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1. 发明申请

WO2008063638A3 MRI DETECTABLE OBTURATOR 审中-公开
标题翻译： MRI检测器
公开(公告)号：WO2008063638A3
公开(公告)日：2008-09-18
申请号：PCT/US2007024255
申请日：2007-11-20
申请人： SENORX INC , LUBOCK PAUL , JONES MICHAEL L , BROADAWAY ETHAN , LOUW FRANK R
发明人： LUBOCK PAUL , JONES MICHAEL L , BROADAWAY ETHAN , LOUW FRANK R
IPC分类号： A61B17/34 , A61B17/00 , A61B19/00
CPC分类号： A61B17/32 , A61B17/3417 , A61B17/3431 , A61B17/3468 , A61B17/3496 , A61B17/3498 , A61B90/39 , A61B2017/00477 , A61B2017/00911 , A61B2090/062 , A61B2090/3908 , A61B2090/3954 , A61B2090/3987
摘要： An obturator (10) with an elongated shaft (11), a proximal end
摘要翻译：具有细长轴（11），近端<12），基本上封闭的远端（14）和MRI可检测的远端轴部分（15）的闭塞器（10），其不干扰组织的磁共振成像于此。优选地，远侧轴部分具有有效的MRI检测质量，以便在磁共振成像时在远侧轴部分的轮廓内提供清晰的，Tl加权的图像。

2. 发明申请

WO2008008089A3 ASYMMETRICAL IRRADIATION OF A BODY CAVITY 审中-公开
标题翻译：身体不对称辐射
公开(公告)号：WO2008008089A3
公开(公告)日：2008-03-06
申请号：PCT/US2006044067
申请日：2006-11-13
申请人： SENORX INC , LUBOCK PAUL , JONES MICHAEL L , LOUW FRANK R
发明人： LUBOCK PAUL , JONES MICHAEL L , LOUW FRANK R
IPC分类号： A61N5/10 , A61M36/04
CPC分类号： A61N5/1014 , A61N5/1002 , A61N5/1015 , A61N2005/1003 , A61N2005/1004 , A61N2005/1005 , A61N2005/1018 , A61N2005/1024
摘要： The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.
摘要翻译：本公开描述了用于在体腔或部位的不对称照射的装置和方法，例如在去除组织之后，例如，活检或癌症。一个装置包括从纵向轴线偏移或不可固定的内腔，以增加围绕体腔的第一组织部分从辐射源接收的辐射的强度，并且减少或最小化由第二组织部分接收的辐射（例如健康组织）。

3. 发明申请

WO2008063636A2 MRI IMAGEABLE ASSEMBLY 审中-公开
标题翻译： MRI成像组件
公开(公告)号：WO2008063636A2
公开(公告)日：2008-05-29
申请号：PCT/US2007024249
申请日：2007-11-20
申请人： SENORX INC , LUBOCK PAUL , QUICK RICHARD L , BROADAWAY ETHAN
发明人： LUBOCK PAUL , QUICK RICHARD L , BROADAWAY ETHAN
IPC分类号： A61B19/00
CPC分类号： A61B17/3468 , A61B5/055 , A61B17/3498 , A61B90/39 , A61B2017/00477 , A61B2090/062 , A61B2090/3908 , A61B2090/3954 , A61B2090/3987
摘要： A marker delivery device is described which has an obturator with an elongated shaft, an inner lumen, a proximal end, and a substantially sealed distal end. One or more tissue markers are deployed within the inner lumen of the elongated shaft of the obturator. Preferably, the tissue marker(s) is disposed within an inner lumen of a marker delivery tube which is disposed within the inner lumen of the elongated shaft of the obturator. The marker delivery tube has an opening for discharging the tissue markers into a body (e.g. biopsy) cavity. The distal tip of the marker delivery tube is configured to penetrate the substantially sealed distal end of the obturator so that tissue markers can be delivered while the obturator is in place within the body. Preferably, the obturator includes a detectable element capable of producing a relatively significant image signature during MRI.
摘要翻译：描述了一种标记输送装置，其具有带有细长轴，内腔，近端和基本上密封的远端的闭孔器。一个或多个组织标记部署在闭孔器的细长轴的内腔内。优选地，组织标记物设置在设置在闭孔器的细长轴的内腔内的标记物输送管的内腔内。标记物输送管具有用于将组织标记物排放到体内（例如活检）腔的开口。标记物输送管的远端构造成穿透填塞物的基本上密封的远端，使得组织标记物可以在囊腔在体内就位的同时被输送。优选地，闭孔器包括能够在MRI期间产生相对显着的图像特征的可检测元件。

4. 发明申请

WO2006017400A3 BIOPSY DEVICE WITH SELECTABLE TISSUE RECEIVING APERTURE ORIENTATION AND SITE ILLUMINATION 审中-公开
标题翻译：具有选择性组织的生物装置接收孔径方位和场地照明
公开(公告)号：WO2006017400A3
公开(公告)日：2006-05-18
申请号：PCT/US2005027071
申请日：2005-07-29
申请人： SENORX INC , SHABAZ MARTIN V , QUICK RICHARD L , LOUW FRANK R , LUBOCK PAUL , SAFABASH JASON H
发明人： SHABAZ MARTIN V , QUICK RICHARD L , LOUW FRANK R , LUBOCK PAUL , SAFABASH JASON H
IPC分类号： A61B10/00 , A61B10/02 , A61B17/00 , A61B17/32 , A61B17/34
CPC分类号： A61B10/0275 , A61B10/0266 , A61B10/0283 , A61B17/32002 , A61B17/3417 , A61B90/30 , A61B2010/0208 , A61B2010/0225 , A61B2017/00473 , A61B2017/00486 , A61B2017/3405 , A61B2090/3908 , A61B2090/3987
摘要： The invention is directed to a system and device for separating and collecting a tissue specimen from a target site within a patient. The device includes a probe component (11) with an elongated tubular section (15), a penetrating distal tip (16) and a tissue receiving aperture (17) in the distal end of the tubular section proximal to the distal tip, and a tissue cutting member (20) which is slidably disposed within the probe member to cut a tissue specimen drawn into the interior of the device through the aperture by applying a vacuum to the inner lumen of the tissue cutting member. The device also has a driver component (12) to which the probe component is releasably secured. The driver has a drive member (22,23) for adjusting the orientation of the tubular section and thus the aperture therein and one or more drive members (30) for moving the tissue cutting member within the tubular section to sever a tissue specimen from tissue extending into the interior of the tubular section through the aperture. The motion imparted to the tissue cutter is at least longitudinal and preferably is also oscillation and/or rotational to effectively separate a tissue specimen from tissue extending through the aperture in the tubular section.
摘要翻译：本发明涉及一种用于从患者内的目标部位分离和收集组织标本的系统和装置。该装置包括具有细长管状部分（15）的探针部件（11），远侧末端的管状部分的远端中的穿透远侧末端（16）和组织接收孔（17），以及组织切割构件（20），其可滑动地设置在所述探针构件内，以通过对所述组织切割构件的内腔施加真空来切割通过所述孔被拉入所述装置的内部的组织样本。该装置还具有驱动器部件（12），探针部件可释放地固定到该部件上。驱动器具有用于调节管状部分的取向并因此调节其中的孔的驱动构件（22,23）和一个或多个驱动构件（30），用于移动管状区段内的组织切割构件以从组织切断组织样本通过孔延伸到管状部分的内部。赋予组织切割器的运动至少是纵向的，并且优选地也是振动和/或旋转以有效地将组织样本与延伸穿过管状部分中的孔的组织分离。

5. 发明申请

WO2006017400A8 BIOPSY DEVICE WITH SELECTABLE TISSUE RECEIVING APERTURE ORIENTATION AND SITE ILLUMINATION 审中-公开
标题翻译：具有选择性组织的生物装置接收孔径方位和场地照明
公开(公告)号：WO2006017400A8
公开(公告)日：2006-10-05
申请号：PCT/US2005027071
申请日：2005-07-29
申请人： SENORX INC , SHABAZ MARTIN V , QUICK RICHARD L , LOUW FRANK R , LUBOCK PAUL , SAFABASH JASON H
发明人： SHABAZ MARTIN V , QUICK RICHARD L , LOUW FRANK R , LUBOCK PAUL , SAFABASH JASON H
IPC分类号： A61B10/00 , A61B10/02 , A61B17/00 , A61B17/32 , A61B17/34
CPC分类号： A61B10/0275 , A61B10/0266 , A61B10/0283 , A61B17/32002 , A61B17/3417 , A61B90/30 , A61B2010/0208 , A61B2010/0225 , A61B2017/00473 , A61B2017/00486 , A61B2017/3405 , A61B2090/3908 , A61B2090/3987
摘要： The invention is directed to a system and device for separating and collecting a tissue specimen from a patient target site. The device includes a probe component (11) with an elongated tubular section (15), a penetrating distal tip (16) and a tissue receiving aperture (17) in the distal end of the tubular section proximal to the distal tip, and a tissue cutting member (20) which is slidably disposed within the probe member to cut a tissue specimen drawn into the interior of the device through the aperture by applying a vacuum to the inner lumen of the tissue cutting member. The device has a driver component (12) to which the probe component is releasably secured. The driver has a drive member (22,23) for adjusting the orientation of the tubular section and one or more drive members (30) for moving the tissue cutting member within the tubular section to sever a tissue specimen. The motion imparted to the tissue cutter is at least longitudinal and preferably is also oscillation and/or rotational.
摘要翻译：本发明涉及一种用于从患者靶位置分离和收集组织标本的系统和装置。该装置包括具有细长管状部分（15）的探针部件（11），远侧末端的管状部分的远端中的穿透远端（16）和组织接收孔（17），以及组织切割构件（20），其可滑动地设置在所述探针构件内，以通过对所述组织切割构件的内腔施加真空来切割通过所述孔被拉入所述装置的内部的组织样本。该装置具有驱动器部件（12），探头部件可释放地固定到该部件上。驱动器具有用于调节管状部分的取向的驱动构件（22,23）和用于移动管状部分内的组织切割构件以切断组织样本的一个或多个驱动构件（30）。赋予组织切割器的运动至少是纵向的，并且优选地也是振动和/或旋转。

6. 发明申请

WO2010039184A2 POROUS BIOABSORBABLE IMPLANT 审中-公开
标题翻译：多孔可生物植入
公开(公告)号：WO2010039184A2
公开(公告)日：2010-04-08
申请号：PCT/US2009005268
申请日：2009-09-22
申请人： SENORX INC , GOVIL AMIT , JONES MICHAEL L , LUBOCK PAUL
发明人： GOVIL AMIT , JONES MICHAEL L , LUBOCK PAUL
IPC分类号： A61L27/20 , A61L27/50 , A61L27/56 , A61L27/58
CPC分类号： A61L31/146 , A61F2/0077 , A61F2/02 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/148 , A61L31/18 , A61L2300/102 , A61L2300/104 , A61L2300/44
摘要： The bioabsorbable implant described has a porous body formed of bioabsorbable materials that have an in vivo life span of at least 2 weeks, preferably at least three weeks and not greater than 20 weeks, preferably no greater than ten weeks. The implant has a scaffolding structure which facilitates tissue in-growth and ultimately tissue replacement of the scaffolding structure. The implant has a radiopaque imaging agent at least at the exterior margins and an orientation plurality of radiopaque elements in the interior of implant. The implant preferably has three radiopaque elements within the interior that form a plane within the implant interior.
摘要翻译：所描述的生物可吸收植入物具有由生物可吸收材料形成的多孔体，其具有至少2周，优选至少3周且不超过20周，优选不超过10周的体内寿命。植入物具有促进组织生长并最终组织替代脚手架结构的脚手架结构。植入物至少在外部边缘具有不透射线的成像剂，并且在植入物内部具有多个不透射线元件的取向。植入物优选地在内部内具有三个不透射线的元件，其在植入物内部形成平面。

7. 发明申请

WO2007097956A3 TEMPORARY CATHETER FOR BIOPSY SITE TISSUE FIXATION 审中-公开
标题翻译：活体组织固定用临时导尿管
公开(公告)号：WO2007097956A3
公开(公告)日：2007-10-11
申请号：PCT/US2007003877
申请日：2007-02-14
申请人： SENORX INC , LUBOCK PAUL , JONES MICHAEL L
发明人： LUBOCK PAUL , JONES MICHAEL L
IPC分类号： A61F2/958 , A61B17/00 , A61B17/22 , A61N5/10
CPC分类号： A61M29/02 , A61B10/0041 , A61B17/0218 , A61B90/02 , A61B2017/00557 , A61B2017/00796 , A61B2090/3908 , A61M25/10 , A61M29/00 , A61M2025/1095 , A61N5/1015
摘要： Devices and methods are provided for temporarily maintaining access to a body cavity in a targeted tissue region within a patient's body. One embodiment of the catheter device includes an elongated shaft having a proximal shaft section which is flexible enough to be folded or coiled into a configuration for deployment within the patient. An alternate embodiment includes a catheter device having one or more detachable proximal shaft sections and having at least one one-way valve to restrict fluid flow of inflation fluid to flow to the balloon. After deployment of the catheter device completely within the patient, the opening through which the catheter device is deployed is closed, e.g. by sutures, adhesives and the like to minimize infection at the site. Within a few days or weeks after the tissue has been evaluated for cancer, the temporary catheter device may be removed from the patient. If cancer or pre-cancer cells are found in the specimen removed from the cavity, then a radiation balloon catheter or other irradiation device can be inserted into the patient to irradiate tissue surrounding the biopsy cavity to ensure that cancer cells within the tissue surrounding the cavity are killed.
摘要翻译：提供了用于临时保持对患者体内目标组织区域中的体腔进入的设备和方法。导管装置的一个实施例包括具有近侧轴部分的细长轴，该近侧轴部分足够柔性以折叠或盘绕成用于在患者体内展开的构造。一个替代实施例包括导管装置，该导管装置具有一个或多个可拆卸的近侧轴部分并且具有至少一个单向阀以限制充胀流体的流体流动以流动到球囊。在将导管装置完全布置在患者体内之后，导管装置所穿过的开口关闭，例如，通过缝合线，粘合剂等来减少现场感染。在组织评估了癌症之后的几天或几周内，临时导管装置可以从患者身上移除。如果在从腔中取出的样本中发现癌症或癌前细胞，则可以将辐射球囊导管或其他照射装置插入患者中以照射活检腔周围的组织，以确保围绕腔的组织内的癌细胞遇难。

8. 发明申请

WO2008019001A3 MARKER FORMED OF STARCH OR OTHER SUITABLE POLYSACCHARIDE 审中-公开
标题翻译：标记为淀粉或其他适用的多糖
公开(公告)号：WO2008019001A3
公开(公告)日：2009-04-02
申请号：PCT/US2007016902
申请日：2007-07-27
申请人： SENORX INC , JONES MICHAEL , LUBOCK PAUL
发明人： JONES MICHAEL , LUBOCK PAUL
IPC分类号： A61B19/00
CPC分类号： A61B90/39 , A61B2017/00004 , A61B2017/00831 , A61B2017/00898 , A61B2090/3908 , A61B2090/3925 , A61B2090/3962 , A61B2090/3987
摘要： The marker member delivery system described has at least one marker member (10) disposed within a delivery tube or cannula is formed at least in part of starch or a suitable polysaccharide. The marker member is preferably in the form of fibrous member.
摘要翻译：所描述的标记物传送系统具有设置在输送管内的至少一个标记构件（10）或插管至少部分地由淀粉或合适的多糖形成。标记构件优选为纤维构件的形式。

9. 发明申请

WO2007061655A3 TISSUE IRRADIATION WITH SHIELDING 审中-公开
标题翻译：用屏蔽进行组织辐照
公开(公告)号：WO2007061655A3
公开(公告)日：2007-11-15
申请号：PCT/US2006043891
申请日：2006-11-13
申请人： SENORX INC , LUBOCK PAUL , JONES MICHAEL
发明人： LUBOCK PAUL , JONES MICHAEL
IPC分类号： A61N5/10 , A61M36/04
CPC分类号： A61N5/1015 , A61B2017/3419 , A61N2005/1005
摘要： Devices and methods are disclosed for treatment to tissue surrounding a body cavity or other intracorporeal site, such as after removal of tissue, e.g. cancer. Such a device includes a treatment location on a distal portion of the device with one or more radiation shielding components that partially encircle a radiation source at the treatment location to control emitted radiation from the radiation source. The device minimizes radiation damage to healthy tissue surrounding the body cavity or other site while irradiating tissue not shielded by the radiation shielding components. A device embodying features of the invention can include a sealing member at a location on a shaft of the device proximal to a treatment location to seal the passageway leading to the body cavity.
摘要翻译：公开了用于对体腔或其他体内部位周围的组织进行治疗的装置和方法，例如在移除组织后，癌症。这样的装置包括在装置的远侧部分上的治疗位置，其具有一个或多个辐射屏蔽部件，所述一个或多个辐射屏蔽部件在治疗位置处部分地环绕辐射源以控制来自辐射源的发射辐射。该装置在辐射未被辐射屏蔽部件屏蔽的组织的同时，使对体腔或其他部位周围的健康组织的辐射损伤最小化。体现本发明特征的装置可以包括位于装置的轴上靠近处理位置的位置处的密封构件，以密封通向体腔的通道。

10. 发明申请

WO2007145926A2 BIOPSY SYSTEM WITH INTEGRATED ULTRASONIC IMAGING 审中-公开
标题翻译：具有集成超声成像的生物系统
公开(公告)号：WO2007145926A2
公开(公告)日：2007-12-21
申请号：PCT/US2007013208
申请日：2007-06-05
申请人： SENORX INC , MALCHOW LLOYD H , LUBOCK PAUL , DAW DEREK
发明人： MALCHOW LLOYD H , LUBOCK PAUL , DAW DEREK
CPC分类号： A61B10/0283 , A61B8/0833 , A61B8/0841 , A61B8/4405 , A61B8/4472 , A61B2017/00199 , A61B2090/378
摘要： A biopsy system is disclosed that has a tissue removal system, an imaging system, an image display system and a common input console for these systems. The tissue removal system can have a mechanical tissue cutting blade or an electrosurgical cutting element and the tissue removal system is capable of handling both tissue cutting configurations. The imaging system is preferably an ultrasound imaging system and the image display system has a video screen for displaying diagnostic ultrasound images from an ultrasound probe. The common input console preferably has a touch screen display and a keyboard to facilitate operation of the tissue removal system, the ultrasound imaging system and the image display system from the same console.
摘要翻译：公开了一种活检系统，其具有用于这些系统的组织去除系统，成像系统，图像显示系统和公共输入控制台。组织去除系统可以具有机械组织切割刀片或电外科切割元件，并且组织去除系统能够处理组织切割构造。成像系统优选地是超声成像系统，并且图像显示系统具有用于从超声波探头显示诊断超声图像的视频屏幕。公共输入控制台优选地具有触摸屏显示器和键盘，以便于来自相同控制台的组织去除系统，超声成像系统和图像显示系统的操作。

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