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1. 发明申请

WO2007029156A3 ISOINDOLEDIONE DERIVATIVES AS ADRENERGIC RECEPTOR ANTAGONISTS 审中-公开
公开(公告)号：WO2007029156A3
公开(公告)日：2007-03-15
申请号：PCT/IB2006/053082
申请日：2006-09-01
申请人： RANBAXY LABORATORIES LIMITED , SARMA, Pakala, Kumara, Savithru , KUTTAN, Ashani , PAL, Arani , KONDASKAR, Atul , GUPTA, Praful , DHARMARAJAN, Sankaranarayanan , SHELKE, Sandeep, Y. , SHARMA, Somesh , CHUGH, Anita , TIWARI, Atul
发明人： SARMA, Pakala, Kumara, Savithru , KUTTAN, Ashani , PAL, Arani , KONDASKAR, Atul , GUPTA, Praful , DHARMARAJAN, Sankaranarayanan , SHELKE, Sandeep, Y. , SHARMA, Somesh , CHUGH, Anita , TIWARI, Atul
IPC分类号： C07D471/08 , C07D403/06 , C07D403/12 , C07D405/14 , C07D491/04 , A61K31/496 , A61P13/08
摘要： Provided are isoindoledione derivatives, which can be used of treating a disease or disorder mediated through αla and/or α1(1 adrenergic receptors. Compounds disclosed herein can be used of treating benign prostatic hyperplasia (BPH) and related symptoms thereof, lower urinary tract symptoms (LUTS) associated with or without BPH. Processes for the preparation of described compounds, pharmaceutical compositions thereof, and methods of treating BPH and related symptoms thereof, LUTS associated with or without BPH are also provided.

2. 发明申请

WO2006117760A1 ADRENERGIC RECEPTOR ANTAGONISTS 审中-公开
公开(公告)号：WO2006117760A1
公开(公告)日：2006-11-09
申请号：PCT/IB2006/051392
申请日：2006-05-03
申请人： RANBAXY LABORATORIES LIMITED , SARMA, Pakala, Kumara, Savithru , SHARMA, Somesh , DHARMARAJAN, Sankaranarayanan , SHELKE, Sandeep Y. , PAL, Arani , KONDASKAR, Atul , GUPTA, Praful , CHUGH, Anita , TIWARI, Atul , NANDA, Kamna
发明人： SARMA, Pakala, Kumara, Savithru , SHARMA, Somesh , DHARMARAJAN, Sankaranarayanan , SHELKE, Sandeep Y. , PAL, Arani , KONDASKAR, Atul , GUPTA, Praful , CHUGH, Anita , TIWARI, Atul , NANDA, Kamna
IPC分类号： C07D401/06 , C07D403/06 , C07D413/06 , C07D417/06 , A61K31/53 , A61K31/536 , A61K31/5415 , A61P13/00
CPC分类号： C07D401/06 , C07D403/06 , C07D413/06 , C07D417/06
摘要： The present invention relates to α 1a and/or α 1b adrenergic receptor antagonists, which can be used to treat a disease or disorder mediated through α 1a and/or α 1b adrenergic receptors. Compounds and pharmaceutical compositions disclosed herein can be used to treat benign prostatic hyperplasia (BPH) and related symptoms thereof. Further, such compounds can be used to treat lower urinary tract symptoms that may or may not be associated with BPH. The present invention also relates to processes to prepare the disclosed compounds, pharmaceutical compositions thereof, and methods of treating BPH or related symptoms thereof.
摘要翻译：本发明涉及可用于治疗通过1a介导的疾病或病症的α1a1和/或1b2肾上腺素能受体拮抗剂和/或1b 1b肾上腺素能受体。本文公开的化合物和药物组合物可用于治疗良性前列腺增生（BPH）及其相关症状。此外，这些化合物可用于治疗可能与也可能不伴有BPH的下尿路症状。本发明还涉及制备所公开的化合物的方法，其药物组合物，以及治疗BPH或其相关症状的方法。

3. 发明申请

WO2007029078A2 SUCCINIMIDE AND GLUTARIMIDE DERIVATIVES AS ADRENERGIC RECEPTOR ANTAGONISTS 审中-公开
标题翻译：作为ADRENERGIC RECEPTOR ANTAGONISTS的SUCCINIMIDE AND GLUTARIMIDE DERIVATIVES
公开(公告)号：WO2007029078A2
公开(公告)日：2007-03-15
申请号：PCT/IB2006/002370
申请日：2006-08-30
申请人： RANBAXY LABORATORIES LIMITED , SARMA, Pakala, Kumara, Savithru , SHELKE, Sandeep Y , ASHANI, K. , GUPTA, Praful , PAL, Arani , KONDASKAR, Atul , DHARMARAJAN, Sankaranarayanan , SHARMA, Somesh , CHUGH, Anita , TIWARI, Atul
发明人： SARMA, Pakala, Kumara, Savithru , SHELKE, Sandeep Y , ASHANI, K. , GUPTA, Praful , PAL, Arani , KONDASKAR, Atul , DHARMARAJAN, Sankaranarayanan , SHARMA, Somesh , CHUGH, Anita , TIWARI, Atul
IPC分类号： C07D401/06 , C07D471/08 , C07D211/88 , C07D487/08
CPC分类号： C07D211/88 , C07D207/40 , C07D209/52 , C07D221/24 , C07D401/06 , C07D403/06 , C07D471/08 , C07D487/08
摘要： The present invention relates to succinimide and glutarimide derivatives, which can be used to treat a disease or disorder mediated through 1a and/or 1d adrenergic receptors. Compounds and pharmaceutical compositions disclosed herein can be used to treat benign prostatic hyperplasia (BPH) and related symptoms thereof. Further, such compounds can be used to treat lower urinary tract symptoms that may or may not be associated with BPH. The present invention also relates to processes to prepare the disclosed compounds, pharmaceutical compositions thereof, and methods of treating BPH or related symptoms thereof.
摘要翻译：本发明涉及琥珀酰亚胺和戊二酰亚胺衍生物，其可用于治疗通过1a和/或1d肾上腺素能受体介导的疾病或病症。本文公开的化合物和药物组合物可用于治疗良性前列腺增生（BPH）及其相关症状。此外，这些化合物可用于治疗可能与也可能不与BPH相关的下尿路症状。本发明还涉及制备所公开的化合物的方法，其药物组合物，以及治疗BPH或其相关症状的方法。

4. 发明申请

WO2006013445A2 THIAZOLIDINEDIONE DERIVATIVES 审中-公开
标题翻译：噻唑烷二酮衍生物
公开(公告)号：WO2006013445A2
公开(公告)日：2006-02-09
申请号：PCT/IB2005/002247
申请日：2005-07-28
申请人： RANBAXY LABORATORIES LIMITED , ANAND, Nitya , SALMAN, Mohammad , SHARMA, Somesh , KAPKOTI, Gobind, Singh , CHUGH, Anita , NANDA, Kamna , SARMA, Pakala, Kumara, Savithru
发明人： ANAND, Nitya , SALMAN, Mohammad , SHARMA, Somesh , KAPKOTI, Gobind, Singh , CHUGH, Anita , NANDA, Kamna , SARMA, Pakala, Kumara, Savithru
IPC分类号： C07D277/00
CPC分类号： C07D277/34
摘要： The present invention relates to alpha 1a and/or alpha 1d adrenergic receptor antagonists. Compounds described can function as alpha 1a and/or alpha 1d adrenergic receptor antagonists and can be used to treat diseases or disorders mediated through alpha 1a and/or alpha 1d adrenergic receptors. Compounds described can also be used to treat benign prostatic hyperplasia or related symptoms thereof. Compounds described can also be used to treat lower urinary tract symptoms associated with or without benign prostatic hyperplasia. Also described are processes to prepare the described compounds, as well as pharmaceutical compositions thereof and methods of treating benign prostatic hyperplasia or related symptoms thereof.
摘要翻译：本发明涉及α1a和/或α1d肾上腺素能受体拮抗剂。所描述的化合物可以作为α1a和/或α1d肾上腺素能受体拮抗剂起作用，并且可用于治疗通过α1a和/或α1d肾上腺素能受体介导的疾病或病症。所描述的化合物也可用于治疗良性前列腺增生或其相关症状。所描述的化合物也可用于治疗与或不伴有良性前列腺增生相关的下尿路症状。还描述了制备所述化合物的方法，以及其药物组合物和治疗良性前列腺增生或其相关症状的方法。

5. 发明申请

WO2005037282A1 1-ALKYLPIPERAZINYL-PYRROLIDIN-2,5-DIONE DERIVATIVES AS ADRENERGIC RECEPTOR ANTAGONISTS 审中-公开
标题翻译：作为ADRENERGIC受体拮抗剂的1-烷基哌嗪 - 吡咯烷-2,5-二酮衍生物
公开(公告)号：WO2005037282A1
公开(公告)日：2005-04-28
申请号：PCT/IB2004/003362
申请日：2004-10-14
申请人： RANBAXY LABORATORIES LIMITED , ANAND, Nitya , SALMAN, Mohammad , SHARMA, Somesh , KAPKOTI, Gobind, Singh , GUPTA, Praful , MISHRA, Anurag , CHUGH, Anita , TIWARI, Atul
发明人： ANAND, Nitya , SALMAN, Mohammad , SHARMA, Somesh , KAPKOTI, Gobind, Singh , GUPTA, Praful , MISHRA, Anurag , CHUGH, Anita , TIWARI, Atul
IPC分类号： A61K31/496
CPC分类号： C07D207/40 , C07D207/408 , C07D207/416 , C07D209/48
摘要： This invention relates to α 1a and/or α 1d adrenergic receptor antagonists of formula 1 Compounds disclosed herein can function as α 1a and/or α 1d adrenergic receptor antagonists and can be used for the treatment of diseases or disorders mediated through α 1a and/or α 1d adrenergic receptors. Compounds disclosed herein can be used for the treatment of benign prostatic hyperplasia and related symptoms thereof. Compounds disclosed herein can also be used for the treatment of lower urinary tract symptoms associated with or without benign prostatic hyperplasia. The invention also relates to a process for the preparation of compounds disclosed herein, pharmaceutical compositions containing these compounds and the methods of treating diseases or disorders mediated through α 1a and/or α 1d receptors.
摘要翻译：本发明涉及式1的α1a和/或α1d肾上腺素能受体拮抗剂。本文公开的化合物可用作α1a和/或α1肾上腺素能受体拮抗剂，并且可用于治疗通过α1a和/或α1d肾上腺素能受体介导的疾病或病症。本文公开的化合物可用于治疗良性前列腺增生及其相关症状。本文公开的化合物也可用于治疗与或不伴有良性前列腺增生相关的下尿路症状。本发明还涉及制备本文公开的化合物的方法，含有这些化合物的药物组合物和治疗通过α1a和/或α1受体介导的疾病或病症的方法。

6. 发明申请

WO2005118537A2 ADRENERGIC RECEPTOR ANTAGONISTS 审中-公开
公开(公告)号：WO2005118537A2
公开(公告)日：2005-12-15
申请号：PCT/IB2005/001534
申请日：2005-05-31
申请人： RANBAXY LABORATORIES LIMITED , SALMAN, Mohammad , SHARMA, Somesh , YADAV, Gyan, Chand , KAPKOTI, Gobind Singh , MISHRA, Anurag , GUPTA, Praful , ANAND, Nitya , CHUGH, Anita , NANDA, Kamna
发明人： SALMAN, Mohammad , SHARMA, Somesh , YADAV, Gyan, Chand , KAPKOTI, Gobind Singh , MISHRA, Anurag , GUPTA, Praful , ANAND, Nitya , CHUGH, Anita , NANDA, Kamna
IPC分类号： C07D209/00
CPC分类号： C07D207/404 , C07D207/416 , C07D207/452 , C07D209/48 , C07D209/94 , C07D211/88 , C07D409/12 , C07D513/04
摘要： The present invention relates to α 1a and/or α 1d adrenergic receptor antagonists, which can function as α 1a and/or α 1d adrenergic receptor antagonist and can be used for the treatment of a disease or disorder mediated through α 1a and/or α 1d adrenergic receptor. Compounds disclosed herein can be used for the treatment of benign prostatic hyperplasia (BPH) and the related symptoms thereof. Further, compounds disclosed herein can be used for the treatment of lower urinary tract symptoms associated with or without BPH. Also provided are processes for preparing such compounds, pharmaceutical compositions thereof, and the methods of treating BPH or related symptoms thereof.
摘要翻译：本发明涉及α1a和/或α1肾上腺素能受体拮抗剂，其可用作α1a和/或α1肾上腺素能受体拮抗剂，并可用于治疗通过α1a和/或α1d肾上腺素能受体介导的疾病或病症。本文公开的化合物可用于治疗良性前列腺增生（BPH）及其相关症状。此外，本文公开的化合物可用于治疗与或不与BPH相关的下尿路症状。还提供了制备这种化合物的方法，其药物组合物，以及治疗BPH或其相关症状的方法。

7. 发明申请

WO2006051374A2 ADRENERGIC RECEPTOR ANTAGONISTS 审中-公开
公开(公告)号：WO2006051374A2
公开(公告)日：2006-05-18
申请号：PCT/IB2005/003295
申请日：2005-11-04
申请人： RANBAXY LABORATORIES LIMITED , SALMAN, Mohammad , ANAND, Nitya , YADAV, Gyan, Chand , SHARMA, Somesh , KAPKOTI, Gobind, Singh , CHUGH, Anita , NANDA, Kamna
发明人： SALMAN, Mohammad , ANAND, Nitya , YADAV, Gyan, Chand , SHARMA, Somesh , KAPKOTI, Gobind, Singh , CHUGH, Anita , NANDA, Kamna
IPC分类号： A61K31/4355 , C07D491/04 , C07D401/12 , C07D209/76
CPC分类号： C07D209/48 , C07D209/76 , C07D491/04
摘要： The present invention relates to α 1a and/or α 1d adrenergic receptor antagonists, which can be used to treat a disease or disorder mediated through α 1a and/or α 1d adrenergic receptors. Compounds and pharmaceutical compositions disclosed herein can be used to treat benign prostatic hyperplasia (BPH) and related symptoms thereof. Further, such compounds can be used to treat lower urinary tract symptoms that may or may not be associated with BPH. The present invention also relates to processes to prepare the disclosed compounds, pharmaceutical compositions thereof, and methods of treating BPH or related symptoms thereof.
摘要翻译：本发明涉及可用于治疗通过1a介导的疾病或病症的<！ - SIPO - >1α1α和/或1β1肾上腺素能受体拮抗剂。 >和/或<1d>肾上腺素能受体。本文公开的化合物和药物组合物可用于治疗良性前列腺增生（BPH）及其相关症状。此外，这些化合物可用于治疗可能与也可能不伴有BPH的下尿路症状。本发明还涉及制备所公开的化合物的方法，其药物组合物，以及治疗BPH或其相关症状的方法。

8. 发明申请

WO2005113498A1 ADRENERGIC RECEPTOR ANTAGONISTS 审中-公开
公开(公告)号：WO2005113498A1
公开(公告)日：2005-12-01
申请号：PCT/IB2004/001641
申请日：2004-05-19
申请人： RANBAXY LABORATORIES LIMITED , SALMAN, Mohammad , SHARMA, Somesh , KAPKOTI, Gobind, Singh , ANAND, Nitya , CHUGH, Anita
发明人： SALMAN, Mohammad , SHARMA, Somesh , KAPKOTI, Gobind, Singh , ANAND, Nitya , CHUGH, Anita
IPC分类号： C07D207/40
CPC分类号： C07D207/408 , C07D207/448 , C07D209/48
摘要： This invention relates to α 1a and/or α 1d adrenergic receptor antagonists. Compounds disclosed herein can function as α 1a and/or α 1d adrenergic receptor antagonist and can be used for the treatment of diseases or disorder mediated through α 1a and/or α 1d adrenergic receptors. Compounds disclosed herein can be used for the treatment of benign prostatic hyperplasia and the related symptoms thereof. Compounds disclosed herein can be used for the treatment of lower urinary tract symptoms associated with or without benign prostatic hyperplasia. Processes for the preparation of compounds disclosed herein, pharmaceutical compositions containing the compounds disclosed herein, and methods of treating benign prostatic hyperplasia or related symptoms thereof are also provided. Formula (I) Its pharmaceutically acceptable acid addition salts,pharmaceutically acceptable solvates, enantiomers, diastereomers, N-oxides, polymorphs or metabolites,wherein; A represents a Formula (F.a or ,F.b or F.c wherein) N represents 1 or 2; Y represents cycloalkyl (C 5- C 7 ) group; optionally substituted with halogen atom(s) or lower alkyl (C 1- C 4 ) group; and R is selected from optionally substituted non_aromatic or aromatic monocyclic or bicyclic ring system having 0 to 4 heteroatom(s),the substituent(s) may be selected from the group consisting of halogen, lower alkyl (C 1- C 4 ),halogenated lower alkyl (C 1- c 4 ),cyano, hydroxy, lower alkoxy (C 1- C 4 ),cycloalkoxy (C 3- C 6 ),amino,lower alkylamino (C 1- C 4 ) and lower alkylamino (C 1- C 4 ) carbonyl group.
摘要翻译：本发明涉及α1a和/或α1d肾上腺素能受体拮抗剂。本文公开的化合物可用作α1a和/或α1肾上腺素能受体拮抗剂，并且可用于治疗通过α1a和/或α1肾上腺素能受体介导的疾病或病症。本文公开的化合物可用于治疗良性前列腺增生及其相关症状。本文公开的化合物可用于治疗与或不伴有良性前列腺增生相关的下尿路症状。还提供了制备本文公开的化合物的方法，含有本文公开的化合物的药物组合物，以及治疗良性前列腺增生或其相关症状的方法。式（I）其药学上可接受的酸加成盐，药学上可接受的溶剂合物，对映异构体，非对映异构体，N-氧化物，多晶型物或代谢物，其中; A表示式（F.a或F.b或F.c，其中N表示1或2; Y代表环烷基（C5-C7）基团; 任选被卤素原子或低级烷基（C 1 -C 4）基团取代; 并且R选自具有0至4个杂原子的任选取代的非芳族或芳族单环或双环体系，所述取代基可以选自卤素，低级烷基（C 1 -C 4），卤代低级烷基（C1-C4），氰基，羟基，低级烷氧基（C1-C4），环烷氧基（C3-C6），氨基，低级烷基氨基（C1-C4）和低级烷基氨基（C1-C4）羰基。

9. 发明申请

WO2006051399A1 PIPERAZINE DERIVATIVES USEFUL AS ADRENERGIC RECEPTOR ANTAGONISTS 审中-公开
标题翻译：哌嗪衍生物作为ADRENERGIC RECEPTOR ANTAGONISTS有用
公开(公告)号：WO2006051399A1
公开(公告)日：2006-05-18
申请号：PCT/IB2005/003373
申请日：2005-11-10
申请人： RANBAXY LABORATORIES LIMITED , SALMAN, Mohammad , ANAND, Nitya , SHARMA, Somesh , KAPKOTI, Gobind, Singh , CHUGH, Anita , NANDA, Kamna
发明人： SALMAN, Mohammad , ANAND, Nitya , SHARMA, Somesh , KAPKOTI, Gobind, Singh , CHUGH, Anita , NANDA, Kamna
IPC分类号： C07D211/88 , C07D207/40 , C07D209/48 , C07D401/04 , C07D401/06 , A61K31/496 , A61P13/00
CPC分类号： C07D207/404 , C07D209/48 , C07D211/88 , C07D401/04 , C07D401/06
摘要： The present invention relates to α 1a and/or α 1d adrenergic receptor antagonists, of formula I, which can be used to treat a disease or disorder mediated through α 1a and/or α 1d adrenergic receptors. Compounds and pharmaceutical compositions described herein can be used to treat benign prostatic hyperplasia (BPH) and related symptoms thereof. Further, such compounds can be used to treat lower urinary tract symptoms that may or may not be associated with BPH. The present invention also relates to processes to prepare the described compounds, pharmaceutical compositions thereof, and methods of treating BPH or related symptoms thereof.
摘要翻译：本发明涉及式I的1α1A和/或1 / 1d肾上腺素能受体拮抗剂，其可用于治疗通过“ 1a和/或1d肾上腺素能受体。本文所述的化合物和药物组合物可用于治疗良性前列腺增生（BPH）及其相关症状。此外，这些化合物可用于治疗可能与也可能不伴有BPH的下尿路症状。本发明还涉及制备所述化合物的方法，其药物组合物，以及治疗BPH或其相关症状的方法。

10. 发明申请

WO2003084541A1 CARBOXIMIDE DERIVATIVES AS USEFUL URO-SELECTIVE ALPHA-1A ADRENOCEPTOR BLOCKERS 审中-公开
标题翻译：碳酰亚胺衍生物作为有用的选择性ALPHA-1A ADRENOCEPTOR阻断剂
公开(公告)号：WO2003084541A1
公开(公告)日：2003-10-16
申请号：PCT/IB2002/001108
申请日：2002-04-08
申请人： RANBAXY LABORATORIES LIMITED , SALMAN, Mohammad , YADAV, Gyan Chand , SHARMA, Somesh , KAPKOTI, Gobind Singh , CHUGH, Anita , GUPTA, Jang Bahadur , ANAND, Nitya
发明人： SALMAN, Mohammad , YADAV, Gyan Chand , SHARMA, Somesh , KAPKOTI, Gobind Singh , CHUGH, Anita , GUPTA, Jang Bahadur , ANAND, Nitya
IPC分类号： A61K31/495
CPC分类号： C07D295/13
摘要： Novel carboximide derivatives, which selectively inhibit binding to the α -1A adrenergic receptor, a receptor which has been shown to be important in the treatment of benign prostatic hyperplasia. The compounds of the present invention are potentially useful in the treatment of benign prostatic hyperplasia.
摘要翻译：新型的甲酰亚胺衍生物，其选择性地抑制与α> -1A <肾上腺素能受体的结合，该受体已被证明在治疗良性前列腺增生中是重要的。本发明的化合物可用于治疗良性前列腺增生。

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