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    • 2. 发明申请
    • MULTIPLY-SUBSTITUTED PROTEASE VARIANT AND AMYLASE VARIANT-CONTAINING CLEANING COMPOSITIONS
    • 多种取代的蛋白质变体和淀粉含有变化的清洁组合物
    • WO9920723A9
    • 1999-09-02
    • PCT/US9822486
    • 1998-10-23
    • PROCTER & GAMBLEGHOSH CHANCHAL KUMARBAECK ANDRE CESAROHTANI RYOHEIBUSCH ALFREDSHOWELL MICHAEL STANTON
    • GHOSH CHANCHAL KUMARBAECK ANDRE CESAROHTANI RYOHEIBUSCH ALFREDSHOWELL MICHAEL STANTON
    • A23G4/00A23G4/12A23K1/165A61K8/00A61K8/25A61K8/36A61K8/37A61K8/40A61K8/41A61K8/44A61K8/46A61K8/60A61K8/64A61K8/66A61Q1/02A61Q1/14A61Q11/00A61Q11/02A61Q19/00A61Q19/10C11D3/386C11D3/395C11D7/42C12N1/15C12N1/19C12N1/21C12N5/10C12N9/50C12N9/54C12N9/56C12N9/58C12N15/09C12N15/57C12R1/07C11D
    • C12N9/54A23G4/123A23K20/189A61K8/66A61K2800/86A61Q11/00A61Q19/00C11D3/386C11D3/38609C11D3/38618C11D3/3907C11D3/3945C12Y304/00C12Y304/21062
    • The present invention relates to cleaning compositions comprising a protease variant. One cleaning composition comprises a protease variant including a substitution of an amino acid residue with another naturally occurring amino acid residue at an amino acid residue position corresponding to position 103 of Bacillus amyloliquefaciens subtilisin in combination with a substitution of an amino acid residue with another naturally occurring amino acid residue at one or more amino acid residue positions corresponding to positions 1, 3, 4, 8, 9, 10, 12, 13, 16, 17, 18, 19, 20, 21, 22, 24, 27, 33, 37, 38, 42, 43, 48, 55, 57, 58, 61, 62, 68, 72, 75, 76, 77, 78, 79, 86, 87, 89, 97, 98, 99, 101, 102, 104, 106, 107, 109, 111, 114, 116, 117, 119, 121, 123, 126, 128, 130, 131, 133, 134, 137, 140, 141, 142, 146, 147, 158, 159, 160, 166, 167, 170, 173, 174, 177, 181, 182, 183, 184, 185, 188, 192, 194, 198, 203, 204, 205, 206, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 222, 224, 227, 228, 230, 232, 236, 237, 238, 240, 242, 243, 244, 245, 246, 247, 248, 249, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 265, 268, 269, 270, 271, 272, 274 and 275 of Bacillus amyloliquefaciens subtilisin; wherein when said protease variant includes a substitution of amino acid residues at positions corresponding to positions 103 and 76, there is also a substitution of an amino acid residue at one or more amino acid residue positions other than amino acid residue positions corresponding to positions 27, 99, 101, 104, 107, 109, 123, 128, 166, 204, 206, 210, 216, 217, 218, 222, 260, 265 or 274 of Bacillus amyloliquefaciens subtilisin; and one or more cleaning adjunct materials. Another cleaning composition comprises a protease variant including a substitution of an amino acid residue with another naturally occurring amino acid residue at one or more amino acid residue positions corresponding to positions 62, 212, 230, 232, 252 and 257 of Bacillus amyloliquefaciens subtilisin; an amylase variant and one or more cleaning adjunct materials. Methods for using the cleaning compositions are also provided.
    • 本发明涉及包含蛋白酶变体的清洁组合物。 一种清洁组合物包含蛋白酶变体,其包括氨基酸残基与对应于解淀粉芽孢杆菌枯草杆菌蛋白酶的位置103的氨基酸残基处的另一个天然存在的氨基酸残基的取代,以及氨基酸残基与另一个天然存在的 在一个或多个对应于1,2,3,4,8,9,10,12,13,16,17,18,19,20,21,22,24,27,33, 37,38,42,43,48,55,57,58,61,62,68,72,75,76,77,78,79,86,87,89,97,98,99,101,102, 104,106,107,109,111,114,116,117,119,121,123,126,128,130,131,133,134,137,140,141,142,146,147, 160,166,167,170,173,174,177,181,182,183,184,185,188,192,194,188,203,204,205,206,209,210,211,212,213, 214,215,216,217,218,222,224,227,228,222,224,227,228,223,232,236,237,238,240,242,243,244,245,246,247,248,249,251,218,222,224,227,218,222,224,227,218,222,224,227,218,222,224,227,218,222,224,227,218,222,224,227,218,222,224,227,218,223,232 253,254,25 5,256,257,258,259,260,261,262,263,265,268,269,270,271,272,274和275的解淀粉芽孢杆菌枯草杆菌蛋白酶; 其中当所述蛋白酶变体包含氨基酸残基在对应于位置103和76的位置上的取代时,还存在氨基酸残基在一个或多个除对应于位置27的氨基酸残基位置之外的一个或多个氨基酸残基位置的取代, 99,101,104,107,109,123,128,166,204,206,210,216,217,218,222,260,265或274的解淀粉芽孢杆菌枯草杆菌蛋白酶; 和一种或多种清洁辅助材料。 另一种清洁组合物包含蛋白酶变体,其包括氨基酸残基与对应于解淀粉芽孢杆菌枯草杆菌蛋白酶的位置62,212,230,232,252和257的一个或多个氨基酸残基处的另一个天然存在的氨基酸残基取代; 淀粉酶变体和一种或多种清洁辅助材料。 还提供了使用清洁组合物的方法。
    • 4. 发明申请
    • CLEANING COMPOSITIONS CONTAINING MULTIPLY-SUBSTITUTED PROTEASE VARIANTS
    • 含有多取代蛋白质变体的清洁组合物
    • WO9920727A9
    • 1999-09-02
    • PCT/US9822588
    • 1998-10-23
    • PROCTER & GAMBLEGENENCOR INTGHOSH CHANCHAL KUMARBAECK ANDRE CESAROHTANI RYOHEIBUSCH ALFREDSHOWELL MICHAEL STANFORDSCHELLENBERGER VOLKERKELLIS JAMES T JRPAECH CHRISTIANNADHERNY JOANNENAKI DONALD PCOLLIER KATHERINE DCALDWELL ROBERT MPOULOSE AYROOKARAN J
    • GHOSH CHANCHAL KUMARBAECK ANDRE CESAROHTANI RYOHEIBUSCH ALFREDSHOWELL MICHAEL STANFORDSCHELLENBERGER VOLKERKELLIS JAMES T JRPAECH CHRISTIANNADHERNY JOANNENAKI DONALD PCOLLIER KATHERINE DCALDWELL ROBERT MPOULOSE AYROOKARAN J
    • A23G4/00A23G4/12A61K8/66A61Q11/00C11D1/74C11D3/37C11D3/386C12N9/54A23G3/30A61K7/28A61K7/48
    • A23G4/123A61K8/66A61Q11/00C11D1/74C11D3/3776C11D3/386C12N9/54C12Y304/21062
    • The present invention relates to cleaning compositions comprising a protease variant. One cleaning composition comprises a protease variant including a substitution of an amino acid residue with another naturally occurring amino acid residue at an amino acid residue position corresponding to position 103 of Bacillus amyloliquefaciens subtilisin in combination with a substitution of an amino acid residue with another naturally occurring amino acid residue at one or more amino acid residue positions corresponding to positions 1, 3, 4, 8, 9, 10, 12, 13, 16, 17, 18, 19, 20, 21, 22, 24, 27, 33, 37, 38, 42, 43, 48, 55, 57, 58, 61, 62, 68, 72, 75, 76, 77, 78, 79, 86, 87, 89, 97, 98, 99, 101, 102, 104, 106, 107, 109, 111, 114, 116, 117, 119, 121, 123, 126, 128, 130, 131, 133, 134, 137, 140, 141, 142, 146, 147, 158, 159, 160, 166, 167, 170, 173, 174, 177, 181, 182, 183, 184, 185, 188, 192, 194, 198, 203, 204, 205, 206, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 222, 224, 227, 228, 230, 232, 236, 237, 238, 240, 242, 243, 244, 245, 246, 247, 248, 249, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 265, 268, 269, 270, 271, 272, 274 and 275 of Bacillus amyloliquefaciens subtilisin; wherein when said protease variant includes a substitution of amino acid residues positions corresponding to positions 103 and 76, there is also a substitution of an amino acid residue at one or more amino acid residue positions other than amino acid residue positions corresponding to positions 27, 99, 101, 104, 107, 109, 123, 128, 166, 204, 206, 210, 216, 217, 218, 222, 260, 265 or 274 of Bacillus amyloliquefaciens subtilisin; and one or more cleaning adjunct materials. Another cleaning composition comprises a protease variant including a substitution of an amino acid residue with another naturally occurring amino acid residue at one or more amino acid residue positions corresponding to positions 62, 212, 230, 232, 252 and 257 of DOLLAR (Bacillus amyloliquefaciens) subtilisin; and one or more cleaning adjunct materials. Methods for using the cleaning compositions are also provided.
    • 本发明涉及包含蛋白酶变体的清洁组合物。 一种清洁组合物包含蛋白酶变体,其包括氨基酸残基与对应于解淀粉芽孢杆菌枯草杆菌蛋白酶的位置103的氨基酸残基处的另一个天然存在的氨基酸残基的取代,以及氨基酸残基与另一天然存在的 一个或多个对应于1,2,3,4,8,9,10,12,13,16,17,18,19,20,21,22,24,27,33, 37,38,42,43,48,55,57,58,61,62,68,72,75,76,77,78,79,86,87,89,97,98,99,101,102, 104,106,107,109,111,114,116,117,119,121,123,126,128,130,131,133,134,137,140,141,142,146, 160,166,167,170,173,174,177,181,182,183,184,185,188,192,194,198,203,204,205,206,209,210,211,212,213, 214,215,216,217,218,222,224,227,228,222,224,227,228,230,232,236,237,238,240,242,243,244,245,246,247,248,249,251,252,225,216,217,218,222,224,227,218,222,224,227,218,222,224,227,218,222,224,227,218,222,224,227,218,222,224,227,218,222,224 253,254,25 5,256,257,258,259,260,261,262,263,265,268,269,270,271,272,274和275的解淀粉芽孢杆菌枯草杆菌蛋白酶; 其中当所述蛋白酶变体包括对位置103和76的氨基酸残基置换时,还有一个或多个除对应于位置27,99的氨基酸残基位置之外的氨基酸残基的氨基酸残基的取代 ,解淀粉芽孢杆菌枯草杆菌蛋白酶的101,104,107,109,123,128,166,204,206,210,216,217,218,222,260,265或274; 和一种或多种清洁辅助材料。 另一种清洁组合物包含蛋白酶变体,其包括氨基酸残基与对应于DOLLAR(解淀粉芽孢杆菌)的位置62,212,230,232,252和257的一个或多个氨基酸残基处的另一个天然存在的氨基酸残基取代, 枯草杆菌蛋白酶; 以及一种或多种清洁辅助材料。 还提供了使用清洁组合物的方法。
    • 9. 发明申请
    • AN ADVERTISEMENT METHOD
    • 广告方法
    • WO2005086806A2
    • 2005-09-22
    • PCT/US2005007553
    • 2005-03-08
    • PROCTER & GAMBLEJANARDANAN NAIR RADHAKRISHNAMOHTANI RYOHEIASHIYA MAYUMI
    • JANARDANAN NAIR RADHAKRISHNAMOHTANI RYOHEIASHIYA MAYUMI
    • A61K9/26G06Q30/00
    • G06Q30/02G06Q30/0241
    • The present invention is directed to a method for advertising a deodorizer. The method has the steps of using a color indicator and a color change reaction caused by the color indicator; and visualizing the malodor removal performance of the product by the color change. The advertising method also has the steps of preparing a promotion product and a comparative product; preparing at least two separate closed spaces; and then, in any order: placing the promotion product inside one of the closed spaces; placing a material inside each closed space, wherein the material comprises a color indicator; adding a malodor substance to each of the closed spaces to thereby cause a color change to the color indicator. Finally, the last step is that of showing the difference of the material color between the promotion product and the comparative product. These steps are visually recorded to form an advertisement and wherein the advertisement is transferred electronically.
    • 本发明涉及一种广告除臭剂的方法。 该方法具有使用颜色指示器和由颜色指示器引起的变色反应的步骤; 并通过颜色变化可视化产品的恶臭去除性能。 广告方式还具有准备推广产品和比较产品的步骤; 至少准备两个封闭空间; 然后,以任何顺序:将促销产品放置在封闭空间之一内; 将材料放置在每个封闭空间内,其中所述材料包括颜色指示器; 向每个封闭空间添加恶臭物质,从而使颜色指示器变色。 最后,最后一步是展示促销产品和比较产品之间材质颜色的差异。 这些步骤被视觉地记录以形成广告,并且其中广告被电子地传送。