEPTIDES AS INTEGRIN MARKERS 审中-公开
标题翻译： CYCLIC AZAPEPTIDES为INTEGRIN MARKERS
公开(公告)号：WO2009018175A2
公开(公告)日：2009-02-05
申请号：PCT/US2008/071266
申请日：2008-07-25
申请人： SIEMENS MEDICAL SOLUTIONS USA, INC. , KOLB, Hartmuth C. , CHEN, Kai , WALSH, Joseph C. , KASI, DHANALAKSHMI , MOCHARLA, Vani P. , CHEN, Gang , LIANG, Qianwa , ZHAO, Tieming
发明人： KOLB, Hartmuth C. , CHEN, Kai , WALSH, Joseph C. , KASI, DHANALAKSHMI , MOCHARLA, Vani P. , CHEN, Gang , LIANG, Qianwa , ZHAO, Tieming
IPC分类号： A61K38/12 , A61K51/08 , A61K47/48
CPC分类号： A61K51/08 , A61K38/00 , A61K47/60 , A61K51/082 , C07K5/021 , C07K7/54 , C07K7/64
摘要： The present application is directed to radiolabeled cyclic polyazapeptides, pharmaceutical compositions comprising radiolabeled cyclic polyazapeptides, and methods of using the radiolabeled cyclic polyazapeptides. Such polyazapeptides can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).
摘要翻译：本申请涉及放射性标记的环状多肽，包含放射性标记的环状多肽的药物组合物，以及使用放射性标记的环状多肽的方法。这样的多肽可用于成像研究，如正电子发射断层扫描（PET）或单光子发射计算机断层扫描（SPECT）。

7. 发明申请

WO2009148554A1 ACHIEVEMENT OF HIGH THERAPEUTIC INDEX THROUGH MOLECULAR IMAGING GUIDED TARGETED DRUG TREATMENT 审中-公开
标题翻译：通过分子成像指导的药物治疗实现高效治疗指标
公开(公告)号：WO2009148554A1
公开(公告)日：2009-12-10
申请号：PCT/US2009/003309
申请日：2009-06-01
申请人： SIEMENS MEDICAL SOLUTIONS USA, INC. , KOLB, Hartmuth, C. , WALSH, Joseph, C. , CHEN, Kai , KASI, Dhanalakshmi , GANGADHARMATH, Umesh, B. , SCOTT, Peter, J.h. , CHEN, Gang , MOCHARLA, Vani, P.
发明人： KOLB, Hartmuth, C. , WALSH, Joseph, C. , CHEN, Kai , KASI, Dhanalakshmi , GANGADHARMATH, Umesh, B. , SCOTT, Peter, J.h. , CHEN, Gang , MOCHARLA, Vani, P.
IPC分类号： A61K51/08 , A61P35/00
CPC分类号： A61K51/088 , A61K51/082
摘要： The present disclosure provides methods for treating cancer in a patient in need of such treatment, the method includes prequalifying a patient's therapeutic treatment by performing a molecular imaging procedure to the patient using a labeled biomarker specific for a cancer target at the tumor site; and administering a therapeutic effective amount of a compound comprising a targeting agent linked to a chemotherapeutic or a targeting agent linked to an antibody. Embodiments of the present invention also include compounds and compositions for using such methods.
摘要翻译：本公开提供了在需要这种治疗的患者中治疗癌症的方法，所述方法包括通过使用在肿瘤部位对癌症靶标特异的标记的生物标志物向患者进行分子成像程序来资格评估患者的治疗性治疗; 以及施用治疗有效量的包含连接于与抗体连接的化学治疗剂或靶向剂的靶向剂的化合物。本发明的实施方案还包括使用这些方法的化合物和组合物。

8. 发明申请

WO2010111303A3 IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS 审中-公开
公开(公告)号：WO2010111303A3
公开(公告)日：2010-09-30
申请号：PCT/US2010/028360
申请日：2010-03-23
申请人： SIEMENS MEDICAL SOLUTIONS USA, INC. , GANGADHARMATH, Umesh, B. , KOLB, Hartmuth, C. , SCOTT, Peter, J.H. , WALSH, Joseph, C. , ZHANG, Wei , SZARDENINGS, Anna, Katrin , SINHA, Anjana , CHEN, Gang , WANG, Eric , MOCHARLA, Vani, P. , YU, Chul , LIU, Changhui , CASHION, Daniel, Kurt , KASI, Dhanalakshmi
发明人： GANGADHARMATH, Umesh, B. , KOLB, Hartmuth, C. , SCOTT, Peter, J.H. , WALSH, Joseph, C. , ZHANG, Wei , SZARDENINGS, Anna, Katrin , SINHA, Anjana , CHEN, Gang , WANG, Eric , MOCHARLA, Vani, P. , YU, Chul , LIU, Changhui , CASHION, Daniel, Kurt , KASI, Dhanalakshmi
IPC分类号： A61K51/04 , C07D215/00 , C07D235/04 , C07D263/52 , C07D277/62 , C07B59/00
摘要： Imaging agents of formula (I) and methods for detecting neurological disorders comprising administering ti a patient in need compounds of formula (I) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Aβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formula (I) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disoders.

9. 发明申请

WO2013176698A1 CARBOLINE AND CARBAZOLE BASED IMAGING AGENTS FOR DETECTING NEUROLOGICAL DYSFUNCTION 审中-公开
标题翻译：基于CARBOLINE和CARBAZOLE的成像剂用于检测神经性功能障碍
公开(公告)号：WO2013176698A1
公开(公告)日：2013-11-28
申请号：PCT/US2012/061912
申请日：2012-10-25
申请人： ELI LILLY AND COMPANY , SZARDENINGS, Anna Katrin , KOLB, Hartmuth C. , WALSH, Joseph C. , CHEN, Gang , GANGADHARMATH, Umesh B. , KASI, Dhanalakshmi , LIU, Changhui , SINHA, Anjana , WANG, Eric , YU, Chul , ZHANG, Wei , CHEN, Kai , MOCHARLA, Vani P. , SCOTT, Peter J.H.
发明人： SZARDENINGS, Anna Katrin , KOLB, Hartmuth C. , WALSH, Joseph C. , CHEN, Gang , GANGADHARMATH, Umesh B. , KASI, Dhanalakshmi , LIU, Changhui , SINHA, Anjana , WANG, Eric , YU, Chul , ZHANG, Wei , CHEN, Kai , MOCHARLA, Vani P. , SCOTT, Peter J.H.
IPC分类号： C07D209/88 , C07D403/12 , C07D471/04 , C07D471/14 , A61K51/04 , A61K49/10 , C07B59/00
CPC分类号： C07D209/88 , C07B59/002 , C07D209/80 , C07D403/12 , C07D471/04 , C07D471/14
摘要： Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, allowing the com¬ pound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal mal is suffering from or is at risk of developing Alzheimer's Disease. The claimed compounds have the structure of formula (I) wherein: L is N or CR5, M is N or CR6; P is N or CR7; and Q is N or CR8; X is a bond or is Cl-14alkyl, wherein at least one carbon is optionally replaced by C(O), 0, S, S02, or NH, NH-Cl-8alkyl, and wherein at least one H of Cl-8alkyl is optionally replaced by halo, OH, Cl-6alkyl; wherein at least one halo is optionally replaced with a radionuclide or a fluorescent tag. The other variables are as defined in the claims.
摘要翻译：本文公开了在哺乳动物中诊断阿尔茨海默氏病或其倾向的化合物和方法，所述方法包括向哺乳动物施用诊断有效量的放射性标记化合物，允许该组分分布于脑组织中，并使脑成像组织，其中与正常对照水平的结合相比，化合物与脑组织的结合增加表明哺乳动物的马曾患有或有发展为阿尔茨海默病的风险。所要求保护的化合物具有式（I）的结构，其中：L是N或CR 5，M是N或CR 6; P为N或CR7; Q为N或CR8; X是一个键或是C 1-4烷基，其中至少一个碳任选地被C（O），O，S，SO 2或NH，NH-C 1-8烷基取代，并且其中至少一个C 1-8烷基的H 任选被卤素，OH，C 1-6烷基取代; 其中至少一个卤素任选被放射性核素或荧光标记替代。其他变量如权利要求中所定义。

10. 发明申请

WO2011119565A1 IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS 审中-公开
标题翻译：用于检测神经疾病的成像剂
公开(公告)号：WO2011119565A1
公开(公告)日：2011-09-29
申请号：PCT/US2011/029368
申请日：2011-03-22
申请人： SIEMENS MEDICAL SOLUTIONS USA, INC. , CASHION, Daniel, Kurt , CHEN, Gang , KASI, Dhanalakshmi , KOLB, Hartmuth C. , LIU, Changhui , SINHA, Anjana , SZARDENINGS, Anna, Katrin , WANG, Eric , YU, Chul , ZHANG, Wei , GANGADHARMATH, Umesh, B. , WALSH, Joseph, C.
发明人： CASHION, Daniel, Kurt , CHEN, Gang , KASI, Dhanalakshmi , KOLB, Hartmuth C. , LIU, Changhui , SINHA, Anjana , SZARDENINGS, Anna, Katrin , WANG, Eric , YU, Chul , ZHANG, Wei , GANGADHARMATH, Umesh, B. , WALSH, Joseph, C.
IPC分类号： C07D235/04 , C07D401/02 , A61K31/4184 , A61K31/4353 , A61P25/00
CPC分类号： C07D235/04 , A61K51/04 , C07B59/002 , C07D215/06 , C07D235/14 , C07D277/62 , C07D401/02 , C07D401/04 , C07D403/06 , C07D413/10 , C07D413/14 , C07D471/04 , C07D487/04
摘要： Imaging agents of formulas (I)-(V) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formulas (I)-(V) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Αβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formulas (I)-(V) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders. Formula (V) or a pharmaceutically acceptable salt thereof, and stereoisomers thereof, wherein: X 25 -X 28 are each independently CH, CR 11 , or N; X 29 is CH, N, O or S; X 30 is CH, C, or N; X 31-34 are each independently CH, CR 12 , CR 13 or N; RII-RU are each independently H, halogen, hydroxy, nitro, cyano, ammo, alkyl, alkylaryl, alkylamino, alkylamine, arylamine, arylamino, alkoxy,— (O-CH 2 - CH 2 ) n -, alkenyL alkynyl, aryloxy, NRl0COOalkyl, NRl0 COOaryU NRW COalkyl, NR 10 CO aryl, COOalkyl, COOaryl, COalkyl, COaryl, aryl, cycloalkyl, cycloalkylamino, cycloalkylamine, bicyclic, saturated heterocycle and unsaturated heterocycle, wherein at least one carbon of R 11 -R 13 is optionally replaced with N, Q, S, triazole, or halo, and, wherein at least one hydrogen is optionally replaced with halo, amine, amino, alkoxy, nitro, alkyl, alkenyL alkynyl, aryloxy, alkylaryl, alkylamino, alkylamine, NRioCOOalkyl, NR 10 COOaryl, NR 10 COalkyl, NR,0 CO aryl, COOalkyl, COOaryl, COalkyl, COaryl, aryl, cycloalkyl, cycloalkylamino, cycloalkylamine, bicyclic saturated heterocycle and unsaturated heterocycle, a leaving group, CN, OH or a radioactive isotope.
摘要翻译：式（I） - （V）的成像剂和用于检测神经障碍的方法包括向需要的患者施用能够结合tau蛋白和β-淀粉样肽的式（I） - （V）化合物。本发明还涉及成像β和tau聚集体的方法，包括引入可检测量的包含放射性标记的式（I） - （V）化合物的药物制剂，并检测与淀粉样蛋白沉积物和/或tau蛋白相关的标记化合物患者。这些方法和组合使得临床前诊断和监测AD和其他神经障碍的进展。式（V）或其药学上可接受的盐及其立体异构体，其中：X25-X28各自独立地为CH，CR11或N; X29是CH，N，O或S; X30是CH，C或N; X31-34各自独立地为CH，CR12，CR13或N; RII-RU各自独立地为H，卤素，羟基，硝基，氰基，氨基，烷基，烷基芳基，烷基氨基，烷基胺，芳基胺，芳基氨基，烷氧基， - （O-CH 2 -CH 2）n - 烯基炔基，芳氧基，NR 10 COO烷基， NR10 COOaryU NRW CO烷基，NR10CO芳基，COO烷基，COO芳基，CO烷基，芳基，芳基，环烷基，环烷基氨基，环烷基胺，双环，饱和杂环和不饱和杂环，其中R11-R13的至少一个碳任选被N，Q，烷基，烯基炔基，芳氧基，烷基芳基，烷基氨基，烷基胺，NROCOO烷基，NR10 COO芳基，NR10CO烷基，NR 芳基，环烷基，环烷基氨基，环烷基胺，双环饱和杂环和不饱和杂环，离去基团，CN，OH或放射性同位素。

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