发明申请
WO2008124703A2 DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY
审中-公开
基本信息:
- 专利标题： DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY
- 专利标题（中）：使用单一化学物质开发碳氢化合物IX的分子成像探针
- 申请号：PCT/US2008/059599 申请日：2008-04-07
- 公开(公告)号：WO2008124703A2 公开(公告)日：2008-10-16
- 发明人： KOLB, Hartmuth C , WALSH, Joseph C. , KASI, Dhanalakshmi , MOCHARLA, Vani , WANG, Bing , GANGADHARMATH, Umesh B. , DUCLOS, Brian A. , CHEN, Kai , ZHANG, Wei , CHEN, Gang , PADGETT, Henry Clifton , KARIMI, Farhad , SCOTT, Peter J. H. , GAO, Zhiyong , LIANG, Qianwa , COLLIER, Thomas Lee , ZHAO, Tieming , XIA, Chunfang
- 申请人： SIEMENS MEDICAL SOLUTIONS USA, INC. , KOLB, Hartmuth C , WALSH, Joseph C. , KASI, Dhanalakshmi , MOCHARLA, Vani , WANG, Bing , GANGADHARMATH, Umesh B. , DUCLOS, Brian A. , CHEN, Kai , ZHANG, Wei , CHEN, Gang , PADGETT, Henry Clifton , KARIMI, Farhad , SCOTT, Peter J. H. , GAO, Zhiyong , LIANG, Qianwa , COLLIER, Thomas Lee , ZHAO, Tieming , XIA, Chunfang
- 申请人地址： 51 Valley Stream Parkway Malvern, PA 19355-1406 US
- 专利权人： SIEMENS MEDICAL SOLUTIONS USA, INC.,KOLB, Hartmuth C,WALSH, Joseph C.,KASI, Dhanalakshmi,MOCHARLA, Vani,WANG, Bing,GANGADHARMATH, Umesh B.,DUCLOS, Brian A.,CHEN, Kai,ZHANG, Wei,CHEN, Gang,PADGETT, Henry Clifton,KARIMI, Farhad,SCOTT, Peter J. H.,GAO, Zhiyong,LIANG, Qianwa,COLLIER, Thomas Lee,ZHAO, Tieming,XIA, Chunfang
- 当前专利权人： SIEMENS MEDICAL SOLUTIONS USA, INC.,KOLB, Hartmuth C,WALSH, Joseph C.,KASI, Dhanalakshmi,MOCHARLA, Vani,WANG, Bing,GANGADHARMATH, Umesh B.,DUCLOS, Brian A.,CHEN, Kai,ZHANG, Wei,CHEN, Gang,PADGETT, Henry Clifton,KARIMI, Farhad,SCOTT, Peter J. H.,GAO, Zhiyong,LIANG, Qianwa,COLLIER, Thomas Lee,ZHAO, Tieming,XIA, Chunfang
- 当前专利权人地址： 51 Valley Stream Parkway Malvern, PA 19355-1406 US
- 代理机构： DOUGLASS, John Kirkland, Jr.
- 优先权： US60/922,065 20070405
- 主分类号： C07D249/04
- IPC分类号： C07D249/04 ; C07D249/06 ; C07D401/04 ; C07D401/12 ; C07D403/04 ; C07D403/12 ; C07D405/04 ; C07D405/12 ; C07D409/12 ; C07D417/04 ; C07D417/12 ; C07D417/14 ; A61P35/00 ; A61K31/4192 ; G01N33/532
摘要：
The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.
摘要（中）：
本申请公开了使用点击化学法鉴定对碳酸酐酶IX（CA-IX）酶具有高结合亲和力的抑制剂的方法，并将其候选用作正电子发射断层摄影（PET）成像剂。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D249/00 | 杂环化合物，含五元环，有3个氮原子作为仅有的杂环原子 |
| --------C07D249/02 | .不与其他环稠合 |
| ----------C07D249/04 | ..1,2,3-三唑；氢化1,2,3-三唑 |