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1. 发明申请

WO2012174362A1 PYRAZOLE DERIVATIVES AS CANNABINOID RECEPTOR 1 ANTAGONISTS 审中-公开
标题翻译：作为CANNABINOID受体1拮抗剂的吡唑衍生物
公开(公告)号：WO2012174362A1
公开(公告)日：2012-12-20
申请号：PCT/US2012/042640
申请日：2012-06-15
申请人： RESEARCH TRIANGLE INSTITUTE , FULP, Alan Bradley , MAITRA, Rangan , ZHANG, Yanan , SELTZMAN, Herbert H.
发明人： FULP, Alan Bradley , MAITRA, Rangan , ZHANG, Yanan , SELTZMAN, Herbert H.
IPC分类号： C07D231/14 , C07D401/06 , C07D401/12 , A61K31/415 , A61P3/00 , A61P25/00 , A61P29/00
CPC分类号： C07D231/14 , A61K31/415 , C07D401/06 , C07D401/12
摘要： The invention provides compounds capable of acting as antagonists at cannabanoid receptors according to the following formula: Such compounds may be used to treat conditions for which the cannabinoid receptor system has been implicated, such as obesity, liver disease, diabetes, pain, and inflammation.
摘要翻译：本发明提供了能够根据下式用作大麻素受体拮抗剂的化合物：这些化合物可用于治疗涉及大麻素受体系统的病症，例如肥胖，肝脏疾病，糖尿病，疼痛和炎症。

2. 发明申请

WO2013123335A1 PERIPHERALLY RESTRICTED DIPHENYL PURINE DERIVATIVES 审中-公开
标题翻译：外用限制性二苯醚衍生物
公开(公告)号：WO2013123335A1
公开(公告)日：2013-08-22
申请号：PCT/US2013/026359
申请日：2013-02-15
申请人： RESEARCH TRIANGLE INSTITUTE
发明人： MAITRA, Rangan , FULP, Alan Bradley , ZHANG, Yanan , SELTZMAN, Herbert H.
IPC分类号： C07D473/32 , C07D401/04 , A61K31/52 , A61P3/00 , A61P29/00
CPC分类号： C07D473/34
摘要： The invention provides compounds capable of acting as antagonists at cannabanoid receptors according to the following formula: Such compounds may be used to treat conditions for which the cannabinoid receptor system has been implicated, such as obesity, liver disease, diabetes, pain, and inflammation.
摘要翻译：本发明提供了能够根据下式用作大麻素受体的拮抗剂的化合物：这些化合物可用于治疗涉及大麻素受体系统的病症，例如肥胖症，肝病，糖尿病，疼痛和炎症。

3. 发明申请

WO2022187231A1 ARYLSULFOXAMIDES AS OREXIN RECEPTOR AGONISTS 审中-公开
公开(公告)号：WO2022187231A1
公开(公告)日：2022-09-09
申请号：PCT/US2022/018321
申请日：2022-03-01
申请人： RESEARCH TRIANGLE INSTITUTE
发明人： ZHANG, Yanan , ZHANG, Dehui
IPC分类号： C07C311/37 , C07C237/40 , C07D211/18 , C07D207/06 , C07D213/16 , C07D213/24 , C07D213/72 , A61P25/20
摘要： The present disclosure provides novel arylsulfonamide compounds as embodiments of the present disclosure. The compounds are believed to be orexin receptor agonists, useful for the treatment of diseases and conditions caused by reduced activity of orexin.

4. 发明申请

WO2018152134A1 PROLINE-BASED NEUROPEPTIDE FF RECEPTOR MODULATORS 审中-公开
公开(公告)号：WO2018152134A1
公开(公告)日：2018-08-23
申请号：PCT/US2018/018074
申请日：2018-02-13
申请人： RESEARCH TRIANGLE INSTITUTE
发明人： ZHANG, Yanan , NGUYEN, Thuy
IPC分类号： C07D207/14 , A61K31/40 , A61K31/485 , A61P25/00
摘要： Neuropeptide FF receptor modulators based on a proline scaffold are provided which offer NPFF receptor potencies in the nanomolar range and antagonistic selectivity for the NPFF 1 receptor. Methods, compounds and compositions for modulating the function of neuropeptide FF receptors are provided for pharmacotherapies capable of influencing conditions or disorders affected by the neuropeptide FF receptors.

5. 发明申请

WO2013086200A1 COMPOSITION AND METHOD FOR NEUROPEPTIDE S RECEPTOR (NPSR) ANTAGONISTS 审中-公开
标题翻译：神经元受体（NPSR）拮抗剂的组合物和方法
公开(公告)号：WO2013086200A1
公开(公告)日：2013-06-13
申请号：PCT/US2012/068257
申请日：2012-12-06
申请人： RESEARCH TRIANGLE INSTITUTE
发明人： RUNYON, Scott , ZHANG, Yanan , HASSLER, Carla , GILMOUR, Brian
IPC分类号： C07D491/04 , A61K31/4355 , A61P25/00
CPC分类号： C07D491/048 , C07D491/04 , C07D491/10 , C07D491/107
摘要： Neuropeptide S receptor antagonists are provided that bind in functional assays to neuropeptide S receptors; methods are provided for use of these antagonists in treatment of conditions or disease states that are ameliorated by blocking of the neuropeptide S receptor, including substance abuse and substance abuse relapse; and for use of neuropeptide S receptor antagonists in the manufacture of therapeutics and pro-drugs for therapeutics useful in disease states and conditions sensitive to binding of the neuropeptide S receptor.
摘要翻译：提供神经肽S受体拮抗剂，其在功能测定中与神经肽S受体结合; 提供了这些拮抗剂用于治疗通过阻断神经肽S受体而改善的病症或疾病状态的方法，包括药物滥用和药物滥用复发; 并且用于神经肽S受体拮抗剂在制备用于治疗疾病状态和治疗神经肽S受体结合敏感的疾病状态的治疗剂的前药中的用途。

6. 发明申请

WO2005065535A1 SYSTEM AND METHOD FOR SENSOR RECALIBRATION 审中-公开
标题翻译：用于传感器回波的系统和方法
公开(公告)号：WO2005065535A1
公开(公告)日：2005-07-21
申请号：PCT/US2004/041856
申请日：2004-12-15
申请人： MEDTRONIC MINIMED, INC. , ZHANG, Yanan , WANG, Lu , SHAH, Rajiv
发明人： ZHANG, Yanan , WANG, Lu , SHAH, Rajiv
IPC分类号： A61B5/00
CPC分类号： A61B5/1486 , A61B5/1495 , A61B5/4839 , G06F19/00
摘要： A system and method for calibrating a sensor. The method may include, without limitation, compiling an array of data relating to the sensor; adjusting a sensor parameter a first time based on data in the array; adjusting a curve representing the sensor output based on data in the array; and adjusting the sensor parameter a second time based on data in the array. The sensor may be an in vivo glucose sensor and the sensor parameter adjusted may be a current. The array may include historical as well as recent data, such as, for example, blood glucose readings and sensor electrode readings.
摘要翻译：一种用于校准传感器的系统和方法。该方法可以包括但不限于编译与传感器相关的数据阵列; 基于阵列中的数据首次调整传感器参数; 基于阵列中的数据调整表示传感器输出的曲线; 并且基于阵列中的数据再次调整传感器参数。传感器可以是体内葡萄糖传感器，并且调节的传感器参数可以是电流。阵列可以包括历史以及近来的数据，例如血糖读数和传感器电极读数。

7. 发明申请

WO2006099544A2 APPARATUS AND METHOD FOR COMPUTER MODELING TYPE 1 DIABETES 审中-公开
标题翻译：计算机建模1型糖尿病的装置和方法
公开(公告)号：WO2006099544A2
公开(公告)日：2006-09-21
申请号：PCT/US2006/009546
申请日：2006-03-15
申请人： ENTELOS, INC. , GADKAR, Kapil , KREUWEL, Huub , PATERSON, Thomas , POLIDORI, David , RAMANUJAN, Saroja , SHODA, Lisl, K. , WHITING, Chan, D. , YOUNG, Daniel, L. , ZHANG, Yanan
发明人： GADKAR, Kapil , KREUWEL, Huub , PATERSON, Thomas , POLIDORI, David , RAMANUJAN, Saroja , SHODA, Lisl, K. , WHITING, Chan, D. , YOUNG, Daniel, L. , ZHANG, Yanan
IPC分类号： G01N33/53
CPC分类号： G06F19/12 , G01N2800/042 , G06F19/00 , G06F19/18 , G06Q50/24 , G16H50/50
摘要： The invention encompasses novel methods for developing a computer model of type 1 diabetes in a mammal. In particular, the models can include representations of biological processes associated with a pancreatic lymph node and one or more pancreatic islets. Alternatively, the models can include representations of biological processes associated with at least two conditions selected from the group consisting of autoreactive T cell production, autoreactive T cell priming, insulitis and hyperglycemia. The invention also provides methods for developing a computer model of a non-insulin replacement treatment of type 1 diabetes. The invention also encompasses computer models of type 1 diabetes, methods of simulating type 1 diabetes and computer systems for simulating type 1 diabetes and the uses thereof.
摘要翻译：本发明包括用于开发哺乳动物中1型糖尿病计算机模型的新方法。特别地，模型可以包括与胰腺淋巴结和一个或多个胰岛相关联的生物过程的表示。或者，模型可以包括与选自自身反应性T细胞产生，自身反应性T细胞引发，胰岛炎和高血糖的至少两种病症相关的生物学过程的表示。本发明还提供了开发1型糖尿病非胰岛素替代治疗计算机模型的方法。本发明还包括1型糖尿病的计算机模型，模拟1型糖尿病的方法和用于模拟1型糖尿病的计算机系统及其用途。

8. 发明申请

WO2006029293A1 BLOOD CONTACTING SENSOR 审中-公开
标题翻译：血液接触传感器
公开(公告)号：WO2006029293A1
公开(公告)日：2006-03-16
申请号：PCT/US2005/032102
申请日：2005-09-08
申请人： MEDTRONIC MINIMED, INC. , VAN ANTWERP, Nannette, M. , ENEGREN, Bradley, J. , MASTROTOTARO, John, J. , SHAH, Rajiv , HOSS, Udo , ZHANG, Yanan , WANG, Jenn-Hann , CLARK, Kent, L.
发明人： VAN ANTWERP, Nannette, M. , ENEGREN, Bradley, J. , MASTROTOTARO, John, J. , SHAH, Rajiv , HOSS, Udo , ZHANG, Yanan , WANG, Jenn-Hann , CLARK, Kent, L.
IPC分类号： A61B5/1473 , A61B5/1486 , A61B5/1459 , A61B5/00
CPC分类号： A61B5/153 , A61B5/0002 , A61B5/14532 , A61B5/15003 , A61B5/150755 , A61B5/150862 , A61B5/150992
摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means (14). The assembly means has a sensor end (20), wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device (10). By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.
摘要翻译：本发明提供了用于检测血液中分析物的方法和装置。该装置特别适于使传感器在体内与血液直接接触。该装置包括检测分析物和组装装置（14）的存在的传感器。组装装置具有传感器端（20），其中组装装置的传感器端固定到传感器，并且组装装置适于与静脉流装置（10）联接。通过与静脉流动装置联接，组装装置使传感器与流过静脉流装置的血液直接接触。将传感器与受试者的血液直接接触的静脉流动装置的实例包括但不限于静脉内导管和外部血液回路，例如用于额外的体外膜氧合或血液透析。

9. 发明申请

WO2012019083A2 BIOSENSOR MEMBRANE COMPOSITION, BIOSENSOR, AND METHODS FOR MAKING SAME 审中-公开
标题翻译：生物传感器膜组合物，生物传感器及其制备方法
公开(公告)号：WO2012019083A2
公开(公告)日：2012-02-09
申请号：PCT/US2011/046714
申请日：2011-08-05
申请人： MICROCHIPS, INC. , ZHANG, Yanan
发明人： ZHANG, Yanan
IPC分类号： C12Q1/54
CPC分类号： G01N27/3335 , A61B5/14865 , B01D67/0088 , B01D69/144 , B01D71/54 , B01D71/70 , B01D2323/12 , B01D2323/16 , B01D2323/30 , B01D2325/36 , C12Q1/002 , C25B13/08 , G01N27/3271
摘要： Selectively permeable membranes for biosensors are provided. In one embodiment, the membrane includes a polymer mixture that includes a polyurethane component, a siloxane component, and a hydrogel component, the components in the mixture in amounts of about 60 to about 80 wt % polyurethane, about 10 to about 20 wt % siloxane, and about 10 to about 20 wt % hydrogel. The membrane has a surface restructured to be hydrophilic, with the restructured surface being crosslinked ed via reactive end groups on at least one of the polyurethane, the siloxane, and the hydrogel components. In another embodiment., the membrane includes a solvent cast film which includes a mixture of a first polyether-based thermoplastic polyurethane copolymer, a polyether-based polyurethane copolymer, and, optionally, a second polyether-based thermoplastic polyurethane copolymer.
摘要翻译：提供了用于生物传感器的选择性渗透膜。在一个实施方案中，所述膜包含聚合物混合物，所述聚合物混合物包含聚氨酯组分，硅氧烷组分和水凝胶组分，所述混合物中组分的量为约60至约80重量％聚氨酯，约10至约20重量％硅氧烷，和约10至约20重量％的水凝胶。膜具有重构为亲水性的表面，重构表面通过聚氨酯，硅氧烷和水凝胶组分中的至少一种上的反应性端基交联。在另一个实施方案中，膜包括溶剂流延膜，其包括第一聚醚基热塑性聚氨酯共聚物，聚醚基聚氨酯共聚物和任选的第二聚醚基热塑性聚氨酯共聚物的混合物。

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