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1. 发明申请

WO2020087135A1 CHARACTERISATION OF NEUROSTIMULATION THERAPEUTIC EFFICACY 审中-公开
公开(公告)号：WO2020087135A1
公开(公告)日：2020-05-07
申请号：PCT/AU2019/051210
申请日：2019-11-02
申请人： SALUDA MEDICAL PTY LTD
发明人： PARKER, John Louis , SINGLE, Peter Scott Vallack
IPC分类号： A61B5/04 , A61N1/36
摘要： Assessing therapeutic efficacy of electrical neurostimulation therapy. A neuromodulation device delivers the electrical neurostimulation therapy. Measurement circuitry captures recordings of neural responses evoked by the electrical neurostimulation therapy. A processor processes the recordings of the neural responses in order to obtain a plurality of measures of neural activation in response to a plurality of stimuli delivered over time, and calculates from the plurality of measures of neural activation at least one statistical measure of neural activation. From the at least one statistical measure the processor produces and outputs an indication of therapeutic efficacy.

2. 发明申请

WO2016191808A1 MONITORING BRAIN NEURAL ACTIVITY 审中-公开
标题翻译：监测脑神经活动
公开(公告)号：WO2016191808A1
公开(公告)日：2016-12-08
申请号：PCT/AU2016/050431
申请日：2016-05-31
申请人： SALUDA MEDICAL PTY LTD
发明人： PARKER, John Louis , GMEL, Gerrit Eduard
IPC分类号： A61B5/0484 , A61N1/36 , A61N1/05
CPC分类号： A61B5/0484 , A61B5/4064 , A61B5/4082 , A61B5/4836 , A61B5/4848 , A61B5/6868 , A61N1/0529 , A61N1/0534 , A61N1/36135
摘要： Monitoring brain neural activity comprises repeatedly applying electrical stimuli to evoke neural responses in the brain. Neural responses evoked by the stimuli are recorded. The recorded neural responses are assessed for changed characteristics over time, to monitor a time-varying effect on the recorded neural responses of local field potentials arising from a source other than the electrical stimuli.
摘要翻译：监测脑神经活动包括重复地施加电刺激以引起脑中的神经反应。记录刺激引起的神经反应。评估所记录的神经反应随时间变化的特征，以监测对来自电刺激源的局部场电位记录的神经反应的时变效应。

3. 发明申请

WO2015143509A1 ASSESSING NEURAL STATE FROM ACTION POTENTIALS 审中-公开
标题翻译：从行动潜力评估神经状态
公开(公告)号：WO2015143509A1
公开(公告)日：2015-10-01
申请号：PCT/AU2015/050135
申请日：2015-03-27
申请人： SALUDA MEDICAL PTY LTD
发明人： PARKER, John Louis
IPC分类号： A61B5/0476 , A61B5/04
CPC分类号： A61B5/4076 , A61B5/04001 , A61B5/0478 , A61B5/4041 , A61B5/407 , A61B5/4824 , A61B5/4836 , A61N1/36071 , A61N1/36135 , A61N1/36185
摘要： The neural health or state of a subject is assessed. A recording is obtained of a compound action potential arising in neural tissue of the subject. The recording is processed to determine whether a profile of the recorded compound action potential is anomalous, such as by exhibiting doublets, peak broadening or deformation, or other anomaly. An indication is output regarding the neural state of the subject based on determined anomalies in the recorded compound action potential.
摘要翻译：评估受试者的神经健康或状态。获得在受试者的神经组织中产生的复合动作电位的记录。处理记录以确定记录的化合物动作电位的轮廓是否是异常的，例如通过显示双峰，峰值变宽或变形或其他异常。基于记录的化合物动作电位中确定的异常，输出关于对象的神经状态的指示。

4. 发明申请

WO2019204884A1 NEUROSTIMULATION OF MIXED NERVES 审中-公开
公开(公告)号：WO2019204884A1
公开(公告)日：2019-10-31
申请号：PCT/AU2019/050384
申请日：2019-04-29
申请人： SALUDA MEDICAL PTY LTD
发明人： PARKER, John Louis , GMEL, Gerrit Eduard
IPC分类号： A61N1/36 , A61N1/05 , A61B5/04
摘要： Neurostimulation of a mixed nerve comprising a plurality of nerve fibre types. An implantable electrode array comprising a plurality of electrodes is positioned proximal to the mixed nerve. An electrical stimulus is delivered from at least one nominal stimulus electrode of the implantable electrode array, in accordance with a set of stimulus parameters. A recording of the electrophysiological response evoked by the electrical stimulus is obtained from at least one nominal recording electrode of the implantable electrode array. The recording is analysed by assessing one or more selected characteristics of the recording, and from the observed selected characteristics a level of recruitment of one or more fibre types recruited by the electrical stimulus is identified. The stimulus parameters are refined in a manner to effect selective recruitment of one or more fibre types relative to other fibre types of the mixed nerve.

5. 发明申请

WO2016115596A1 METHOD AND DEVICE FOR NEURAL IMPLANT COMMUNICATION 审中-公开
标题翻译：用于神经植入通讯的方法和装置
公开(公告)号：WO2016115596A1
公开(公告)日：2016-07-28
申请号：PCT/AU2016/050019
申请日：2016-01-19
申请人： SALUDA MEDICAL PTY LTD
发明人： PARKER, John Louis , STAPLES, Mark
IPC分类号： A61N1/36 , A61B5/04
CPC分类号： A61N1/37217 , A61B5/0028 , A61B5/0031 , A61B5/04001 , A61B5/686 , A61B5/7475 , A61B2560/0487 , A61N1/37211 , G06F3/015
摘要： Communications along a neural pathway are provided. The neural pathway is stimulated at a first location, in order to evoke neural responses which propagate along the neural pathway, the neural responses being modulated with data. At a second location spaced apart from the first location along the neural pathway the evoked neural responses are sensed. The sensed neural responses are then demodulated to retrieve the data. The stimulation could comprise peripheral sensory stimulation, and the second location could be at an implanted electrode array.
摘要翻译：提供了沿神经通路的通讯。神经通路在第一个位置被刺激，以便引发沿神经通路传播的神经反应，用数据调制神经反应。在沿着神经路径与第一位置间隔开的第二位置处，感测到诱发的神经反应。然后解调所感测的神经反应以检索数据。刺激可以包括外周感觉刺激，并且第二位置可以是植入电极阵列。

6. 发明申请

WO2015070281A1 MONITORING BRAIN NEURAL POTENTIALS 审中-公开
标题翻译：监测脑神经电位
公开(公告)号：WO2015070281A1
公开(公告)日：2015-05-21
申请号：PCT/AU2014/001049
申请日：2014-11-14
申请人： SALUDA MEDICAL PTY LTD
发明人： PARKER, John Louis , GMEL, Gerrit Eduard
IPC分类号： A61B5/0476 , A61N1/05
CPC分类号： A61B5/0484 , A61B5/04012 , A61B5/0478 , A61B5/4064 , A61B5/4076 , A61B5/4839 , A61B5/4848 , A61B5/6868 , A61N1/36067 , A61N1/36139 , A61N1/36153 , A61N1/36175
摘要： Neural activity in the brain arising from a stimulus is monitored. A stimulus is applied to a target structure of the brain and a neural measurement is obtained from at least one electrode implanted in contact with the target structure. The neural measurement is configured to capture a measure of any late response arising in the target structure, typically being a neural response arising after conclusion of an ECAP, such as in the period 1.5 – 10 ms after stimulus onset. The late response(s) can be a useful biomarker such as of therapeutic ranges of deep brain stimulation, disease progression, medication efficacy, and intra-operative changes.
摘要翻译：监测刺激引起的大脑神经活动。刺激被施加到脑的目标结构，并且从与目标结构接触植入的至少一个电极获得神经测量。神经测量被配置为捕获在目标结构中产生的任何晚期反应的量度，通常是在ECAP结束后产生的神经反应，例如在刺激开始后1.5-10ms的时期。晚期反应可以是有用的生物标志物，例如深部脑刺激，疾病进展，药物疗效和术中变化的治疗范围。

7. 发明申请

WO2020082118A1 METHOD AND DEVICE FOR CONTROLLED NEURAL STIMULATION 审中-公开
公开(公告)号：WO2020082118A1
公开(公告)日：2020-04-30
申请号：PCT/AU2019/051151
申请日：2019-10-22
申请人： SALUDA MEDICAL PTY LTD
发明人： PARKER, John Louis , GORMAN, Robert Bruce
IPC分类号： A61N1/36
摘要： A neurostimulation device has at least three stimulation electrodes configured to deliver an electrical stimulus to neural tissue. A control unit is configured to deliver a first stimulus phase in which a first stimulus electrode delivers a supra-threshold stimulus component, returned by at least two other of the stimulation electrodes. The control unit is further configured to deliver at least a second stimulus phase in which at least two of the stimulus electrodes deliver a sub-threshold stimulus component, returned by the first stimulus electrode.

8. 发明申请

WO2016191807A1 BRAIN NEUROSTIMULATOR ELECTRODE FITTING 审中-公开
标题翻译：脑神经细胞电极配件
公开(公告)号：WO2016191807A1
公开(公告)日：2016-12-08
申请号：PCT/AU2016/050430
申请日：2016-05-31
申请人： SALUDA MEDICAL PTY LTD
发明人： PARKER, John Louis , GMEL, Gerrit Eduard
IPC分类号： A61N1/36 , A61N1/05 , A61B5/0484
CPC分类号： A61N1/0534 , A61B5/0484 , A61B5/4064 , A61B5/4082 , A61B5/4836 , A61B5/6868 , A61N1/36067 , A61N1/36135 , A61N1/36185
摘要： ABSTRACT Fitting a brain neurostimulator electrode array comprises positioning at least a first electrode in a desired target structure in a first cerebral hemisphere, and positioning at least a second electrode in a corresponding target structure in a contralateral cerebral hemisphere. Electrical stimuli are applied from the first electrode to the desired target structure. Neural responses observed at the second electrode in response to the electrical stimuli are recorded. The fitting of at least one of the first electrode and second electrode is assessed by reference to the recorded neural responses.
摘要翻译：摘要拟合脑神经刺激器电极阵列包括将至少第一电极定位在第一大脑半球中的期望目标结构中，并将至少第二电极定位在对侧脑半球中的相应目标结构中。电刺激从第一电极施加到期望的目标结构。记录响应于电刺激在第二电极处观察到的神经反应。通过参考记录的神经反应来评估第一电极和第二电极中的至少一个的配合。

9. 发明申请

WO2016011512A1 NEURAL STIMULATION DOSING 审中-公开
标题翻译：神经刺激剂量
公开(公告)号：WO2016011512A1
公开(公告)日：2016-01-28
申请号：PCT/AU2015/050422
申请日：2015-07-27
申请人： SALUDA MEDICAL PTY LTD
发明人： PARKER, John Louis
IPC分类号： A61N1/05 , A61N1/34 , A61N1/36 , A61B5/04
CPC分类号： A61N1/3605 , A61N1/05 , A61N1/0551 , A61N1/06 , A61N1/36 , A61N1/36071 , A61N1/36146 , A61N1/36171 , A61N1/36175 , A61N1/36178 , A61N1/36185 , A61N1/37247 , A61N2001/34
摘要： Applying therapeutic neural stimuli involves monitoring for at least one of sensory input and movement of a user. In response to detection of sensory input or user movement, an increased stimulus dosage is delivered within a period of time corresponding to a duration of time for which the detected sensory input or user movement gives rise to masking, the increased stimulus dosage being configured to give rise to increased neural recruitment.
摘要翻译：施用治疗神经刺激涉及监测用户的感觉输入和运动中的至少一个。响应于感觉输入或用户移动的检测，在对应于检测到的感觉输入或用户移动引起掩蔽的持续时间的时间段内传送增加的刺激剂量，增加的刺激剂量被配置为给予增加神经募集增加。

10. 发明申请

WO2016161484A2 ELECTRODE TO NERVE DISTANCE ESTIMATION 审中-公开
标题翻译：电极到神经距离估计
公开(公告)号：WO2016161484A2
公开(公告)日：2016-10-13
申请号：PCT/AU2016/050263
申请日：2016-04-08
申请人： SALUDA MEDICAL PTY LTD
发明人： PARKER, John Louis
IPC分类号： A61B3/00
CPC分类号： A61N1/36062 , A61N1/36067 , A61N1/36075 , A61N1/36139 , A61N1/36185
摘要： Estimating a nerve-to-electrode distance involves applying a stimulus from a stimulus electrode to a nerve. Neural measurements of at least one evoked compound action potential are obtained, and processed in order to estimate an originating state of stimulation exhibiting at least one characteristic defined by a single fibre size. A single fibre model is then applied to produce a measure of the nerve-to-electrode distance. Also provided for is estimation of a distribution of recruited fibres. Measurements of a compound action potential are obtained from sense electrodes spaced apart along a neural pathway. A conduction velocity of the compound action potential is determined from the latency between the measurements. From the conduction velocity a dominant recruited fibre diameter is determined. A rate of dispersion of the compound action potential between the sense electrodes is determined. From the rate of dispersion a distribution of diameters of the recruited fibre population is determined.
摘要翻译：估计神经到电极的距离包括从刺激电极向神经施加刺激。获得至少一种诱发复合动作电位的神经测量结果，并对其进行处理，以便估计表现出由单一纤维尺寸限定的至少一个特征的刺激的起始状态。然后应用单纤维模型来产生神经到电极距离的量度。还提供了估计招募光纤的分布。从沿着神经通路间隔开的感测电极获得复合动作电位的测量值。复合动作电位的传导速度由测量之间的潜伏期确定。从传导速度确定占主导地位的纤维直径。确定感测电极之间的复合动作电位的分散速率。从分散率中确定招募的纤维种群的直径分布。

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