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1. 发明申请

WO2011041495A1 TISSUE PROCESSING CASSETTE 审中-公开
标题翻译：组织加工CASSETTE
公开(公告)号：WO2011041495A1
公开(公告)日：2011-04-07
申请号：PCT/US2010/050843
申请日：2010-09-30
申请人： RICHARD-ALLAN SCIENTIFIC COMPANY , MILLER, Andrew, David , DAVIES, Robert, Paul , POUNCEY, Mathew
发明人： MILLER, Andrew, David , DAVIES, Robert, Paul , POUNCEY, Mathew
IPC分类号： C12M3/00
CPC分类号： G01N1/31 , G01N2035/00306
摘要： A device (10, 100) for use in handling and processing of a sample. The device (10, 100) includes a sample processing cassette (12, 1 12) having a sample container portion (14, 1 14) configured to contain a sample therein and an extension member (26, 126) operatively coupled to the sample container portion (14, 1 14). The device (10, 1 10) is size-adjustable to present a first footprint of a standard sized cassette for use during certain automated steps designed to function with standard sized cassettes, such as labeling, embedding and sectioning (microtomy), and a second reduced footprint for use during chemical processing, such as fixation and dehydration.
摘要翻译：一种用于处理和处理样品的装置（10,100）。装置（10,100）包括具有构造成容纳样品的样品容器部分（14,144）的样品处理盒（12,122）和可操作地连接到样品容器的延伸构件（26,126）部分（14,144）。所述装置（10,110）可调节尺寸，以呈现标准尺寸盒的第一印迹，以便在设计成与标准尺寸的盒（例如标签，嵌入和切片（切片））一起工作的某些自动化步骤期间使用，以及第二减少化学处理过程中使用的占地面积，如固定和脱水。

2. 发明申请

WO2003047549A3 POST-COATED LIPOSOME/LIPOPLEX FOR TARGETED DRUG/GENE DELIVERY AND LIPID LINKED TO A DELIVERY, TARGETING OR STABILISING MOIETY 审中-公开
公开(公告)号：WO2003047549A3
公开(公告)日：2003-06-12
申请号：PCT/GB2002/005471
申请日：2002-12-04
申请人： MITSUBISHI CHEMICAL CORPORATION , JORGENSEN, Michael , KELLER, Michael , MILLER, Andrew, David , PEROUZEL, Eric
发明人： JORGENSEN, Michael , KELLER, Michael , MILLER, Andrew, David , PEROUZEL, Eric
IPC分类号： A61K47/48
摘要： The present invention provides a delivery vehicle for a therapeutic agent comprising a modified lipid and a therapeutic agent; wherein the modified lipid comprises a lipid and a delivery, targeting or stabilising moiety (DTS moiety); wherein the lipid is linked to the DTS moiety via a linker which is stable in biological fluid and which is unstable in defined conditions; and wherein the DTS moiety is linked to the lipid alter formation of a complex of lipid and therapeutic agent.

3. 发明申请

WO2003011252A1 PHARMACEUTICAL COMPOSITION COMPRISING LIPIDS COMPRISING A POLAR AND A NONPOLAR MOIETY 审中-公开
标题翻译：包含极性和非极性环境的脂肪的药物组合物
公开(公告)号：WO2003011252A1
公开(公告)日：2003-02-13
申请号：PCT/GB2002/003488
申请日：2002-07-29
申请人： MITSUBISHI CHEMICAL CORPORATION , FLETCHER, Steven , JORGENSEN, Michael, R. , MILLER, Andrew, David
发明人： FLETCHER, Steven , JORGENSEN, Michael, R. , MILLER, Andrew, David
IPC分类号： A61K9/127
CPC分类号： A61K9/1273
摘要： The present invention provides a composition comprising (i) a lipid compound comprising at least one non-polar moiety and a polar moiety, wherein the non-polar moiety is of the formula X-Y-Z- wherein X is an acetylenic hydrocarbyl group containing a single C≡C bond, Y is O or CH 2 , and Z is an optional hydrocarbyl group, wherein the polar moiety is of the formula -[T] m PHG, wherein [T] m is an optional group selected from C(O), NH, NR 1 , NHC(O), C(O)NH, NR 1 C(O) and C(O)NR 1 and CH 2 , where R 1 is a hydrocarbyl group, wherein PHG is a polar head group, and wherein m is the number of non-polar moieties (ii) a therapeutic agent.
摘要翻译：本发明提供一种组合物，其包含（i）包含至少一个非极性部分和极性部分的脂质化合物，其中所述非极性部分具有式XYZ-，其中X是含有单个CC键的炔属烃基，Y是O或CH 2，Z是任选的烃基，其中极性部分具有式 - [T] m PHG，其中[T] m是选自C（O），NH，NR 1，NHC （O），C（O）NH，NR1C（O）和C（O）NR1和CH2，其中R1是烃基，其中PHG是极性头基，其中m是非极性部分的数目 ii）治疗剂。

4. 发明申请

WO2007072042A2 METHODS 审中-公开
标题翻译：方法
公开(公告)号：WO2007072042A2
公开(公告)日：2007-06-28
申请号：PCT/GB2006/004898
申请日：2006-12-22
申请人： IMPERIAL INNOVATIONS LIMITED , FREEMAN, Thomas, Charles , MILLER, Andrew, David , PALMER, Ella, Louise
发明人： FREEMAN, Thomas, Charles , MILLER, Andrew, David , PALMER, Ella, Louise
CPC分类号： C07K14/4747
摘要： The present invention relates to the treatment and/or prophylaxis of a disease through the regulation of one or more genes involved in apoptosis. The invention also relates to a vector for use in regulating expression of the one or more genes in the treatment and/or prophylaxis of a disease involving apoptosis.
摘要翻译：本发明涉及通过调节参与凋亡的一种或多种基因治疗和/或预防疾病。本发明还涉及用于调节一种或多种基因在治疗和/或预防涉及凋亡的疾病中的表达的载体。

5. 发明申请

WO2003047549A2 COMPOUND 审中-公开
标题翻译：复合
公开(公告)号：WO2003047549A2
公开(公告)日：2003-06-12
申请号：PCT/GB2002/005471
申请日：2002-12-04
申请人： MITSUBISHI CHEMICAL CORPORATION , JORGENSEN, Michael , KELLER, Michael , MILLER, Andrew, David , PEROUZEL, Eric
发明人： JORGENSEN, Michael , KELLER, Michael , MILLER, Andrew, David , PEROUZEL, Eric
IPC分类号： A61K9/00
CPC分类号： C07J41/0055 , A61K9/1272 , A61K47/54 , A61K47/541 , A61K47/543 , A61K47/544
摘要： The present invention provides a delivery vehicle for a therapeutic agent comprising a modified lipid and a therapeutic agent; wherein the modified lipid comprises a lipid and a delivery, targeting or stabilising moiety (DTS moiety); wherein the lipid is linked to the DTS moiety via a linker which is stable in biological fluid and which is unstable in defined conditions; and wherein the DTS moiety is linked to the lipid alter formation of a complex of lipid and therapeutic agent.
摘要翻译：本发明提供了包含改性脂质和治疗剂的治疗剂的递送载体; 其中所述修饰的脂质包含脂质和递送，靶向或稳定部分（DTS部分）; 其中所述脂质通过在生物流体中稳定且在限定条件下不稳定的接头连接到DTS部分; 并且其中DTS部分与脂质和治疗剂复合体的脂质变化形成有关。

6. 发明申请

WO2011061541A1 LIPOSOME NANOPARTICLES FOR TUMOR MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：用于肿瘤磁共振成像的脂质体纳米颗粒
公开(公告)号：WO2011061541A1
公开(公告)日：2011-05-26
申请号：PCT/GB2010/051925
申请日：2010-11-19
申请人： MEDICAL RESEARCH COUNCIL , IMPERIAL INNOVATIONS LIMITED , KAMALY, Nazila , KALBER, Tammy, Louise , KENNY, Gavin, David , THANOU, Maya , MILLER, Andrew, David , BELL, Jimmy
发明人： KAMALY, Nazila , KALBER, Tammy, Louise , KENNY, Gavin, David , THANOU, Maya , MILLER, Andrew, David , BELL, Jimmy
IPC分类号： A61K49/18
CPC分类号： A61K49/1812 , B82Y5/00 , Y10S977/773
摘要： The present invention provides novel liposomes comprising Gd.DOTA.DSA (gadolinium (III) 2-{4,7-bis-carboxymethyl-10-[( N , N -distearylamidomethyl- N `-amido-methyl]-1,4,7,10- tetra-azacyclododec-1-yl}-acetic acid), characterised in that said liposome further comprises a neutral, fully saturated phospholipid component ( e.g. DSPC (1,2-distearoyl- sn -glycero-3-phospocholine]), which are of particular use in the preparation of magnetic resonance contrast agents for enhancing a magnetic resonance image of tumours in a mammal.
摘要翻译：本发明提供了包含Gd.DOTA.DSA（钆（III）2- {4,7-双 - 羧甲基-10 - [（N，N-二硬脂酰氨基甲基-N'-酰胺基 - 甲基] 7,10-四氮杂环十二烷-1-基} - 乙酸），其特征在于所述脂质体还包含中性完全饱和的磷脂组分（例如DSPC（1,2-二硬脂酰-sn-甘油-3-磷酸胆碱）），其特别用于制备用于增强哺乳动物肿瘤的磁共振图像的磁共振造影剂。

7. 发明申请

WO2008078102A3 LIPIDS AND THEIR USE AS NON-VIRAL DELIVERY VEHICLE 审中-公开
公开(公告)号：WO2008078102A3
公开(公告)日：2008-07-03
申请号：PCT/GB2007/004967
申请日：2007-12-21
申请人： IMUTHES LIMITED , UNIVERSITY OF THE WITWATERSRAND , MILLER, Andrew, David , ARBUTHNOT, Patrick , JORGENSEN, Michael , KELLER, Michael , KAMALY, Nazila , AISSAOUI, Abderrahim , THANOU, Maya
发明人： MILLER, Andrew, David , ARBUTHNOT, Patrick , JORGENSEN, Michael , KELLER, Michael , KAMALY, Nazila , AISSAOUI, Abderrahim , THANOU, Maya
IPC分类号： A61K9/127 , A61K47/34 , A61K47/48 , C07C237/22 , C07F9/10 , C07J41/00 , C08G73/02 , C12N15/88
摘要： The present invention provides a lipid of the formula (I) R 3 R 4 N-[Y] q -(C p H 2p )-X-Linker-NR 1 R 2 (I) wherein R 3 and R 4 are independently selected from H and hydrocarbyl groups; q is an integer selected from 1 to 10; Y represents a group (C n H 2n )NR 5 , wherein (i) when q is 1, n is 2, or (ii) when q is greater than 1, each Y may be the same or different and each n is an integer independently selected from 1 to 10, with the proviso that for at least one unit Y, n is 2, and (iii) each R 5 is independently selected from H and hydrocarbyl groups; p is an integer selected from 1 to 10; X is an optional group selected from -NR 7 -, -C(=O)-N R 8 -, -NR 9 -C(=O)-, -C(=O)-, -O-, and -NR 10 -C(=0)0-, wherein each R 7 , R 8 , R 9 and R 10 is independently selected from H and hydrocarbyl groups, Linker is an optional group selected from amino acid residues, peptide residues and groups of the formula -(OCH 2 CH 2 ) 1-10 , -NR 6 -(CvH 2v )-C(=O)-, wherein R 6 is H or a hydrocarbyl group and v is an integer selected from 1 to 11, and -C(=0)-(CH 2 ) 0-10 -CH 2 -C(=0)-; R 1 is selected from acyclic groups having from 4 to 30 carbon atoms; and R 2 is selected from H and acyclic groups having from 4 to 30 carbon atoms. Said lipids can be used in a delivery vehicle (e.g. micelle or liposome) for the delivery of one or more (therapeutic or diagnostic) agents.

8. 发明申请

WO2006082397A1 NEW USES OF DINUCLEOTIDE POLYPHOSPHATE DERIVATIVES 审中-公开
标题翻译：新型磷酸二氢钙衍生物的应用
公开(公告)号：WO2006082397A1
公开(公告)日：2006-08-10
申请号：PCT/GB2006/000343
申请日：2006-02-01
申请人： IC VEC LIMITED , MILLER, Andrew, David , WRIGHT, Michael , TANNER, Julian, Alexander , LOZOVAYA, Natalya
发明人： MILLER, Andrew, David , WRIGHT, Michael , TANNER, Julian, Alexander , LOZOVAYA, Natalya
IPC分类号： A61K31/7084 , C07H21/00 , C07H21/02 , C07H21/04
CPC分类号： A61K31/7084 , C07H21/00 , C07H21/02 , C07H21/04
摘要： The present invention provides the use of analogues and derivatives of dinucleoside polyphosphates with formula (I) or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in one or more of: the treatment of ischemia, inducing ischemic tolerance, modulating cerebral ischemia, to delay the onset of a hypoxic depolarisation stage when ischemic events are initiated; as a neurological protection agent; as a tissue protection agent; the treatment of pain; and the treatment of inflammation, wherein X, is selected from wherein X 1 and X 2 are independently selected from H, Cl, Br and F; each Y is independently selected from S and O; each Z is independently selected from -CX 3 X 4 -,-NH-,-O- ; wherein X 3 and X 4 are selected from H, CI, Br and F; B1 and B2 are independently selected from adenine, guanine, xanthine, thymine, uracil, cytosine and inosine; S 1 and S 2 are independently selected from ribose, open chain ribose, 2'-deoxyribose, 3'deoxyribose and arabinofuranoside. V is selected from 0, 1 , 2, 3, 4 and 5; W is selected from 0, 1 , 2, 3, 4 and 5; and V plus W is an integer from 2 to 6.
摘要翻译：本发明提供了式（I）的二核苷多磷酸类似物和衍生物或其药学上可接受的盐在制备用于以下一种或多种中的一种或多种药物中的用途：治疗缺血，诱导缺血耐受，调节脑缺血，当缺血事件发生时延迟缺氧去极化阶段的发作; 作为神经保护剂; 作为组织保护剂; 治疗疼痛; 和炎症的治疗，其中X选自其中X 1和X 2独立地选自H，Cl，Br和F; 每个Y独立地选自S和O; 每个Z独立地选自-CX 3 - ， - NH - ， - O - ; - 其中X 3和X 4选自H，Cl，Br和F; B1和B2独立地选自腺嘌呤，鸟嘌呤，黄嘌呤，胸腺嘧啶，尿嘧啶，胞嘧啶和肌苷; S 1和S 2独立地选自核糖，开链核糖，2'-脱氧核糖，3'-脱氧核糖和阿拉伯呋喃糖苷。 V选自0，1，2，3，4和5; W选自0，1，2，3，4和5; V加W是2〜6的整数。

9. 发明申请

WO2006016097A2 VECTOR 审中-公开
标题翻译：向量
公开(公告)号：WO2006016097A2
公开(公告)日：2006-02-16
申请号：PCT/GB2005/002634
申请日：2005-07-06
申请人： IC VEC LIMITED , KELLER, Michael , JORGENSEN, Michael , MILLER, Andrew, David , PEROUZEL, Eric
发明人： KELLER, Michael , JORGENSEN, Michael , MILLER, Andrew, David , PEROUZEL, Eric
IPC分类号： A61K48/00
CPC分类号： A61K9/1272 , A61K48/00 , A61K48/0091 , A61K2121/00 , C12N15/88 , Y10T428/2984
摘要： The present invention relates to a non-viral delivery vector comprising a liposome, wherein one or more lipids of the liposome are coupled, reversibly or irreversibly, to one or more polymers, and wherein the liposome comprises siRNA.
摘要翻译：本发明涉及包含脂质体的非病毒递送载体，其中所述脂质体的一种或多种脂质可逆地或不可逆地与一种或多种聚合物偶联，并且其中所述脂质体包含siRNA。

10. 发明申请

WO2004000854A1 SULFUR-CONTAINING PHOSPHOLIPID DERIVATIVES 审中-公开
标题翻译：含硫的磷脂衍生物
公开(公告)号：WO2004000854A1
公开(公告)日：2003-12-31
申请号：PCT/GB2003/002582
申请日：2003-06-16
申请人： IC VEC LIMITED , THIA MEDICA AS , MILLER, Andrew, David , JORGENSEN, Michael, Rael , BERGE, Rolf , SKORVE, Jon
发明人： MILLER, Andrew, David , JORGENSEN, Michael, Rael , BERGE, Rolf , SKORVE, Jon
IPC分类号： C07F9/09
CPC分类号： C07C329/06 , A61K9/1272 , C07C323/52 , C07F9/10
摘要： The present invention provides a lipid compound comprising at least one non-polar moiety and a polar moiety, wherein each or at least one non-polar moiety is of the formula X-Y-Z-, wherein X is a hydrocarbyl chain, Y is selected from at least one of S, Se, SO 2 , SO, and O, and Z is an optional hydrocarbyl group, wherein the polar moiety is of the formula -[C(O)] m PHG, wherein PHG is a polar head group, and wherein m is the number of non-polar moieties.
摘要翻译：本发明提供了包含至少一个非极性部分和极性部分的脂质化合物，其中每个或至少一个非极性部分具有式XYZ-，其中X是烃基链，Y至少选自 S，Se，SO2，SO和O之一，Z是任选的烃基，其中极性部分具有式 - [C（O）] m PHG，其中PHG是极性头基，其中m是非极性部分的数量。

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