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1. 发明申请

WO2014028518A1 APPARATUSES AND METHODS FOR CURING UV FINGERNAIL GEL WITH MINIMAL UV EXPOSURE 审中-公开
标题翻译：具有最小紫外线照射的固定紫外线手指凝胶的装置和方法
公开(公告)号：WO2014028518A1
公开(公告)日：2014-02-20
申请号：PCT/US2013/054772
申请日：2013-08-13
申请人： PARK, Fa, Young , CHOI, Yu, Chul
发明人： PARK, Fa, Young , CHOI, Yu, Chul
IPC分类号： A45D29/18 , B05C9/14
CPC分类号： B05D3/067 , A45D29/00
摘要： A UV curing device (10) that includes a UV light source (29), a lens (30) positioned proximate the UV light source (29), control means (32) for actuating the UV light source (29); and safety means for minimizing inadvertent pointing of a UV light beam from said UV curing device (10) into an eye. The UV curing device (10) is used to sequentially, separately and individually apply UV light to cure UV gel on each of a plurality of fingernails.
摘要翻译：包括UV光源（29），靠近UV光源（29）定位的透镜（30）的UV固化装置（10），用于致动UV光源（29）的控制装置（32）; 以及用于将来自所述UV固化装置（10）的UV光束的无意指向最小化到眼睛中的安全装置。 UV固化装置（10）用于依次，单独和单独地施加UV光以固化多个指甲中的每一个上的UV凝胶。

2. 发明申请

WO2008035894A1 ANTIVIRAL AGENT AGAINST ANIMAL VIRUSES 审中-公开
标题翻译：抗病毒药物抗动物病毒
公开(公告)号：WO2008035894A1
公开(公告)日：2008-03-27
申请号：PCT/KR2007/004498
申请日：2007-09-18
申请人： SUNGKYUNKWAN UNIVERSITY FOUNDATION FOR CORPORATE COLLABORATION , AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION , INVITROPLANT CO., LTD. , LEE, Suk-Chan , KIM, Yong-Sung , KWON, Myung-Hee , KIM, Tai-Hyun , KIM, Jeong-Sun , LEE, Gun-Sup , SHIM, Hye-Kyung , PARK, Eul-Yong , JUNG, Yu-Chul , KIM, Ki-Yoon , JUNG, Yi-Jung , LEE, Woo-Ram , KIM, Young-Rim , SOHN, Jong-Nam , LEE, Seung-Hyun
发明人： LEE, Suk-Chan , KIM, Yong-Sung , KWON, Myung-Hee , KIM, Tai-Hyun , KIM, Jeong-Sun , LEE, Gun-Sup , SHIM, Hye-Kyung , PARK, Eul-Yong , JUNG, Yu-Chul , KIM, Ki-Yoon , JUNG, Yi-Jung , LEE, Woo-Ram , KIM, Young-Rim , SOHN, Jong-Nam , LEE, Seung-Hyun
IPC分类号： A61K38/16
CPC分类号： C07K16/10 , A61K39/00 , A61K39/395 , A61K2039/505 , A61K2300/00 , C07K14/47 , C07K16/44 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： Disclosed herein is an antiviral agent against animal viruses. The antiviral agent contains a protein or a nucleic acid sequence encoding the protein, as an active ingredient, the protein having binding ability and degrading ability to foreign nucleic acid chains invaded in an animal cell and that has no cytotoxicity to the animal cell itself. Disclosed herein is further an antiviral animal cell containing the protein according to the present invention, or the nucleic acid sequence encoding the protein. The antiviral agent and antiviral animal cell exhibit advantageous effects in that they se¬ lectively degrade foreign nucleic acid chains invaded in an animal cell and have no cytotoxicity to the animal cell, thus causing no death of the animal cell.
摘要翻译：本文公开了抗动物病毒的抗病毒剂。抗病毒剂含有蛋白质或编码作为活性成分的蛋白质的蛋白质或核酸序列，该蛋白质对动物细胞中侵入的外来核酸链具有结合能力和降解能力，并且对动物细胞本身没有细胞毒性。本文还公开了含有本发明蛋白质或编码该蛋白质的核酸序列的抗病毒动物细胞。抗病毒剂和抗病毒动物细胞表现出有利的作用，因为它们选择性降解在动物细胞中侵入的外源核酸链，并且对动物细胞没有细胞毒性，因此不会导致动物细胞的死亡。

3. 发明申请

WO2007013964A1 PYRAZOLO PYRIMIDINES USEFUL AS AURORA KINASE INHIBITORS 审中-公开
标题翻译： PYRAZOLO PYRIMIDINES有效用作AURORA激酶抑制剂
公开(公告)号：WO2007013964A1
公开(公告)日：2007-02-01
申请号：PCT/US2006/028154
申请日：2006-07-21
申请人： SUNESIS PHARMACEUTICALS, INC. , OSLOB, Johan, D. , YU, Chul, Hyun
发明人： OSLOB, Johan, D. , YU, Chul, Hyun
IPC分类号： C07D487/04 , C07D487/16 , A61K31/519 , A61P9/00 , A61P19/00 , A61P25/00 , A61P29/00 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention provides compounds having the formula: (I) wherein A-B together represent one of the following structures: (II) or (III) wherein one of ---- is a double bond, as valency permits; and R 2 , R 4 , X 1A , X 2A , X 1B , X 2B , L 1 , L 2 , Y an Z are as defined in classes and subclasess herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as inhibitors of protein kinase (e.g., Aurora), and thus are useful, for example, for the treatment of Aurora mediated diseases.
摘要翻译：本发明提供具有下式的化合物：其中A-B一起代表以下结构之一：（II）或（III）其中一个是双键，化合价允许; 和R 2，R 4，X 1A，X 2A，X 1B，，X 2B，L 1，L 2，Y和Z如本文中的类别和亚临界所定义，及其药物组合物，如所述通常和在本文中的亚类中，哪些化合物可用作蛋白激酶（例如，Aurora）的抑制剂，因此可用于例如治疗Aurora介导的疾病。

4. 发明申请

WO2013028664A1 PSMA IMAGING AGENTS 审中-公开
标题翻译： PSMA成像代理
公开(公告)号：WO2013028664A1
公开(公告)日：2013-02-28
申请号：PCT/US2012/051674
申请日：2012-08-21
申请人： SIEMENS MEDICAL SOLUTIONS USA, INC. , WANG, Eric , KOLB, Hartmuth C. , SZARDENINGS, Anna Katrin , LIU, Changhui , WALSH, Joseph C. , CHEN, Gang , SINHA, Anjana , KASI, Dhanalakshmi , YU, Chul , GANGADHARMATH, Umesh B. , ZHANG, Wei , ZHAO, Tieming , MOCHARLA, Vani P.
发明人： WANG, Eric , KOLB, Hartmuth C. , SZARDENINGS, Anna Katrin , LIU, Changhui , WALSH, Joseph C. , CHEN, Gang , SINHA, Anjana , KASI, Dhanalakshmi , YU, Chul , GANGADHARMATH, Umesh B. , ZHANG, Wei , ZHAO, Tieming , MOCHARLA, Vani P.
IPC分类号： A61K51/08 , C07K5/02 , C07K5/06 , C07D223/16 , A61P35/00
CPC分类号： C07K5/0215 , A61K38/00 , A61K51/0453 , A61K51/088 , C07D207/16 , C07D209/48 , C07D213/81 , C07D213/82 , C07D233/78 , C07D233/96 , C07D239/60 , C07D249/04 , C07D249/06 , C07D251/30 , C07D263/34 , C07D277/56 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07K5/06026 , C07K5/06113
摘要： Compounds for targeting and agents for imaging, Prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.
摘要翻译：公开了靶向化合物和成像剂，前列腺特异性膜抗原（PSMA）。还公开了合成化合物和成像剂的方法以及PSMA成像方法。所公开的成像剂适用于PET和SPECT成像。

5. 发明申请

WO2011152626A3 PEDAL 审中-公开
标题翻译：踏板
公开(公告)号：WO2011152626A3
公开(公告)日：2012-01-26
申请号：PCT/KR2011003800
申请日：2011-05-24
申请人： KIM YU CHUL
发明人： KIM YU CHUL
IPC分类号： B62M3/08
CPC分类号： B62M3/08 , Y10T74/2172
摘要： The present invention relates to a pedal of a pedal exerciser including, for example, a bicycle, and more particularly to a pedal that is configured to enable a stable fit of a foot sole to a pedal body, while making it possible to concentrate foot effort for driving on the pedal. The pedal for a pedal exerciser according to the present invention comprises: a coupling axis coupled to a crank rod of the pedal exerciser; a pedal body rotatably coupled to the coupling axis; a pair of first slope adjustment plates installed at front and rear faces of the pedal body, wherein sides of the plates coupled to the crank rod are hinged to the pedal body, so that other sides opposite to those coupled to the crank rod can protrude toward the upper or lower end of the pedal body; a pair of second slope adjustment plates installed at the front and rear faces of the pedal body, wherein sides of the plates coupled to the crank rod are hinged to the pedal body together with the first slope adjustment plates, so that other sides opposite to those coupled to the crank rod can protrude toward the upper or lower end of the pedal body; and a pair of fixing screws passing through the first and second adjustment plates and being coupled to the pedal body to thereby fix the first and second adjustment plates. With the pedal of the pedal exerciser according to the present invention, a contact angle of the foot sole greater than zero degrees is set such that the power can be efficiently transferred to the sides of the plates coupled to the crank rod of the pedal body. Accordingly, it is possible to obtain greater drive power only with small force, while preventing the foot sole from deviating from the pedal body. Also, it is possible to freely adjust the contact angle of the foot sole within a certain range depending on the physique type of a user.
摘要翻译：本发明涉及踏板锻炼器的踏板，其包括例如自行车，更具体地说，涉及一种脚蹬，其被配置为能够使足底部稳定地配合到踏板本体，同时能够集中脚部力量用于在踏板上行驶。根据本发明的用于踏板锻炼者的踏板包括：联接到踏板锻炼器的曲柄杆的联接轴; 可旋转地联接到联接轴线的踏板体; 一对安装在踏板本体的前后表面上的第一斜坡调节板，其中耦合到曲柄杆的板的侧面铰接到踏板本体上，使得与曲柄杆连接的那些侧面相对的其它侧面可朝向踏板本体的上端或下端; 一对安装在踏板本体的前表面和后表面上的第二倾斜调节板，其中联接到曲柄杆的板的侧面与第一斜面调节板一起铰接到踏板本体，使得与那些耦合到曲柄杆可以朝向踏板本体的上端或下端突出; 以及一对固定螺钉，其通过第一和第二调节板并且联接到踏板本体，从而固定第一和第二调节板。利用根据本发明的踏板锻炼器的踏板，设定足底大于零度的接触角，使得动力可以有效地传递到联接到踏板本体的曲柄杆的板的侧面。因此，能够以较小的力量获得更大的驱动力，同时防止脚踏板偏离踏板本体。此外，根据使用者的体格类型，可以自由地将脚底的接触角度调整到一定范围内。

6. 发明申请

WO2010111303A3 IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS 审中-公开
公开(公告)号：WO2010111303A3
公开(公告)日：2010-09-30
申请号：PCT/US2010/028360
申请日：2010-03-23
申请人： SIEMENS MEDICAL SOLUTIONS USA, INC. , GANGADHARMATH, Umesh, B. , KOLB, Hartmuth, C. , SCOTT, Peter, J.H. , WALSH, Joseph, C. , ZHANG, Wei , SZARDENINGS, Anna, Katrin , SINHA, Anjana , CHEN, Gang , WANG, Eric , MOCHARLA, Vani, P. , YU, Chul , LIU, Changhui , CASHION, Daniel, Kurt , KASI, Dhanalakshmi
发明人： GANGADHARMATH, Umesh, B. , KOLB, Hartmuth, C. , SCOTT, Peter, J.H. , WALSH, Joseph, C. , ZHANG, Wei , SZARDENINGS, Anna, Katrin , SINHA, Anjana , CHEN, Gang , WANG, Eric , MOCHARLA, Vani, P. , YU, Chul , LIU, Changhui , CASHION, Daniel, Kurt , KASI, Dhanalakshmi
IPC分类号： A61K51/04 , C07D215/00 , C07D235/04 , C07D263/52 , C07D277/62 , C07B59/00
摘要： Imaging agents of formula (I) and methods for detecting neurological disorders comprising administering ti a patient in need compounds of formula (I) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Aβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formula (I) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disoders.

7. 发明申请

WO2010111303A2 IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS 审中-公开
标题翻译：用于检测神经疾病的成像剂
公开(公告)号：WO2010111303A2
公开(公告)日：2010-09-30
申请号：PCT/US2010028360
申请日：2010-03-23
申请人： SIEMENS MEDICAL SOLUTIONS , GANGADHARMATH UMESH B , KOLB HARTMUTH C , SCOTT PETER J H , WALSH JOSEPH C , ZHANG WEI , SZARDENINGS ANNA KATRIN , SINHA ANJANA , CHEN GANG , WANG ERIC , MOCHARLA VANI P , YU CHUL , LIU CHANGHUI , CASHION DANIEL KURT , KASI DHANALAKSHMI
发明人： GANGADHARMATH UMESH B , KOLB HARTMUTH C , SCOTT PETER J H , WALSH JOSEPH C , ZHANG WEI , SZARDENINGS ANNA KATRIN , SINHA ANJANA , CHEN GANG , WANG ERIC , MOCHARLA VANI P , YU CHUL , LIU CHANGHUI , CASHION DANIEL KURT , KASI DHANALAKSHMI
IPC分类号： A61K51/04 , C07B59/00 , C07D215/00 , C07D235/04 , C07D263/52 , C07D277/62
CPC分类号： A61K51/0455 , A61K51/04 , A61K51/0453 , A61K51/0459 , A61K51/0463 , C07B59/002 , C07D215/06 , C07D235/14 , C07D277/62 , C07D401/04 , C07D403/06 , C07D413/10 , C07D413/14 , C07D487/04
摘要： Imaging agents of formula (I) and methods for detecting neurological disorders comprising administering ti a patient in need compounds of formula (I) capable of binding to tau proteins and ß-amyloid peptides are presented herein. The invention also relates to methods of imaging Aß and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formula (I) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disoders.
摘要翻译：式（I）的成像剂和用于检测神经障碍的方法包括给予需要能够结合tau蛋白和β-淀粉样蛋白肽的式（I）化合物的化合物。本发明还涉及成像Aβ和tau聚集体的方法，包括引入可检测量的包含放射性标记的式（I）化合物的药物制剂，并检测患者中与淀粉样蛋白沉积物和/或tau蛋白相关的标记化合物。这些方法和组合使得AD和其他神经系统解剖器的临床前诊断和监测进展。

8. 发明申请

WO2013176698A1 CARBOLINE AND CARBAZOLE BASED IMAGING AGENTS FOR DETECTING NEUROLOGICAL DYSFUNCTION 审中-公开
标题翻译：基于CARBOLINE和CARBAZOLE的成像剂用于检测神经性功能障碍
公开(公告)号：WO2013176698A1
公开(公告)日：2013-11-28
申请号：PCT/US2012/061912
申请日：2012-10-25
申请人： ELI LILLY AND COMPANY , SZARDENINGS, Anna Katrin , KOLB, Hartmuth C. , WALSH, Joseph C. , CHEN, Gang , GANGADHARMATH, Umesh B. , KASI, Dhanalakshmi , LIU, Changhui , SINHA, Anjana , WANG, Eric , YU, Chul , ZHANG, Wei , CHEN, Kai , MOCHARLA, Vani P. , SCOTT, Peter J.H.
发明人： SZARDENINGS, Anna Katrin , KOLB, Hartmuth C. , WALSH, Joseph C. , CHEN, Gang , GANGADHARMATH, Umesh B. , KASI, Dhanalakshmi , LIU, Changhui , SINHA, Anjana , WANG, Eric , YU, Chul , ZHANG, Wei , CHEN, Kai , MOCHARLA, Vani P. , SCOTT, Peter J.H.
IPC分类号： C07D209/88 , C07D403/12 , C07D471/04 , C07D471/14 , A61K51/04 , A61K49/10 , C07B59/00
CPC分类号： C07D209/88 , C07B59/002 , C07D209/80 , C07D403/12 , C07D471/04 , C07D471/14
摘要： Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, allowing the com¬ pound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal mal is suffering from or is at risk of developing Alzheimer's Disease. The claimed compounds have the structure of formula (I) wherein: L is N or CR5, M is N or CR6; P is N or CR7; and Q is N or CR8; X is a bond or is Cl-14alkyl, wherein at least one carbon is optionally replaced by C(O), 0, S, S02, or NH, NH-Cl-8alkyl, and wherein at least one H of Cl-8alkyl is optionally replaced by halo, OH, Cl-6alkyl; wherein at least one halo is optionally replaced with a radionuclide or a fluorescent tag. The other variables are as defined in the claims.
摘要翻译：本文公开了在哺乳动物中诊断阿尔茨海默氏病或其倾向的化合物和方法，所述方法包括向哺乳动物施用诊断有效量的放射性标记化合物，允许该组分分布于脑组织中，并使脑成像组织，其中与正常对照水平的结合相比，化合物与脑组织的结合增加表明哺乳动物的马曾患有或有发展为阿尔茨海默病的风险。所要求保护的化合物具有式（I）的结构，其中：L是N或CR 5，M是N或CR 6; P为N或CR7; Q为N或CR8; X是一个键或是C 1-4烷基，其中至少一个碳任选地被C（O），O，S，SO 2或NH，NH-C 1-8烷基取代，并且其中至少一个C 1-8烷基的H 任选被卤素，OH，C 1-6烷基取代; 其中至少一个卤素任选被放射性核素或荧光标记替代。其他变量如权利要求中所定义。

9. 发明申请

WO2011152627A3 PEDAL 审中-公开
标题翻译：踏板
公开(公告)号：WO2011152627A3
公开(公告)日：2012-01-26
申请号：PCT/KR2011003804
申请日：2011-05-24
申请人： KIM YU CHUL
发明人： KIM YU CHUL
IPC分类号： B62M3/08
CPC分类号： B62M3/08
摘要： The present invention relates to a pedal for various pedal exercising equipment, including a bike, and more particularly, to a pedal that allows focusing of the pedal force for operation and stable footing of the sole of the foot on the pedal. The present invention comprises: an insertion axle (110) that is inserted into the crank rod of the pedal of the pedal exercise equipment; a pedal body (120) that is rotatably inserted into the insertion axle (110); tilt-controlling plates (300) installed in such a manner that one end of each of the plates are rotatably inserted into the upper front portion, upper back portion, lower front portion, and lower back portion of the pedal body respectively, using hinges (500) so that the other end of each of the plates can move in and out of the pedal body (120); and control bolts (400) that control the extent of the in and out movement of the tilt controlling plates (300). The pedal of the pedal exercising equipment of the present invention allows the angle of the footing to be set to more than 0°, so that the user can effectively step on the opposite side of the crank inserting-side of the pedal body, which produces a large driving force with little effort, prevents the sole of the foot from separating from the pedal body, and enables flexible control of the angle of footing within a certain range according to the user's body shape.
摘要翻译：本发明涉及一种用于各种踏板锻炼设备的踏板，包括自行车，更具体地说，涉及一种踏板，该踏板允许将脚踏板的焦点集中在脚踏板上，并稳定地将踏板的底脚放置在踏板上。本发明包括：插入踏板（110），其插入踏板运动设备的踏板的曲柄杆中; 可旋转地插入到插入轴（110）中的踏板本体（120）; 倾斜控制板（300）以使得每个板的一端分别可旋转地插入踏板体的上前部，上后部，下前部和下后部中的方式安装，使用铰链 500），使得每个板的另一端能够进入和离开踏板本体（120）; 以及控制倾斜控制板（300）的进出运动程度的控制螺栓（400）。本发明的踏板运动装置的踏板允许基脚的角度设定为大于0°，使得使用者能够有效地踏入踏板本体的曲柄插入侧的相反侧，从而产生具有很小的力量的大的驱动力，防止脚的脚部与踏板本体分离，并且能够根据使用者的身体形状灵活地控制一定范围内的脚底角度。

10. 发明申请

WO2011119565A1 IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS 审中-公开
标题翻译：用于检测神经疾病的成像剂
公开(公告)号：WO2011119565A1
公开(公告)日：2011-09-29
申请号：PCT/US2011/029368
申请日：2011-03-22
申请人： SIEMENS MEDICAL SOLUTIONS USA, INC. , CASHION, Daniel, Kurt , CHEN, Gang , KASI, Dhanalakshmi , KOLB, Hartmuth C. , LIU, Changhui , SINHA, Anjana , SZARDENINGS, Anna, Katrin , WANG, Eric , YU, Chul , ZHANG, Wei , GANGADHARMATH, Umesh, B. , WALSH, Joseph, C.
发明人： CASHION, Daniel, Kurt , CHEN, Gang , KASI, Dhanalakshmi , KOLB, Hartmuth C. , LIU, Changhui , SINHA, Anjana , SZARDENINGS, Anna, Katrin , WANG, Eric , YU, Chul , ZHANG, Wei , GANGADHARMATH, Umesh, B. , WALSH, Joseph, C.
IPC分类号： C07D235/04 , C07D401/02 , A61K31/4184 , A61K31/4353 , A61P25/00
CPC分类号： C07D235/04 , A61K51/04 , C07B59/002 , C07D215/06 , C07D235/14 , C07D277/62 , C07D401/02 , C07D401/04 , C07D403/06 , C07D413/10 , C07D413/14 , C07D471/04 , C07D487/04
摘要： Imaging agents of formulas (I)-(V) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formulas (I)-(V) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Αβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formulas (I)-(V) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders. Formula (V) or a pharmaceutically acceptable salt thereof, and stereoisomers thereof, wherein: X 25 -X 28 are each independently CH, CR 11 , or N; X 29 is CH, N, O or S; X 30 is CH, C, or N; X 31-34 are each independently CH, CR 12 , CR 13 or N; RII-RU are each independently H, halogen, hydroxy, nitro, cyano, ammo, alkyl, alkylaryl, alkylamino, alkylamine, arylamine, arylamino, alkoxy,— (O-CH 2 - CH 2 ) n -, alkenyL alkynyl, aryloxy, NRl0COOalkyl, NRl0 COOaryU NRW COalkyl, NR 10 CO aryl, COOalkyl, COOaryl, COalkyl, COaryl, aryl, cycloalkyl, cycloalkylamino, cycloalkylamine, bicyclic, saturated heterocycle and unsaturated heterocycle, wherein at least one carbon of R 11 -R 13 is optionally replaced with N, Q, S, triazole, or halo, and, wherein at least one hydrogen is optionally replaced with halo, amine, amino, alkoxy, nitro, alkyl, alkenyL alkynyl, aryloxy, alkylaryl, alkylamino, alkylamine, NRioCOOalkyl, NR 10 COOaryl, NR 10 COalkyl, NR,0 CO aryl, COOalkyl, COOaryl, COalkyl, COaryl, aryl, cycloalkyl, cycloalkylamino, cycloalkylamine, bicyclic saturated heterocycle and unsaturated heterocycle, a leaving group, CN, OH or a radioactive isotope.
摘要翻译：式（I） - （V）的成像剂和用于检测神经障碍的方法包括向需要的患者施用能够结合tau蛋白和β-淀粉样肽的式（I） - （V）化合物。本发明还涉及成像β和tau聚集体的方法，包括引入可检测量的包含放射性标记的式（I） - （V）化合物的药物制剂，并检测与淀粉样蛋白沉积物和/或tau蛋白相关的标记化合物患者。这些方法和组合使得临床前诊断和监测AD和其他神经障碍的进展。式（V）或其药学上可接受的盐及其立体异构体，其中：X25-X28各自独立地为CH，CR11或N; X29是CH，N，O或S; X30是CH，C或N; X31-34各自独立地为CH，CR12，CR13或N; RII-RU各自独立地为H，卤素，羟基，硝基，氰基，氨基，烷基，烷基芳基，烷基氨基，烷基胺，芳基胺，芳基氨基，烷氧基， - （O-CH 2 -CH 2）n - 烯基炔基，芳氧基，NR 10 COO烷基， NR10 COOaryU NRW CO烷基，NR10CO芳基，COO烷基，COO芳基，CO烷基，芳基，芳基，环烷基，环烷基氨基，环烷基胺，双环，饱和杂环和不饱和杂环，其中R11-R13的至少一个碳任选被N，Q，烷基，烯基炔基，芳氧基，烷基芳基，烷基氨基，烷基胺，NROCOO烷基，NR10 COO芳基，NR10CO烷基，NR 芳基，环烷基，环烷基氨基，环烷基胺，双环饱和杂环和不饱和杂环，离去基团，CN，OH或放射性同位素。

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