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1. 发明申请

WO2011048033A2 METHODS AND SYSTEMS FOR PHARMACOGENOMIC TREATMENT OF CARDIOVASCULAR CONDITIONS 审中-公开
标题翻译：用于药物治疗心血管病症的方法和系统
公开(公告)号：WO2011048033A2
公开(公告)日：2011-04-28
申请号：PCT/EP2010/065589
申请日：2010-10-18
申请人： ROSTAQUO S.p.A. , BIANCHI, Giuseppe , FERRARI, Patrizia , MACCIARDI, Fabio
发明人： BIANCHI, Giuseppe , FERRARI, Patrizia , MACCIARDI, Fabio
IPC分类号： A61K31/56 , A61P9/00
CPC分类号： A61K31/56 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156
摘要： Methods and systems are provided herein that are based on the effects of genetic variations on the biological activities associated to rostafuroxin in an individual. In particular, compositions, methods and systems are herein described that are based on an indentified influence on an individual response to rostafuroxin of one or more polymorphisms in an intergenic or intragenic region of a gene selected from the group consisting of KCNS3, THSD7A, FAM46A, LOC389970, HLA-G, and TTC29, and/or a genetic variation in linkage disequilibrium therewith.
摘要翻译：本文提供了基于遗传变异对与个体中罗他福辛相关的生物活性的影响的方法和系统。具体而言，本文描述了组合物，方法和系统，所述组合物，方法和系统基于对选自KCNS3，THSD7A，FAM46A，FH46A和FH46A的基因的基因间或基因内区域中一种或多种多态性对罗他福辛的个体反应的识别影响。 LOC389970，HLA-G和TTC29，和/或与其连锁不平衡的遗传变异。

2. 发明申请

WO2010108855A1 5-β, 14-β-ANDROSTANE DERIVATIVES USEFUL FOR THE TREATMENT OF PROTEINURIA, GLOMERULOSCLEROSIS AND RENAL FAILURE 审中-公开
标题翻译：用于治疗蛋白质，GLOMULULOSOSOSISIS和肾功能衰竭的5-β，14-β-ANDROSTANE衍生物
公开(公告)号：WO2010108855A1
公开(公告)日：2010-09-30
申请号：PCT/EP2010/053571
申请日：2010-03-18
申请人： SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. , FERRARI, Patrizia , BIANCHI, Giuseppe , FERRANDI, Mara
发明人： FERRARI, Patrizia , BIANCHI, Giuseppe , FERRANDI, Mara
IPC分类号： A61K31/58 , A61P13/12
CPC分类号： C07J17/00 , C07J41/0038 , C07J43/003
摘要： Compound of formula (I), wherein the symbol have the meaning reported in the text; for preparing a medicament for the prevention and/or treatment of proteinuria, glomerulosclerosis or renal failure.
摘要翻译：式（I）的化合物，其中符号具有文本中报道的含义; 用于制备用于预防和/或治疗蛋白尿，肾小球硬化或肾衰竭的药物。

3. 发明申请

WO2007147713A1 AMINO DERIVATIVES OF B-HOMOANDROSTANES AND B-HETEROANDROSTANES 审中-公开
标题翻译：苯酚衍生物和B-异烟肼的氨基衍生物
公开(公告)号：WO2007147713A1
公开(公告)日：2007-12-27
申请号：PCT/EP2007/055366
申请日：2007-05-31
申请人： SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. , CERRI, Alberto , MORO, Barbara , TORRI, Maco , CARZANA, Giulio , BIANCHI, Giuseppe , FERRANDI, Mara , FERRARI, Patrizia , ZAPPAVIGNA, Maria Pia , BANFI, Leonardo , GIACALONE, Giuseppe
发明人： CERRI, Alberto , MORO, Barbara , TORRI, Maco , CARZANA, Giulio , BIANCHI, Giuseppe , FERRANDI, Mara , FERRARI, Patrizia , ZAPPAVIGNA, Maria Pia , BANFI, Leonardo , GIACALONE, Giuseppe
IPC分类号： C07J3/00 , C07J63/00 , A61K31/58 , A61K31/565 , A61K31/566 , A61P9/04 , A61P9/06
CPC分类号： C07J73/005 , C07J63/004 , C07J73/003
摘要： New aminoalkoxyimino derivatives at position 3 of substituted B- homoandrostanes and B-heteroandrostanes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hypertension. In particular compounds having the general formula (I) are described, where the radicals have the meanings described in detail in the application.
摘要翻译：取代的B-雄性雄甾烷和B-异雄甾烷砜的3位的新的氨基烷氧基亚氨基衍生物，其制备方法，以及含有它们用于治疗心力衰竭和高血压的心血管疾病的药物组合物。特别地描述了具有通式（I）的化合物，其中基团具有本申请中详细描述的含义。

4. 发明申请

WO2007118832A2 AMINO DERIVATIVES OF ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS 审中-公开
标题翻译：安非他明的氨基酸衍生物和作为心血管疾病药物的安慰剂
公开(公告)号：WO2007118832A2
公开(公告)日：2007-10-25
申请号：PCT/EP2007/053524
申请日：2007-04-11
申请人： SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. , CERRI, Alberto , TORRI, Marco , ARMAROLI, Silvia , BANFI, Leonardo , BIANCHI, Giuseppe , CARZANA, Giulio , FERRARI, Patrizia , MICHELETTI, Rosamaria , SPUTORE, Simona , ZAPPAVIGNA, Maria Pia
发明人： CERRI, Alberto , TORRI, Marco , ARMAROLI, Silvia , BANFI, Leonardo , BIANCHI, Giuseppe , CARZANA, Giulio , FERRARI, Patrizia , MICHELETTI, Rosamaria , SPUTORE, Simona , ZAPPAVIGNA, Maria Pia
IPC分类号： C07J41/00 , C07J43/00 , A61K31/58 , A61K31/565
CPC分类号： C07J41/0038 , C07J41/0016 , C07J43/003
摘要： Compounds of formula (I) wherein:the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na + ,K + -ATPase. Said compounds are used for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms.
摘要翻译：式（I）化合物其中：所述基团如说明书中所定义，可用于制备用于治疗心血管疾病，特别是心力衰竭和高血压的药物。这些化合物是Na +，K + + ATP酶的酶活性的抑制剂。所述化合物用于制备用于治疗由内源性哇巴因的高血压作用引起的疾病的药物，例如常染色体显性多囊肾病（ADPKD）的肾衰竭进展，先兆子痫高血压和蛋白尿以及患者肾衰竭进展与adducin多态性。

5. 发明申请

WO2012055894A1 DITERPENOID DERIVATIVES ENDOWED OF BIOLOGICAL PROPERTIES 审中-公开
标题翻译：生物特性的DITERPENOID衍生物
公开(公告)号：WO2012055894A1
公开(公告)日：2012-05-03
申请号：PCT/EP2011/068702
申请日：2011-10-26
申请人： SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. , CERRI, Alberto , GOBBINI, Mauro , TORRI, Marco , FERRARI, Patrizia , FERRANDI, Mara , BIANCHI, Giuseppe
发明人： CERRI, Alberto , GOBBINI, Mauro , TORRI, Marco , FERRARI, Patrizia , FERRANDI, Mara , BIANCHI, Giuseppe
IPC分类号： C07C211/31 , C07C251/34 , C07C251/54 , A61K31/15 , C07D211/46
CPC分类号： C07C251/58 , C07B2200/07 , C07C211/31 , C07C217/10 , C07C249/04 , C07C251/44 , C07C251/54 , C07C251/60 , C07C277/00 , C07C279/12 , C07C281/16 , C07C281/18 , C07C309/66 , C07C323/25 , C07C2603/26 , C07D207/12 , C07D211/46
摘要： The present invention relates to new diterpenoid derivatives of formula (I), processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, urinary incontinence, asthma, or Alzheimer's disease and/or to prevent obstructive vascular lesions consequently to arteriotomy and/or angioplasty, and to prevent organ damage in hypertensive patients.
摘要翻译：本发明涉及式（I）的新二萜衍生物，其制备方法，以及含有它们用于治疗心血管疾病，尿失禁，哮喘或阿尔茨海默病的药物组合物和/或预防阻塞性血管损伤动脉切开术和/或血管成形术，并预防高血压患者的器官损伤。

6. 发明申请

WO2009047101A1 AMINOOXIME DERIVATIVES OF 2- AND/OR 4-SUBSTITUTED ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS 审中-公开
标题翻译： 2-和/或4-取代的安慰剂和安慰剂作为心血管疾病药物的氨基酸衍生物
公开(公告)号：WO2009047101A1
公开(公告)日：2009-04-16
申请号：PCT/EP2008/062483
申请日：2008-09-18
申请人： SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. , CERRI, Alberto , BIANCHI, Giuseppe , FEDRIZZI, Giorgio , FERRARI, Patrizia , GOBBINI, Mauro , MARAZZI, Giuseppe , TORRI, Marco , CABRI, Walter
发明人： CERRI, Alberto , BIANCHI, Giuseppe , FEDRIZZI, Giorgio , FERRARI, Patrizia , GOBBINI, Mauro , MARAZZI, Giuseppe , TORRI, Marco , CABRI, Walter
IPC分类号： C07J41/00 , C07J43/00 , A61K31/565 , A61K31/58 , A61P9/04 , A61P9/06 , A61P9/12
CPC分类号： C07J41/0016 , C07J43/003
摘要： New aminooxime derivatives at position 3 of 2-and/or 4-substituted androstanes and androstenes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hypertension. In particular compounds having the general formula (I) are described,where the radicals have the meanings described in detail in the application.
摘要翻译： 2-和/或4-取代的雄甾烷和雄甾烯酯3位的新的氨基肟衍生物，其制备方法以及含有它们用于治疗心力衰竭和高血压的心血管疾病的药物组合物。特别地描述了具有通式（I）的化合物，其中基团具有在本申请中详细描述的含义。

7. 发明申请

WO2007118830A1 AZAHETEROCYCLYL DERIVATIVES OF ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS 审中-公开
标题翻译：安非他酮和安慰剂作为心血管疾病药物的偶氮胆碱衍生物
公开(公告)号：WO2007118830A1
公开(公告)日：2007-10-25
申请号：PCT/EP2007/053521
申请日：2007-04-11
申请人： SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. , CERRI, Alberto , FEDRIZZI, Giorgio , BENICCHIO, Alessandra , BIANCHI, Giuseppe , FERRARI, Patrizia , GOBBINI, Mauro , MICHELETTI, Rosamaria , POZZI, Marco , SCOTTI, Piero Enrico
发明人： CERRI, Alberto , FEDRIZZI, Giorgio , BENICCHIO, Alessandra , BIANCHI, Giuseppe , FERRARI, Patrizia , GOBBINI, Mauro , MICHELETTI, Rosamaria , POZZI, Marco , SCOTTI, Piero Enrico
IPC分类号： C07J43/00 , A61K31/58 , A61K31/565 , A61P9/04
CPC分类号： C07J43/003
摘要： Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+,K+-ATPase. They are useful for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms.
摘要翻译：式（I）化合物其中：所述基团如说明书中所定义，可用于制备用于治疗心血管疾病，特别是心力衰竭和高血压的药物。这些化合物是Na +，K + -ATP酶的酶活性的抑制剂。它们可用于制备用于治疗由内源性哇巴因的高血压作用引起的疾病的药物，例如常染色体显性多囊肾病（ADPKD）的肾衰竭进展，先兆子痫高血压和蛋白尿和肾衰竭进展 adducin多态性。

8. 发明申请

WO2008148812A1 5BETA, 14BETA-ANDROSTANE DERIVATIVES USEFUL FOR THE TREATMENT OF RESTENOSIS AFTER ANGIOPLASTIC OR ENDOARTHERECTOMY AND DISEASES DUE TO ORGAN FIBROSIS 审中-公开
标题翻译： 5BETA，14BETA-ANDROSTANE衍生物有助于治疗放射治疗或内吞治疗后由于机体性纤维化引起的疾病
公开(公告)号：WO2008148812A1
公开(公告)日：2008-12-11
申请号：PCT/EP2008/056928
申请日：2008-06-04
申请人： SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. , BERRINO, Liberato , CASCINO, Antonio , CIPOLLARO, Marilena , FORTE, Amalia , ROSSI, Francesco , BIANCHI, Giuseppe , FERRARI, Patrizia
发明人： BERRINO, Liberato , CASCINO, Antonio , CIPOLLARO, Marilena , FORTE, Amalia , ROSSI, Francesco , BIANCHI, Giuseppe , FERRARI, Patrizia
IPC分类号： A61K31/58 , A61P9/14 , A61P17/02 , A61P1/16
CPC分类号： A61K31/58
摘要： Compound of formula (I), wherein the symbol have the meaning reported in the text; for preparing a medicament for the prevention and/ or treatment of obstructive vascular lesions following vascular surgery and for the prevention and/or treatment of diseases due to organ fibrosis.
摘要翻译：式（I）的化合物，其中符号具有文本中报道的含义; 用于制备用于预防和/或治疗血管手术后的阻塞性血管病变以及用于预防和/或治疗由于器官纤维化引起的疾病的药物。

9. 发明申请

WO2009109694A2 PRE-CHAMBER ARRANGEMENT 审中-公开
标题翻译：预制安排
公开(公告)号：WO2009109694A2
公开(公告)日：2009-09-11
申请号：PCT/FI2009/050124
申请日：2009-02-16
申请人： WÄRTSILÄ FINLAND OY , SILLANPÄÄ, Hannu , HATTAR, Christer , CAFARI, Alberto , BIANCHI, Giuseppe , ZERNETTI, Gianpaolo , TREMULI, Paolo
发明人： SILLANPÄÄ, Hannu , HATTAR, Christer , CAFARI, Alberto , BIANCHI, Giuseppe , ZERNETTI, Gianpaolo , TREMULI, Paolo
IPC分类号： F02B19/00
CPC分类号： F02B19/08 , F02B19/10 , F02B19/1014 , F02B19/1023 , Y02T10/125
摘要： The invention relates to a pre-chamber arrangement for a cylinder (1) of an internal combustion engine fitted for premixed combustion (Otto cycle), the pre- chamber arrangement including a first chamber (7) for mixing and igniting of the fuel and a second chamber (8) of substantially smaller volume for communication between the first chamber (7) and the main combustion chamber (4) of the cylinder (1), the first chamber (7) being provided with pilot injection means (9) and having a chamber top substantially opposite to the second chamber (8). The first chamber (7) has substantially oval shape with curved walls between the chamber top and the second chamber (8). The second chamber (8) is asymmetrically positioned with regard to the first chamber (7) so as to provide a tumble flow motion (A) in the first chamber (7) for the gaseous fuel pressed from the main combustion chamber (4) and guided by curved wall of the first chamber (7) towards and past the fuel of pilot injection means (9) to be ignited.
摘要翻译：本发明涉及一种用于预混合燃烧（Otto循环）的内燃机的气缸（1）的预腔室装置，该预制室装置包括用于混合和点燃燃料的第一室（7）和第二室（8）具有基本上较小的体积，用于在第一室（7）和气缸（1）的主燃烧室（4）之间连通，第一室（7）设有先导喷射装置（9）基本上与第二室（8）相对的室顶部。第一腔室（7）具有大致椭圆形的形状，在腔室顶部和第二腔室（8）之间具有弯曲的壁。第二室（8）相对于第一室（7）不对称地定位，以便在第一室（7）中为从主燃烧室（4）压缩的气体燃料提供滚筒流动（A），以及由第一腔室（7）的弯曲壁引导并朝向要点燃的引燃喷射装置（9）的燃料喷射。

10. 发明申请

WO2013174447A1 A METHOD FOR IDENTIFYING POTENTIALLY MALICIOUS NETWORK ELEMENTS WITHIN A NETWORK USING CROSS-DOMAIN COLLABORATIVE DATA SHARING 审中-公开
标题翻译：使用跨域协作数据共享在网络中识别潜在恶性网络元素的方法
公开(公告)号：WO2013174447A1
公开(公告)日：2013-11-28
申请号：PCT/EP2012/059878
申请日：2012-05-25
申请人： NEC EUROPE LTD. , BOHLI, Jens-Matthias , BIANCHI, Giuseppe
发明人： BOHLI, Jens-Matthias , BIANCHI, Giuseppe
IPC分类号： H04L29/06
CPC分类号： H04L63/1441 , H04L9/085 , H04L9/3013 , H04L9/3066 , H04L63/0209 , H04L63/0227 , H04L63/0428 , H04L63/061 , H04L63/065 , H04L63/1408 , H04L63/1458 , H04L2463/144
摘要： For allowing a very effective and privacy friendly identification of potentially malicious network elements within a network a method for identifying potentially malicious network elements within a network, wherein the network comprises multiple domains administrated by different operators, is claimed. The method is characterized in that at least some of said operators transmit qualifying information regarding at least one network element, said at least one network element being qualified as being potentially malicious, to a functional entity, and wherein the functional entity provides an alarm information and/or alarm activity, if a predefined number of operators has transmitted such qualifying information regarding the same potentially malicious network element to the functional entity. Further, an according network is claimed, preferably for carrying out the above mentioned method.
摘要翻译：为了允许在网络内非常有效和隐私地识别潜在的恶意网络元件，用于识别网络内的潜在恶意网络元件的方法，其中所述网络包括由不同运营商管理的多个域。该方法的特征在于，至少一些所述运营商向功能实体发送关于至少一个网络元件（所述至少一个网络元件被认定为潜在恶意的）的资格信息，并且其中所述功能实体提供报警信息和 /或报警活动，如果预定义数量的操作者向功能实体发送了关于相同潜在的恶意网元的这种限定信息。此外，要求保护网络，优选地用于执行上述方法。

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