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2. 发明申请

WO2014144842A2 PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：药物组合物
公开(公告)号：WO2014144842A2
公开(公告)日：2014-09-18
申请号：PCT/US2014/029421
申请日：2014-03-14
申请人： RHYTHM METABOLIC, INC.
发明人： SHARMA, Shubh , VAN DER PLOEG, Leonardus, H.T. , HENDERSON, Bart
IPC分类号： C07K14/435
CPC分类号： A61K38/12 , A61K9/08 , A61K9/10 , A61K9/146 , A61K38/08 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/24 , A61K47/38 , A61K47/541 , A61K47/542 , A61K47/544
摘要： The present invention relates to an ionic complex comprising a cationic polypeptide and an anionic excipient selected from: a PEG-carboxylic acid; a fatty acid having 10 or more carbon atoms; an anionic phospholipid; and a combination thereof. The invention also relates to a pharmaceutical composition comprising the ionic complex of the invention and a pharmaceutically acceptable carrier. The cationic polypeptide of the ionic complex has pharmacological activity and the complex can provide a more desirable pharmacokinetic profile for the cationic polypeptide of the complex as compared to the cationic polypeptide alone following administration. As such, the invention also relates to the use of the the ionic complex and pharmaceuctical composition comprising same to treat a subject suffering from a disease or disorder that is responsive to the cationic polypeptide of the ionic complex.
摘要翻译：本发明涉及包含阳离子多肽和阴离子赋形剂的离子络合物，其选自：PEG-羧酸; 具有10个或更多个碳原子的脂肪酸; 阴离子磷脂; 及其组合。本发明还涉及包含本发明的离子络合物和药学上可接受的载体的药物组合物。离子络合物的阳离子多肽具有药理活性，并且与施用后单独的阳离子多肽相比，复合物可以为复合物的阳离子多肽提供更理想的药代动力学特征。因此，本发明还涉及包含其的离子络合物和药物组合物用于治疗患有对离子复合物的阳离子多肽有响应的疾病或病症的受试者的用途。

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