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1. 发明申请

WO2012108676A2 NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREFOR 审中-公开
公开(公告)号：WO2012108676A2
公开(公告)日：2012-08-16
申请号：PCT/KR2012000898
申请日：2012-02-08
申请人： PUSAN NAT UNIV IND COOP FOUND , CHUNG HAE-YOUNG , PARK MIN-HI , CHUNG KI-WUNG , KIM JIN-AH , PARK JI-YOUNG , PARK YUN-JUNG , MOON HYUNG-RYONG
发明人： CHUNG HAE-YOUNG , PARK MIN-HI , CHUNG KI-WUNG , KIM JIN-AH , PARK JI-YOUNG , PARK YUN-JUNG , MOON HYUNG-RYONG
IPC分类号： A61K31/136 , A61K8/34 , A61P17/00 , A61Q19/02
CPC分类号： C07C245/08 , A61K8/40 , A61K31/136 , A61Q19/02 , A61Q19/08 , C07C309/73
摘要： The present invention relates to a novel compound having skin-whitening, anti-oxidizing and PPAR activities and to a medical use therefor. Compounds according to the present invention can be used to advantage in skin-whitening pharmaceutical compositions or cosmetics as they have a skin-whitening activity whereby tyrosinase is inhibited, and can be used to advantage in the prevention or treatment of skin ageing or the like as they have an anti-oxidizing activity, and can also be used as pharmaceutical compositions or health foods which are useful in preventing and treating obesity, metabolic disease or cardiovascular disease as they have PPAR activity and, more particularly, PPARa and PPAR? activity.

2. 发明申请

WO2012108677A3 NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREFOR 审中-公开
标题翻译：具有皮肤白化，抗氧化和PPAR活性的新化合物及其医疗用途
公开(公告)号：WO2012108677A3
公开(公告)日：2012-11-01
申请号：PCT/KR2012000899
申请日：2012-02-08
申请人： PUSAN NAT UNIVERSITY INDUSTRYUNIVERSITY , CHUNG HAE-YOUNG , MOON HYUNG-RYONG , PARK MIN-HI , HA YOUNG-MI , PARK YUN-JUNG , PARK JI-YOUNG , KIM JIN-AH , LEE JI-YEON , LEE KYUNG-JIN
发明人： CHUNG HAE-YOUNG , MOON HYUNG-RYONG , PARK MIN-HI , HA YOUNG-MI , PARK YUN-JUNG , PARK JI-YOUNG , KIM JIN-AH , LEE JI-YEON , LEE KYUNG-JIN
IPC分类号： C07D277/34
CPC分类号： C07D263/42 , A61K8/49 , A61K8/4913 , A61K8/4946 , A61K8/4953 , A61Q19/02 , A61Q19/04 , A61Q19/08 , C07D207/18 , C07D207/448 , C07D233/96 , C07D239/62 , C07D277/34
摘要： The present invention relates to a novel compound having skin-whitening, anti-oxidizing and PPAR activities and to a medical use therefor. Compounds according to the present invention can be used to advantage in skin-whitening pharmaceutical compositions or cosmetics as they have a skin-whitening activity whereby tyrosinase is inhibited, and can be used to advantage in the prevention or treatment of skin ageing or the like as they have an anti-oxidizing activity, and can also be used as pharmaceutical compositions or health foods which are useful in preventing and treating obesity, metabolic disease or cardiovascular disease as they have PPAR activity and, more particularly, PPARa and PPAR? activity.
摘要翻译：本发明涉及具有皮肤增白，抗氧化和PPAR活性的新型化合物及其医学应用。根据本发明的化合物可以有利地用于美白药物组合物或化妆品中，因为它们具有抑制酪氨酸酶的皮肤增白活性，并且可以有利地用于预防或治疗皮肤老化等，如它们具有抗氧化活性，并且因为它们具有PPAR活性，并且更具体地说是PPARα和PPARα，所以它们也可以用作用于预防和治疗肥胖症，代谢疾病或心血管疾病的药物组合物或保健食品。活动。

3. 发明申请

WO2012108689A3 NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREFOR 审中-公开
公开(公告)号：WO2012108689A3
公开(公告)日：2012-11-01
申请号：PCT/KR2012000935
申请日：2012-02-08
申请人： PUSAN NAT UNIVERSITY INDUSTRYUNIVERSITY , CHUNG HAE-YOUNG , PARK MIN-HI , HA YOUNG-MI , HAN YU-KYEONG , PARK JI-YOUNG , PARK YUN-JUNG , KIM JIN-AH , LEE JI-YEON , SONG YU-MIN , MOON HYUNG-RYONG
发明人： CHUNG HAE-YOUNG , PARK MIN-HI , HA YOUNG-MI , HAN YU-KYEONG , PARK JI-YOUNG , PARK YUN-JUNG , KIM JIN-AH , LEE JI-YEON , SONG YU-MIN , MOON HYUNG-RYONG
IPC分类号： C07D277/06 , A61K31/426 , A61P17/00 , C07D235/18
CPC分类号： A61K8/49 , A61K8/4946 , A61K8/4986 , A61K31/426 , A61K2800/78 , A61Q19/02 , A61Q19/06 , C07D235/18 , C07D277/06 , C07D277/66
摘要： The present invention relates to a novel compound having skin-whitening, anti-oxidizing and PPAR activities and to a medical use therefor. Compounds according to the present invention can be used to advantage in skin-whitening pharmaceutical compositions or cosmetics as they have a skin-whitening activity whereby tyrosinase is inhibited, and can be used to advantage in the prevention or treatment of skin ageing or the like as they have an anti-oxidizing activity, and can also be used as pharmaceutical compositions or health foods which are useful in preventing and treating obesity, metabolic disease or cardiovascular disease as they have PPAR activity and, more particularly, PPARa and PPAR? activity.

4. 发明申请

WO2012096515A3 HYBRID PHOTONIC CRYSTAL FIBER, AND METHOD FOR MANUFACTURING SAME 审中-公开
标题翻译：杂化光子晶体纤维及其制造方法
公开(公告)号：WO2012096515A3
公开(公告)日：2012-11-29
申请号：PCT/KR2012000277
申请日：2012-01-11
申请人： UNIV YONSEI IACF , OH KYUNG-HWAN , PARK JI-YOUNG
发明人： OH KYUNG-HWAN , PARK JI-YOUNG
IPC分类号： G02B6/032
CPC分类号： G02B6/02314 , C03B37/15 , G02B6/02328 , G02B6/032
摘要： The present invention relates to a hybrid photonic crystal fiber, into the core of which a functional material is injected. The hybrid photonic crystal fiber of the present invention comprises: a cavity extending in a lengthwise direction through the center of the photonic crystal fiber and having a diameter of 4 to 15 µm; an inner clad which is formed along an outer surface of the cavity and which extends in the lengthwise direction of the photonic crystal fiber such that a plurality of air holes, each having a diameter of 2 to 5 µm, are formed into a hexagonal shape around the cavity, wherein the spacing between the air holes is 4.5 to 7 µm; a ring-shaped outer clad which covers an outer periphery of the inner clad; and a core formed by injecting a functional material into the cavity and air holes. According to the present invention, changes in the state, i.e. the liquid, liquid-crystal, or biofluid states, of the functional material that fills the core that has a variety of shapes may enable the modulation of light intensity, wavelength, phase, and polarization, and thus enable various photonic networks to be produced. The hybrid photonic crystal fiber of the present invention may serve as various optical sensors capable of sensing changes in refractive index caused by external stresses such as temperature and pressure. The hybrid photonic crystal fiber of the present invention may be used as a light source for a fluorescent dye laser for a visible ray zone using fluorescent dye, or for an ultra-wideband laser of 700 nm or higher using high nonlinear liquid.
摘要翻译：本发明涉及一种混合光子晶体光纤，其中功能材料被注入其中。本发明的混合光子晶体光纤包括：腔室，其沿光子晶体光纤的中心在长度方向上延伸并且具有4至15μm的直径; 沿着光子晶体光纤的长度方向延伸的内侧包层，该内侧包层沿着光子晶体光纤的长度方向延伸形成，使得多个直径为2〜5μm的空气孔形成为六边形所述空腔之间的间隔为4.5至7μm; 覆盖内包层的外周的环形外包层; 以及通过将功能材料注入空腔和空气孔而形成的芯。根据本发明，填充具有各种形状的芯的功能性材料的状态（即，液体，液晶或生物流体状态）的变化可以使得能够调制光强度，波长，相位和极化，从而能够生产各种光子网络。本发明的混合光子晶体光纤可以用作能够感测由诸如温度和压力之类的外部应力引起的折射率变化的各种光学传感器。本发明的混合光子晶体光纤可以用作使用荧光染料的可见光区域的荧光染料激光器的光源，或者使用高非线性液体用于700nm或更高的超宽带激光器。

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