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1. 发明申请

WO2014151690A1 DEVICE AND METHOD FOR ACCURATE PH MONITORING ON TRANSPARENT MICROARRAYS 审中-公开
标题翻译：用于精确监测透明微波的装置和方法
公开(公告)号：WO2014151690A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/026250
申请日：2014-03-13
申请人： ROBERT BOSCH GMBH , FOMINA, Nadezda , JOHNSON, Christopher , KAVUSI, Sam , AHMAD, Habib
发明人： FOMINA, Nadezda , JOHNSON, Christopher , KAVUSI, Sam , AHMAD, Habib
IPC分类号： G01N27/327 , G01N33/543
CPC分类号： G01N33/5438 , G01N27/3272
摘要： Device for use in a biosensor comprising a multisite array of test sites, the device being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest from a biological by modulating the pH or ionic gradient near the electrodes in such biosensor. The device provides a biosensor which is more accurate, reliable and the results of which are more reproducible. Analytic methods for more accurately measuring an analyte of interest in a biological sample are also provided.
摘要翻译：用于生物传感器的装置，其包括测试位点的多位阵列，该装置可用于通过调节电极附近的pH或离子梯度来调节生物学上的（生物分子）探针或检测剂和目标分析物之间的结合相互作用在这样的生物传感器。该装置提供了更准确，可靠的生物传感器，其结果更加可重现。还提供了用于更精确地测量生物样品中感兴趣的分析物的分析方法。

2. 发明申请

WO2022016087A1 ELECTRONIC CONTROL OF THE PH OF A SOLUTION CLOSE TO AN ELECTRODE SURFACE 审中-公开
公开(公告)号：WO2022016087A1
公开(公告)日：2022-01-20
申请号：PCT/US2021/042031
申请日：2021-07-16
申请人： ROBERT BOSCH GMBH , JOHNSON, Christopher , KAVUSI, Sam , FOMINA, Nadezda , AHMAD, Habib , MARUNIAK, Autumn , LANG, Christoph , RAGHUNATHAN, Ashwin , SHIN, Young Shik , DARVISH, Armin , PAPAGEORGIOU, Efthymios
发明人： JOHNSON, Christopher , KAVUSI, Sam , FOMINA, Nadezda , AHMAD, Habib , MARUNIAK, Autumn , LANG, Christoph , RAGHUNATHAN, Ashwin , SHIN, Young Shik , DARVISH, Armin , PAPAGEORGIOU, Efthymios
IPC分类号： C12Q1/00 , G01N27/30 , G01N27/34
摘要： Device and methods for controlling pH or ionic gradient comprising a multisite array of feedback electrode sets comprising electrodes and pH sensing elements. The electrodes can include a reference electrode, counter electrode, and a working electrode. The device and methods iteratively select an amount of current and/or voltage to be applied to each working electrode, apply the selected amount of current and/or voltage to each working electrode to change pH of a solution close to the working electrode, and measure the signal output of the sensing element. The multisite array can include feedback and non-feedback electrode sets.

3. 发明申请

WO2014165198A1 GENERATION OF pH/TEMPERATURE/IONIC GRADIENTS IN LATERAL FLOW IMMUNOASSAYS FOR MODULATING BIOMOLECULAR INTERACTIONS AND ITS APPLICATIONS 审中-公开
标题翻译：用于调节生物分子相互作用的流动免疫测定中pH /温度/离子梯度的产生及其应用
公开(公告)号：WO2014165198A1
公开(公告)日：2014-10-09
申请号：PCT/US2014/024760
申请日：2014-03-12
申请人： ROBERT BOSCH GMBH , JOHNSON, Christopher , KAVUSI, Sam , AHMAD, Habib , LANG, Christoph
发明人： JOHNSON, Christopher , KAVUSI, Sam , AHMAD, Habib , LANG, Christoph
IPC分类号： B01L3/00 , G01N33/50
CPC分类号： G01N27/3276 , B01L3/5027 , B01L2300/0636 , B01L2300/0645 , B01L2300/069 , B01L2300/089 , B01L2400/0406 , G01N33/5438 , G01N33/558
摘要： Lateral flow assay devices comprising a multisite array of test sites (8) for measuring a biomolecule analyte (3) having a solid support (5) including absorbent material for providing capillary flow, one device being divided into parallel lanes (7) in the flow direction. The devices comprising a sample portion for receiving a sample; a diagnostic portion comprising a multisite array of test sites (8) each comprising a probe for the biomolecular analyte (3), wherein at each test site of the multisite array the conditions for the interaction between the biomolecular analyte and the probe can be varied independently; an absorbent portion of absorbent material for providing capillary flow; and electrodes (10) for actuating and controlling conditions. The sample portion, diagnostic portion, and absorbent portion are in capillary flow communication resulting in a capillary flow from sample portion towards absorbent portion, whereby the sample flows across the probe at each test site in the diagnostic portion to provide contact between the sample and such probe. Methods for measuring analyte concentration in a sample using such lateral flow assay devices.
摘要翻译：包括用于测量具有固体支持物（5）的生物分子分析物（3）的测试位点（8）的多部分阵列的横向流动测定装置，所述固体支撑物包括用于提供毛细血管流动的吸收材料，一个装置被分成流动的平行通道（7）方向。所述装置包括用于接收样品的样品部分; 诊断部分包括测试部位（8）的多部分阵列，每个测试部位包括用于生物分子分析物（3）的探针，其中在多位点阵列的每个测试位置处，生物分子分析物和探针之间的相互作用条件可以独立变化 ; 用于提供毛细管流的吸收材料的吸收部分; 以及用于致动和控制条件的电极（10）。样品部分，诊断部分和吸收部分处于毛细管流动连通，导致从样品部分向吸收部分的毛细管流动，由此样品在诊断部分的每个测试部位处流过探针，以提供样品与其间的接触探测。使用这种侧流测定装置测量样品中分析物浓度的方法。

4. 发明申请

WO2014008038A1 METHODS FOR GENERATING PH/IONIC CONCENTRATION GRADIENT NEAR ELECTRODE SURFACES FOR MODULATING BIOMOLECULAR INTERACTIONS 审中-公开
标题翻译：用于生成用于调节生物分子相互作用的靠近电极表面的PH /离子浓度梯度的方法
公开(公告)号：WO2014008038A1
公开(公告)日：2014-01-09
申请号：PCT/US2013/047563
申请日：2013-06-25
申请人： ROBERT BOSCH GMBH , KAVUSI, Sam , GANGADHARAN, Rajan , JOHNSON, Christopher , LAU, Aldrich, N.K. , VERMA, Piyush
发明人： KAVUSI, Sam , GANGADHARAN, Rajan , JOHNSON, Christopher , LAU, Aldrich, N.K. , VERMA, Piyush
IPC分类号： G01N33/50 , G01N33/53
CPC分类号： G01N33/50 , G01N27/3275 , G01N33/5306
摘要： Methods of modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest from a biological sample in a biosensor having a multisite array of test sites. In particular, the methods modulate the pH or ionic concentration gradient near the electrodes in such biosensor. The methods of modulating the binding interactions provide a biosensor and analytic methods for more accurately measuring an analyte of interest in a biological sample.
摘要翻译：在生物传感器中调节生物样品中生物分子探针或检测剂与目的分析物之间的结合相互作用的方法，该生物传感器具有多个测试位点阵列。特别地，该方法调节这种生物传感器中电极附近的pH或离子浓度梯度。调节结合相互作用的方法提供了生物传感器和分析方法，用于更精确地测量生物样品中感兴趣的分析物。

5. 发明申请

WO2010101823A1 VERTICAL HALL EFFECT SENSOR WITH CURRENT FOCUS 审中-公开
标题翻译：垂直霍尔效应传感器与当前聚焦
公开(公告)号：WO2010101823A1
公开(公告)日：2010-09-10
申请号：PCT/US2010/025758
申请日：2010-03-01
申请人： ROBERT BOSCH GMBH , ROCZNIK, Thomas , LANG, Christoph , KAVUSI, Sam
发明人： ROCZNIK, Thomas , LANG, Christoph , KAVUSI, Sam
IPC分类号： H01L43/06 , G01R33/07 , H01L43/14
CPC分类号： H01L43/065 , G01R33/07 , G01R33/077 , H01L43/14
摘要： A complimentary metal oxide semiconductor (CMOS) sensor system (100) in one embodiment includes a doped substrate (102), a doped central island (108) extending downwardly within the doped substrate from an upper surface of the doped substrate, and a first doped outer island (106) extending downwardly within the doped substrate from the upper surface of the doped substrate, the first outer island electrically isolated from the central island within an upper portion of the substrate, and electrically coupled to the central island within a lower portion of the substrate.
摘要翻译：在一个实施例中，互补金属氧化物半导体（CMOS）传感器系统（100）包括掺杂衬底（102），从掺杂衬底的上表面向下延伸到掺杂衬底内的掺杂中心岛（108）和第一掺杂所述外岛（106）从所述掺杂衬底的上表面在所述掺杂衬底内向下延伸，所述第一外岛与所述衬底的上部内的所述中心岛电隔离，并且电耦合到所述中心岛的下部底物。

6. 发明申请

WO2013106790A1 DEVICE AND METHOD FOR INDIRECT ELECTRONIC CONDITION CONTROL IN BIOMOLECULE DETECTION PLATFORMS 审中-公开
标题翻译：生物分子检测平台中间接电子条件控制的装置和方法
公开(公告)号：WO2013106790A1
公开(公告)日：2013-07-18
申请号：PCT/US2013/021333
申请日：2013-01-12
申请人： ROBERT BOSCH GMBH , CHEN, Michael , CHEN, Vincent , KAVUSI, Sam , LANG, Christoph
发明人： CHEN, Michael , CHEN, Vincent , KAVUSI, Sam , LANG, Christoph
IPC分类号： G01N33/543
CPC分类号： G01N33/54306 , G01N33/54366 , G01N33/54393
摘要： A system and method of indirectly modifying an environmental condition at a test site in one embodiment includes providing a test site on a substrate, providing a hydrogel composition loaded with a chemical factor at the test site, providing an actuator configured to activate the hydrogel composition to release a chemical factor at the test site, controlling the actuator to activate the hydrogel composition to release a chemical factor at the test site, and modifying the local chemical environment at the test site with the chemical factor.
摘要翻译：在一个实施方案中间接改变测试部位的环境条件的系统和方法包括在基底上提供测试部位，在测试部位提供装载有化学因子的水凝胶组合物，提供构造成将水凝胶组合物活化的致动器在试验现场释放化学因子，控制致动器激活水凝胶组合物以释放在试验部位的化学因子，并用化学因子改变试验部位的局部化学环境。

7. 发明申请

WO2011143188A1 DEVICE AND METHOD FOR INDIRECT MODULATION OF DETECTION ENVIRONMENT 审中-公开
标题翻译：检测环境的间接调制装置和方法
公开(公告)号：WO2011143188A1
公开(公告)日：2011-11-17
申请号：PCT/US2011/035882
申请日：2011-05-10
申请人： ROBERT BOSCH GMBH , KAVUSI, Sam , CHEN, Yi, Wei , CHEN, Michael , LANG, Christoph
发明人： KAVUSI, Sam , CHEN, Yi, Wei , CHEN, Michael , LANG, Christoph
IPC分类号： G01N33/543
CPC分类号： G01N33/54306 , G01N33/54366 , G01N33/54393 , Y10T436/25
摘要： A system and method of indirectly modifying an environmental condition at a test site in one embodiment includes providing a test site on a substrate, providing a first activatable stimulant at the test site, providing an actuator configured to activate the first activatable stimulant at the test site, controlling the actuator to activate the first activatable stimulant, and modifying the local chemical environment at the test site with the first activated stimulant.
摘要翻译：在一个实施方案中间接改变测试部位环境条件的系统和方法包括在基底上提供测试部位，在测试部位提供第一可激活的刺激剂，提供构造成在测试部位激活第一可活化刺激物的致动器控制致动器来激活第一可激活的兴奋剂，以及用第一个激活的兴奋剂改变测试部位的局部化学环境。

8. 发明申请

WO2014085647A1 METHODS TO COMBINE RADIATION-BASED TEMPERATURE SENSOR AND INERTIAL SENSOR AND/OR CAMERA OUTPUT IN A HANDHELD/MOBILE DEVICE 审中-公开
标题翻译：在手持/移动设备中组合基于辐射的温度传感器和惯性传感器和/或摄像机输出的方法
公开(公告)号：WO2014085647A1
公开(公告)日：2014-06-05
申请号：PCT/US2013/072321
申请日：2013-11-27
申请人： ROBERT BOSCH GMBH , FEYH, Ando , KAVUSI, Sam , VANDERHAEGEN, Johan , YAMA, Gary , PURKL, Fabian
发明人： FEYH, Ando , KAVUSI, Sam , VANDERHAEGEN, Johan , YAMA, Gary , PURKL, Fabian
IPC分类号： H04N5/349 , G01J5/02 , G01J5/08
CPC分类号： H04N5/33 , G01J5/025 , G01J5/0265 , G01J5/0831 , G01J5/0859 , G01J5/089 , H04N5/2258 , H04N5/23232 , H04N5/23258 , H04N5/332 , H04N13/25
摘要： A device for generating thermal images includes a low resolution infrared (IR) sensor supported within a housing and having a field of view. The IR sensor is configured to generate thermal images of objects within the field of view having a first resolution. A spatial information sensor supported within the housing is configured to determine a position for each of the thermal images generated by the IR sensor. A processing unit supported within the housing is configured to receive the thermal images and to combine the thermal images based on the determined positions of the thermal images to produce a combined thermal image having a second resolution that is greater than the first resolution.
摘要翻译：用于产生热图像的装置包括支撑在壳体内并且具有视野的低分辨率红外（IR）传感器。 IR传感器被配置为产生具有第一分辨率的视场内的物体的热图像。支撑在壳体内的空间信息传感器被配置为确定由IR传感器产生的每个热图像的位置。支撑在壳体内的处理单元被配置为接收热图像并且基于所确定的热图像的位置来组合热图像以产生具有大于第一分辨率的第二分辨率的组合热图像。

9. 发明申请

WO2012106194A3 BIOMARKER MONITORING DEVICE AND METHOD 审中-公开
公开(公告)号：WO2012106194A3
公开(公告)日：2012-08-09
申请号：PCT/US2012/022862
申请日：2012-01-27
申请人： ROBERT BOSCH GMBH , KAVUSI, Sam , LANG, Christoph
发明人： KAVUSI, Sam , LANG, Christoph
IPC分类号： G06F19/28
摘要： A biomarker monitoring method and system in one embodiment includes a communications network, a portable wellness device configured to form a communication link with the communications network, the portable wellness device including a detector configured to detect at least one biomarker in a biologic sample, a first memory, a plurality of program instructions stored in the first memory, and a processing circuit operably connected to the first memory and configured to execute the program instructions to generate wellness data based upon detection of the at least one biomarker in the biologic sample, and a remote user interface operably connected to the communications network and configured to render the wellness data.

10. 发明申请

WO2011097552A1 ARRAY WITH EXTENDED DYNAMIC RANGE AND ASSOCIATED METHOD 审中-公开
标题翻译：具有扩展的动态范围和相关方法的阵列
公开(公告)号：WO2011097552A1
公开(公告)日：2011-08-11
申请号：PCT/US2011/023863
申请日：2011-02-07
申请人： ROBERT BOSCH GMBH , KAVUSI, Sam , LAUPHEIMER, Michaela , LANG, Christoph
发明人： KAVUSI, Sam , LAUPHEIMER, Michaela , LANG, Christoph
IPC分类号： G01N33/543 , G01N33/558
CPC分类号： G01N33/54306 , G01N33/558
摘要： A system and method of quantitating the concentration of a molecule of interest in one embodiment includes establishing a plurality of test environments at a plurality of test sites, each of the plurality of test environments associated with one of a plurality of response curves, each of the plurality of response curves different from the other of the plurality of response curves, storing a combined response curve resulting from a summation of the plurality of response curves, exposing the plurality of test sites to a sample having a concentration of a molecule of interest, obtaining a plurality of quantitation signals, each of the plurality of quantitation signals associated with one of the plurality of test sites, associating a summation of the plurality of quantitation signals with the stored combined response curve, and generating a signal related to the concentration of the molecule of interest based upon the association.
摘要翻译：在一个实施方案中定量感兴趣的分子的浓度的系统和方法包括在多个测试位置建立多个测试环境，所述多个测试环境中的每一个与多个响应曲线之一相关联，每个测试环境多个响应曲线不同于多个响应曲线中的另一个响应曲线，存储由多个响应曲线的总和产生的组合响应曲线，将多个测试位置暴露于具有感兴趣分子浓度的样本，获得多个定量信号，所述多个定量信号中的每一个与所述多个测试点之一相关联，将所述多个定量信号的总和与所存储的组合响应曲线相关联，并产生与所述分子的浓度相关的信号基于协会的兴趣。

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