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1. 发明申请

WO2008007211A8 SUBSTITUTED N-BICYCLICALKYL BICYCLIC CARBOXYAMIDE COMPOUNDS 审中-公开
公开(公告)号：WO2008007211A8
公开(公告)日：2008-01-17
申请号：PCT/IB2007/001984
申请日：2007-07-02
申请人： PFIZER JAPAN INC. , PFIZER INC. , KAWASHIMA, Tadashi , NAGAYAMA, Satoshi , NAKAO, Kazunari , TANAKA, Hirotaka
发明人： KAWASHIMA, Tadashi , NAGAYAMA, Satoshi , NAKAO, Kazunari , TANAKA, Hirotaka
IPC分类号： C07D209/34 , C07D215/06 , C07D231/56 , C07D249/18 , C07D403/12 , A61K31/395 , A61P25/00
摘要： This invention provides a compound of the formula (I): And their use for the treatment of disease conditions caused by overactivation of the VR1 receptor such as pain, or the like in mammal. This invention also provides a pharmaceutical composition comprising the above compound.

2. 发明申请

WO2007129188A1 CYCLOPROPANECARBOXAMIDE COMPOUND 审中-公开
标题翻译：环磷酰胺化合物
公开(公告)号：WO2007129188A1
公开(公告)日：2007-11-15
申请号：PCT/IB2007/001143
申请日：2007-04-27
申请人： PFIZER JAPAN INC. , PFIZER INC. , HANAZAWA, Takeshi , NAGAYAMA, Satoshi , NAKAO, Kazunari , SHISHIDO, Yuji , TANAKA, Hirotaka
发明人： HANAZAWA, Takeshi , NAGAYAMA, Satoshi , NAKAO, Kazunari , SHISHIDO, Yuji , TANAKA, Hirotaka
IPC分类号： C07D213/24 , A61K31/435 , A61P29/00
CPC分类号： C07D213/24
摘要： This invention relates to novel substituted N-(N-sulfonylaminoarylmethyl)cyclopropanecarboxamide compound and to their use in therapy. This invention provides 2-(6-tert-butylpyridin-3-yl)-N-((1R)-1-{3,5-difluoro-4-[(methylsulfonyl)amino]phenyl}ethyl)-2-methylcyclopropanecarboxamide, or a pharmaceutically acceptable salt or solvate thereof. This compound is particularly useful as an antagonist of the VR1 (Type I Vanilloid) receptor, and is thus useful for the treatment of pain, neuralgia, neuropathies, nerve injury, burns, migraine, carpal tunnel syndrome, fibromyalgia, neuritis, sciatica, pelvic hypersensitivity, bladder disease, inflammation, or the like in mammals, especially humans. The present invention also relates to a pharmaceutical composition comprising the above compound.
摘要翻译：本发明涉及新的取代的N-（N-磺酰基氨基芳基甲基）环丙烷甲酰胺化合物及其在治疗中的用途。本发明提供2-（6-叔丁基吡啶-3-基）-N - （（1R）-1- {3,5-二氟-4 - [（甲基磺酰基）氨基]苯基}乙基）-2-甲基环丙烷甲酰胺，或其药学上可接受的盐或溶剂合物。该化合物特别可用作VR1（I型香草素）受体的拮抗剂，因此可用于治疗疼痛，神经痛，神经病，神经损伤，烧伤，偏头痛，腕管综合征，纤维肌痛，神经炎，坐骨神经痛，骨盆哺乳动物，特别是人类中的超敏反应，膀胱疾病，炎症等。本发明还涉及包含上述化合物的药物组合物。

3. 发明申请

WO2006016218A1 ARYL OR HETEROARYL CARBONYL DERIVATIVES DERIVATIVES USEFUL AS VANILLOID RECEPTOR 1 (VR1) ANTAGONISTS 审中-公开
标题翻译：作为VANILLOID受体1（VR1）拮抗剂有用的ARYL或HETEROARYL CARBONYL衍生物衍生物
公开(公告)号：WO2006016218A1
公开(公告)日：2006-02-16
申请号：PCT/IB2005/002183
申请日：2005-07-21
申请人： PFIZER JAPAN INC. , PFIZER INC. , MIYAKE, Yoriko , NAGAYAMA, Satoshi , NAKAO, Kazunari , SUDO, Masaki , TANAKA, Hirotaka
发明人： MIYAKE, Yoriko , NAGAYAMA, Satoshi , NAKAO, Kazunari , SUDO, Masaki , TANAKA, Hirotaka
IPC分类号： C07C235/78 , C07D213/50 , C07D277/20 , C07D233/54 , A61K31/16 , A61K31/4164 , A61K31/44 , A61K31/426
CPC分类号： C07D277/20 , C07C235/20 , C07D213/50 , C07D233/54
摘要： This invention provides a compound of the formula (I): wherein R 1 and R 2 independently represent hydrogen or (C 1 -C 6 )alkyl or the like; R 3 and R 4 independently represent hydrogen or (C 1 -C 3 )alkyl; n represents 1 or 2; A represents phenyl or a monocyclic heteroaryl having from 5 to 6 atoms or the like; and R 5 and R 6 each independently represent halogen, (C 1 -C 6 )alkyl, cyano, hydroxy, hydroxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylthio, (C 1 -C 6 )alkylsulfinyl and (C 1 -C 6 )alkylsulfonyl; or a pharmaceutically acceptable ester of such compound, or a pharmaceutically acceptable salt thereof. These compounds are useful for the treatment of disease conditions caused by overactivation of VR1 receptor such of pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供式（I）的化合物：其中R

4. 发明申请

WO2006097817A1 N- (N-SULFONYLAMINOMETHYL) CYCLOPROPANECARBOXAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF PAIN 审中-公开
标题翻译：用于治疗疼痛的N-（N-磺酰氨基乙基）环磷酰胺酰胺衍生物
公开(公告)号：WO2006097817A1
公开(公告)日：2006-09-21
申请号：PCT/IB2006/000557
申请日：2006-03-07
申请人： PFIZER JAPAN INC. , PFIZER, INC. , HANAZAWA, Takeshi , HIRANO, Misato , INOUE, Tadashi , NAGAYAMA, Satoshi , NAKAO, Kazunari , SHISHIDO, Yuji , TANAKA, Hirotaka
发明人： HANAZAWA, Takeshi , HIRANO, Misato , INOUE, Tadashi , NAGAYAMA, Satoshi , NAKAO, Kazunari , SHISHIDO, Yuji , TANAKA, Hirotaka
IPC分类号： C07C311/08 , C07C317/44 , C07C323/62 , C07D213/56 , C07D213/74 , C07D213/76 , A61P29/00 , A61K31/145 , A61K31/44
CPC分类号： C07C61/28 , C07C61/40 , C07C311/08 , C07C317/44 , C07C323/62 , C07C2601/02 , C07D213/26 , C07D213/56 , C07D213/74 , C07D213/76
摘要： This invention provides a compound of the formula (I) or a pharmaceutically acceptable salt or solvate thereof. These compounds are useful for the treatment of disease conditions caused by overactivation of VR1 receptor such of pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compounds.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的盐或溶剂化物。这些化合物可用于治疗由哺乳动物中VR1受体过度活化引起的疼痛等疼痛引起的疾病状况。本发明还提供包含上述化合物的药物组合物。

5. 发明申请

WO2007133637A2 AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME 审中-公开
标题翻译：作为离子通道配体和药物组合物的酰胺衍生物及使用该组合物的方法
公开(公告)号：WO2007133637A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/011310
申请日：2007-05-10
申请人： RENOVIS, INC. , PFIZER INC. , SHISHIDO, Yuji , NAKAO, Kazunari , NAGAYAMA, Satoshi , TANAKA, Hirotaka , DUNCTON, Matthew, Alexander James , COX, Matthew , KINCAID, John , SAHASRABUDHE, Kiran , ESTIARTE-MARTINEZ, Maria de Los Angeles
发明人： SHISHIDO, Yuji , NAKAO, Kazunari , NAGAYAMA, Satoshi , TANAKA, Hirotaka , DUNCTON, Matthew, Alexander James , COX, Matthew , KINCAID, John , SAHASRABUDHE, Kiran , ESTIARTE-MARTINEZ, Maria de Los Angeles
IPC分类号： B82B1/00
CPC分类号： C07D215/48 , C07C311/08 , C07C2601/02 , C07D205/04 , C07D215/54 , C07D217/26 , C07D231/12 , C07D239/94 , C07D241/44 , C07D295/155 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/12 , C07D471/04 , C07D498/04 , C07D498/12
摘要： Compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译：公开了具有由下式表示的化学式的化合物：式（I）。所述化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的多种病症，包括作为非限制性实例的疼痛，炎症，创伤性损伤等。

6. 发明申请

WO2006051378A1 SUBSTITUTED N-SULFONYLAMINOBENZYL-2-PHENOXY ACETAMIDE COMPOUNDS 审中-公开
标题翻译：取代的N-磺酰基苯甲酰基-2-苯氧基乙酸酯化合物
公开(公告)号：WO2006051378A1
公开(公告)日：2006-05-18
申请号：PCT/IB2005/003321
申请日：2005-10-31
申请人： PFIZER JAPAN INC. , PFIZER INC. , INOUE, Tadashi , NAGAYAMA, Satoshi , NAKAO, Kazunari
发明人： INOUE, Tadashi , NAGAYAMA, Satoshi , NAKAO, Kazunari
IPC分类号： C07D295/08 , C07D311/58 , C07C311/08 , A61K31/4453 , A61K31/353 , A61K31/18 , A61P25/00
CPC分类号： C07D295/096 , C07C311/08 , C07C2601/02 , C07C2602/08 , C07C2602/10 , C07D311/58
摘要： This invention provides a compound of the formula (I): wherein R 1 represents a (C 1 ,-C 6 )alkyl group; R 2 represents a hydrogen atom, a halogen atom, a hydroxy group, a (C 1 -C 6 ) alkyl group or a (C 1 -C 6 ) alkoxy group; R 3 , R 4 , R 5 and R 6 each independently represents a hydrogen atom, a (C 1 -C 6 ) alkyl, or a halogen atom; R 7 represents a hydrogen atom, a halogen atom, a hydroxy group, a (C 1 -C 6 ) alkyl group optionally substituted with a piperidino group, a (C 1 -C 6 )alkoxy group optionally substituted with a 3-7 membered cycloalkyl ring, a hydroxy(C 1 -C 6 )alkoxy group, a (C 1 -C 8 )alkoxy- (C 1 -C 8 )alkyl group, a (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkoxy group, a halo (C 1 -C 6 )alkyl group, a (C 1 -C 6 )alkylthio group, a (C 1 -C 6 )alkylsulfinyl group or a (C 1 -C 6 )alkylsulfonyl group; R 8 represents a (C 1 -C 6 )alkyl group, a halo(C 1 -C 6 ,)aIkyl group, a (C 1 -C 6 )alkoxy group, a hydroxy(C 1 -C 6 )alkoxy group, a (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyl group or a (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkoxy group; or R 7 and R 8 , when adjacent to each other, taken together with the carbon atoms to which they are attached form a 5-8 membered carbocyclic or heterocyclic ring, wherein the carbocyclic ring or the heterocyclic ring is unsubstituted or substituted with one or more substituents selected from the group consisting of a hydroxy group, a (C 1 -C 6 )alkyl group, a (C 1 -C 6 )alkoxy group and a hydroxy(C 1 -C 6 )alkyl group; and R 9 represents a hydrogen atom or a halogen atom; or a pharmaceutically acceptable salt or solvate thereof. These compounds are useful for the treatment of disease conditions caused by overactivation of VR1 receptor, such as pain or the like in mammalian. The present invention also provides a pharmaceutical composition comprising the compound of formula (I).
摘要翻译：本发明提供式（I）化合物：其中R 1表示（C 1 -C 6）C 6烷基; R 2表示氢原子，卤素原子，羟基，（C 1 -C 6 -C 6）烷基或（C 1 -C 6 -C 6）烷基 C 1 -C 6烷氧基; R 3，R 4，R 5和R 6各自独立地表示氢原子，（C 1〜或者卤素原子; R 7表示氢原子，卤素原子，羟基，（C 1 -C 6 -C 6）烷基，任选被哌啶子基，任选被3-7元环烷基环取代的（C 1 -C 6 -C 6）烷氧基，羟基（C 1 -C 6 - -C（C 1 -C 6）烷氧基，（C 1 -C 8 - ）烷氧基 - （C 1 -C 6 - （C 1 -C 6）烷基，（C 1 -C 6 -C 6）烷氧基 - （C 1 -C 6 - 亚烷基）（C 1 -C 6）烷氧基，卤代（C 1 -C 6 -C 6）烷基，（C 1 -C 6）烷氧基，（C 1 -C 6）烷硫基，（C 1 -C 6）烷基亚磺酰基或（C 1 -C 6 - 烷基磺酰基; R 8表示（C 1 -C 6 -C 6）烷基，卤代（C 1 -C 6 - （C 1 -C 6）烷基，（C 1 -C 6 -C 6）烷氧基，羟基（C 1 -C 6 - C 1 -C 6烷氧基，（C 1 -C 6 -C 6）烷氧基 - （C 1 -C 6 - （C 1 -C 6）烷基或（C 1 -C 6 -C 6）烷氧基 - （C 1 -C 6 - 6个）烷氧基; 或R 7和R 8彼此相邻时，与它们所连接的碳原子一起形成5-8元碳环或杂环，其中碳环或杂环是未取代的或被一个或多个选自羟基，（C 1 -C 6 -C 6）烷基的取代基取代，（C 1 -C 6 -C 6）烷氧基和羟基（C 1 -C 6 -C 6）烷基组; R 9表示氢原子或卤素原子; 或其药学上可接受的盐或溶剂合物。这些化合物可用于治疗由VR1受体过度活化引起的疾病状况，例如哺乳动物的疼痛等。本发明还提供包含式（I）化合物的药物组合物。

7. 发明申请

WO2005095329A1 SUBSTITUTED BENZAMIDE COMPOUNDS AS VR1 RECEPTOR ANTAGONISTS 审中-公开
标题翻译：替代苄基化合物作为VR1受体拮抗剂
公开(公告)号：WO2005095329A1
公开(公告)日：2005-10-13
申请号：PCT/IB2005/000728
申请日：2005-03-21
申请人： PFIZER JAPAN INC. , PFIZER INC. , NAGAYAMA, Satoshi , SHISHIDO, Yuji , JINNO, Madoka , NAKAO, Kazunari
发明人： NAGAYAMA, Satoshi , SHISHIDO, Yuji , JINNO, Madoka , NAKAO, Kazunari
IPC分类号： C07C235/48
CPC分类号： C07C235/48 , C07C2602/10
摘要： This invention provides a compound of the formula (I): wherein R 1 represents a (C 1 -C 6 )alkoxy group, a halo(C 1 -C 6 )alkoxy group, R 2 represents a hydrogen atom or a (C 1 -C 6 )alkyl group, and R 3 represents a hydrogen atom, a (C 1 -C 6 )alkoxy group or a hydroxy group; or a pharmaceutically acceptable ester of such compound, or a pharmaceutically acceptable salt thereof. These compounds are useful for the treatment of disease conditions caused by overactivation of VR1 receptor such of pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供式（I）化合物：其中R 1表示（C 1 -C 6）烷氧基，卤代（C 1 -C 6）烷氧基，R 2表示氢原子或（C1- C6）烷基，R 3表示氢原子，（C1-C6）烷氧基或羟基; 或这种化合物的药学上可接受的酯，或其药学上可接受的盐。这些化合物可用于治疗由哺乳动物VR1受体过度活化引起的疼痛等疼痛引起的疾病状况。本发明还提供了包含上述化合物的药物组合物。

8. 发明申请

WO2006095263A1 SUBSTITUTED N-SULFONYLAMINOPHENYLETHYL-2-PHENOXY ACETAMIDE COMPOUNDS 审中-公开
标题翻译：取代的N-磺酰氨基苯乙烯基-2-苯氧基乙酰胺化合物
公开(公告)号：WO2006095263A1
公开(公告)日：2006-09-14
申请号：PCT/IB2006/000539
申请日：2006-02-24
申请人： PFIZER JAPAN INC. , PFIZER INC. , HANAZAWA, Takeshi , HIRANO, Misato , INOUE, Tadashi , NAHAYAMA, Satoshi , NAKAO, Kazunari , SHISHIDO, Yuji , TANAKA, Hirotaka
发明人： HANAZAWA, Takeshi , HIRANO, Misato , INOUE, Tadashi , NAHAYAMA, Satoshi , NAKAO, Kazunari , SHISHIDO, Yuji , TANAKA, Hirotaka
IPC分类号： C07D295/08 , C07D311/58 , C07C311/08 , A61K31/4453 , A61K31/353 , A61K31/18 , A61P25/00
CPC分类号： C07C311/08
摘要： This invention provides a compound of the formula (I), wherein R 1 represents (C 1 -C 6 )alkyl; R 2 represents a hydrogen atom, a halogen atom, a hydroxy group, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, hydroxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyl or halo(C 1 -C 6 )alkyl; R 3 represents a halogen atom, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, hydroxy(C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyll, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylthio, (C 1 -C 6 )alkylsulfinyl, (C 1 C 6 )alkyllsulfonyl, [(C 1 -C 6 )alkyl]NH-, or [(C 1 -C 6 ) alkyl] 2 N-; R 4 represents a halogen atom, (C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, hydroxy(C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkoxy, [(C 1 -C 6 )alkyl]NH-, or [(C 1 -C 6 )alkyl] 2 N-; R 5 represents a halogen atom, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, hydroxy(C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyll, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylthio, (C 1 -C 6 )alkylsulfinyl, (C 1 -C 6 )alkyIsulfonyl, [(C 1 -C 6 )alkyl]NH-, [(C 1 -C 6 ) alkyl] 2 N-, H 2 N-(C 1 -C 6 )alkoxy, (C 1 -C 6 )alkyl-NH-(C 1 -C 6 )alkoxy, [(C 1 -C 6 )alkyl] 2 N(C 1 -C 6 )alkoxy, H 2 N-(C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl-NH-(C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyl, or [(C 1 -C 6 )alkyl] 2 N(C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyl; and *indicates a chiral centre; or a pharmaceutically acceptable salt or solvate thereof. These compounds are useful for the treatment of disease conditions caused by overactivation of VR1 receptor such of pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供式（I）化合物，其中R 1代表（C 1 -C 6 -C 6）烷基; R 2表示氢原子，卤素原子，羟基，（C 1 -C 6 -C 6）烷基，（C 1 -C 6）（C 1 -C 6）烷基，（C 1 -C 6）烷基，（C 1 -C 6）烷基，（C 1 -C 6）（C 1 -C 6）烷氧基 - （C 1 -C 6 -C 6）烷基或卤代（C 1 -C 6 - ç_{6 ）烷基; R 3表示卤素原子，（C 1 -C 6 -C 6）烷基，（C 1 -C 6 - （C 1 -C 6）烷氧基，（C 1 -C 6）烷氧基，（C 1 -C 6）烷氧基，C 1 -C 6 - （C 1 -C 6）烷基，（C 1 -C 6）烷氧基 - （C 1 -C 6 - ）烷基，（C 1 -C 6））烷氧基 - （C 1 -C 6 -C 6）烷氧基，卤代（C 1 -C 6 -C 6）烷基，（C 1 -C 6 -C 6）烷硫基，（C 1 -C 6 -C 6）烷基亚磺酰基，（C _{2 N-; R 5表示卤素原子，（C 1 -C 6 -C 6）烷基，（C 1 -C 6 - （C 1 -C 6）烷氧基，（C 1 -C 6）烷氧基，（C 1 -C 6）烷氧基，C 1 -C 6 - （C 1 -C 6）烷基，（C 1 -C 6）烷氧基 - （C 1 -C 6 - ）烷基，（C 1 -C 6））烷氧基 - （C 1 -C 6 -C 6）烷氧基，卤代（C 1 -C 6 -C 6）烷基，（C 1 -C 6 -C 6）烷硫基，（C 1 -C 6 -C 6）烷基亚磺酰基，（C _{1 -C _{6 ）烷基] _{2 N（ç_{1 -C _{6 ）烷氧基 - （C _{1 < / SUB> -C _{6 ）烷基; 和*表示手性中心; 或其药学上可接受的盐或溶剂合物。这些化合物可用于治疗由哺乳动物VR1受体过度活化引起的疼痛等疼痛引起的疾病状况。本发明还提供了包含上述化合物的药物组合物。}}}}}}}}}

9. 发明申请

WO2005105733A1 ORTHO SUBSTITUTED ARYL OR HETEROARYL AMIDE COMPOUNDS 审中-公开
标题翻译： ORTHO取代的芳基或杂芳基化合物
公开(公告)号：WO2005105733A1
公开(公告)日：2005-11-10
申请号：PCT/IB2005/001135
申请日：2005-04-22
申请人： PFIZER JAPAN INC. , PFIZER INC. , KOIKE, Hiroki , MATSUMOTO, Yukari , YAMAGISHI, Tatsuya , OKUMURA, Yoshiyuki , NAKAO, Kazunari
发明人： KOIKE, Hiroki , MATSUMOTO, Yukari , YAMAGISHI, Tatsuya , OKUMURA, Yoshiyuki , NAKAO, Kazunari
IPC分类号： C07C235/60
CPC分类号： C07D261/08 , C07C235/60 , C07C255/54 , C07C2601/04 , C07C2601/14 , C07D213/61 , C07D213/82 , C07D213/89 , C07D307/12 , C07D307/42 , C07D309/06 , C07D405/12
摘要： The invention provides a compound of the formula (I): wherein X represents a carbon atom or the like : Y represents imino, or the like: Z represents a hydrogen atom or the like: R 1 represents an alkyl group having from 1 to 6 carbon atoms or the like: R 2 and R 3 independently represents a hydrogen atom or the like. These compounds are useful for the treatment of disease conditions mediated by prostaglandin such as pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供式（I）的化合物：其中X表示碳原子等：Y表示亚氨基等：Z表示氢原子等：R 1表示具有1个至6个碳原子等：R 2和R 3独立地表示氢原子等。这些化合物可用于治疗由前列腺素介导的疾病状况，例如哺乳动物中的疼痛等。本发明还提供了包含上述化合物的药物组合物。

10. 发明申请

WO2005021508A1 PHENYL OR PYRIDYL AMIDE COMPOUNDS AS PROSTAGLANDIN E2 ANTAGONISTS 审中-公开
标题翻译：苯基或吡啶基化合物作为PROSTAGLANDIN E2拮抗剂
公开(公告)号：WO2005021508A1
公开(公告)日：2005-03-10
申请号：PCT/IB2004/002735
申请日：2004-08-23
申请人： PFIZER INC. , PFIZER JAPAN, INC. , YAMAGISHI, Tatsuya , OKUMURA, Yoshiyuki , NUKUI, Seiji , NAKAO, Kazunari
发明人： YAMAGISHI, Tatsuya , OKUMURA, Yoshiyuki , NUKUI, Seiji , NAKAO, Kazunari
IPC分类号： C07D213/82
CPC分类号： C07C233/87 , C04B35/632 , C07C235/60 , C07C255/57 , C07D213/643 , C07D213/65 , C07D213/82 , C07D257/04 , C07D401/12 , C07D417/12
摘要： This invention provides a compound of the formula (I): wherein A represents a phenyl group or the like: B represents an aryl or the like: E represents a 1,4-phenylene group; R 1 and R 2 independently represent a hydrogen atom or the like: R 3 and R 4 independently represent a hydrogen atom or the like: R 5 represents -CO 2 H or the like:R 6 represents an alkyl group having from 1 to 6 carbon atoms or the like: X represents a methylene group or the like. These compounds are useful for the treatment of disease conditions mediated by prostaglandin such as pain, or the like in mammalian. The compounds act as antagonists of the prostaglandin E2 receptor. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供式（I）的化合物：其中A表示苯基等：B表示芳基等：E表示1,4-亚苯基; R 1和R 2独立地表示氢原子等：R 3和R 4独立地表示氢原子等：R 5表示-CO 2 H等：R 6 >表示具有1〜6个碳原子的烷基等：X表示亚甲基等。这些化合物可用于治疗由前列腺素介导的疾病状况，例如哺乳动物中的疼痛等。化合物作为前列腺素E2受体的拮抗剂。本发明还提供了包含上述化合物的药物组合物。

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