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1. 发明申请

WO2012006469A1 METHODS AND SYSTEMS FOR THREE-MEMRISTOR SYNAPSE WITH STDP AND DOPAMINE SIGNALING 审中-公开
标题翻译：具有STDP和DOPAMINE信号的三重仪器共振的方法和系统
公开(公告)号：WO2012006469A1
公开(公告)日：2012-01-12
申请号：PCT/US2011/043256
申请日：2011-07-07
申请人： QUALCOMM Incorporated , TANG, Yi , LEVIN, Jeffrey A. , APARIN, Vladimir , RANGAN, Venkat
发明人： TANG, Yi , LEVIN, Jeffrey A. , APARIN, Vladimir , RANGAN, Venkat
IPC分类号： G06N3/063
CPC分类号： G06N3/0635 , G06N3/049
摘要： The present disclosure proposes implementation of a three-memristor synapse where an adjustment of synaptic strength is based on Spike-Timing-Dependent Plasticity (STDP) with dopamine signaling.
摘要翻译：本公开提出了三忆阻突触的实施，其中突触强度的调整基于具有多巴胺信号传导的尖峰时间依赖性可塑性（STDP）。

2. 发明申请

WO2012006471A1 METHODS AND SYSTEMS FOR MEMRISTOR-BASED NEURON CIRCUITS 审中-公开
标题翻译：用于基于神经元的神经元电路的方法和系统
公开(公告)号：WO2012006471A1
公开(公告)日：2012-01-12
申请号：PCT/US2011/043258
申请日：2011-07-07
申请人： QUALCOMM Incorporated , TANG, Yi , RANGAN, Venkat , LEVIN, Jeffrey A. , VENKATRAMAN, Subramaniam
发明人： TANG, Yi , RANGAN, Venkat , LEVIN, Jeffrey A. , VENKATRAMAN, Subramaniam
IPC分类号： G06N3/063
CPC分类号： G06N3/0635 , G06N3/049 , G06N3/063 , G11C11/54 , G11C13/0002
摘要： Certain embodiments of the present disclosure support techniques for designing neuron circuits based on memristors. Bulky capacitors as electrical current integrators can be eliminated and nanometer scale memristors can be utilized instead. Using the nanometer feature-sized memristors, the neuron hardware area can be substantially reduced.
摘要翻译：本公开的某些实施例支持基于忆阻器设计神经元电路的技术。可以消除作为电流积分器的大电容器，而可以使用纳米级忆阻器。使用纳米特征尺寸的忆阻器，神经元硬件区域可以大大减少。

3. 发明申请

WO2012006470A1 COMMUNICATION AND SYNAPSE TRAINING METHOD AND HARDWARE FOR BIOLOGICALLY INSPIRED NETWORKS 审中-公开
标题翻译：通信和仿真培训方法和生物信息网络的硬件
公开(公告)号：WO2012006470A1
公开(公告)日：2012-01-12
申请号：PCT/US2011/043257
申请日：2011-07-07
申请人： QUALCOMM Incorporated , APARIN, Vladimir , TANG, Yi
发明人： APARIN, Vladimir , TANG, Yi
IPC分类号： G06N3/063
CPC分类号： G06N3/0635 , G06N3/02 , G06N3/06 , G06N3/08 , G06N99/005
摘要： Certain embodiments of the present disclosure support techniques for training of synapses in biologically inspired networks. Only one device based on a memristor can be used as a synaptic connection between a pair of neurons. The training of synaptic weights can be achieved with a low current consumption. A proposed synapse training circuit may be shared by a plurality of incoming/outgoing connections, while only one digitally implemented pulse-width modulation (PWM) generator can be utilized per neuron circuit for generating synapse-training pulses. Only up to three phases of a slow clock can be used for both the neuron-to-neuron communications and synapse training. Some special control signals can be also generated for setting up synapse training events. By means of these signals, the synapse training circuit can be in a high-impedance state outside the training events, thus the synaptic resistance (i.e., the synaptic weight) is not affected outside the training process.
摘要翻译：本公开的某些实施例支持在生物启发网络中训练突触的技术。只有一个基于忆阻器的设备可以用作一对神经元之间的突触连接。突触体重的训练可以用低电流消耗来实现。所提出的突触训练电路可以由多个输入/输出连接共享，而每个神经元电路只能使用一个数字实现的脉宽调制（PWM）发生器来产生突触训练脉冲。只有三个阶段的慢时钟可用于神经元到神经元通信和突触训练。还可以生成一些特殊控制信号来设置突触训练事件。通过这些信号，突触训练电路可以处于训练事件之外的高阻抗状态，因此突触电阻（即突触重量）在训练过程之外不受影响。

4. 发明申请

WO2010011636A1 SWITCHING POWER AMPLIFIER FOR QUANTIZED SIGNALS 审中-公开
标题翻译：切换功率放大器进行量化信号
公开(公告)号：WO2010011636A1
公开(公告)日：2010-01-28
申请号：PCT/US2009/051229
申请日：2009-07-21
申请人： QUALCOMM INCORPORATED , GARUDADRI, Harinath , MAJUMDAR, Somdeb , BUTTERFIELD, Daniel, Keyes , TANG, Yi , MARTHANDA, Sanjay
发明人： GARUDADRI, Harinath , MAJUMDAR, Somdeb , BUTTERFIELD, Daniel, Keyes , TANG, Yi , MARTHANDA, Sanjay
IPC分类号： H03F3/217
CPC分类号： H03F3/2173
摘要： An apparatus and method for communications are disclosed. The apparatus may include an a quantizer having three levels, and a switching power amplifier configured to drive a load having first and second terminals, wherein the switching power amplifier is further configured to switch the first and second terminals between first and second power rails only if the output from the quantizer is at one of the three levels.
摘要翻译：公开了一种用于通信的装置和方法。该装置可以包括具有三个电平的量化器和被配置为驱动具有第一和第二端子的负载的开关功率放大器，其中开关功率放大器还被配置为仅在第一和第二电力轨之间切换第一和第二端子量化器的输出处于三个级别之一。

5. 发明申请

WO2006047452A2 REACTIVE 1,3’-CROSSLINKED CARBOCYANINES AND THEIR BIOCONJUGATES 审中-公开
标题翻译：反应性1,3-交联的羰基及其生物共轭物
公开(公告)号：WO2006047452A2
公开(公告)日：2006-05-04
申请号：PCT/US2005/038259
申请日：2005-10-21
申请人： ANASPEC, INC. , DIWU, Zhenjun , ZHANG, Jianheng , TANG, Yi , XIANG, Guobing
发明人： DIWU, Zhenjun , ZHANG, Jianheng , TANG, Yi , XIANG, Guobing
IPC分类号： C12Q1/68 , G01N33/00 , C07F15/00 , C07D487/22 , C07D498/22
CPC分类号： C09B23/06 , C07D487/14 , C07D487/22 , C07D498/22 , C09B23/0066 , C09B23/02 , G01N33/52 , G01N33/533 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3’-position, their bioconjugates and their uses are described. 1,3’-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1’-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.
摘要翻译：描述了在1位和3'位之间分子内交联的化学活性羰花青染料，它们的生物共轭物及其用途。 1,3'-交联的羰花青优于光谱相似的1,1'-交联或非交联染料的共轭物。本发明包括具有一个或多个苯并氮的衍生化合物。

6. 发明申请

WO2006039343A2 EMMPRIN ANTAGONISTS AND USES THEREOF 审中-公开
标题翻译： EMMPRIN ANTAGONISTS及其用途
公开(公告)号：WO2006039343A2
公开(公告)日：2006-04-13
申请号：PCT/US2005/034839
申请日：2005-09-29
申请人： CENTOCOR, INC. , JOHNSON & JOHNSON RESEARCH PARTY LIMITED , ARNDT, Gregory , NAKADA, Marian , LOMAS, Mehnaaz , RIVORY, Laurent , TANG, Yi , YAN, Li
发明人： ARNDT, Gregory , NAKADA, Marian , LOMAS, Mehnaaz , RIVORY, Laurent , TANG, Yi , YAN, Li
IPC分类号： A61K48/00
CPC分类号： C12N15/1138 , C07K16/2803 , C07K2317/76 , C12N2310/111 , C12N2310/12 , C12N2310/14
摘要： EMMPRIN (Extracellular Matrix Metalloproteinase Inducer) antagonists, such as antibodies, including specified portions or variants, siRNA, shRNA, and DNAzymes, can be used to treat pathological processes associated with proliferative diseases, such as cancer, by specifically preventing or inhibiting the ability of proliferating tissue to develop a blood supply.
摘要翻译：包括特定部分或变体的siRNA，shRNA和DNA酶等拮抗剂可以用于治疗与增殖性疾病如癌症有关的病理过程，特异性地预防或抑制细胞外基质金属蛋白酶（细胞外基质金属蛋白酶诱导剂）增殖组织发展血液供应。

7. 发明申请

WO2005092381A1 USE OF EMMPRIN ANTAGONISTS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH EXCESSIVE ANGIOGENESIS 审中-公开
标题翻译：使用EMMPRIN拮抗剂治疗与过度血管生成有关的疾病
公开(公告)号：WO2005092381A1
公开(公告)日：2005-10-06
申请号：PCT/US2004/009151
申请日：2004-03-25
申请人： CENTOCOR, INC. , NAKADA, Marian , YAN, Li , TANG, Yi
发明人： NAKADA, Marian , YAN, Li , TANG, Yi
IPC分类号： A61K39/395
CPC分类号： C07K16/2803 , A61K39/39558 , A61K2039/505 , C07K14/70503 , C07K16/2896 , C07K2317/76 , A61K2300/00
摘要： A method of using EMMPRIN antagonists to treat pathological processes associated with proliferative diseases, such as cancer, by specifically preventing or inhibiting the ability of new tissue to develop a blood supply. The invention more specifically relates to methods of treating such diseases by the use of EMMPRIN antagonists such as antibodies directed toward EMMPRIN, including specified portions or variants, specific for at least one EMMPRIN protein or fragment thereof, in an amount effective to inhibit angiogenesis.
摘要翻译：通过特异性预防或抑制新组织发展血液供应的能力，使用EMMPRIN拮抗剂治疗与增殖性疾病如癌症相关的病理过程的方法。本发明更具体地涉及通过使用有效抑制血管生成的量的EMMPRIN拮抗剂（例如针对EMMPRIN的抗体，包括对至少一种EMMPRIN蛋白或其片段特异性的特定部分或变体）来治疗这些疾病的方法。

8. 发明申请

WO2004079789A2 INTERSTAGE ISOLATION IN DARLINGTON TRANSISTORS 审中-公开
标题翻译：达林顿晶体管的间隔隔离
公开(公告)号：WO2004079789A2
公开(公告)日：2004-09-16
申请号：PCT/US2004/006278
申请日：2004-03-01
申请人： RENSSELAER POLYTECHNIC INSTITUTE , CHOW, Tat-Sing Paul , TANG, Yi
发明人： CHOW, Tat-Sing Paul , TANG, Yi
IPC分类号： H01L
CPC分类号： H01L27/0825
摘要： A Darlington transistor has a semiconductor collector region of one conductivity type adapted to form a collector for the device. A conductive collector contact and a semiconductor base region of opposite conductivity type are connected to the collector region. First and spaced apart second semiconductor emitter regions of the one conductivity type are connected to the base region and a first conductive emitter contact is connected to the first emitter region with a second conductive emitter contact connected to the second emitter region. A first conductive base contact is connected to the base region and is conductively connected to the first emitter contact. A second conductive base contact is conductively isolated from the first base contact and is connected to the base region. A resistive trench region extends at least partly into the base region for resistively separating the base region into a first base region communicating with the first emitter contact and the second base contact, and a second base region communicating with the first base contact and the second emitter contact.
摘要翻译：达林顿晶体管具有一种导电类型的半导体集电极区域，适合于形成器件的集电极。导电集电极触点和相反导电类型的半导体基极区域连接到集电极区域。一种导电类型的第一和间隔开的第二半导体发射极区域连接到基极区域，并且第一导电发射极触点连接到第一发射极区域，其中第二导电发射极触点连接到第二发射极区域。第一导电基极触点连接到基极区并导电连接到第一发射极触点。第二导电基极触点与第一基极触点导电隔离并连接到基极区域。电阻沟槽区至少部分地延伸到基极区中，用于将基极区电阻分离成与第一发射极触点和第二基极触点连通的第一基极区和与第一基极触头和第二发射极连通的第二基极区接触。

9. 发明申请

WO2012142410A3 REDOX RESPONSIVE POLYMERIC NANOCAPSULES FOR PROTEIN DELIVERY 审中-公开
公开(公告)号：WO2012142410A3
公开(公告)日：2012-10-18
申请号：PCT/US2012/033515
申请日：2012-04-13
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , TANG, Yi , GU, Zhen , ZHAO, Muxun
发明人： TANG, Yi , GU, Zhen , ZHAO, Muxun
IPC分类号： A61K38/17 , A61K38/16 , A61K47/48 , A61K47/30 , A61K9/16 , A61K9/14
摘要： The invention provides methods of making and using compositions comprising a polymer shell designed to deliver polypeptides to selected environments. In embodiments of the invention, different environmental conditions are harnessed to allow the selective degradation of the polymer shell and the consequential release of one or polypeptides encapsulated therein. In illustrative embodiments, polymer components of the shell are interconnected by disulfide-containing crosslinker moieties, linkages which maintain the integrity of the polymer shell under certain enviromental conditions including those occuring outside of cells, but degrade in an intracellular environment.

10. 发明申请

WO2011044496A3 LovD MUTANTS EXHIBITING IMPROVED PROPERTIES TOWARDS SIMVASTATIN SYNTHESIS 审中-公开
公开(公告)号：WO2011044496A3
公开(公告)日：2011-04-14
申请号：PCT/US2010/052038
申请日：2010-10-08
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , TANG, Yi , GAO, Xue , XIE, Xinkai
发明人： TANG, Yi , GAO, Xue , XIE, Xinkai
IPC分类号： C12N9/10
摘要： The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin. In particular, the disclosure teaches that variants of the LovD acyltransferase polypeptide can be engineered to exhibit properties that facilitate their use in the production of simvastatin and/or huvastatin. The materials and processes disclosed herein are designed so that fermentation facilities currently producing lovastatin can be converted to producing simvastatin and related compounds with minimal modifications.

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