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1. 发明申请

WO2017005626A1 METHODS FOR GENERATING pH/IONIC CONCENTRATION GRADIENT NEAR ELECTRODE SURFACES FOR MODULATING BIOMOLECULAR INTERACTIONS, AND BUBBLE DETECTION USING ELECTRODES 审中-公开
标题翻译：用于产生pH /离子浓度梯度的方法用于调节生物分子相互作用的电极表面和使用电极的气泡检测
公开(公告)号：WO2017005626A1
公开(公告)日：2017-01-12
申请号：PCT/EP2016/065505
申请日：2016-07-01
申请人： ROBERT BOSCH GMBH
发明人： FUNK, Tobias , KAVUSI, Sam
IPC分类号： G01N27/22 , G01N27/327
CPC分类号： G01N27/3274 , G01N27/226 , G01N27/228 , G01N27/3271 , G01N27/3272 , G01N27/3276
摘要： Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest from a biological by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample.
摘要翻译：用于生物传感器的装置和方法，其包括测试位点的多位阵列，所述装置和方法可用于通过调节pH或离子来调节生物学上的（生物分子）探针或检测剂和目标分析物之间的结合相互作用在这样的生物传感器中靠近电极的梯度。适用于改变生物缓冲液pH值的生物缓冲液中的电化学活性剂。使用电化学活性剂改变生物缓冲液的pH的方法。调节生物传感器中提供的结合相互作用的方法，用于更准确地控制和测量这些生物传感器中电极附近的pH或离子梯度的分析方法，以及用于更精确地测量生物样品中感兴趣分析物的分析方法。

2. 发明申请

WO2014165198A1 GENERATION OF pH/TEMPERATURE/IONIC GRADIENTS IN LATERAL FLOW IMMUNOASSAYS FOR MODULATING BIOMOLECULAR INTERACTIONS AND ITS APPLICATIONS 审中-公开
标题翻译：用于调节生物分子相互作用的流动免疫测定中pH /温度/离子梯度的产生及其应用
公开(公告)号：WO2014165198A1
公开(公告)日：2014-10-09
申请号：PCT/US2014/024760
申请日：2014-03-12
申请人： ROBERT BOSCH GMBH , JOHNSON, Christopher , KAVUSI, Sam , AHMAD, Habib , LANG, Christoph
发明人： JOHNSON, Christopher , KAVUSI, Sam , AHMAD, Habib , LANG, Christoph
IPC分类号： B01L3/00 , G01N33/50
CPC分类号： G01N27/3276 , B01L3/5027 , B01L2300/0636 , B01L2300/0645 , B01L2300/069 , B01L2300/089 , B01L2400/0406 , G01N33/5438 , G01N33/558
摘要： Lateral flow assay devices comprising a multisite array of test sites (8) for measuring a biomolecule analyte (3) having a solid support (5) including absorbent material for providing capillary flow, one device being divided into parallel lanes (7) in the flow direction. The devices comprising a sample portion for receiving a sample; a diagnostic portion comprising a multisite array of test sites (8) each comprising a probe for the biomolecular analyte (3), wherein at each test site of the multisite array the conditions for the interaction between the biomolecular analyte and the probe can be varied independently; an absorbent portion of absorbent material for providing capillary flow; and electrodes (10) for actuating and controlling conditions. The sample portion, diagnostic portion, and absorbent portion are in capillary flow communication resulting in a capillary flow from sample portion towards absorbent portion, whereby the sample flows across the probe at each test site in the diagnostic portion to provide contact between the sample and such probe. Methods for measuring analyte concentration in a sample using such lateral flow assay devices.
摘要翻译：包括用于测量具有固体支持物（5）的生物分子分析物（3）的测试位点（8）的多部分阵列的横向流动测定装置，所述固体支撑物包括用于提供毛细血管流动的吸收材料，一个装置被分成流动的平行通道（7）方向。所述装置包括用于接收样品的样品部分; 诊断部分包括测试部位（8）的多部分阵列，每个测试部位包括用于生物分子分析物（3）的探针，其中在多位点阵列的每个测试位置处，生物分子分析物和探针之间的相互作用条件可以独立变化 ; 用于提供毛细管流的吸收材料的吸收部分; 以及用于致动和控制条件的电极（10）。样品部分，诊断部分和吸收部分处于毛细管流动连通，导致从样品部分向吸收部分的毛细管流动，由此样品在诊断部分的每个测试部位处流过探针，以提供样品与其间的接触探测。使用这种侧流测定装置测量样品中分析物浓度的方法。

3. 发明申请

WO2010101823A1 VERTICAL HALL EFFECT SENSOR WITH CURRENT FOCUS 审中-公开
标题翻译：垂直霍尔效应传感器与当前聚焦
公开(公告)号：WO2010101823A1
公开(公告)日：2010-09-10
申请号：PCT/US2010/025758
申请日：2010-03-01
申请人： ROBERT BOSCH GMBH , ROCZNIK, Thomas , LANG, Christoph , KAVUSI, Sam
发明人： ROCZNIK, Thomas , LANG, Christoph , KAVUSI, Sam
IPC分类号： H01L43/06 , G01R33/07 , H01L43/14
CPC分类号： H01L43/065 , G01R33/07 , G01R33/077 , H01L43/14
摘要： A complimentary metal oxide semiconductor (CMOS) sensor system (100) in one embodiment includes a doped substrate (102), a doped central island (108) extending downwardly within the doped substrate from an upper surface of the doped substrate, and a first doped outer island (106) extending downwardly within the doped substrate from the upper surface of the doped substrate, the first outer island electrically isolated from the central island within an upper portion of the substrate, and electrically coupled to the central island within a lower portion of the substrate.
摘要翻译：在一个实施例中，互补金属氧化物半导体（CMOS）传感器系统（100）包括掺杂衬底（102），从掺杂衬底的上表面向下延伸到掺杂衬底内的掺杂中心岛（108）和第一掺杂所述外岛（106）从所述掺杂衬底的上表面在所述掺杂衬底内向下延伸，所述第一外岛与所述衬底的上部内的所述中心岛电隔离，并且电耦合到所述中心岛的下部底物。

4. 发明申请

WO2017114947A1 INTELLIGENT DISTRIBUTED VISION TRAFFIC MARKER AND METHOD THEREOF 审中-公开
标题翻译：智能分布式视觉交通标志及其方法
公开(公告)号：WO2017114947A1
公开(公告)日：2017-07-06
申请号：PCT/EP2016/082914
申请日：2016-12-30
申请人： ROBERT BOSCH GMBH
发明人： FARAJPOUR, Pouya , LAJEVARDI, Pedram , KAVUSI, Sam , VANDERHAEGEN, Johan
IPC分类号： G08G1/017 , G08G1/02 , G08G1/054 , E01F9/50 , G08G1/01
CPC分类号： G08G1/0175 , E01F9/30 , E01F9/553 , G08G1/0116 , G08G1/0133 , G08G1/02 , G08G1/054
摘要： A vision traffic markernetwork system comprises a plurality of vision traffic markersor traffic nodes configured to capture information such as an event, an environment, a profile, or a condition of an object such as vehicle, human, combination thereof, or the like, for example. The environment information may be time of day, day of week, weather, traffic condition, and the like. The nodes may be one of a traffic node, an ambient node, a repeater, a gateway, or a combination thereof. These nodes are arranged in network neighborhoods and configured to communicate withat least oneof the communication networks with at least one of the vision traffic markersor nodes, a control system, the automotive, a server, a global navigation system, other non-vision devices, traffic lights, street lights, electronic devices, or combination thereof, via one more links, either wirelessly or wired communication. The vision traffic marker network system analysis, process, distribute, and report the information to any vision traffic marker network system,client machines, and a server over a network.
摘要翻译：视觉交通标记网络系统包括多个视觉交通标记或交通节点，该多个视景交通标记或交通节点被配置为捕获诸如车辆，人，组合等对象的事件，环境，概况或状况的信息例如，等等。环境信息可以是一天中的时间，星期几，天气，交通状况等。节点可以是业务节点，环境节点，中继器，网关或其组合中的一个。这些节点被布置在网络邻域中，并且被配置为与至少一个通信网络与视觉交通标记或节点，控制系统，汽车，服务器，全球导航系统，其他非视觉设备，交通灯，路灯，电子设备或其组合，通过一条或多条链路进行无线或有线通信。视觉交通标记网络系统通过网络对任何视觉交通标记网络系统，客户端机器和服务器进行分析，处理，分发和报告信息。

5. 发明申请

WO2017005645A1 METHODS FOR GENERATING pH/IONIC CONCENTRATION GRADIENT NEAR ELECTRODE SURFACES FOR MODULATING BIOMOLECULAR INTERACTIONS 审中-公开
标题翻译：用于产生pH /离子浓度梯度的方法用于调节生物分子相互作用的电极表面
公开(公告)号：WO2017005645A1
公开(公告)日：2017-01-12
申请号：PCT/EP2016/065564
申请日：2016-07-01
申请人： ROBERT BOSCH GMBH
发明人： GANGADHARAN, Rajan , VERMA, Piyush , JOHNSON, Christopher , KAVUSI, Sam , LAU, Aldrich
IPC分类号： G01N33/53 , G01N27/327 , G01N33/543
CPC分类号： G01N33/5306 , G01N27/3274 , G01N27/3277 , G01N27/3278 , G01N33/5438
摘要： Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest by modulating the p H or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the p H of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample.
摘要翻译：用于生物传感器的装置和方法，包括测试点的多位阵列，所述装置和方法可用于通过调节p H或离子梯度附近的p H或离子梯度来调节（生物分子）探针或检测剂与所分析物之间的结合相互作用这些生物传感器中的电极。适用于生物缓冲液中用于改变生物缓冲液的p H的电化学活性剂。使用电化学活性剂改变生物缓冲液的pH的方法。调节生物传感器中提供的结合相互作用的方法，用于更精确地控制和测量这些生物传感器中电极附近的pH或离子梯度的分析方法，以及用于更准确地测量生物样品中感兴趣的分析物的分析方法。

6. 发明申请

WO2017005638A1 METHODS FOR GENERATING pH/IONIC CONCENTRATION GRADIENT NEAR ELECTRODE SURFACES FOR MODULATING BIOMOLECULAR INTERACTIONS 审中-公开
标题翻译：在电极表面产生调节生物分子相互作用的pH /离子浓度梯度的方法
公开(公告)号：WO2017005638A1
公开(公告)日：2017-01-12
申请号：PCT/EP2016/065546
申请日：2016-07-01
申请人： ROBERT BOSCH GMBH
发明人： GANGADHARAN, Rajan , VERMA, Piyush , JOHNSON, Christopher , KAVUSI, Sam , LAU, Aldrich
IPC分类号： G01N33/53 , G01N27/327 , G01N33/543
CPC分类号： G01N33/5306 , G01N27/3274 , G01N27/3277 , G01N27/3278 , G01N33/5438
摘要： Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest by modulating the p H or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the p H of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample.
摘要翻译：用于包含测试位点的多位点阵列的生物传感器中的装置和方法，所述装置和方法可用于调节（生物分子）探针或检测剂与感兴趣分析物之间的结合相互作用调节这种生物传感器中电极附近的p H或离子梯度。一种适用于生物缓冲液中改变生物缓冲液pH值的电化学活性剂。使用电化学活性剂改变生物缓冲液的pH的方法。调节生物传感器中提供的结合相互作用的方法，用于更精确地控制和测量此类生物传感器中电极附近的pH或离子梯度的分析方法，以及用于更准确地测量生物样品中感兴趣的分析物的分析方法。 p>

7. 发明申请

WO2014151690A1 DEVICE AND METHOD FOR ACCURATE PH MONITORING ON TRANSPARENT MICROARRAYS 审中-公开
标题翻译：用于精确监测透明微波的装置和方法
公开(公告)号：WO2014151690A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/026250
申请日：2014-03-13
申请人： ROBERT BOSCH GMBH , FOMINA, Nadezda , JOHNSON, Christopher , KAVUSI, Sam , AHMAD, Habib
发明人： FOMINA, Nadezda , JOHNSON, Christopher , KAVUSI, Sam , AHMAD, Habib
IPC分类号： G01N27/327 , G01N33/543
CPC分类号： G01N33/5438 , G01N27/3272
摘要： Device for use in a biosensor comprising a multisite array of test sites, the device being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest from a biological by modulating the pH or ionic gradient near the electrodes in such biosensor. The device provides a biosensor which is more accurate, reliable and the results of which are more reproducible. Analytic methods for more accurately measuring an analyte of interest in a biological sample are also provided.
摘要翻译：用于生物传感器的装置，其包括测试位点的多位阵列，该装置可用于通过调节电极附近的pH或离子梯度来调节生物学上的（生物分子）探针或检测剂和目标分析物之间的结合相互作用在这样的生物传感器。该装置提供了更准确，可靠的生物传感器，其结果更加可重现。还提供了用于更精确地测量生物样品中感兴趣的分析物的分析方法。

8. 发明申请

WO2014085647A1 METHODS TO COMBINE RADIATION-BASED TEMPERATURE SENSOR AND INERTIAL SENSOR AND/OR CAMERA OUTPUT IN A HANDHELD/MOBILE DEVICE 审中-公开
标题翻译：在手持/移动设备中组合基于辐射的温度传感器和惯性传感器和/或摄像机输出的方法
公开(公告)号：WO2014085647A1
公开(公告)日：2014-06-05
申请号：PCT/US2013/072321
申请日：2013-11-27
申请人： ROBERT BOSCH GMBH , FEYH, Ando , KAVUSI, Sam , VANDERHAEGEN, Johan , YAMA, Gary , PURKL, Fabian
发明人： FEYH, Ando , KAVUSI, Sam , VANDERHAEGEN, Johan , YAMA, Gary , PURKL, Fabian
IPC分类号： H04N5/349 , G01J5/02 , G01J5/08
CPC分类号： H04N5/33 , G01J5/025 , G01J5/0265 , G01J5/0831 , G01J5/0859 , G01J5/089 , H04N5/2258 , H04N5/23232 , H04N5/23258 , H04N5/332 , H04N13/25
摘要： A device for generating thermal images includes a low resolution infrared (IR) sensor supported within a housing and having a field of view. The IR sensor is configured to generate thermal images of objects within the field of view having a first resolution. A spatial information sensor supported within the housing is configured to determine a position for each of the thermal images generated by the IR sensor. A processing unit supported within the housing is configured to receive the thermal images and to combine the thermal images based on the determined positions of the thermal images to produce a combined thermal image having a second resolution that is greater than the first resolution.
摘要翻译：用于产生热图像的装置包括支撑在壳体内并且具有视野的低分辨率红外（IR）传感器。 IR传感器被配置为产生具有第一分辨率的视场内的物体的热图像。支撑在壳体内的空间信息传感器被配置为确定由IR传感器产生的每个热图像的位置。支撑在壳体内的处理单元被配置为接收热图像并且基于所确定的热图像的位置来组合热图像以产生具有大于第一分辨率的第二分辨率的组合热图像。

9. 发明申请

WO2014008038A1 METHODS FOR GENERATING PH/IONIC CONCENTRATION GRADIENT NEAR ELECTRODE SURFACES FOR MODULATING BIOMOLECULAR INTERACTIONS 审中-公开
标题翻译：用于生成用于调节生物分子相互作用的靠近电极表面的PH /离子浓度梯度的方法
公开(公告)号：WO2014008038A1
公开(公告)日：2014-01-09
申请号：PCT/US2013/047563
申请日：2013-06-25
申请人： ROBERT BOSCH GMBH , KAVUSI, Sam , GANGADHARAN, Rajan , JOHNSON, Christopher , LAU, Aldrich, N.K. , VERMA, Piyush
发明人： KAVUSI, Sam , GANGADHARAN, Rajan , JOHNSON, Christopher , LAU, Aldrich, N.K. , VERMA, Piyush
IPC分类号： G01N33/50 , G01N33/53
CPC分类号： G01N33/50 , G01N27/3275 , G01N33/5306
摘要： Methods of modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest from a biological sample in a biosensor having a multisite array of test sites. In particular, the methods modulate the pH or ionic concentration gradient near the electrodes in such biosensor. The methods of modulating the binding interactions provide a biosensor and analytic methods for more accurately measuring an analyte of interest in a biological sample.
摘要翻译：在生物传感器中调节生物样品中生物分子探针或检测剂与目的分析物之间的结合相互作用的方法，该生物传感器具有多个测试位点阵列。特别地，该方法调节这种生物传感器中电极附近的pH或离子浓度梯度。调节结合相互作用的方法提供了生物传感器和分析方法，用于更精确地测量生物样品中感兴趣的分析物。

10. 发明申请

WO2012106194A3 BIOMARKER MONITORING DEVICE AND METHOD 审中-公开
公开(公告)号：WO2012106194A3
公开(公告)日：2012-08-09
申请号：PCT/US2012/022862
申请日：2012-01-27
申请人： ROBERT BOSCH GMBH , KAVUSI, Sam , LANG, Christoph
发明人： KAVUSI, Sam , LANG, Christoph
IPC分类号： G06F19/28
摘要： A biomarker monitoring method and system in one embodiment includes a communications network, a portable wellness device configured to form a communication link with the communications network, the portable wellness device including a detector configured to detect at least one biomarker in a biologic sample, a first memory, a plurality of program instructions stored in the first memory, and a processing circuit operably connected to the first memory and configured to execute the program instructions to generate wellness data based upon detection of the at least one biomarker in the biologic sample, and a remote user interface operably connected to the communications network and configured to render the wellness data.

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