专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007133637A2 AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME 审中-公开
标题翻译：作为离子通道配体和药物组合物的酰胺衍生物及使用该组合物的方法
公开(公告)号：WO2007133637A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/011310
申请日：2007-05-10
申请人： RENOVIS, INC. , PFIZER INC. , SHISHIDO, Yuji , NAKAO, Kazunari , NAGAYAMA, Satoshi , TANAKA, Hirotaka , DUNCTON, Matthew, Alexander James , COX, Matthew , KINCAID, John , SAHASRABUDHE, Kiran , ESTIARTE-MARTINEZ, Maria de Los Angeles
发明人： SHISHIDO, Yuji , NAKAO, Kazunari , NAGAYAMA, Satoshi , TANAKA, Hirotaka , DUNCTON, Matthew, Alexander James , COX, Matthew , KINCAID, John , SAHASRABUDHE, Kiran , ESTIARTE-MARTINEZ, Maria de Los Angeles
IPC分类号： B82B1/00
CPC分类号： C07D215/48 , C07C311/08 , C07C2601/02 , C07D205/04 , C07D215/54 , C07D217/26 , C07D231/12 , C07D239/94 , C07D241/44 , C07D295/155 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/12 , C07D471/04 , C07D498/04 , C07D498/12
摘要： Compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译：公开了具有由下式表示的化学式的化合物：式（I）。所述化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的多种病症，包括作为非限制性实例的疼痛，炎症，创伤性损伤等。

2. 发明申请

WO2009064449A1 AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME 审中-公开
标题翻译：作为离子通道配体和药物组合物的酰胺衍生物及其使用方法
公开(公告)号：WO2009064449A1
公开(公告)日：2009-05-22
申请号：PCT/US2008/012763
申请日：2008-11-13
申请人： RENOVIS, INC. , PFIZER GLOBAL RESEARCH AND DEVELOPMENT , COX, Matthew , O'MAHONY, Donogh John, Roger , ESTIARTE-MARINEZ, Maria, De Los Angeles , KAWASHIMA, Tadashi , NAGAYAMA, Satoshi , SHISIDO, Yuji , TANAKA, Hirotaka , DUNCTON, Matthew, Alexander, James , CALABRESE, Andrew, Antony
发明人： COX, Matthew , O'MAHONY, Donogh John, Roger , ESTIARTE-MARINEZ, Maria, De Los Angeles , KAWASHIMA, Tadashi , NAGAYAMA, Satoshi , SHISIDO, Yuji , TANAKA, Hirotaka , DUNCTON, Matthew, Alexander, James , CALABRESE, Andrew, Antony
IPC分类号： C07C311/08 , C07D239/72 , C07D239/94 , C07D401/12 , C07D471/04 , A61K31/18 , A61K31/47 , A61K31/436 , A61K31/497
CPC分类号： C07D215/48 , C07C311/08 , C07C2602/10 , C07D265/36 , C07D311/58 , C07D311/66 , C07D319/20 , C07D405/04
摘要： Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译：公开了具有下列化学式的化合物：化合物可以制备成药物组合物，并且可以用于预防和治疗哺乳动物包括人的多种病症，包括作为非限制性实例的疼痛，炎症，创伤性损伤等。

3. 发明申请

WO2007129188A1 CYCLOPROPANECARBOXAMIDE COMPOUND 审中-公开
标题翻译：环磷酰胺化合物
公开(公告)号：WO2007129188A1
公开(公告)日：2007-11-15
申请号：PCT/IB2007/001143
申请日：2007-04-27
申请人： PFIZER JAPAN INC. , PFIZER INC. , HANAZAWA, Takeshi , NAGAYAMA, Satoshi , NAKAO, Kazunari , SHISHIDO, Yuji , TANAKA, Hirotaka
发明人： HANAZAWA, Takeshi , NAGAYAMA, Satoshi , NAKAO, Kazunari , SHISHIDO, Yuji , TANAKA, Hirotaka
IPC分类号： C07D213/24 , A61K31/435 , A61P29/00
CPC分类号： C07D213/24
摘要： This invention relates to novel substituted N-(N-sulfonylaminoarylmethyl)cyclopropanecarboxamide compound and to their use in therapy. This invention provides 2-(6-tert-butylpyridin-3-yl)-N-((1R)-1-{3,5-difluoro-4-[(methylsulfonyl)amino]phenyl}ethyl)-2-methylcyclopropanecarboxamide, or a pharmaceutically acceptable salt or solvate thereof. This compound is particularly useful as an antagonist of the VR1 (Type I Vanilloid) receptor, and is thus useful for the treatment of pain, neuralgia, neuropathies, nerve injury, burns, migraine, carpal tunnel syndrome, fibromyalgia, neuritis, sciatica, pelvic hypersensitivity, bladder disease, inflammation, or the like in mammals, especially humans. The present invention also relates to a pharmaceutical composition comprising the above compound.
摘要翻译：本发明涉及新的取代的N-（N-磺酰基氨基芳基甲基）环丙烷甲酰胺化合物及其在治疗中的用途。本发明提供2-（6-叔丁基吡啶-3-基）-N - （（1R）-1- {3,5-二氟-4 - [（甲基磺酰基）氨基]苯基}乙基）-2-甲基环丙烷甲酰胺，或其药学上可接受的盐或溶剂合物。该化合物特别可用作VR1（I型香草素）受体的拮抗剂，因此可用于治疗疼痛，神经痛，神经病，神经损伤，烧伤，偏头痛，腕管综合征，纤维肌痛，神经炎，坐骨神经痛，骨盆哺乳动物，特别是人类中的超敏反应，膀胱疾病，炎症等。本发明还涉及包含上述化合物的药物组合物。

4. 发明申请

WO2006097817A1 N- (N-SULFONYLAMINOMETHYL) CYCLOPROPANECARBOXAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF PAIN 审中-公开
标题翻译：用于治疗疼痛的N-（N-磺酰氨基乙基）环磷酰胺酰胺衍生物
公开(公告)号：WO2006097817A1
公开(公告)日：2006-09-21
申请号：PCT/IB2006/000557
申请日：2006-03-07
申请人： PFIZER JAPAN INC. , PFIZER, INC. , HANAZAWA, Takeshi , HIRANO, Misato , INOUE, Tadashi , NAGAYAMA, Satoshi , NAKAO, Kazunari , SHISHIDO, Yuji , TANAKA, Hirotaka
发明人： HANAZAWA, Takeshi , HIRANO, Misato , INOUE, Tadashi , NAGAYAMA, Satoshi , NAKAO, Kazunari , SHISHIDO, Yuji , TANAKA, Hirotaka
IPC分类号： C07C311/08 , C07C317/44 , C07C323/62 , C07D213/56 , C07D213/74 , C07D213/76 , A61P29/00 , A61K31/145 , A61K31/44
CPC分类号： C07C61/28 , C07C61/40 , C07C311/08 , C07C317/44 , C07C323/62 , C07C2601/02 , C07D213/26 , C07D213/56 , C07D213/74 , C07D213/76
摘要： This invention provides a compound of the formula (I) or a pharmaceutically acceptable salt or solvate thereof. These compounds are useful for the treatment of disease conditions caused by overactivation of VR1 receptor such of pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compounds.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的盐或溶剂化物。这些化合物可用于治疗由哺乳动物中VR1受体过度活化引起的疼痛等疼痛引起的疾病状况。本发明还提供包含上述化合物的药物组合物。

5. 发明申请

WO2008032204A1 SUBSTITUTED PYRIDYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS 审中-公开
标题翻译：取代的吡咯烷基双环氧基酰胺化合物
公开(公告)号：WO2008032204A1
公开(公告)日：2008-03-20
申请号：PCT/IB2007/002694
申请日：2007-09-10
申请人： PFIZER JAPAN INC. , PFIZER INC. , NAGAYAMA, Satoshi , SHISHIDO, Yuji , TANAKA, Hirotaka
发明人： NAGAYAMA, Satoshi , SHISHIDO, Yuji , TANAKA, Hirotaka
IPC分类号： C07D213/40 , C07D401/12 , A61K31/4406 , A61K31/4409 , A61K31/444 , A61P25/04 , A61P25/02
CPC分类号： C07D213/40 , C07D401/12
摘要： This invention provides a compound of the formula (I): wherein A 1 is N and A 2 is CR 7 , or A 1 is CR 7 and A 2 is N; Y 1 , Y 2 and Y 3 are each independently CH or N, Y 4 and Y 5 are each independently CR 8 or N, with the proviso that when one of Y 1 , Y 2 , Y 3 , Y 4 and Y 5 is N, the others are not N; R 1 and R 2 are each independently hydrogen, halogen, (C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkyl or hydroxy(C 1 -C 6 )alkyl; R 3 and R 8 are each independently hydrogen, halogen, hydroxy, (C 1 -C 6 )alkyl, hydroxy(C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylthio, (C 1 -C 6 )alkylsulfinyl or (C 1 -C 6 )alkylsulfonyl; R 4 is halogen, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, halo(C 1 -C 6 )alkyl, hydroxy(C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkoxy, hydroxy(C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyl, (C 1 -C 6 )aIkoxy-(C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkylsuIfonyl, halo(C 1 -C 6 )alkylsulfinyl, halo(C 1 -C 6 )alkylthio, [(C 1 -C 6 )alkyl]NH- or [(C 1 -C 6 )alkyl] 2 N-; and R 5 , R 6 and R 7 are each independently hydrogen, halogen, (C 1 -C 6 )alkyl, hydroxy(C 1 -C 6 )alkyI, or (C 1 -C 6 )alkoxy; or a pharmaceutically acceptable salt, solvate thereof. These compounds are useful for the treatment of disease conditions caused by overactivation of the VR1 receptor such as pain, or the like in mammal. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供了式（I）的化合物：其中A 1是N且A 2是CR 7，或者A < 1 是CR 7，A 2是N; Y 1，Y 2和Y 3各自独立地为CH或N，Y 4和Y 4， 5 各自独立地为CR 8或N，条件是当Y 1，Y 2之一，Y SUP > 3 ，Y 4和Y 5是N，其他不是N; R 1和R 2各自独立地为氢，卤素，（C 1 -C 6 -C 6）烷基，卤代（C 1 -C 6）烷基或羟基（C 1 -C 6 -C 6）烷基;（C 1 -C 6） R 3和R 8各自独立地为氢，卤素，羟基，（C 1 -C 6 -C 6）烷基，羟基（C 1 -C 6 -C 6）烷氧基，（C 1 -C 6 -C 6）烷氧基 - （C （C 1 -C 6 -C 6烷基）（C 1 -C 6 -C 6）烷氧基 - （C 1 -C 6烷基） C 1 -C 6烷氧基，卤代（C 1 -C 6 -C 6）烷基，（C 1 -C 6）烷基，（C 1 -C 6）烷硫基，（C 1 -C 6 -C 6）烷基亚磺酰基或（C 1 -C 6 - SUB> 6 ）烷基磺酰基; R 4是卤素，（C 1 -C 6 -C 6）烷基，（C 3 -C 6 - （C 1 -C 6）烷基，羟基（C 1 -C 6）烷基，C 1 -C 6 - （C 1 -C 6）烷基，卤代（C 1 -C 6 -C 6）烷氧基，羟基（C 1 -C 6 - （C 1 -C 6）烷氧基，（C 1 -C 6 - ）烷氧基，（C 1 -C 6 -C 6）烷基，（C 1 -C 6）烷氧基 - （C 1 -C 6 -C 6）烷氧基，卤代（C 1 -C 6）卤代（C 1 -C 6）烷基亚磺酰基，卤代（C 1 -C 6）烷基亚磺酰基，C 1 -C 6烷基亚磺酰基， C 1 -C 6烷基硫基，[（C 1 -C 6 - ）烷基] NH-或[（C < > 1 -C _{6 ）烷基] _{2 N-; 和R 5，R 6和R 7各自独立地为氢，卤素，（C 1 -C 6 - 或（C 1 -C 6）烷基，羟基（C 1 -C 6）烷基，或（C 1 -C 6）烷基， 6 ）烷氧基; 或其药学上可接受的盐，溶剂化物。这些化合物可用于治疗哺乳动物VR1受体过度活化（如疼痛等）引起的疾病状况。本发明还提供了包含上述化合物的药物组合物。}}

6. 发明申请

WO2006016218A1 ARYL OR HETEROARYL CARBONYL DERIVATIVES DERIVATIVES USEFUL AS VANILLOID RECEPTOR 1 (VR1) ANTAGONISTS 审中-公开
标题翻译：作为VANILLOID受体1（VR1）拮抗剂有用的ARYL或HETEROARYL CARBONYL衍生物衍生物
公开(公告)号：WO2006016218A1
公开(公告)日：2006-02-16
申请号：PCT/IB2005/002183
申请日：2005-07-21
申请人： PFIZER JAPAN INC. , PFIZER INC. , MIYAKE, Yoriko , NAGAYAMA, Satoshi , NAKAO, Kazunari , SUDO, Masaki , TANAKA, Hirotaka
发明人： MIYAKE, Yoriko , NAGAYAMA, Satoshi , NAKAO, Kazunari , SUDO, Masaki , TANAKA, Hirotaka
IPC分类号： C07C235/78 , C07D213/50 , C07D277/20 , C07D233/54 , A61K31/16 , A61K31/4164 , A61K31/44 , A61K31/426
CPC分类号： C07D277/20 , C07C235/20 , C07D213/50 , C07D233/54
摘要： This invention provides a compound of the formula (I): wherein R 1 and R 2 independently represent hydrogen or (C 1 -C 6 )alkyl or the like; R 3 and R 4 independently represent hydrogen or (C 1 -C 3 )alkyl; n represents 1 or 2; A represents phenyl or a monocyclic heteroaryl having from 5 to 6 atoms or the like; and R 5 and R 6 each independently represent halogen, (C 1 -C 6 )alkyl, cyano, hydroxy, hydroxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylthio, (C 1 -C 6 )alkylsulfinyl and (C 1 -C 6 )alkylsulfonyl; or a pharmaceutically acceptable ester of such compound, or a pharmaceutically acceptable salt thereof. These compounds are useful for the treatment of disease conditions caused by overactivation of VR1 receptor such of pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供式（I）的化合物：其中R

7. 发明申请

WO2006095263A1 SUBSTITUTED N-SULFONYLAMINOPHENYLETHYL-2-PHENOXY ACETAMIDE COMPOUNDS 审中-公开
标题翻译：取代的N-磺酰氨基苯乙烯基-2-苯氧基乙酰胺化合物
公开(公告)号：WO2006095263A1
公开(公告)日：2006-09-14
申请号：PCT/IB2006/000539
申请日：2006-02-24
申请人： PFIZER JAPAN INC. , PFIZER INC. , HANAZAWA, Takeshi , HIRANO, Misato , INOUE, Tadashi , NAHAYAMA, Satoshi , NAKAO, Kazunari , SHISHIDO, Yuji , TANAKA, Hirotaka
发明人： HANAZAWA, Takeshi , HIRANO, Misato , INOUE, Tadashi , NAHAYAMA, Satoshi , NAKAO, Kazunari , SHISHIDO, Yuji , TANAKA, Hirotaka
IPC分类号： C07D295/08 , C07D311/58 , C07C311/08 , A61K31/4453 , A61K31/353 , A61K31/18 , A61P25/00
CPC分类号： C07C311/08
摘要： This invention provides a compound of the formula (I), wherein R 1 represents (C 1 -C 6 )alkyl; R 2 represents a hydrogen atom, a halogen atom, a hydroxy group, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, hydroxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyl or halo(C 1 -C 6 )alkyl; R 3 represents a halogen atom, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, hydroxy(C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyll, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylthio, (C 1 -C 6 )alkylsulfinyl, (C 1 C 6 )alkyllsulfonyl, [(C 1 -C 6 )alkyl]NH-, or [(C 1 -C 6 ) alkyl] 2 N-; R 4 represents a halogen atom, (C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, hydroxy(C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkoxy, [(C 1 -C 6 )alkyl]NH-, or [(C 1 -C 6 )alkyl] 2 N-; R 5 represents a halogen atom, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, hydroxy(C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyll, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylthio, (C 1 -C 6 )alkylsulfinyl, (C 1 -C 6 )alkyIsulfonyl, [(C 1 -C 6 )alkyl]NH-, [(C 1 -C 6 ) alkyl] 2 N-, H 2 N-(C 1 -C 6 )alkoxy, (C 1 -C 6 )alkyl-NH-(C 1 -C 6 )alkoxy, [(C 1 -C 6 )alkyl] 2 N(C 1 -C 6 )alkoxy, H 2 N-(C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl-NH-(C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyl, or [(C 1 -C 6 )alkyl] 2 N(C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyl; and *indicates a chiral centre; or a pharmaceutically acceptable salt or solvate thereof. These compounds are useful for the treatment of disease conditions caused by overactivation of VR1 receptor such of pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供式（I）化合物，其中R 1代表（C 1 -C 6 -C 6）烷基; R 2表示氢原子，卤素原子，羟基，（C 1 -C 6 -C 6）烷基，（C 1 -C 6）（C 1 -C 6）烷基，（C 1 -C 6）烷基，（C 1 -C 6）烷基，（C 1 -C 6）（C 1 -C 6）烷氧基 - （C 1 -C 6 -C 6）烷基或卤代（C 1 -C 6 - ç_{6 ）烷基; R 3表示卤素原子，（C 1 -C 6 -C 6）烷基，（C 1 -C 6 - （C 1 -C 6）烷氧基，（C 1 -C 6）烷氧基，（C 1 -C 6）烷氧基，C 1 -C 6 - （C 1 -C 6）烷基，（C 1 -C 6）烷氧基 - （C 1 -C 6 - ）烷基，（C 1 -C 6））烷氧基 - （C 1 -C 6 -C 6）烷氧基，卤代（C 1 -C 6 -C 6）烷基，（C 1 -C 6 -C 6）烷硫基，（C 1 -C 6 -C 6）烷基亚磺酰基，（C _{2 N-; R 5表示卤素原子，（C 1 -C 6 -C 6）烷基，（C 1 -C 6 - （C 1 -C 6）烷氧基，（C 1 -C 6）烷氧基，（C 1 -C 6）烷氧基，C 1 -C 6 - （C 1 -C 6）烷基，（C 1 -C 6）烷氧基 - （C 1 -C 6 - ）烷基，（C 1 -C 6））烷氧基 - （C 1 -C 6 -C 6）烷氧基，卤代（C 1 -C 6 -C 6）烷基，（C 1 -C 6 -C 6）烷硫基，（C 1 -C 6 -C 6）烷基亚磺酰基，（C _{1 -C _{6 ）烷基] _{2 N（ç_{1 -C _{6 ）烷氧基 - （C _{1 < / SUB> -C _{6 ）烷基; 和*表示手性中心; 或其药学上可接受的盐或溶剂合物。这些化合物可用于治疗由哺乳动物VR1受体过度活化引起的疼痛等疼痛引起的疾病状况。本发明还提供了包含上述化合物的药物组合物。}}}}}}}}}

8. 发明申请

WO2008007211A8 SUBSTITUTED N-BICYCLICALKYL BICYCLIC CARBOXYAMIDE COMPOUNDS 审中-公开
公开(公告)号：WO2008007211A8
公开(公告)日：2008-01-17
申请号：PCT/IB2007/001984
申请日：2007-07-02
申请人： PFIZER JAPAN INC. , PFIZER INC. , KAWASHIMA, Tadashi , NAGAYAMA, Satoshi , NAKAO, Kazunari , TANAKA, Hirotaka
发明人： KAWASHIMA, Tadashi , NAGAYAMA, Satoshi , NAKAO, Kazunari , TANAKA, Hirotaka
IPC分类号： C07D209/34 , C07D215/06 , C07D231/56 , C07D249/18 , C07D403/12 , A61K31/395 , A61P25/00
摘要： This invention provides a compound of the formula (I): And their use for the treatment of disease conditions caused by overactivation of the VR1 receptor such as pain, or the like in mammal. This invention also provides a pharmaceutical composition comprising the above compound.

9. 发明申请

WO2006103503A1 SUBSTITUTED ARYLOXOETHYL CYCLOPROPANECARBOXAMIDE COMPOUNDS AS VR1 RECEPTOR ANTAGONISTS 审中-公开
标题翻译：作为VR1受体拮抗剂的取代的芳基乙氧基环丙酰氧基化合物
公开(公告)号：WO2006103503A1
公开(公告)日：2006-10-05
申请号：PCT/IB2006/000585
申请日：2006-03-15
申请人： PFIZER JAPAN INC. , PFIZER INC. , HANAZAWA, Takeshi , NAGAYAMA, Satoshi , NAKAO, Kazumari , TANAKA, Hirotaka
发明人： HANAZAWA, Takeshi , NAGAYAMA, Satoshi , NAKAO, Kazumari , TANAKA, Hirotaka
IPC分类号： C07C233/61 , C07D213/50 , C07D233/00 , A61K31/165 , A61K31/4164 , A61K31/44 , A61P29/00
CPC分类号： C07C233/61 , C07C2601/02 , C07D213/50 , C07D233/56 , C07D233/64
摘要： This invention provides a compound of the formula (I): (I) These compounds are useful for the treatment of disease conditions caused by overactivation of the VR1 receptor, such as pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供式（I）的化合物：（I）这些化合物可用于治疗由哺乳动物中的VR1受体过度活化引起的疾病，例如疼痛等。本发明还提供了包含上述化合物的药物组合物。

10. 发明申请

WO2008050199A2 SUBSTITUTED PHENYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS 审中-公开
标题翻译：取代的苯甲基双环氧基酰胺化合物
公开(公告)号：WO2008050199A2
公开(公告)日：2008-05-02
申请号：PCT/IB2007/003106
申请日：2007-10-11
申请人： PFIZER JAPAN INC. , PFIZER INC. , ANDO, Koji , TANAKA, Hirotaka
发明人： ANDO, Koji , TANAKA, Hirotaka
CPC分类号： C07D215/48 , C07C233/73
摘要： This invention provides a compound of the formula (I). These compounds are useful for the treatment of disease conditions caused by overactivation of the VR1 receptor such as pain, or the like in mammal. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供式（I）化合物。这些化合物可用于治疗哺乳动物VR1受体过度活化（如疼痛等）引起的疾病状况。本发明还提供了包含上述化合物的药物组合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式