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1. 发明申请

WO2018002314A1 DRUG DELIVERY DEVICE 审中-公开
标题翻译：药物递送装置
公开(公告)号：WO2018002314A1
公开(公告)日：2018-01-04
申请号：PCT/EP2017/066296
申请日：2017-06-30
申请人： SANOFI , SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： BAXTER, Elliot , PLUMPTRE, David Aubrey , VEASEY, Robert , SLADEN, Sophie Louise , SALTER, Jamie
IPC分类号： A61M5/20 , A61M5/24 , A61M5/315
摘要： The present invention is generally directed to a drug delivery device for selecting and dispensing a number of doses of a medicament. The drug delivery device comprises a medicament reservoir attached to a housing (10; 10'; 10'), a drive mechanism (30, 40) comprising a plunger (30; 30') axially movable relative to the housing (10; 10'; 10') for dispensing doses of the medicament from the medicament reservoir, a dose selecting element (60, 80; 60') releasably coupled to the drive mechanism and rotatable relative to the housing (10; 10'; 10') in a first direction for selecting a dose, a trigger (70; 70') axially movable relative to the housing (10; 10'; 10') for initiating dispensing of a dose selected by the dose selecting element (60, 80; 60'), and a limiter (100; 100'; 100''; 100') selectively permitting and preventing axial movement of the trigger (70; 70') depending on the amount of the selected dose. The limiter (100; 100'; 100''; 100') is rotationally constrained to the dose selecting element (60, 80; 60') and is axially constrained to the trigger (70; 70'). One of the limiter (100; 100'; 100''; 100') and a component part (110; 10') axially coupled to the housing (10; 10'; 10') comprises a track which is in engagement with a blocking feature (112; 112'; 12') of the other of the limiter (100; 100'; 100''; 100') and the component part axially coupled to the housing (10; 10'; 10'). The track comprises at least one narrow section limiting relative axial movement between the track and the blocking feature (112; 112'; 112') and at least one wide section permitting relative axial movement between the track and the blocking feature (112; 112'; 112').
摘要翻译：本发明总体上涉及用于选择和分配多个剂量的药物的药物输送装置。所述药物输送装置包括附接到壳体（10; 10'; 10'）的药物储存器，包括相对于所述壳体（10; 10'）可轴向移动的柱塞（30; 30'）的驱动机构（30,40） ; 10'），用于从所述药物储存器分配药物剂量;剂量选择元件（60,80; 60'），所述剂量选择元件可释放地联接到所述驱动机构并且相对于所述壳体（10; 10'; 10'）可旋转用于选择剂量的第一方向，可相对于壳体（10; 10'; 10'）轴向移动的触发器（70; 70'），用于开始分配由剂量选择元件（60,80; 60'）选择的剂量; ，以及取决于所选剂量的量，选择性地允许和防止触发器（70; 70'）的轴向移动的限制器（100; 100'; 100“; 100'）。限制器（100; 100'; 100“; 100'）被旋转地约束到剂量选择元件（60,80; 60'）并且被轴向约束到触发器（70; 70'）。轴向联接到壳体（10; 10'; 10'）的限制器（100; 100'; 100“; 100'）和构件部分（110; 10'）中的一个包括轨道，该轨道与（100; 100'; 100“; 100'）中的另一个和与所述壳体（10; 10'; 10'）轴向耦合的所述部件部分的阻塞特征（112; 112'; 12'）。轨道包括限制轨道与阻挡特征（112; 112'; 112'）之间的相对轴向移动的至少一个窄部分，以及允许轨道与阻挡特征（112; 112'）之间的相对轴向移动的至少一个宽部分， ; 112'）。

2. 发明申请

WO2016128425A1 DRIVE MECHANISM FOR AN INJECTION DEVICE 审中-公开
标题翻译：用于注射装置的驱动机构
公开(公告)号：WO2016128425A1
公开(公告)日：2016-08-18
申请号：PCT/EP2016/052765
申请日：2016-02-10
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： PLUMPTRE, David Aubrey , VEASEY, Robert , CROSS, John David
IPC分类号： A61M5/315
CPC分类号： A61M5/31535 , A61M5/31541 , A61M5/31551 , A61M5/31575 , A61M5/31585 , A61M2205/581 , A61M2205/582
摘要： The present invention relates to a drive mechanism for an injection device for setting and dispensing of a dose of a medicament, the drive mechanism comprising: - a tubular shaped housing component (12, 45) extending in an axial direction (z) and comprising an inner thread (46), - a tubular shaped display member (80) having an outer thread (81) engaged with the inner thread (46), and - a dose member (90) axially displaceable between a dose setting position (S) and a dose dispensing position relative to the display member (80), - wherein the display member (80) comprises at least one blocking member (87) on its outer circumference to axially engage with a blocking structure (18) on an inside facing sidewall portion (12a) of the housing component (12, 45) to block an axial displacement of the dose member (90) from the dose setting position (S) towards the dose dispensing position.
摘要翻译：技术领域本发明涉及一种用于设置和分配药物剂量的注射装置的驱动机构，所述驱动机构包括： - 沿轴向（z）延伸的管状壳体部件（12,45），并且包括内螺纹（46）， - 具有与所述内螺纹（46）接合的外螺纹（81）的管状显示构件（80），以及剂量构件（90），可在剂量设定位置（S）和相对于显示构件（80）的剂量分配位置， - 其中所述显示构件（80）在其外周上包括至少一个阻挡构件（87），以与位于所述显示构件（80）的内侧面侧壁部分上的阻挡结构（18）轴向接合（12a，45），以阻止剂量构件（90）从剂量设定位置（S）向剂量分配位置的轴向位移。

3. 发明申请

WO2015181193A1 DIFFERENTIAL GEAR MECHANISM FOR A DRUG DELIVERY DEVICE AND DRUG DELIVERY DEVICE 审中-公开
标题翻译：用于药物递送装置和药物递送装置的差分齿轮机构
公开(公告)号：WO2015181193A1
公开(公告)日：2015-12-03
申请号：PCT/EP2015/061629
申请日：2015-05-27
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： JONES, Matthew , STEEL, Samuel , BLUNDRED, Neal Alexander , BUTLER, Joseph , VEASEY, Robert , PLUMPTRE, David Aubrey , MORRIS, Anthony Paul
IPC分类号： A61M5/19 , A61M5/20 , A61M5/178
CPC分类号： A61M5/31575 , A61M5/19 , A61M5/2448 , A61M5/31515 , A61M5/31528 , A61M5/31538 , A61M5/31551 , A61M5/31561 , A61M5/31585 , A61M5/31591 , A61M5/31593 , A61M5/31596 , A61M5/3295 , A61M2005/1787 , A61M2005/244 , A61M2005/3126
摘要： The invention is directed to a differential gear mechanism (26) for a drug delivery device with a primary drug delivery assembly (3) and a secondary drug delivery assembly (4), wherein the primary drug delivery assembly (3) comprises a primary dose dial sleeve (17) and wherein the secondary drug delivery assembly (4) comprises a secondary drive sleeve (24). The invention is also directed to a respective drug delivery device.
摘要翻译：本发明涉及一种用于具有初级药物递送组件（3）和辅助药物递送组件（4）的药物递送装置的差速齿轮机构（26），其中主要药物递送组件（3）包括主剂量拨号套管（17），并且其中所述辅助药物输送组件（4）包括次级驱动套筒（24）。本发明还涉及各自的药物递送装置。

4. 发明申请

WO2014180745A1 SUPPLEMENTAL DEVICE FOR ATTACHMENT TO AN INJECTION DEVICE 审中-公开
标题翻译：用于与注射装置连接的补充装置
公开(公告)号：WO2014180745A1
公开(公告)日：2014-11-13
申请号：PCT/EP2014/058970
申请日：2014-05-02
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： VEASEY, Robert , PLUMPTRE, David Aubrey , DRAPER, Paul Richard , MERCER, David Richard
IPC分类号： A61M5/315
CPC分类号： A61M5/3155 , A61M2205/3327 , A61M2205/505 , G01D5/26 , G01F22/00 , G06F19/00 , G06F19/3468
摘要： A supplemental device for attachment to an injection device, the supplemental device comprising: an electromechanical switch arrangement (110) having an open state and a closed state, the electromechanical switch arrangement (110) comprising a protrusion (118) configured to contact a surface (116, 117) of the injection device when a dose of zero units is dialled into the injection device, wherein the state of the switch arrangement (110) is configured to change when a dose dialled into the attached injection device is decreased from one unit to zero units; and a processor arrangement configured to: detect one or more changes in the state of the electromechanical switch arrangement (110); and determine from the one or more state changes that a dose of zero units is dialled into the injection device.
摘要翻译：一种用于附接到注射装置的补充装置，所述补充装置包括：具有打开状态和闭合状态的机电开关装置（110），所述机电开关装置（110）包括被构造成接触表面的突起（118）当将零单位的剂量拨入所述注射装置时，所述注射装置的所述状态被配置为当拨入所述附着的注射装置的剂量从一个单元减小到零单位以及处理器装置，被配置为：检测所述机电开关装置（110）的状态中的一个或多个变化; 并且从所述一个或多个状态变化确定将零单位的剂量拨入所述注射装置。

5. 发明申请

WO2014180744A1 A SUPPLEMENTAL DEVICE FOR ATTACHMENT TO AN INJECTION DEVICE 审中-公开
标题翻译：一种用于与注射装置连接的补充装置
公开(公告)号：WO2014180744A1
公开(公告)日：2014-11-13
申请号：PCT/EP2014/058969
申请日：2014-05-02
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： VEASEY, Robert , PLUMPTRE, David Aubrey , DRAPER, Paul Richard , MERCER, David Richard
IPC分类号： A61M5/315
CPC分类号： A61M5/31568 , A61M5/3155 , A61M2205/3327 , A61M2205/505
摘要： A Supplemental Device for Attachment to an Injection Device A supplemental device for attachment to an injection device, the supplemental device comprising: a housing containing at least two electromechanical switches each having an open state and a closed state and a protrusion associated with each switch configured to protrude from the housing so as to contact a rotatable surface of the injection device while the supplemental device is attached to the injection device; and a processor arrangement configured to: detect a change in the state of each of the switches; and determine a direction of rotation of the rotatable surface of the injection device from the detected state changes.
摘要翻译：用于附接到注射装置的补充装置用于附接到注射装置的补充装置，所述补充装置包括：包含至少两个机电开关的壳体，每个机电开关各自具有打开状态和关闭状态，以及与每个开关相关联的突起，所述突起配置成从所述壳体突出以便在所述补充装置附接到所述注射装置的同时接触所述注射装置的可旋转表面; 以及处理器装置，被配置为：检测每个所述开关的状态的变化; 并且从检测到的状态确定注射装置的可旋转表面的旋转方向改变。

6. 发明申请

WO2011039237A1 A RESETTABLE DRIVE MECHANISM FOR A DRUG DELIVERY DEVICE 审中-公开
标题翻译：用于药物递送装置的可重置驱动机构
公开(公告)号：WO2011039237A1
公开(公告)日：2011-04-07
申请号：PCT/EP2010/064430
申请日：2010-09-29
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , VEASEY, Robert , CAVE, George , JONES, Christopher , KOUYOUMJIAN, Garen , MACDONALD, Catherine, Anne
发明人： VEASEY, Robert , CAVE, George , JONES, Christopher , KOUYOUMJIAN, Garen , MACDONALD, Catherine, Anne
IPC分类号： A61M5/315
CPC分类号： A61M5/3158 , A61M5/24 , A61M5/31535 , A61M5/31543 , A61M5/31555 , A61M5/31558 , A61M5/31575 , A61M2005/2407 , A61M2005/2488 , A61M2005/3152 , Y10T74/18128
摘要： The present disclosure relates to a resettable drive mechanism for use in a drug delivery device (10). The drug delivery device (10) is having a distal direction (14) and a proximal direction (12). The drive mechanism comprises a drive rack (20) engaged with a drive gear (22), a piston rack (30) engaged with a piston gear (32) and coupling means (50) for coupling the drive gear (22) with the piston gear (32). In a first state of the drive mechanism, the drive gear (22) and the piston gear (32) are coupled and the piston rack (30) moves in distal direction (14) when the drive rack (20) is moved in distal direction (14). In a second state of the drive mechanism, the drive gear (22) and the piston gear (32) are decoupled and the piston rack (30) is moveable in proximal direction (12) for resetting the drive mechanism.
摘要翻译：本公开涉及一种用于药物输送装置（10）中的可复位驱动机构。药物输送装置（10）具有远端方向（14）和近端方向（12）。驱动机构包括与驱动齿轮（22）接合的驱动齿条（20），与活塞齿轮（32）接合的活塞齿条（30）和用于将驱动齿轮（22）与活塞齿轮（32）。在驱动机构的第一状态下，当驱动齿条（20）沿远端方向移动时，驱动齿轮（22）和活塞齿轮（32）联接并且活塞齿条（30）沿远侧方向（14）移动（14）。在驱动机构的第二状态下，驱动齿轮（22）和活塞齿轮（32）被解耦，并且活塞齿条（30）能够在近端方向（12）移动，以重新设定驱动机构。

7. 发明申请

WO2011039230A2 DRUG DELIVERY SYSTEM, DRUG DELIVERY DEVICE, NEEDLE ASSEMBLY AND METHOD FOR PRIMING 审中-公开
标题翻译：药物递送系统，药物递送装置，针头组件和用于引发的方法
公开(公告)号：WO2011039230A2
公开(公告)日：2011-04-07
申请号：PCT/EP2010/064423
申请日：2010-09-29
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , KOUYOUMJIAN, Garen , VEASEY, Robert , JONES, Christopher , MACDONALD, Catherine, Anne , GILMORE, Stephen , CAVE, George
发明人： KOUYOUMJIAN, Garen , VEASEY, Robert , JONES, Christopher , MACDONALD, Catherine, Anne , GILMORE, Stephen , CAVE, George
IPC分类号： A61M5/24
CPC分类号： A61M5/34 , A61M5/002 , A61M5/1456 , A61M5/2466 , A61M5/3146 , A61M5/31525 , A61M5/31533 , A61M5/31571 , A61M5/3202 , A61M5/3293 , A61M5/345
摘要： A drug delivery system comprises a drug delivery device (22) which comprises a housing (1) and a cartridge (2). The drug delivery device (22) has a proximal end and a distal end. The drug delivery system further comprises a needle assembly (10) which is attachable to the drug delivery device (22). The needle assembly (10) and the drug delivery device (22) are configured such that the cartridge (2) is moved in the proximal direction with respect to the housing (1) when the needle assembly (10) is attached to the drug delivery device (22).
摘要翻译：药物输送系统包括药物输送装置（22），其包括壳体（1）和药筒（2）。药物输送装置（22）具有近端和远端。药物输送系统还包括可连接到药物输送装置（22）的针组件（10）。针组件（10）和药物输送装置（22）被构造成使得当针组件（10）附接到药物输送装置（1）时，药筒（2）相对于壳体（1）设备（22）。

8. 发明申请

WO2011039216A2 DRIVE ASSEMBLY, PISTON ROD, DRUG DELIVERY DEVICE, AND USE OF A SPRING 审中-公开
标题翻译：驱动装配，活塞杆，药物递送装置和弹簧的使用
公开(公告)号：WO2011039216A2
公开(公告)日：2011-04-07
申请号：PCT/EP2010/064407
申请日：2010-09-29
申请人： Sanofi-Aventis Deutschland GmbH , VEASEY, Robert , BILTON, Simon Lewis , JONES, Christopher , KOUYOUMJIAN, Garen , MACDONALD, Catherine Anne
发明人： VEASEY, Robert , BILTON, Simon Lewis , JONES, Christopher , KOUYOUMJIAN, Garen , MACDONALD, Catherine Anne
IPC分类号： A61M5/24 , A61M5/315
CPC分类号： A61M5/3158 , A61M5/24 , A61M5/31541 , A61M5/31543 , A61M5/31555 , A61M5/31556 , A61M2005/2407 , A61M2005/2477 , A61M2005/3126
摘要： According to one aspect, a resettable drive assembly for a drug delivery device is provided for. The resettable drive assembly may comprise a housing (10A, 10B, 10C) having a proximal end (100P) and a distal end (100D), a piston rod (20) being rotatable with respect to the housing (10A, 10B, 10C) and being axially displaceable with respect to the housing (10A, 10B, 10C) between a proximal start position and a distal end position, a drive member (30) for distally displacing the piston rod (20) towards the end position when dispensing a dose, and a stop member (50). The drive assembly may be configured such that the drive member (30) is operable to interact with the piston rod (20) for forming an unlockable first interlock, the first interlock being operable to block proximal movement of the piston rod (20) with respect to the drive member (30). The drive assembly may be configured such that the stop member (50) is operable to interact with the piston rod (20) for forming an unlockable second interlock, the second interlock being operable to block proximal movement of the piston rod (20) with respect to the housing (10A, 10B, 10C). The drive assembly may be configured such that, when the drive assembly is in a drive mode, the first and second interlocks are locked such that proximal movement of the piston rod (20) from the end position to the start position is prevented by the first interlock and the second interlock. The drive assembly may be configured such that, for switching the drive assembly from the drive mode to a reset mode, the piston rod (20) is rotatable with respect to the drive member (30) for unlocking the first interlock and the stop member (50) and the piston rod (20) are rotatable with respect to each other for unlocking the second interlock. The drive assembly may be configured such that, when the drive assembly is in the reset mode, the first interlock and the second interlock are unlocked such that proximal movement of the piston rod (20) to the start position is allowed. Further, a drug delivery device and a use of a spring are provided for.
摘要翻译：根据一个方面，提供了一种用于药物递送装置的可重置驱动组件。可复位驱动组件可以包括具有近端（100P）和远端（100D）的壳体（10A，10B，10C），可相对于壳体（10A，10B，10C）旋转的活塞杆（20）并且在近端起始位置和远端位置之间相对于所述壳体（10A，10B，10C）可轴向移动;驱动构件（30），用于当分配剂量时将所述活塞杆（20）朝向所述终端位置远端移位，和止动件（50）。驱动组件可以被配置为使得驱动构件（30）可操作以与活塞杆（20）相互作用，以形成可解锁的第一互锁，所述第一互锁件可操作以阻挡活塞杆（20）的近端运动到驱动构件（30）。驱动组件可以被配置为使得止动构件（50）可操作以与活塞杆（20）相互作用以形成可解锁的第二互锁，所述第二互锁可操作以阻止活塞杆（20）的近端运动（10A，10B，10C）。驱动组件可以构造成使得当驱动组件处于驱动模式时，第一和第二互锁被锁定，使得活塞杆（20）从终端位置到起始位置的近端运动被第一互锁和第二个互锁。驱动组件可以被配置成使得为了将驱动组件从驱动模式切换到复位模式，活塞杆（20）可相对于驱动构件（30）旋转，用于解锁第一互锁和止动构件 50）和活塞杆（20）可相对于彼此旋转以解锁第二互锁。驱动组件可以被配置成使得当驱动组件处于复位模式时，第一互锁和第二联锁被解锁，使得允许活塞杆（20）向起始位置的近端运动。此外，提供了药物递送装置和弹簧的使用。

9. 发明申请

WO2011039209A1 ASSEMBLY AND PISTON ROD FOR A DRUG DELIVERY DEVICE 审中-公开
标题翻译：用于药物递送装置的组装和活塞杆
公开(公告)号：WO2011039209A1
公开(公告)日：2011-04-07
申请号：PCT/EP2010/064400
申请日：2010-09-29
申请人： Sanofi-Aventis Deutschland GmbH , MACDONALD, Catherine Anne , VEASEY, Robert , JONES, Christopher , KOUYOUMJIAN, Garen
发明人： MACDONALD, Catherine Anne , VEASEY, Robert , JONES, Christopher , KOUYOUMJIAN, Garen
IPC分类号： A61M5/315
CPC分类号： A61M5/3146 , A61M5/24 , A61M5/31543 , A61M5/31555 , A61M5/31556 , A61M5/3156 , A61M5/31575 , A61M5/3158 , A61M2005/2407 , A61M2005/2488 , A61M2005/2492
摘要： A drive mechanism for a drug delivery device (1) comprises a housing (2), a drive member (5) and a piston rod assembly (32). The drive member (5) is configured to be axially displaced in a dose setting direction with respect to the housing (2) for setting a dose of a drug (24) and to be axially displaced in a dose delivery direction with respect to the housing (2) for delivering the set dose of the drug (24). The drive member (5) comprises a drive feature (15). The piston rod assembly (32) comprises a set of interaction surfaces (17) for mechanical interaction with the drive feature (15), with at least two interaction surfaces (17) being axially and angularly offset with respect to each other. When the drive member (5) is displaced in the dose delivery direction for delivering the set dose, the drive feature (15) mechanically interacts with one of the interaction surfaces (17) and the piston rod assembly (32) rotates with respect to the housing (2), thereby rotating and axially displacing another one of the interaction surfaces (17) from a non-interaction position into an interaction position in which the drive feature (15) may interact with the other one of the interaction surfaces (17) when the drive mechanism is actuated once more for setting and delivering a further dose. Also, a piston rod (3) is proposed.
摘要翻译：用于药物输送装置（1）的驱动机构包括壳体（2），驱动构件（5）和活塞杆组件（32）。驱动构件（5）被构造成相对于壳体（2）在剂量设定方向上轴向移位，用于设定药物（24）的剂量并相对于壳体沿剂量递送方向轴向移位（2）用于递送药物的设定剂量（24）。驱动构件（5）包括驱动特征（15）。活塞杆组件（32）包括用于与驱动特征（15）机械相互作用的一组相互作用表面（17），其中至少两个相互作用表面（17）相对于彼此轴向和角度偏移。当驱动构件（5）在剂量递送方向上移位以输送设定剂量时，驱动构件（15）与相互作用表面（17）中的一个机械地相互作用，并且活塞杆组件（32）相对于从而将另一个相互作用表面（17）从非相互作用位置旋转并轴向移位到相互作用位置，在该相互作用位置中，驱动特征（15）可与相互作用表面（17）中的另一个相互作用，当驱动机构再次被致动以设定和递送另外的剂量时。另外，提出了活塞杆（3）。

10. 发明申请

WO2011039205A2 DRUG DELIVERY DEVICE AND DRIVE MEMBER FOR A DRUG DELIVERY DEVICE 审中-公开
标题翻译：药物递送装置和用于药物递送装置的驱动部件
公开(公告)号：WO2011039205A2
公开(公告)日：2011-04-07
申请号：PCT/EP2010/064395
申请日：2010-09-29
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , PLUMPTRE, David , LINDSAY, Adrew Mark , MACDONALD, Catherine Anne , VEASEY, Robert , JONES, Christopher , KOUYOUMJIAN, Garen
发明人： PLUMPTRE, David , LINDSAY, Adrew Mark , MACDONALD, Catherine Anne , VEASEY, Robert , JONES, Christopher , KOUYOUMJIAN, Garen
IPC分类号： A61M5/315
CPC分类号： A61M5/31585 , A61M5/24 , A61M5/3146 , A61M5/31543 , A61M5/31555 , A61M5/3157 , A61M5/31575 , A61M2005/2407 , A61M2005/3126 , A61M2205/581 , A61M2205/582
摘要： A drive member (1) for driving a piston rod (5) in a drug delivery device (4) is provided. The drive member (1) is configured to be driven in a rotational movement by an actuating member. The drive member (1) comprises a track (12) for transmitting a driving load from the actuating member to the drive member (1). The track (12) comprises both sections running in a distal and sections running in a proximal direction of the drive member (1). Moreover, a drug delivery device (4) comprising such a drive member (1) is provided.
摘要翻译：提供了用于驱动药物输送装置（4）中的活塞杆（5）的驱动构件（1）。驱动构件（1）构造成通过致动构件以旋转运动被驱动。驱动构件（1）包括用于将驱动负载从致动构件传递到驱动构件（1）的轨道（12）。轨道（12）包括在远端延伸的两个部分和沿着驱动部件（1）的近端方向延伸的部分。此外，提供了包括这种驱动构件（1）的药物输送装置（4）。

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