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1. 发明申请

WO2012110474A1 DISPENSE INTERFACE FOR USE WITH A DRUG DELIVERY DEVICE FOR DELIVERY OF TWO OR MORE DRUG AGENTS 审中-公开
标题翻译：与用于输送两种或更多种药物的药物递送装置一起使用的界面
公开(公告)号：WO2012110474A1
公开(公告)日：2012-08-23
申请号：PCT/EP2012/052451
申请日：2012-02-14
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , HOLTWICK, Marc , EGGERT, Ilona , DAVIES, James Alexander , BILTON, Simon Lewis , MOORE, David , WIMPENNY, Steven , LANGLEY, Christopher Nigel , ZAJAC, Jeffrey
发明人： HOLTWICK, Marc , EGGERT, Ilona , DAVIES, James Alexander , BILTON, Simon Lewis , MOORE, David , WIMPENNY, Steven , LANGLEY, Christopher Nigel , ZAJAC, Jeffrey
IPC分类号： A61M5/19
CPC分类号： A61M5/20 , A61M5/19 , A61M5/2066 , A61M5/31546 , A61M5/345 , A61M2005/2407 , A61M2005/2474 , A61M2005/2496 , A61M2005/3125 , A61M2005/3126 , A61M2005/3128 , A61M2005/31588 , A61M2205/3584 , A61M2205/50 , A61M2205/502 , A61M2205/6072 , A61M2205/8206
摘要： A dispense interface for use with a drug delivery device. The dispense interface comprises a main outer body (1210) and an inner body (2000). The inner body may be configured for connection to a drug delivery device and defines a first reservoir and a second reservoir. A first piercing needle (4000) is in fluid communication with the first reservoir and positioned for piercing a first cartridge of a drug delivery device. A second piercing needle (4050) is provided and in fluid communication with the second reservoir and positioned for piercing a second cartridge contained with a drug delivery device. A manifold (2300) is positioned adjacent the inner body and comprises a fluid groove arrangement. A valve arrangement is positioned between the inner body and the manifold and controls fluid communication of a first fluid contained in the first cartridge and a second fluid contained in the second cartridge by way of the fluid groove arrangement to a holding chamber. The dispense interface may further comprise a lockout preventing dispense interface reuse.
摘要翻译：用于药物输送装置的分配界面。分配界面包括主外体（1210）和内体（2000）。内部主体可以被配置为连接到药物输送装置并且限定第一储存器和第二储存器。第一穿刺针（4000）与第一容器流体连通，并定位成刺穿药物递送装置的第一药筒。提供第二穿刺针（4050）并与第二容器流体连通并定位成刺穿包含药物递送装置的第二药筒。歧管（2300）定位成邻近内部主体并且包括流体槽布置。阀装置定位在内体和歧管之间，并且通过流体槽装置控制容纳在第一盒中的第一流体和容纳在第二盒中的第二流体的流体连通到保持室。分配接口还可以包括防止分配接口重新使用的锁定。

2. 发明申请

WO2012146677A1 LOCKOUT ELEMENT FOR DISPENSE INTERFACE 审中-公开
标题翻译：用于歧视界面的锁定元件
公开(公告)号：WO2012146677A1
公开(公告)日：2012-11-01
申请号：PCT/EP2012/057692
申请日：2012-04-26
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , HOLTWICK, Marc , EGGERT, Ilona , DAVIES, James Alexander , BILTON, Simon Lewis , MOORE, David , WIMPENNY, Steven , LANGLEY, Christopher Nigel
发明人： HOLTWICK, Marc , EGGERT, Ilona , DAVIES, James Alexander , BILTON, Simon Lewis , MOORE, David , WIMPENNY, Steven , LANGLEY, Christopher Nigel
IPC分类号： A61M5/50 , A61M5/34 , A61M5/19 , A61M5/00
CPC分类号： A61M5/50 , A61M5/19 , A61M5/31535 , A61M5/31538 , A61M5/34
摘要： The invention is related to an apparatus comprising a dispense interface (1200, 5025, 6205) for use with a drug delivery device, the dispense interface (1200, 5025, 6205) comprising a lockout element (5000, 5600, 6200) being arranged at least partially between an outer body (1210) of the dispense interface (1200, 5025, 6205) and an inner body (2000) of the dispense interface (1200, 5025, 6205) and wherein the lockout element (5000, 5200, 5600, 6200) is configured to be removeably maintained in a first position, such that when the dispense interface (1200, 5025, 6205) is first attached and then removed from said drug delivery device, the lockout element (5000, 5200, 5600, 6200) moves into a second position, wherein the lockout element (5000, 5200, 5600, 6200) in the second position is configured to prevent said dispense interface (1200, 025, 6205) from being reattached to a drug delivery device.
摘要翻译：本发明涉及一种包括用于药物输送装置的分注界面（1200,5025,6205）的装置，所述分配界面（1200,5025,6205）包括锁定元件（5000,5600,6200）至少部分地在分配界面（1200,5025,6205）的外主体（1210）和分配接口（1200,5025,6205）的内体（2000）之间，并且其中所述锁定元件（5000,5200,5600， 6200）构造成可移除地保持在第一位置，使得当分配界面（1200,5025,6205）首先被附接并且然后从所述药物输送装置移除时，锁定元件（5000,5200,5600,6200）移动到第二位置，其中处于第二位置的锁定元件（5000,5200,5600,6200）被配置为防止所述分配接口（1200,025,6205）重新附接到药物递送装置。

3. 发明申请

WO2012146671A1 VALVE ARRANGEMENT FOR MEDICAL DEVICE 审中-公开
标题翻译：医疗器械的阀门安排
公开(公告)号：WO2012146671A1
公开(公告)日：2012-11-01
申请号：PCT/EP2012/057682
申请日：2012-04-26
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , EGGERT, Ilona , DAVIES, James Alexander , BILTON, Simon Lewis , MOORE, David , WIMPENNY, Steven , LANGLEY, Christopher Nigel
发明人： EGGERT, Ilona , DAVIES, James Alexander , BILTON, Simon Lewis , MOORE, David , WIMPENNY, Steven , LANGLEY, Christopher Nigel
IPC分类号： A61M5/19 , A61M5/24 , A61M5/31
CPC分类号： A61M39/22 , A61M5/19 , A61M5/24 , A61M5/3134 , A61M2005/3128
摘要： The invention faces the technical problem of reducing the uncertainty over exact doses ejected from a medical device and at the same time providing a homogeneous, but controlled mixture of at least two fluids while a simple production should be maintained. The technical problem is solved by a medical device comprising a first valve (262, 308, 508), a second valve (268, 310, 510), a first pre-valve ullage (264, 304, 504), a second pre-valve ullage (266, 306, 506), a post-valve ullage ( 280, 312, 512) with a first end ( 281, 316, 516) and a second end ( 282, 318, 518) and a needle (406). The first pre-valve ullage is connected to the post- valve ullage by the first valve and the second pre-valve ullage is connected to the post- valve ullage by the second valve. A first fluid (92) is guidable from the first pre-valve ullage to the post-valve ullage and a second fluid (102) is guidable from the second pre-valve ullage to the post-valve ullage. A first end (407) of said needle is inserted into the post-valve ullage and the post-valve ullage is designed such that there is a flow inversion between the post- valve ullage and the needle.
摘要翻译：本发明面临技术问题，即降低从医疗装置喷出的精确剂量的不确定性，同时提供至少两种流体的均匀但可控的混合物，同时应保持简单的生产。该技术问题通过包括第一阀（262,308,508），第二阀（268,310,510），第一阀前空位（264,304,504），第二预阀具有第一端（281,316,516）和第二端（282,318,518）和针（406）的后阀缺位（280,312,512）的阀缺口（266,306,506）。第一个阀门前端通过第一个阀门连接到后阀门排空口，第二个阀门前端通过第二个阀门连接到后阀门。第一流体（92）可从第一阀门前空位引导至后阀排空，并且第二流体（102）可从第二预阀闭合引导至阀后排空。所述针头的第一端（407）被插入后瓣膜缺损中，并且后瓣膜缺损被设计成使得在后瓣膜与针之间存在流动反转。

4. 发明申请

WO2012146674A1 DISPENSE INTERFACE WITH LOCKOUT ELEMENT 审中-公开
标题翻译：具有锁定元件的接口
公开(公告)号：WO2012146674A1
公开(公告)日：2012-11-01
申请号：PCT/EP2012/057687
申请日：2012-04-26
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , EGGERT, Ilona , DAVIES, James Alexander , BILTON, Simon Lewis , MOORE, David , WIMPENNY, Steven , LANGLEY, Christopher Nigel
发明人： EGGERT, Ilona , DAVIES, James Alexander , BILTON, Simon Lewis , MOORE, David , WIMPENNY, Steven , LANGLEY, Christopher Nigel
IPC分类号： A61M5/34 , A61M5/50
CPC分类号： A61M5/348 , A61M5/19 , A61M5/2066 , A61M5/2448 , A61M5/34 , A61M5/345 , A61M5/50 , A61M2005/2414 , A61M2005/3125 , A61M2005/3128 , A61M2205/502 , F04C2270/0421
摘要： The invention relates to a dispense interface for use with a drug delivery device with an inner body (7207) and with a lockout element (7200), wherein the lockout element (7200) is coupled to the inner body (7207), wherein the lockout element (7200) is movable from a receptive condition to a locked condition, wherein in the receptive condition the dispense interface (7205) is attachable to the drug delivery device, wherein in the locked condition the dispense interface (7205) is not-attachable to the drug delivery device and wherein the lockout element (7200) is configured to move from the receptive condition to the locked condition when said dispense interface (7205) is attached to and detached from said drug delivery device. The invention solves the technical problem of reducing the risk of reuse of a dispense interface, after it has already been used with a drug delivery device. The invention furthermore relates to an apparatus with a dispense interface (7205) according to the invention and with a drug delivery device, wherein the dispense interface (7205) is removably attached to the drug delivery device.
摘要翻译：本发明涉及一种用于与具有内体（7207）和锁定元件（7200）的药物输送装置一起使用的分配界面，其中锁定元件（7200）联接到内体（7207），其中锁定元件（7200）可从接受状态移动到锁定状态，其中在接收状态下，分配接口（7205）可附接到药物输送装置，其中在锁定状态下，分配接口（7205）不可连接到所述药物递送装置，并且其中所述锁定元件（7200）构造成当所述分配界面（7205）附接到所述药物递送装置并从所述药物递送装置分离时，从所述接受状态移动到所述锁定状态。本发明解决了在已经与药物递送装置一起使用之后降低分配界面的再利用风险的技术问题。本发明还涉及具有根据本发明的分配界面（7205）和药物递送装置的装置，其中分配界面（7205）可移除地附接到药物递送装置。

5. 发明申请

WO2012146673A1 DISPENSE INTERFACE WITH LOCKOUT ELEMENT 审中-公开
标题翻译：具有锁定元件的接口
公开(公告)号：WO2012146673A1
公开(公告)日：2012-11-01
申请号：PCT/EP2012/057685
申请日：2012-04-26
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , EGGERT, Ilona , DAVIES, James, Alexander , BILTON, Simon, Lewis , MOORE, David , WIMPENNY, Steven , LANGLEY, Christopher, Nigel
发明人： EGGERT, Ilona , DAVIES, James, Alexander , BILTON, Simon, Lewis , MOORE, David , WIMPENNY, Steven , LANGLEY, Christopher, Nigel
IPC分类号： A61M5/34 , A61M5/50
CPC分类号： A61M5/34 , A61M5/19 , A61M5/31535 , A61M5/50 , A61M5/504
摘要： The invention relates to a dispense interface (6605,6805,7005) for use with a drug delivery device with an inner body (6607,6807,7007) and with a lockout element (6600,6800,7000), wherein the lockout element (6600,6800,7000) is coupled to the inner body (6607,6807,7007), wherein the lockout element (6600,6800,7000) is movable from a receptive condition to a locked condition, wherein in the receptive condition the dispense interface (6605,6805,7005) is attachable to the drug delivery device, wherein in the locked condition the dispense interface (6605,6805,7005) is not-attachable to the drug delivery device and wherein the lockout element (6600,6800,7000) is configured to move from the receptive condition to the locked condition when said dispense interface (6605,6805,7005) is attached to and detached from said drug delivery device. The invention solves the technical problem of reducing the risk of reuse of a dispense interface, after it has already been used with a drug delivery device. The invention furthermore relates to an apparatus with a dispense interface (6605,6805,7005) and with a drug delivery device, wherein the dispense interface (6605,6805,7005) is removably attached to the drug delivery device.
摘要翻译：本发明涉及一种用于具有内部主体（6607,6807,7007）和具有锁定元件（6600,6800,7000）的药物输送装置的分配接口（6605,6805,7005），其中锁定元件 6600,6800,7000）联接到所述内部主体（6607,6807,7007），其中所述锁定元件（6600,6800,7000）可从接受状态移动到锁定状态，其中在接受状态下，所述分配接口（6605,6805,7005）可附接到药物输送装置，其中在锁定状态下，分配界面（6605,6805,7005）不可附接到药物输送装置，并且其中锁定元件（6600,6800,7000 ）配置成当所述分配接口（6605,6805,7005）附接到所述药物递送装置并从所述药物递送装置分离时，从所述接受状态移动到所述锁定状态。本发明解决了在已经与药物递送装置一起使用之后降低分配界面的再利用风险的技术问题。本发明还涉及具有分配界面（6605,6805,7005）和药物递送装置的装置，其中分配界面（6605,6805,7005）可移除地附接到药物递送装置。

6. 发明申请

WO2012160165A1 EJECT BUTTON FOR A MEDICAMENT DELIVERY DEVICE 审中-公开
标题翻译：用于药物递送设备的弹出按钮
公开(公告)号：WO2012160165A1
公开(公告)日：2012-11-29
申请号：PCT/EP2012/059758
申请日：2012-05-24
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , HOLTWICK, Marc , EGGERT, Ilona , LANGLEY, Christopher, Nigel , JAMES, Aled, Meredydd
发明人： HOLTWICK, Marc , EGGERT, Ilona , LANGLEY, Christopher, Nigel , JAMES, Aled, Meredydd
IPC分类号： A61M5/34 , A61M5/00
CPC分类号： A61M5/34 , A61M5/343 , A61M5/344 , A61M5/348
摘要： A medicament delivery device comprises a housing having a longitudinal axis, a medicament delivery mechanism within the housing, a dispense interface disengagement actuator and a detachable dispense interface. The interface is moveable between a first operative position in which the dispense interface is securely engaged and at least partially contained within the housing, and a second non-operative position in which the dispense interface is partially engaged and at least partially extending from the housing such that it can be detached from the housing manually. The travel of the dispense interface from the first position to the second position is along the longitudinal axis in a direction away from the housing and the movement from the first to the second position is actuated by the dispense interface disengagement actuator.
摘要翻译：药物输送装置包括具有纵向轴线的壳体，壳体内的药物输送机构，分配界面分离致动器和可分离的分配界面。接口可在第一操作位置和第二非操作位置之间移动，在第一操作位置，分配接口被牢固地接合并且至少部分地容纳在壳体内;第二非操作位置，其中分配界面部分地接合并且至少部分地从壳体延伸，它可以手动从外壳拆下。分配界面从第一位置到第二位置的行进沿远离壳体的方向沿着纵向轴线，并且从第一位置到第二位置的移动由分配界面分离致动器致动。

7. 发明申请

WO2012160156A3 MEDICAMENT DELIVERY DEVICE AND METHOD OF CONTROLLING THE DEVICE 审中-公开
公开(公告)号：WO2012160156A3
公开(公告)日：2012-11-29
申请号：PCT/EP2012/059747
申请日：2012-05-24
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , EGGERT, Ilona , LANGLEY, Christopher, Nigel , DAY, Shane, Alistair
发明人： EGGERT, Ilona , LANGLEY, Christopher, Nigel , DAY, Shane, Alistair
IPC分类号： A61M5/142 , A61M5/20 , A61M5/145 , A61M5/19 , A61M5/168
摘要： A medicament delivery device is shown for the administration of one or more drug agents. The device has a priming mode and a drug delivery mode for administering delivery of the one or more drug agents. The device comprises a controller configured to set the device in a priming mode when one or more predetermined states of the device are identified and to disable the drug delivery mode during said predetermined state(s). When states of the device are different from said predetermined states, the controller can set the device in the drug delivery mode. A priming mode may still be enabled through a user interface.

8. 发明申请

WO2012160160A1 MEDICAMENT DELIVERY DEVICE WITH DISPENSE INTERFACE SENSOR AND METHOD CONTROLLING THE DEVICE 审中-公开
标题翻译：具有歧管接口传感器的药物输送装置和控制装置的方法
公开(公告)号：WO2012160160A1
公开(公告)日：2012-11-29
申请号：PCT/EP2012/059752
申请日：2012-05-24
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , EGGERT, Ilona , LANGLEY, Christopher Nigel , DAY, Shane Alistair
发明人： EGGERT, Ilona , LANGLEY, Christopher Nigel , DAY, Shane Alistair
IPC分类号： A61M5/24 , A61M5/20 , A61M5/142 , A61M5/34
CPC分类号： A61M5/16831 , A61M5/20 , A61M5/2066 , A61M5/24 , A61M5/2448 , A61M5/31576 , A61M5/34 , A61M2005/14268 , A61M2205/14 , A61M2205/50 , A61M2205/6018
摘要： A medicament delivery device is shown for the administration of one or more drug agents. The device comprises a medicament cartridge retainer for holding a medicament cartridge. A dispense interface can be attached to an attachment of the device for facilitating fluidic communication from the device. Further, an interface sensor is configured to provide an output indicative of whether the dispense interface is attached to the attachment. The device also comprises a piston rod for driving a bung of the medicament cartridge, and a drive train for advancing the piston rod to the bung. A controller is configured to control the drive train to advance the piston rod towards the bung when the output of the interface sensor indicates that the dispense interface is not on the attachment. The controller is further configured to disable advancement of the piston rod when the output of the interface sensor indicates that the dispense interface is at least partially on the attachment.
摘要翻译：示出了用于施用一种或多种药剂的药物递送装置。该装置包括用于保持药剂盒的药剂盒保持器。分配接口可以附接到设备的附件，以便于从设备的流体通信。此外，接口传感器被配置为提供指示分配接口是否附接到附件的输出。该装置还包括用于驱动药剂盒的塞子的活塞杆和用于将活塞杆推进到塞子的传动系。当接口传感器的输出指示分配接口不在附件上时，控制器被配置为控制传动系将活塞杆推向塞子。控制器还被配置为当接口传感器的输出指示分配接口至少部分地在附件上时，禁止活塞杆的前进。

9. 发明申请

WO2012160159A1 MEDICAMENT DELIVERY DEVICE WITH CARTRIDGE SENSOR AND CARTRIDGE HOLDER DOOR SENSOR AND METHOD OF CONTROLLING THE DEVICE 审中-公开
标题翻译：具有盒式传感器和盒式支架门传感器的药物输送装置及其装置的控制方法
公开(公告)号：WO2012160159A1
公开(公告)日：2012-11-29
申请号：PCT/EP2012/059751
申请日：2012-05-24
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , EGGERT, Ilona , LANGLEY, Christopher Nigel , DAY, Shane Alistair , JAMES, Aled Meredydd
发明人： EGGERT, Ilona , LANGLEY, Christopher Nigel , DAY, Shane Alistair , JAMES, Aled Meredydd
IPC分类号： A61M5/24 , A61M5/20 , A61M5/142 , A61M5/34
CPC分类号： A61M5/5086 , A61M5/20 , A61M5/2066 , A61M5/24 , A61M5/2448 , A61M5/31543 , A61M5/34 , A61M2005/14268 , A61M2205/14 , A61M2205/50 , A61M2205/6018 , F04C2270/041
摘要： A medicament delivery device is presented for the administration of one or more drug agents, wherein the device comprises a retainer for holding a medicament cartridge. The retainer is moveable between an open and closed position. A position sensor for generating a position output is indicative of whether the retainer is in the open or closed position. Further, a cartridge sensor generates a cartridge output indicative of whether the retainer is holding a medicament cartridge. A controller controls a predetermined operation of the device in dependence on the output of the position sensor and on the output of the cartridge sensor.
摘要翻译：呈现用于施用一种或多种药剂的药物输送装置，其中所述装置包括用于保持药剂盒的保持器。保持器可在打开和关闭位置之间移动。用于产生位置输出的位置传感器指示保持器是处于打开或关闭位置。此外，盒式传感器产生指示保持器是否保持药剂盒的盒输出。控制器根据位置传感器的输出和墨盒传感器的输出来控制设备的预定操作。

10. 发明申请

WO2012160167A1 USE OF SWITCHES TO FACILITATE A SAFE AND CONVENIENT ATTACHMENT AND REMOVAL PROCEDURE 审中-公开
标题翻译：使用开关以便安全和方便的附件和拆卸程序
公开(公告)号：WO2012160167A1
公开(公告)日：2012-11-29
申请号：PCT/EP2012/059760
申请日：2012-05-24
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , HOLTWICK, Marc , CASPERS, Michael , EGGERT, Ilona
发明人： HOLTWICK, Marc , CASPERS, Michael , EGGERT, Ilona
IPC分类号： A61M5/34 , A61M5/00
CPC分类号： A61M5/5086 , A61M5/19 , A61M5/34 , A61M2205/14 , A61M2205/3306
摘要： The present invention inter alia relates to an apparatus, comprising a detecting arrangement comprising a first and a second detecting unit, wherein the detecting arrangement is configured to at least detect a partial attaching of an attachable unit to the apparatus and a complete attaching of the attachable unit to the apparatus, wherein the attachable unit is configured to be removably attached to the apparatus, and wherein the detecting arrangement is configured to only enable at least one function of the apparatus, when a complete attaching of the attachable unit to the apparatus is detected.
摘要翻译：本发明尤其涉及一种装置，其包括检测装置，该检测装置包括第一和第二检测单元，其中所述检测装置被配置为至少检测可附接单元对所述装置的部分附接，并且可附接的装置单元到所述设备，其中所述可连接单元被配置为可移除地附接到所述设备，并且其中所述检测装置被配置为仅当检测到所述可附接单元完全附接到所述设备时才能够进行所述设备的至少一个功能。

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