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1. 发明申请

WO2012108676A2 NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREFOR 审中-公开
公开(公告)号：WO2012108676A2
公开(公告)日：2012-08-16
申请号：PCT/KR2012000898
申请日：2012-02-08
申请人： PUSAN NAT UNIV IND COOP FOUND , CHUNG HAE-YOUNG , PARK MIN-HI , CHUNG KI-WUNG , KIM JIN-AH , PARK JI-YOUNG , PARK YUN-JUNG , MOON HYUNG-RYONG
发明人： CHUNG HAE-YOUNG , PARK MIN-HI , CHUNG KI-WUNG , KIM JIN-AH , PARK JI-YOUNG , PARK YUN-JUNG , MOON HYUNG-RYONG
IPC分类号： A61K31/136 , A61K8/34 , A61P17/00 , A61Q19/02
CPC分类号： C07C245/08 , A61K8/40 , A61K31/136 , A61Q19/02 , A61Q19/08 , C07C309/73
摘要： The present invention relates to a novel compound having skin-whitening, anti-oxidizing and PPAR activities and to a medical use therefor. Compounds according to the present invention can be used to advantage in skin-whitening pharmaceutical compositions or cosmetics as they have a skin-whitening activity whereby tyrosinase is inhibited, and can be used to advantage in the prevention or treatment of skin ageing or the like as they have an anti-oxidizing activity, and can also be used as pharmaceutical compositions or health foods which are useful in preventing and treating obesity, metabolic disease or cardiovascular disease as they have PPAR activity and, more particularly, PPARa and PPAR? activity.

2. 发明申请

WO2012108677A3 NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREFOR 审中-公开
标题翻译：具有皮肤白化，抗氧化和PPAR活性的新化合物及其医疗用途
公开(公告)号：WO2012108677A3
公开(公告)日：2012-11-01
申请号：PCT/KR2012000899
申请日：2012-02-08
申请人： PUSAN NAT UNIVERSITY INDUSTRYUNIVERSITY , CHUNG HAE-YOUNG , MOON HYUNG-RYONG , PARK MIN-HI , HA YOUNG-MI , PARK YUN-JUNG , PARK JI-YOUNG , KIM JIN-AH , LEE JI-YEON , LEE KYUNG-JIN
发明人： CHUNG HAE-YOUNG , MOON HYUNG-RYONG , PARK MIN-HI , HA YOUNG-MI , PARK YUN-JUNG , PARK JI-YOUNG , KIM JIN-AH , LEE JI-YEON , LEE KYUNG-JIN
IPC分类号： C07D277/34
CPC分类号： C07D263/42 , A61K8/49 , A61K8/4913 , A61K8/4946 , A61K8/4953 , A61Q19/02 , A61Q19/04 , A61Q19/08 , C07D207/18 , C07D207/448 , C07D233/96 , C07D239/62 , C07D277/34
摘要： The present invention relates to a novel compound having skin-whitening, anti-oxidizing and PPAR activities and to a medical use therefor. Compounds according to the present invention can be used to advantage in skin-whitening pharmaceutical compositions or cosmetics as they have a skin-whitening activity whereby tyrosinase is inhibited, and can be used to advantage in the prevention or treatment of skin ageing or the like as they have an anti-oxidizing activity, and can also be used as pharmaceutical compositions or health foods which are useful in preventing and treating obesity, metabolic disease or cardiovascular disease as they have PPAR activity and, more particularly, PPARa and PPAR? activity.
摘要翻译：本发明涉及具有皮肤增白，抗氧化和PPAR活性的新型化合物及其医学应用。根据本发明的化合物可以有利地用于美白药物组合物或化妆品中，因为它们具有抑制酪氨酸酶的皮肤增白活性，并且可以有利地用于预防或治疗皮肤老化等，如它们具有抗氧化活性，并且因为它们具有PPAR活性，并且更具体地说是PPARα和PPARα，所以它们也可以用作用于预防和治疗肥胖症，代谢疾病或心血管疾病的药物组合物或保健食品。活动。

3. 发明申请

WO2012108689A3 NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREFOR 审中-公开
公开(公告)号：WO2012108689A3
公开(公告)日：2012-11-01
申请号：PCT/KR2012000935
申请日：2012-02-08
申请人： PUSAN NAT UNIVERSITY INDUSTRYUNIVERSITY , CHUNG HAE-YOUNG , PARK MIN-HI , HA YOUNG-MI , HAN YU-KYEONG , PARK JI-YOUNG , PARK YUN-JUNG , KIM JIN-AH , LEE JI-YEON , SONG YU-MIN , MOON HYUNG-RYONG
发明人： CHUNG HAE-YOUNG , PARK MIN-HI , HA YOUNG-MI , HAN YU-KYEONG , PARK JI-YOUNG , PARK YUN-JUNG , KIM JIN-AH , LEE JI-YEON , SONG YU-MIN , MOON HYUNG-RYONG
IPC分类号： C07D277/06 , A61K31/426 , A61P17/00 , C07D235/18
CPC分类号： A61K8/49 , A61K8/4946 , A61K8/4986 , A61K31/426 , A61K2800/78 , A61Q19/02 , A61Q19/06 , C07D235/18 , C07D277/06 , C07D277/66
摘要： The present invention relates to a novel compound having skin-whitening, anti-oxidizing and PPAR activities and to a medical use therefor. Compounds according to the present invention can be used to advantage in skin-whitening pharmaceutical compositions or cosmetics as they have a skin-whitening activity whereby tyrosinase is inhibited, and can be used to advantage in the prevention or treatment of skin ageing or the like as they have an anti-oxidizing activity, and can also be used as pharmaceutical compositions or health foods which are useful in preventing and treating obesity, metabolic disease or cardiovascular disease as they have PPAR activity and, more particularly, PPARa and PPAR? activity.

4. 发明申请

WO2010128807A2 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING NEURONAL DAMAGE AND NEUROLOGICAL DISEASES 审中-公开
标题翻译：用于预防或治疗神经损伤和神经病的药物组合物
公开(公告)号：WO2010128807A2
公开(公告)日：2010-11-11
申请号：PCT/KR2010002879
申请日：2010-05-06
申请人： MOON & J INC , JUNG JAE-HOON , MOON HYUNG-RYONG
发明人： JUNG JAE-HOON , MOON HYUNG-RYONG
IPC分类号： A61K31/688 , A61P25/00 , A61P25/16 , A61P25/28 , A61P35/00
CPC分类号： A61K36/886 , A61K9/0014 , A61K9/107 , A61K31/661 , A61K31/685 , A61K31/688
摘要： The present invention relates to a pharmaceutical composition for preventing or treating neuronal damage and neurological diseases, and more particularly, to a pharmaceutical composition for preventing or treating neuronal damage and neurological diseases containing, as active ingredients, any one or two or more compounds selected from a group consisting of the compound of chemical formula 1, the compound of chemical formula 2, and the acceptable salts thereof. The pharmaceutical composition repairs nerve tissue damaged by herpes zoster to reduce the acute pain caused by herpes zoster, prevents postherpetic neuralgia, and enables a fundamental treatment through the recovery of nerve tissue in the postherpetic neuralgia. Further, the pharmaceutical composition can be effectively used for neuronal damage, including sciatic nerve crushing damage or the like, in a neuropathy including diabetic neuropathy or the like and for neuropathic pain, as well as for a variety of diseases caused by nerve tissue damage, such as brain diseases including strokes or the like.
摘要翻译：本发明涉及用于预防或治疗神经元损伤和神经疾病的药物组合物，更具体地涉及用于预防或治疗神经元损伤和神经疾病的药物组合物，其含有任何一种或两种或多种选自以下的化合物作为活性成分：由化学式1的化合物，化学式2的化合物及其可接受的盐组成的组。药物组合物修复由带状疱疹损伤的神经组织，以减少由带状疱疹引起的急性疼痛，防止带状疱疹后神经痛，并且通过恢复带状疱疹后神经痛中的神经组织进行基础治疗。此外，药物组合物可以有效地用于包括糖尿病性神经病变等神经病变以及神经性疼痛的神经元损伤，包括坐骨神经破坏损伤等，以及由神经组织损伤引起的各种疾病，例如包括中风等的脑疾病。

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