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1. 发明申请

WO2004089357A2 ANTI-FUNGAL FORMULATION OF TRITERPENE AND ESSENTIAL OIL 审中-公开
标题翻译：抗真菌和基础油的抗真菌配方
公开(公告)号：WO2004089357A2
公开(公告)日：2004-10-21
申请号：PCT/US2004/010351
申请日：2004-04-02
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , CARLSON, Robert, M. , GIBSON, David, J.
发明人： CARLSON, Robert, M. , GIBSON, David, J.
IPC分类号： A61K31/00
CPC分类号： C07J63/008 , A61K31/56 , A61K36/09 , A61K36/13 , A61K36/14 , A61K36/15 , A61K36/17 , A61K36/185 , A61K36/23 , A61K36/232 , A61K36/235 , A61K36/25 , A61K36/258 , A61K36/28 , A61K36/282 , A61K36/30 , A61K36/32 , A61K36/324 , A61K36/328 , A61K36/355 , A61K36/38 , A61K36/45 , A61K36/47 , A61K36/48 , A61K36/482 , A61K36/52 , A61K36/53 , A61K36/532 , A61K36/534 , A61K36/537 , A61K36/54 , A61K36/57 , A61K36/61 , A61K36/63 , A61K36/67 , A61K36/736 , A61K36/738 , A61K36/75 , A61K36/752 , A61K36/81 , A61K36/82 , A61K36/84 , A61K36/85 , A61K36/86 , A61K36/87 , A61K36/88 , A61K36/886 , A61K36/889 , A61K36/8895 , A61K36/896 , A61K36/8962 , A61K36/898 , A61K36/899 , A61K36/9064 , A61K36/9066 , A61K36/9068 , A61K2300/00
摘要： The present invention provides for pharmaceutical compositions that includes a triterpene (e.g., betulin) and an essential oil (Vicks® Vapor Rub). The present invention also provides for a cosmetic formulation that includes a triterpene (e.g., betulin) and an essential oil (Vicks® Vapor Rub). The present invention also provides a method of treating a fungal infection that includes administering (e.g., topically applying) an effective amount of the pharmaceutical composition to the tissue afflicted with the fungal infection, or the tissue at risk of being afflicted with the fungal infection.
摘要翻译：本发明提供了包含三萜（例如桦木醇）和精油（Vicks Vapor Rub）的药物组合物。本发明还提供了包含三萜（例如桦木醇）和精油（Vicks Vapor Rub）的化妆品制剂。本发明还提供了一种治疗真菌感染的方法，其包括将有效量的药物组合物施用（例如，局部施用）到患有真菌感染的组织或被感染真菌感染的风险的组织。

2. 发明申请

WO2005077377A1 COMPOSITIONS THAT INCLUDE A TRITERPENE AND A CARRIER 审中-公开
标题翻译：包含TRITERPEN和CARRIER的组合物
公开(公告)号：WO2005077377A1
公开(公告)日：2005-08-25
申请号：PCT/US2005/003660
申请日：2005-02-07
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , KRASUTSKY, Pavel, A. , KHOTKEVYCH, Andriy, B. , CARLSON, Robert, M.
发明人： KRASUTSKY, Pavel, A. , KHOTKEVYCH, Andriy, B. , CARLSON, Robert, M.
IPC分类号： A61K31/56
CPC分类号： A61K31/56 , A61K8/31 , A61K8/34 , A61K8/345 , A61K8/365 , A61K8/37 , A61K31/137 , A61K31/496 , A61K31/57 , A61K31/704 , A61K31/7048 , A61Q19/00 , A61Q19/004 , A61Q19/007 , A61K2300/00
摘要： The present invention provides for compositions that includes a triterpene ( e.g., betulin) and a carrier ( e.g., lanolin). The compositions are useful for skin care ( e.g ., as cosmetic formulations), and as therapeutic formulations, e.g., for treating topical fungal infections.
摘要翻译：本发明提供了包含三萜（例如，桦木醇）和载体（例如羊毛脂）的组合物。该组合物可用于皮肤护理（例如，作为化妆品制剂），以及用作治疗剂型，例如用于治疗局部真菌感染。

3. 发明申请

WO2003080080A1 CYCLODEXTRIN COMPOSITIONS AND METHODS OF TREATING VIRAL INFECTIONS 审中-公开
标题翻译：环糊精组合物和治疗病毒感染的方法
公开(公告)号：WO2003080080A1
公开(公告)日：2003-10-02
申请号：PCT/US2003/008915
申请日：2003-03-21
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , WALLACE, Kendall, B. , KHAN, Muhammad, Ayub , CARLSON, Robert, M. , RICE, Stephen, A. , FROBERG, Mervin, Kent
发明人： WALLACE, Kendall, B. , KHAN, Muhammad, Ayub , CARLSON, Robert, M. , RICE, Stephen, A. , FROBERG, Mervin, Kent
IPC分类号： A61K31/724
CPC分类号： A61K31/724 , A61K31/522 , A61K31/662 , A61K2300/00
摘要： The present invention provides methods and therapeutic compositions for treating viral infections.
摘要翻译：本发明提供了治疗病毒感染的方法和治疗组合物。

4. 发明申请

WO2008070347A2 TRITERPENES 审中-公开
标题翻译：三萜
公开(公告)号：WO2008070347A2
公开(公告)日：2008-06-12
申请号：PCT/US2007/082694
申请日：2007-10-26
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , CARLSON, Robert, M. , KRASUTSKY, Pavel, A. , KACHAROVA, Liliya
发明人： CARLSON, Robert, M. , KRASUTSKY, Pavel, A. , KACHAROVA, Liliya
IPC分类号： C07K5/06 , A61K47/48 , C07J63/00 , A61P31/00 , A61P33/06
CPC分类号： C07K5/0613 , A61K47/542 , A61K47/62 , C07J63/008
摘要： The present invention provides for novel compounds of formula I, II, III and IV, as described herein. The present invention also provides for novel methods of manufacturing compounds of formula I, II and III from compounds of formula IV, that include contacting the compound of formula IV and an amino acid (or peptide). The present invention also provides for methods of killing or inhibiting a virus, bacteria and/or fungus. The methods include contacting a virus, bacteria and/or fungus, respectively, with a suitable amount of a compound of formula I, II or III. The present invention also provides for a method of treating a mammal afflicted with a viral infection, bacterial infection and/or fungal infection. The method includes administering to a mammal in need of such treatment an effective amount of a compound of formula I, II or III.
摘要翻译：本发明提供如本文所述的新颖的式I，II，III和IV化合物。本发明还提供从式IV化合物制备式I，II和III化合物的新方法，包括使式IV化合物与氨基酸（或肽）接触。本发明还提供杀死或抑制病毒，细菌和/或真菌的方法。所述方法包括分别将病毒，细菌和/或真菌与合适量的式I，II或III化合物接触。本发明还提供了治疗患有病毒感染，细菌感染和/或真菌感染的哺乳动物的方法。该方法包括向需要这种治疗的哺乳动物施用有效量的式I，II或III化合物。

5. 发明申请

WO2002098924A2 COMPOSITIONS INCLUDING FLUORINATED PEROXIDES, METHODS OF MAKING, AND THE USE THEREOF 审中-公开
标题翻译：包含氟化过氧化物的组合物，制备方法及其用途
公开(公告)号：WO2002098924A2
公开(公告)日：2002-12-12
申请号：PCT/US2002/018082
申请日：2002-06-05
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , KRASUTSKY, Pavel, A. , CARLSON, Robert, M. , KOLOMITSYN, Igor, V. , WANG, Hong
发明人： KRASUTSKY, Pavel, A. , CARLSON, Robert, M. , KOLOMITSYN, Igor, V. , WANG, Hong
IPC分类号： C08F
CPC分类号： C07C409/34 , C07B39/00
摘要： Methods of making compositions including fluorinated peroxides are disclosed. The compositions are useful, for example, for reacting with organic compounds. In one embodiment, novel peroxides are provided.
摘要翻译：公开了制备包括氟化过氧化物的组合物的方法。组合物可用于例如与有机化合物反应。在一个实施方案中，提供了新的过氧化物。

6. 发明申请

WO2009006178A1 METHOD FOR PRODUCING DIAMOND-LIKE CARBON COATINGS USING DIAMONDOID PRECURSORS ON INTERNAL SURFACES 审中-公开
标题翻译：在内表面上使用金刚石前驱体制造金刚石碳涂层的方法
公开(公告)号：WO2009006178A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/068279
申请日：2008-06-26
申请人： SUB-ONE TECHNOLOGY, INC. , CHEVRON U.S.A. INC. , TUDHOPE, Andrew, W. , BOARDMAN, William, J. , SCIAMANNA, Steven, F. , CASSERLY, Thomas, B. , CARLSON, Robert, M.
发明人： TUDHOPE, Andrew, W. , BOARDMAN, William, J. , SCIAMANNA, Steven, F. , CASSERLY, Thomas, B. , CARLSON, Robert, M.
IPC分类号： C23C16/00
CPC分类号： C23C16/045 , C23C16/26 , C23C16/50 , C23C16/503 , C23C16/509 , C23C16/52
摘要： The invention relates to a method for forming high sp 3 content amorphous carbon coatings deposited by plasma enhanced chemical vapor deposition on internal surfaces and employing the hollow-cathode technique. This method allows adjustment of tribological properties, such as hardness, Young's modulus, wear resistance and coefficient of friction as well as optical properties, such as refractive index. In addition the resulting coatings are uniform and have high corrosion resistance. By controlling pressure, type of diamondoid precursor and bias voltage, the new method prevents the diamondoid precursor from fully breaking upon impact with the substrate. The diamondoid retains sp 3 bonds which yields a high sp 3 content film at higher pressure. This enables a faster deposition rate than would be possible without the use of a diamondoid precursor.
摘要翻译：本发明涉及一种用于形成通过等离子体增强化学气相沉积在内表面上并采用中空阴极技术沉积的高含量无定形碳涂层的方法。该方法允许调节摩擦学性能，例如硬度，杨氏模量，耐磨性和摩擦系数以及光学性质如折射率。此外，所得涂层是均匀的并且具有高耐腐蚀性。通过控制压力，类金刚石前体和偏置电压，新方法可防止金刚石类前体在与基材碰撞时完全破裂。金刚石保留sp3键，其在较高压力下产生高的sp3含量的膜。这使得能够在不使用金刚石前体的情况下实现比可能更快的沉积速率。

7. 发明申请

WO2008153779A1 SPIRO AND OTHER DERIVATIVES OF DIAMONDOIDS POSSESSING THERAPEUTIC ACTIVITY IN THE TREATMENT OF VIRAL DISORDERS 审中-公开
标题翻译：治疗病毒治疗的治疗药物的二氧化钛和其他衍生物
公开(公告)号：WO2008153779A1
公开(公告)日：2008-12-18
申请号：PCT/US2008/006666
申请日：2008-05-23
申请人： CHEVRON U.S.A. INC. , KONG, Deyuan , LAM, Frederick, W. , SCIAMANNA, Steven, F. , SHELTON, Earl , LIU, Shenggao , CARLSON, Robert, M.
发明人： KONG, Deyuan , LAM, Frederick, W. , SCIAMANNA, Steven, F. , SHELTON, Earl , LIU, Shenggao , CARLSON, Robert, M.
IPC分类号： A01N37/18 , A61K31/165
CPC分类号： C07D209/96 , C07C211/19 , C07C2603/94 , C07D221/20
摘要： This invention relates to diamondoid derivatives which exhibit therapeutic activity. Specifically, the diamondoid derivatives herein exhibit therapeutic effects in the treatment of viral disorders. Also provided are methods of treatment, prevention and inhibition of viral disorders in a subject in need.
摘要翻译：本发明涉及显示出治疗活性的类金刚石衍生物。具体地，本文中的类金刚石衍生物在治疗病毒性疾病中表现出治疗效果。还提供了在需要的受试者中治疗，预防和抑制病毒性疾病的方法。

8. 发明申请

WO2012088476A2 IN-SITU KEROGEN CONVERSION AND RECOVERY 审中-公开
标题翻译：现场转换和恢复
公开(公告)号：WO2012088476A2
公开(公告)日：2012-06-28
申请号：PCT/US2011/067023
申请日：2011-12-22
申请人： CHEVRON U.S.A. INC. , WIGAND, Marcus , CARLSON, Robert, M. , LOONEY, Mark
发明人： WIGAND, Marcus , CARLSON, Robert, M. , LOONEY, Mark
IPC分类号： C10G1/04 , C10G7/00 , C10G9/00 , C10G47/00
CPC分类号： C10G1/04 , C10G9/00 , C10G27/06 , C10G27/12 , C10G49/00 , C10G2300/4081 , C10G2400/10 , E21B43/24 , Y02P30/44
摘要： Disclosed herein are methods for extracting a kerogen-based product from subsurface (oil) shale formations. These methods rely on chemically modifying the shale-bound kerogen using a chemical oxidant so as to render it mobile. The oxidant is provided to a formation fluid in contact with the kerogen in the subsurface shale. An alkaline material is also provided to the formation fluid to mobilize organic acids which are produced during oxidation of the kerogen. A mobile kerogen-based product which includes the organic acids is withdrawn from the subsurface shale formation and further processed to isolate the organic acids contained therein. An exemplary method for isolating the acids includes treating the mobile kerogen- based product such that at least a portion of the organic acids form a separate phase from the mobile kerogen-based product. The organic acids may further be extracted from the mobile kerogen-based product using an organic extraction fluid. The isolated organic acids can be upgraded by a reaction process that make the products suitable as refinery feedstocks, fuel or lubricant blendstocks, reaction intermediates, chemical feedstocks, or chemical intermediate blendstocks.
摘要翻译：本文公开了从地下（油）页岩层中提取基于油母质的产品的方法。这些方法依靠使用化学氧化剂对页岩结合的干酪根进行化学修饰，以使其移动。将氧化剂提供给与地下页岩中的干酪根接触的地层流体。还向地层流体提供碱性物质以移动在干酪根氧化期间产生的有机酸。包括有机酸的基于移动干酪根的产品从地下页岩地层中取出并进一步处理以分离其中所含的有机酸。用于分离酸的示例性方法包括处理可移动的基于油母质的产品，使得至少一部分有机酸与可移动的基于干酪根的产品形成分离的相。有机酸可以使用有机萃取液从可移动的基于油母质的产品中进一步提取。分离的有机酸可以通过使产物适合作为炼油原料，燃料或润滑剂共混物，反应中间体，化学原料或化学中间体共混物的反应过程来升级。

9. 发明申请

WO2006122054A1 DIAMONDOID DERIVATIVES POSSESSING THERAPEUTIC ACTIVITY 审中-公开
标题翻译：接触治疗活性的金刚石衍生物
公开(公告)号：WO2006122054A1
公开(公告)日：2006-11-16
申请号：PCT/US2006/017771
申请日：2006-05-08
申请人： CHEVRON U.S.A. INC. , LIU, Shenggao , LAM, Frederick, W. , SCIAMANNA, Steven. F. , CARLSON, Robert, M. , DAHL, Jeremy, E.
发明人： LIU, Shenggao , LAM, Frederick, W. , SCIAMANNA, Steven. F. , CARLSON, Robert, M. , DAHL, Jeremy, E.
IPC分类号： C07C233/00
CPC分类号： C07C211/38 , C07C13/64 , C07C35/44 , C07C211/41 , C07C233/06 , C07C233/41 , C07C2603/90
摘要： This invention relates to diamondoid derivatives which exhibit therapeutic activity. Specifically, the diamondoid derivatives herein exhibit therapeutic effects in the treatment of neurologic disorders. Also provided are methods of treatment, prevention and inhibition of neurologic disorders in a subject in need.
摘要翻译：本发明涉及显示出治疗活性的类金刚石衍生物。具体地，本文中的类金刚石衍生物在治疗神经障碍中表现出治疗效果。还提供了治疗，预防和抑制需要的受试者神经系统疾病的方法。

10. 发明申请

WO2002096804A3 PROCESSES FOR THE PURIFICATION OF HIGHER DIAMONDOIDS AND COMPOSITIONS COMPRISING SUCH DIAMONDOIDS 审中-公开
公开(公告)号：WO2002096804A3
公开(公告)日：2002-12-05
申请号：PCT/US2002/004549
申请日：2002-01-17
申请人： CHEVRON U.S.A. INC. , DAHL, Jeremy, E. , CARLSON, Robert, M.
发明人： DAHL, Jeremy, E. , CARLSON, Robert, M.
IPC分类号： C07C13/64
摘要： Disclosed are processes for the recovery and purification of higher diamondoids from a hydrocarbonaceous feedstock. Specifically disclosed is a multi-step recovery process for obtaining diamondoid compositions enhanced in tetramantane components and other higher diamondoid components. Also disclosed are compositions comprising at least about 10 weight percent of non-ionized tetramantane components and other higher diamondoid components and at least about 0.5 weight percent of non-ionized pentamantane components and other higher diamondoid components based on the total weight of diamondoid components present.

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