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1. 发明申请

WO2004091713A2 FLEXIBLE EMBOLIC DEVICE DELIVERY SYSTEM 审中-公开
标题翻译：灵活的装置输送系统
公开(公告)号：WO2004091713A2
公开(公告)日：2004-10-28
申请号：PCT/US2004009364
申请日：2004-03-25
申请人： SCIMED LIFE SYSTEMS INC , JAEGER KEVIN , PORTER STEPHEN C , TEOH CLIFFORD , WALLACE MICHAEL P , PIZARRO MARIA
发明人： JAEGER KEVIN , PORTER STEPHEN C , TEOH CLIFFORD , WALLACE MICHAEL P , PIZARRO MARIA
IPC分类号： A61B17/00 , A61B17/12 , A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12154 , A61B2017/00862 , A61B2017/00867 , A61B2017/1205 , A61B2017/12063
摘要： An embolic assembly delivery apparatus having superior flexibility characteristics at its distal end, that is, at the point of attachment of the embolic assembly to the delivery apparatus.
摘要翻译：栓塞组件输送装置在其远端具有优异的柔性特性，即在栓塞组件与输送装置的连接点处。

2. 发明申请

WO0103607A3 ANEURYSM CLOSURE DEVICE ASSEMBLY 审中-公开
标题翻译： ANEURYSM闭合装置总成
公开(公告)号：WO0103607A3
公开(公告)日：2001-07-26
申请号：PCT/US0017550
申请日：2000-06-26
申请人： SCIMED LIFE SYSTEMS INC
发明人： SLAIKEU PAUL C , WALLACE MICHAEL P , EDER JOSEPH C , BARRY JAMES J , ABRAMS ROBERT M
IPC分类号： A61B17/12 , A61F2/82 , A61F2/90 , A61L31/04 , A61F2/06
CPC分类号： A61F2/82 , A61B17/12022 , A61B17/12118 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61F2/90 , A61F2002/823 , A61L31/043
摘要： This is an implantable medical device assembly for use in surgical procedures. It is most preferably an implantable structure having stenting properties but only partially coated with or partially associated with a material causing a localized angiogenic response. One variation of is an artificial occlusion kit having the inventive implantable stenting structure situatable and vaso-occlusive devices. The implantable stenting structure is typically situated so to prevent migration of artificial occlusion devices or implants from an occlusion site, such as an aneurysm, and into an adjacent body space, such as a blood vessel.
摘要翻译：这是用于外科手术的植入式医疗装置组件。最优选的是具有支架特性的植入式结构，但仅部分涂覆或部分地与导致局部血管生成应答的材料相关联。一种变体是具有本发明的可植入支架结构可置换和血管闭塞装置的人造闭塞试剂盒。植入式支架结构通常被设置为防止人工闭塞装置或植入物从诸如动脉瘤的闭塞部位移动到相邻的身体空间（例如血管）中。

3. 发明申请

WO02096272A3 ABSORBABLE IMPLANTABLE VASO-OCCLUSIVE MEMBER 审中-公开
标题翻译：可吸收的可植入VASO-OCCLUSIVE会员
公开(公告)号：WO02096272A3
公开(公告)日：2003-05-01
申请号：PCT/US0217283
申请日：2002-05-29
申请人： SCIMED LIFE SYSTEMS INC
发明人： WALLACE MICHAEL P , HUI DELILAH YIN , LEE ELAINE
IPC分类号： A61B17/00 , A61B17/12 , A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/12154 , A61B2017/00004 , A61B2017/00477 , A61B2017/12063
摘要： Compositions comprising absorbable implantable vaso-occlusive members are described. Also described are methods of making and using these absorbable vaso-occlusive compositions.
摘要翻译：描述了包含可吸收植入式血管闭塞构件的组合物。还描述了制备和使用这些可吸收的血管闭塞组合物的方法。

4. 发明申请

WO02096272A9 ABSORBABLE IMPLANTABLE VASO-OCCLUSIVE MEMBER 审中-公开
标题翻译：可吸收的植入式血管成员
公开(公告)号：WO02096272A9
公开(公告)日：2003-01-30
申请号：PCT/US0217283
申请日：2002-05-29
申请人： SCIMED LIFE SYSTEMS INC
发明人： WALLACE MICHAEL P , HUI DELILAH YIN , LEE ELAINE
IPC分类号： A61B17/00 , A61B17/12 , A61B
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/12154 , A61B2017/00004 , A61B2017/00477 , A61B2017/12063
摘要： Compositions comprising absorbable implantable vaso-occlusive members are described. Also described are methods of making and using these absorbable vaso-occlusive compositions.
摘要翻译：描述了包含可吸收的可植入血管闭塞构件的组合物。还描述了制造和使用这些可吸收的血管闭塞组合物的方法。

5. 发明申请

WO0103666A3 LIQUID BASED VASO-OCCLUSIVE COMPOSITIONS 审中-公开
标题翻译：基于液体的血管闭塞组合物
公开(公告)号：WO0103666A3
公开(公告)日：2001-07-26
申请号：PCT/US0017886
申请日：2000-06-28
申请人： SCIMED LIFE SYSTEMS INC
发明人： ABRAMS ROBERT M , SLAIKEU PAUL C , BARRY JAMES J , EDER JOSEPH C , WALLACE MICHAEL P
IPC分类号： A61K9/00 , A61L24/00 , A61L24/04 , A61K9/08
CPC分类号： A61K9/0024 , A61L24/0015 , A61L24/046 , A61L24/102 , A61L24/106 , A61L24/108 , A61L2300/25 , A61L2300/252 , A61L2300/258 , A61L2300/414 , C08L67/04
摘要： This relates to a composition for forming a biologically active anatomical occlusion typically within the vasculature of a patient. More particularly, it concerns an occlusive agent which may be made from a precursor composition containing at least one biodegradable, polymeric component and at least one biologically active agent. The occlusive agent may further include solid or dissolved radio-opacifiers and known vaso-occlusive devices. The resulting occlusion, a bioactive solid, encourages cellular attachment and growth while maintaining favorable handling, deployment, and visualization characteristics.
摘要翻译：这涉及用于形成典型地在患者的脉管系统内的生物活性解剖闭塞的组合物。更具体地说，涉及可由含有至少一种可生物降解的聚合物组分和至少一种生物活性剂的前体组合物制成的封闭剂。闭塞剂可以进一步包括固体或溶解的不透射线遮光剂和已知的血管闭塞装置。由此产生的阻塞，一种生物活性固体，鼓励细胞附着和生长，同时保持有利的处理，部署和可视化特征。

6. 发明申请

WO2004069059A3 APPARATUS FOR DE-ENDOTHELIALIZATION OF ANEURYSMS AND OTHER BODY LUMENS 审中-公开
标题翻译： ANEURYSMS和其他身体灯的去内皮化的装置
公开(公告)号：WO2004069059A3
公开(公告)日：2004-09-30
申请号：PCT/US0338464
申请日：2003-12-02
申请人： SCIMED LIFE SYSTEMS INC
发明人： SEIFERT PAUL S , LEE ELAINE , WALLACE MICHAEL P , PORTER STEPHEN C
IPC分类号： A61B17/00 , A61B17/12 , A61F2/82 , A61M29/00 , A61N1/28 , A61N1/40
CPC分类号： A61N1/403 , A61B17/00491 , A61B17/12022 , A61B17/12036 , A61B17/12113 , A61B17/12118 , A61B17/12136 , A61B17/12145 , A61B17/1215 , A61B17/12181 , A61B17/12186 , A61B17/1219 , A61B2017/1205 , A61B2017/12063 , A61F2/82 , A61M29/02 , A61N1/28
摘要： Apparatus for at least partially de-endothelializing a wall of an aneurysm or other body lumen includes an elongate core member having one or more fibers on an outer surface of the core member, the one or more fibers carrying a de-endothelialization agent. The core member is introduced into the aneurysm or other body lumen, thereby releasing the agent from the one or more fibers within the aneurysm or other body lumen, the agent (e.g., a fluid) disrupting at least a portion of the endothelium of the wall thereof. Alternatively, the core member may have a coating carrying a de-endothelialization agent, the coating being degradable when exposed to blood to release the de-endothelialization agent. Further alternatively, a fluid is delivered via a lumen of the tubular member into the aneurysm or other body lumen to at least partially de-endothelialize the wall thereof, thereby causing an endothelium of the wall to generate fibrous tissue to strengthen the wall.
摘要翻译：用于至少部分去内皮化动脉瘤或其他体腔的壁的装置包括细长的芯构件，其在芯构件的外表面上具有一个或多个纤维，所述一个或多个纤维携带去内皮化剂。将核心构件引入动脉瘤或其他体腔，从而从动脉瘤或其他体腔内的一种或多种纤维释放药剂，破坏壁的内皮的至少一部分的药剂（例如流体）它们。或者，芯构件可以具有携带去内皮化剂的涂层，当暴露于血液以释放去内皮化剂时，该涂层可降解。或者，流体通过管状构件的内腔被输送到动脉瘤或其他体腔中，以使其壁的至少部分去内皮化，从而使壁的内皮产生纤维组织以加强壁。

7. 发明申请

WO02053041A9 APPARATUS AND METHOD FOR CONTROLLING A MAGNETICALLY CONTROLLABLE EMBOLIC IN THE EMBOLIZATION OF AN ANEURYSM 审中-公开
标题翻译：用于控制神经元嵌入中的可控制控制的装置和方法
公开(公告)号：WO02053041A9
公开(公告)日：2003-04-17
申请号：PCT/US0150612
申请日：2001-12-26
申请人： SCIMED LIFE SYSTEMS INC
发明人： WALLACE MICHAEL P , EDER JOSEPH C , TEOH CLIFFORD
IPC分类号： A61B17/12 , A61N2/10
CPC分类号： A61B17/12022 , A61B17/12186
摘要： The present invention involves a magnetic embolization apparatus and method for embolizing an aneurysm of a blood vessel. The magnetic embolization apparatus includes a catheter having a distal portion adapted for insertion within an aneurysm of a blood vessel, a permanent magnet carried by the distal portion of the catheter to internally induce a magnetic field from within the aneurysm to control a magnetic field controllable embolic to embolize the aneurysm, and an electromagnet carried by the distal portion of the catheter to internally induce a magnetic field to control delivery of the magnetic field controllable embolic. The method includes delivering a magnetic-field controllable embolic into an aneurysm, inducing a magnetic field in the aneurysm to control the magnetic-field controllable embolic to embolize the aneurysm with the permanent magnet of the catheter, and controlling the delivery of the magnetic-field controllable embolic into the aneurysm with an electromagnet.
摘要翻译：本发明涉及用于栓塞血管的动脉瘤的磁性栓塞装置和方法。磁性栓塞装置包括具有适于插入血管动脉瘤的远侧部分的导管，由导管的远端部分携带的永磁体，以内部诱导来自动脉瘤内的磁场，以控制磁场可控制栓塞栓塞动脉瘤和由导管的远端部分携带的电磁体，以内部诱导磁场来控制磁场可控栓塞的传递。该方法包括将磁场可控制的栓塞递送到动脉瘤中，在动脉瘤中引起磁场以控制磁场可控制栓塞以将动脉瘤与导管的永久磁体栓塞，并且控制磁场的传递用电磁铁将动脉瘤栓塞入动脉瘤。

8. 发明申请

WO02053042A2 IMPROVED APPARATUS AND METHOD FOR INTERNALLY INDUCING A MAGNETIC FIELD IN AN ANEURYSM TO EMBOLIZE ANEURYSM WITH MAGNETICALLY-CONTROLLABLE SUBSTANCE 审中-公开
标题翻译：改进的装置和方法，用于内部诱导磁场中的磁场，用可控制的物质来刺激神经元
公开(公告)号：WO02053042A2
公开(公告)日：2002-07-11
申请号：PCT/US0150849
申请日：2001-12-26
申请人： SCIMED LIFE SYSTEMS INC
发明人： WALLACE MICHAEL P , EDER JOSEPH C
IPC分类号： A61B17/00 , A61B17/12
CPC分类号： A61B17/12022 , A61B17/00491 , A61B17/12113 , A61B17/12145 , A61B17/12163 , A61B17/12172 , A61B2017/00876 , A61B2017/1205 , A61B2017/12063
摘要： The present invention involves a magnetic embolization apparatus for embolizing an aneurysm of a blood vessel. The apparatus includes a coiled element adapted for insertion within an aneurysm of a blood vessel, the coiled element shaped to be retained within the aneurysm, and one or more permanent magnetic segments carried by the coiled element to internally induce a magnetic field from within the aneurysm to control a magnetic field controllable embolic to embolize the aneurysm.
摘要翻译：本发明涉及用于栓塞血管的动脉瘤的磁性栓塞装置。该装置包括适于插入血管的动脉瘤内的盘绕元件，成形为保持在动脉瘤内的盘绕元件，以及一个或多个由盘绕元件承载的永久磁段，以内部诱发来自动脉瘤内的磁场控制磁场可控栓塞栓塞动脉瘤。

9. 发明申请

WO02053041A2 APPARATUS AND METHOD FOR CONTROLLING A MAGNETICALLY CONTROLLABLE EMBOLIC IN THE EMBOLIZATION OF AN ANEURYSM 审中-公开
标题翻译：用于控制动脉瘤栓塞中的磁控可控栓塞的装置和方法
公开(公告)号：WO02053041A2
公开(公告)日：2002-07-11
申请号：PCT/US0150612
申请日：2001-12-26
申请人： SCIMED LIFE SYSTEMS INC
发明人： WALLACE MICHAEL P , EDER JOSEPH C , TEOH CLIFFORD
IPC分类号： A61B17/12 , A61N2/10
CPC分类号： A61B17/12022 , A61B17/12186
摘要： The present invention involves a magnetic embolization apparatus and method for embolizing an aneurysm of a blood vessel. The magnetic embolization apparatus includes a catheter having a distal portion adapted for insertion within an aneurysm of a blood vessel, a permanent magnet carried by the distal portion of the catheter to internally induce a magnetic field from within the aneurysm to control a magnetic field controllable embolic to embolize the aneurysm, and an electromagnet carried by the distal portion of the catheter to internally induce a magnetic field to control delivery of the magnetic field controllable embolic. The method includes delivering a magnetic-field controllable embolic into an aneurysm, inducing a magnetic field in the aneurysm to control the magnetic-field controllable embolic to embolize the aneurysm with the permanent magnet of the catheter, and controlling the delivery of the magnetic-field controllable embolic into the aneurysm with an electromagnet.
摘要翻译：本发明涉及用于栓塞血管动脉瘤的磁性栓塞装置和方法。磁性栓塞装置包括导管，该导管具有适于插入血管动脉瘤内的远端部分，由导管远端部分携带的永磁体从内部诱导动脉瘤内的磁场以控制磁场可控的栓塞以栓塞动脉瘤，并且由导管的远侧部分携带的电磁体在内部诱导磁场以控制磁场可控栓塞的输送。该方法包括将磁场可控栓塞输送到动脉瘤中，在动脉瘤中诱导磁场以控制磁场可控栓塞以使动脉瘤与导管的永磁体栓塞，并且控制磁场的输送用电磁铁控制栓塞入动脉瘤。

10. 发明申请

WO2004091712A3 BIOACTIVE COMPONENTS FOR INCORPORATION WITH VASO-OCCLUSIVE MEMBERS 审中-公开
标题翻译：与VASO-OCCLUSIVE会员合作的生物成分
公开(公告)号：WO2004091712A3
公开(公告)日：2005-04-21
申请号：PCT/US2004011091
申请日：2004-04-09
申请人： SCIMED LIFE SYSTEMS INC
发明人： HO HANH , QUAN KENNTH W JR , TEOH CLIFFORD , EDER JOSEPH C , SLAIKEU PAUL C , WALLACE MICHAEL P , BARRY JAMES
IPC分类号： A61B17/00 , A61B17/12 , A61B19/00 , A61F2/00 , A61L31/04 , A61L31/06 , A61L31/10 , A61L31/16 , A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12172 , A61B17/12177 , A61B90/39 , A61B2017/00004 , A61B2017/12063 , A61F2/0077 , A61L31/044 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2430/36 , C08L67/04 , C08L65/04
摘要： A vaso-occlusive device is disclosed. The device includes a vaso-occlusive member (200, 1100) having a coating disposed thereon. In accordance with one embodiment, the coating comprises a polyacrylic material. In accordance with another embodiment, the coating comprises a polyvinyl alcohol-based material. In accordance with other embodiments, various other materials and coatings are applied to at least a portion of a vaso-occlusive device.
摘要翻译：公开了一种血管闭塞装置。该装置包括其上设置有涂层的血管闭塞构件（200,1100）。根据一个实施方案，涂层包含聚丙烯酸材料。根据另一个实施方案，涂层包含聚乙烯醇基材料。根据其他实施例，各种其它材料和涂层被应用于血管闭塞装置的至少一部分。

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