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    • 2. 发明申请
    • REGULATION OF MAMMALIAN KERATINOUS TISSUE USING HEXAMIDINE COMPOSITIONS
    • 使用HEXAMIDINE组合物调理马马里兰KERATINOUS组织
    • WO2004078158A3
    • 2005-01-13
    • PCT/US2004006499
    • 2004-03-04
    • PROCTER & GAMBLEBISSETT DONALD LYNN
    • BISSETT DONALD LYNN
    • A61K8/34A61K8/40A61K8/43A61K8/60A61K8/67A61Q19/00A61Q19/02A61Q19/06A61Q19/08A61K7/48
    • A61K8/40A61K8/347A61K8/43A61K8/606A61K8/671A61K8/675A61Q19/00A61Q19/007A61Q19/02A61Q19/06A61Q19/08
    • The present invention relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods each comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of a skin care composition comprising: a) a safe and effective amount of a hexamidine compound selected from the group consisting of hexamidine, its salts, and derivatives; b) a safe and effective amount of one or more skin care active selected from the group consisting of sugar amine, vitamin B3, retinoid, peptide, phytosterol, butylated hydroxytoluene and butylated hydroxyanisole, their derivatives, and combinations thereof; and c) a dermatologically acceptable carrier for the hexamidine and the skin care active. In additional embodiments, the above composition is suitable for preventing, retarding, and/or treating dark under-eye circles, puffy eyes, sagging, sallowness as well as spider vessels and/or red blotchiness of skin, promoting skin desquamation, exfoliation, and/or turnover, regulating and/or reducing pore size appearance, preventing/retarding tanning, regulating oily/shiny appearance, preventing, retarding, and/or treating hyperpigmentation in mammalian skin, preventing, retarding, and/or treating itchiness of mammalian skin, preventing, retarding, and/or treating dryness of skin, preventing, retarding, and/or treating fine lines and wrinkles, preventing, retarding, and/or treating skin atrophy of mammalian skin, softening and/or smoothing lips, hair and nails of a mammal, and preventing, retarding, and/or treating the appearance of cellulite in mammalian skin.
    • 本发明涉及用于调节哺乳动物角质组织状况的方法,其中各方法包括局部施用于需要这种治疗的哺乳动物的角质组织的步骤,安全有效量的皮肤护理组合物,其包含:a) 安全有效量的选自己脒,其盐和衍生物的己脒化合物; b)安全有效量的一种或多种选自糖胺,维生素B3,类视色素,肽,植物甾醇,丁基化羟基甲苯和丁基化羟基苯甲醚,其衍生物及其组合的护肤活性物质; 和c)用于己脒和皮肤护理活性的皮肤病学可接受的载体。 在另外的实施方案中,上述组合物适合于预防,延缓和/或治疗黑眼圈,浮肿眼睛,下垂,黄斑以及蜘蛛血管和/或皮肤红斑,促进皮肤脱屑,剥脱和 /或周转,调节和/或减少毛孔外观,防止/阻滞鞣制,调节油性/光泽外观,预防,延缓和/或治疗哺乳动物皮肤色素沉着过度,预防,延缓和/或治疗哺乳动物皮肤的瘙痒, 防止,延缓和/或治疗皮肤的干燥,预防,延缓和/或治疗细纹和皱纹,预防,延缓和/或治疗哺乳动物皮肤的萎缩,软化和/或平滑唇,头发和指甲 哺乳动物,并且预防,延缓和/或治疗哺乳动物皮肤中脂肪团的外观。
    • 8. 发明申请
    • REGULATION OF MAMMALIAN KERATINOUS TISSUE USING PERSONAL CARE COMPOSITIONS COMPRISING CETYL PYRIDINIUM CHLORIDE
    • 使用包含氯乙酸氯化钠的个人护理组合物对马马里兰卡那霉素组织的调节
    • WO2006124990A2
    • 2006-11-23
    • PCT/US2006019067
    • 2006-05-17
    • PROCTER & GAMBLEBISSETT DONALD LYNN
    • BISSETT DONALD LYNN
    • A61K8/37A61K8/41A61Q7/00A61Q19/00A61Q19/02
    • A61K8/40A61K8/416A61K8/4926A61K8/675A61Q19/00G06Q50/22
    • Personal care composition including a first skin and/or hair care active cetyl pyridinium chloride; and at least one additional skin and/or hair care active selected from the group consisting of tetrahydrocurcumin, sugar amine, vitamin B3, retinoids, hydroquinone, peptides, phytosterol, dialkanoyl hydroxyproline, hexamidine, salicylic acid, n-acyl amino acid compounds, sunscreen actives, water soluble vitamins, oil soluble vitamins, hesperedin, mustard seed extract, glycyrrhizic acid, glycyrrhetinic acid, carnosine, Butylated Hydroxytoluene (BHT) and Butylated Hydroxyanisole (BHA), ergothioneine, vanillin or its derivatives, diethylhexyl syrinylidene malonate, melanostatine, sterol esters, idebenone, dehydroacetic acid, Licohalcone A, creatine, creatinine, feverfew extract, yeast extract, beta glucans, alpha glucans, their salts, their derivatives, their precursors, and/or combinations thereof; and a dermatologically acceptable carrier. The invention further relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods each comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of the personal care composition of the invention.
    • 个人护理组合物,包括第一皮肤和/或头发护理活性十六烷基吡啶鎓氯化物; 和至少一种另外的皮肤和/或毛发护理活性物质,其选自四氢姜黄素,糖胺,维生素B3,类视黄醇,氢醌,肽,植物甾醇,二烷酰基羟脯氨酸,己脒,水杨酸,n-酰基氨基酸化合物,防晒剂 活性物质,水溶性维生素,油溶性维生素,黄曲霉素,芥子籽提取物,甘草酸,甘草次酸,肌肽,丁酰化羟基甲苯(BHT)和丁基化羟基苯甲醚(BHA),麦角硫素,香草醛或其衍生物,二乙基己基亚乙烯基丙二酸酯,黑色素, 酯,艾地苯醌,脱氢乙酸,Licohalcone A,肌酸,肌酸酐,发热提取物,酵母提取物,β葡聚糖,α葡聚糖,其盐,其衍生物,其前体和/或其组合; 和皮肤病学上可接受的载体。 本发明还涉及用于调节哺乳动物角质组织状况的方法,其中所述方法各自包括局部施用于需要这种治疗的哺乳动物的角质组织的步骤,安全有效量的本发明的个人护理组合物。