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1. 发明申请

WO2008078102A3 LIPIDS AND THEIR USE AS NON-VIRAL DELIVERY VEHICLE 审中-公开
公开(公告)号：WO2008078102A3
公开(公告)日：2008-07-03
申请号：PCT/GB2007/004967
申请日：2007-12-21
申请人： IMUTHES LIMITED , UNIVERSITY OF THE WITWATERSRAND , MILLER, Andrew, David , ARBUTHNOT, Patrick , JORGENSEN, Michael , KELLER, Michael , KAMALY, Nazila , AISSAOUI, Abderrahim , THANOU, Maya
发明人： MILLER, Andrew, David , ARBUTHNOT, Patrick , JORGENSEN, Michael , KELLER, Michael , KAMALY, Nazila , AISSAOUI, Abderrahim , THANOU, Maya
IPC分类号： A61K9/127 , A61K47/34 , A61K47/48 , C07C237/22 , C07F9/10 , C07J41/00 , C08G73/02 , C12N15/88
摘要： The present invention provides a lipid of the formula (I) R 3 R 4 N-[Y] q -(C p H 2p )-X-Linker-NR 1 R 2 (I) wherein R 3 and R 4 are independently selected from H and hydrocarbyl groups; q is an integer selected from 1 to 10; Y represents a group (C n H 2n )NR 5 , wherein (i) when q is 1, n is 2, or (ii) when q is greater than 1, each Y may be the same or different and each n is an integer independently selected from 1 to 10, with the proviso that for at least one unit Y, n is 2, and (iii) each R 5 is independently selected from H and hydrocarbyl groups; p is an integer selected from 1 to 10; X is an optional group selected from -NR 7 -, -C(=O)-N R 8 -, -NR 9 -C(=O)-, -C(=O)-, -O-, and -NR 10 -C(=0)0-, wherein each R 7 , R 8 , R 9 and R 10 is independently selected from H and hydrocarbyl groups, Linker is an optional group selected from amino acid residues, peptide residues and groups of the formula -(OCH 2 CH 2 ) 1-10 , -NR 6 -(CvH 2v )-C(=O)-, wherein R 6 is H or a hydrocarbyl group and v is an integer selected from 1 to 11, and -C(=0)-(CH 2 ) 0-10 -CH 2 -C(=0)-; R 1 is selected from acyclic groups having from 4 to 30 carbon atoms; and R 2 is selected from H and acyclic groups having from 4 to 30 carbon atoms. Said lipids can be used in a delivery vehicle (e.g. micelle or liposome) for the delivery of one or more (therapeutic or diagnostic) agents.

2. 发明申请

WO2003047549A3 POST-COATED LIPOSOME/LIPOPLEX FOR TARGETED DRUG/GENE DELIVERY AND LIPID LINKED TO A DELIVERY, TARGETING OR STABILISING MOIETY 审中-公开
公开(公告)号：WO2003047549A3
公开(公告)日：2003-06-12
申请号：PCT/GB2002/005471
申请日：2002-12-04
申请人： MITSUBISHI CHEMICAL CORPORATION , JORGENSEN, Michael , KELLER, Michael , MILLER, Andrew, David , PEROUZEL, Eric
发明人： JORGENSEN, Michael , KELLER, Michael , MILLER, Andrew, David , PEROUZEL, Eric
IPC分类号： A61K47/48
摘要： The present invention provides a delivery vehicle for a therapeutic agent comprising a modified lipid and a therapeutic agent; wherein the modified lipid comprises a lipid and a delivery, targeting or stabilising moiety (DTS moiety); wherein the lipid is linked to the DTS moiety via a linker which is stable in biological fluid and which is unstable in defined conditions; and wherein the DTS moiety is linked to the lipid alter formation of a complex of lipid and therapeutic agent.

3. 发明申请

WO2003047549A2 COMPOUND 审中-公开
标题翻译：复合
公开(公告)号：WO2003047549A2
公开(公告)日：2003-06-12
申请号：PCT/GB2002/005471
申请日：2002-12-04
申请人： MITSUBISHI CHEMICAL CORPORATION , JORGENSEN, Michael , KELLER, Michael , MILLER, Andrew, David , PEROUZEL, Eric
发明人： JORGENSEN, Michael , KELLER, Michael , MILLER, Andrew, David , PEROUZEL, Eric
IPC分类号： A61K9/00
CPC分类号： C07J41/0055 , A61K9/1272 , A61K47/54 , A61K47/541 , A61K47/543 , A61K47/544
摘要： The present invention provides a delivery vehicle for a therapeutic agent comprising a modified lipid and a therapeutic agent; wherein the modified lipid comprises a lipid and a delivery, targeting or stabilising moiety (DTS moiety); wherein the lipid is linked to the DTS moiety via a linker which is stable in biological fluid and which is unstable in defined conditions; and wherein the DTS moiety is linked to the lipid alter formation of a complex of lipid and therapeutic agent.
摘要翻译：本发明提供了包含改性脂质和治疗剂的治疗剂的递送载体; 其中所述修饰的脂质包含脂质和递送，靶向或稳定部分（DTS部分）; 其中所述脂质通过在生物流体中稳定且在限定条件下不稳定的接头连接到DTS部分; 并且其中DTS部分与脂质和治疗剂复合体的脂质变化形成有关。

4. 发明申请

WO2006016097A2 VECTOR 审中-公开
标题翻译：向量
公开(公告)号：WO2006016097A2
公开(公告)日：2006-02-16
申请号：PCT/GB2005/002634
申请日：2005-07-06
申请人： IC VEC LIMITED , KELLER, Michael , JORGENSEN, Michael , MILLER, Andrew, David , PEROUZEL, Eric
发明人： KELLER, Michael , JORGENSEN, Michael , MILLER, Andrew, David , PEROUZEL, Eric
IPC分类号： A61K48/00
CPC分类号： A61K9/1272 , A61K48/00 , A61K48/0091 , A61K2121/00 , C12N15/88 , Y10T428/2984
摘要： The present invention relates to a non-viral delivery vector comprising a liposome, wherein one or more lipids of the liposome are coupled, reversibly or irreversibly, to one or more polymers, and wherein the liposome comprises siRNA.
摘要翻译：本发明涉及包含脂质体的非病毒递送载体，其中所述脂质体的一种或多种脂质可逆地或不可逆地与一种或多种聚合物偶联，并且其中所述脂质体包含siRNA。

5. 发明申请

WO2008055497A1 APPARATUS FOR THE COMBUSTION OF VARIOUS TYPES OF OIL 审中-公开
标题翻译：用于燃烧各种油类的装置
公开(公告)号：WO2008055497A1
公开(公告)日：2008-05-15
申请号：PCT/DK2007/000437
申请日：2007-10-09
申请人： FIRE GREEN Aps , JORGENSEN, Michael , SORENSEN, Martin
发明人： JORGENSEN, Michael , SORENSEN, Martin
IPC分类号： F23C7/00 , F23D11/40 , F23G7/05 , F23K5/20 , F23D11/44
CPC分类号： F23D11/408 , F23C7/004 , F23C2900/99009 , F23D11/448 , F23G7/05 , F23K5/20
摘要： Apparatus for the combustion of various types of oil where the apparatus comprises: - a nozzle creating an oil mist; - ignition means arranged adjacent the nozzle for igniting the oil mist; - combustion air supply means in which the combustion air supply means comprises an air flow channel in the shape of a cylinder, said cylinder having an air inlet opening and an outlet opening arranged in opposite ends of said cylinder, and where inside of the cylinder the nozzle and ignition means are arranged, and where in or adjacent the outlet opening, air and/or mist distribution means in the shape of a non-rotatable disc having an outer and inner diameter is arranged, wherein the disc has a conical section shape, such that the inner diameter of the disc is closer to the cylinder's air inlet opening and the outer diameter of the disc is arranged proximate the outlet opening of the cylinder, and where a plurality of wings are arranged radially around the disc, for directing the airflow leaving the cylinder.
摘要翻译：用于各种类型油的燃烧的装置，其中所述装置包括： - 产生油雾的喷嘴; - 点火装置，布置在喷嘴附近以点燃油雾; - 燃烧空气供给装置，其中所述燃烧空气供应装置包括气缸形状的气流通道，所述气缸具有设置在所述气缸的相对端的进气口和出口，并且所述气缸内部喷嘴和点火装置被布置，并且在出口处或其附近布置有具有外径和内径的不可旋转盘形状的空气和/或雾分布装置，其中盘具有圆锥形截面形状，使得盘的内径更靠近气缸的空气入口开口，并且盘的外径靠近气缸的出口设置，并且其中多个翼沿径向围绕盘布置，用于引导气流离开缸。

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