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1. 发明申请

WO2020214073A1 IN-LINE X-RAY FOCUSING OPTICS USED FOR MANIPULATION OF X-RAYS IN MEDICAL TRANSMISSION RADIOGRAPHY 审中-公开
公开(公告)号：WO2020214073A1
公开(公告)日：2020-10-22
申请号：PCT/SE2019/050950
申请日：2019-10-02
申请人： PRISMATIC SENSORS AB
发明人： FREDENBERG, Erik , LOBERG, Johannes , DANIELSSON, Mats
IPC分类号： G01T1/36 , A61B6/00 , G01T1/16 , G01T1/24
摘要： There is provided an arrangement comprising an x-ray detector (20) arranged in conjunction with in- line x-ray focusing optics (15) configured for manipulation of x-rays in medical transmission radiography, wherein the in-line x-ray optics (15) comprises an array of lenses, in which the lenses cover parts of, or the entire, field of view, and in which the x-ray detector (20) is a photon-counting detector. Furthermore, the x-ray detector (20) is an energy-resolving detector and chromatic aberration of the lens array and/or limited coherence of the source is compensated for by the energy resolution of the energy-resolving detector, and/or the x-ray detector (20) is a depth-resolving detector and chromatic aberration of the lens array and/or limited coherence of the source (10) is compensated for by depth resolution or volumetric resolution in the detector (20).

2. 发明申请

WO2020106197A1 X-RAY IMAGING SYSTEM FOR PHASE CONTRAST IMAGING USING PHOTON-COUNTING EVENTS 审中-公开
公开(公告)号：WO2020106197A1
公开(公告)日：2020-05-28
申请号：PCT/SE2019/051010
申请日：2019-10-14
申请人： PRISMATIC SENSORS AB
发明人： DANIELSSON, Mats , SUNDBERG, Christel
IPC分类号： G01T1/24 , A61B6/03 , G01N23/04 , G01T1/29
摘要： There is provided an x-ray imaging system (100) comprising an x-ray source (10), and an associated x-ray detector (20), wherein the x-ray detector (20) is a photon counting x-ray detector for enabling detection of photon-counting events. The x-ray imaging system (100) is configured for enabling acquisition of at least one phase contrast image based on detected photon-counting events. The x-ray detector (20) is based on a number of x-ray detector sub-modules, also referred to as wafers, each of which comprises detector elements, wherein the x-ray detector sub-modules are oriented in edge-on geometry with their edge directed towards the x-ray source, assuming the x- rays enter through the edge. Each x-ray detector sub-module or wafer has a thickness with two opposite sides of different potentials to enable charge drift towards the side, where the detector elements, also referred to as pixels, are arranged. The x-ray imaging system (100) is further configured to determine an estimate or measure of charge diffusion originating from a Compton interaction or an interaction through photoeffect related to an incident x-ray photon in an x-ray detector sub-module or wafer of the x-ray detector, and to determine an estimate of a point of interaction of the incident x-ray photon in the x-ray detector sub-module based on the determined estimate or measure of charge diffusion.

3. 发明申请

WO2017209662A1 X-RAY IMAGING FOR ENABLING ASSESSMENT OF SCOLIOSIS 审中-公开
标题翻译：用于评估SCOLIOSIS的X射线成像
公开(公告)号：WO2017209662A1
公开(公告)日：2017-12-07
申请号：PCT/SE2016/050497
申请日：2016-05-30
申请人： PRISMATIC SENSORS AB
发明人： DANIELSSON, Mats , LIU, Xuejin , SJÖLIN, Martin
IPC分类号： A61B6/00 , G03B42/02
摘要： There is provided an arrangement (100) for enabling assessment of scoliosis. The arrangement (100) is configured to obtain at least one x-ray image by means of one or more photon-counting x-ray detectors. The arrangement (100) is further configured to determine at least one characteristic of the spine of a patient having possible scoliosis based on said at least one x-ray image obtained by means of the photon-counting x-ray detector(s) to enable assessment of scoliosis.
摘要翻译：提供了用于评估脊柱侧凸的装置（100）。该装置（100）被配置成通过一个或多个光子计数X射线探测器获得至少一个X射线图像。装置（100）还被配置为基于通过光子计数X射线探测器获得的所述至少一个X射线图像来确定具有可能的脊柱侧凸的患者的脊柱的至少一个特征，评估脊柱侧凸。

4. 发明申请

WO2016076767A1 X-RAY IMAGING BASED ON IMAGE DATA FROM A PHOTON-COUNTING MULTI BIN X-RAY DETECTOR 审中-公开
标题翻译：基于图像数据的X射线成像来自光子计数多光子X射线探测器
公开(公告)号：WO2016076767A1
公开(公告)日：2016-05-19
申请号：PCT/SE2014/051330
申请日：2014-11-10
申请人： PRISMATIC SENSORS AB
发明人： DANIELSSON, Mats , BORNEFALK, Hans , LIU, Xuejin , HUBER, Ben , CHEN, Han
IPC分类号： G06T11/00 , A61B6/03 , G01N23/04
CPC分类号： A61B6/03 , A61B6/42 , A61B6/4241 , A61B6/482 , A61B6/5205 , A61B6/583 , A61B6/585 , G01N23/04 , G01N23/087 , G01N2223/206 , G01N2223/401 , G01N2223/423 , G01T1/17 , G01T1/171 , G01T1/24 , G01T1/247 , G01T7/005 , G01V5/0041 , G06T11/003 , G06T11/005 , H01L27/14658 , H04N5/32 , H04N5/3745 , H05G1/60
摘要： There is provided a method and corresponding system and apparatus for image reconstruction based on image data from a photon-counting multi-bin x-ray detector. The method comprises determining (S1) parameter(s) of a given functional form of the relationship between comparator settings expressed in voltage in the read-out chain of the x-ray detector and the corresponding energy threshold values expressed in energy based on a fitting procedure between a first set of data representative of a measured pulse height spectrum and a second set of data representative of a reference pulse height spectrum. The method also comprises performing (S2) image reconstruction based on the image data and the determined parameter(s). In this way, efficient high-quality image reconstruction can be achieved.
摘要翻译：提供了一种基于来自光子计数多仓x射线检测器的图像数据的用于图像重建的方法和相应的系统和装置。该方法包括确定（S1）给定功能形式的参数，该参数以x射线检测器的读出链中的电压表示的比较器设置与基于拟合的能量表达的相应的能量阈值之间的关系表示测量的脉冲高度谱的第一组数据与表示参考脉冲高度谱的第二组数据之间的过程。该方法还包括基于图像数据和确定的参数执行（S2）图像重建。以这种方式，可以实现高效率的高质量图像重建。

5. 发明申请

WO2020171748A1 ENHANCED SPECTRAL X-RAY IMAGING 审中-公开
公开(公告)号：WO2020171748A1
公开(公告)日：2020-08-27
申请号：PCT/SE2019/051238
申请日：2019-12-06
申请人： PRISMATIC SENSORS AB
发明人： BORNEFALK, Hans , GRÖNBERG, Fredrik , DANIELSSON, Mats
IPC分类号： A61B6/03 , G01N23/04
摘要： There is provided an apparatus (100) for x-ray imaging comprising an x-ray source (10) and an x-ray detector (20) having a number of detector elements, wherein the x-ray source (10) and the x-ray detector (20) are arranged on a support that is able to rotate around a subject or object to be imaged to enable a set of projections at different view angles. The apparatus (100) is configured to operate the x-ray source (10) in switched kVp mode for alternately applying at least two different voltages, including a lower voltage and a higher voltage, during rotation to enable lower-energy and higher- energy exposures over the set of projections, thereby providing for lower-energy projections and higher-energy projections. The x-ray detector (20) is a photon-counting multi-bin detector configured to allocate photon counts to multiple energy bins, and the apparatus is configured to select counts from at least a subset of the energy bins to provide corresponding photon count information for both lower-energy projections and higher-energy projections. The apparatus (100) is configured to perform material basis decomposition for each of a number of the lower-energy projections and higher- energy projections and/or for each of a number of combinations of at least one lower- energy projection and at least one higher-energy projection, based on the corresponding photon count information.

6. 发明申请

WO2019009784A1 MANAGING GEOMETRIC MISALIGNMENT IN X-RAY IMAGING SYSTEMS 审中-公开
公开(公告)号：WO2019009784A1
公开(公告)日：2019-01-10
申请号：PCT/SE2018/050660
申请日：2018-06-20
申请人： PRISMATIC SENSORS AB
发明人： DANIELSSON, Mats , LIU, Xuejin , SJÖLIN, Martin
IPC分类号： G01T1/24 , A61B6/03 , G01N23/04 , G01T1/29
摘要： There is provided a method for management of geometric misalignment in an x-ray imaging system having an x-ray source, a photon-counting x-ray detector and an intermediate collimator structure in the x-ray path between the x-ray source and the x- ray detector. The x-ray detector comprises a plurality of pixels, and the collimator structure comprises a plurality of collimator cells, wherein each of at least a subset of the collimator cells corresponds to a N x M matrix of pixels, where at least one of N and M is greater than one. The method comprises monitoring (S1), for a designated subset of pixels including at least two pixels that are affected differently by shadowing from the collimator structure due to geometric misalignment, output signals from the pixels of the designated subset of pixels, and determining (S2) the occurrence of geometric misalignment based on the monitored output signals from the pixels of the designated subset of pixels.

7. 发明申请

WO2016209138A1 SCATTER ESTIMATION AND/OR CORRECTION IN X-RAY IMAGING 审中-公开
标题翻译： X射线成像中的散射估计和/或校正
公开(公告)号：WO2016209138A1
公开(公告)日：2016-12-29
申请号：PCT/SE2015/051072
申请日：2015-10-08
申请人： PRISMATIC SENSORS AB
发明人： DANIELSSON, Mats , HOFFMAN, David Michael
IPC分类号： G01T1/24 , A61B6/00 , G01T1/29 , G01T1/36
CPC分类号： A61B6/5282 , A61B6/032 , A61B6/4233 , A61B6/4241 , A61B6/4266 , A61B6/4291 , G01T1/2985
摘要： There is provided methods and devices for estimating object scatter and/or internal scatter in a multi-level photon-counting x-ray detector (102, 103), as well as methods and devices for x-ray tomographic imaging of an object while correcting for object scatter and/or internal scatter. The x-ray detector has at least two layers of detector diodes mounted in an edge- on geometry, e.g. designed for 1 ) estimating the object scatter contribution to the counts in a top layer of said at least two layers based on difference(s) in counts between the top layer and lower layer(s) under the assuption the object scatter has a slowly varying spatial distribution, and/or 2) estimating counts from reabsorption of photons that have Compton scattered inside the detector based on selectively blinding some detector elements from primary radiation by placing a highly attenuating beam stop on top of the detector elements, in lower layer(s) or in both top layer and lower layer(s), and measuring the counts in those detector elements.
摘要翻译：提供了用于估计多级光子计数X射线检测器（102,103）中的物体散射和/或内部散射的方法和装置，以及用于物体的X射线层析成像的方法和装置，同时校正用于物体散射和/或内部散射。 x射线检测器具有安装在边缘几何上的至少两层检测器二极管，例如。设计用于1）基于所述顶层和下层之间的计数的差异来估计对所述至少两个层的顶层中的计数的对象散射贡献，所述对象散射具有缓慢变化空间分布和/或2）基于通过将检测器元件的高度衰减的光束停止放置在检测器元件的顶部的下层（s）中，基于通过选择性地将一些检测器元件从初级辐射中盲目地估计具有康普顿散射在检测器内部的光子的重新吸收的计数）或在顶层和下层中，并且测量那些检测器元件中的计数。

8. 发明申请

WO2020106198A1 A METHOD AND A SYSTEM FOR ENABLING ESTIMATION OF AN INITIAL POINT OF INTERACTION OF AN X-RAY PHOTON IN A PHOTON-COUNTING X-RAY DETECTOR 审中-公开
公开(公告)号：WO2020106198A1
公开(公告)日：2020-05-28
申请号：PCT/SE2019/051011
申请日：2019-10-14
申请人： PRISMATIC SENSORS AB
发明人： DANIELSSON, Mats
IPC分类号： G01T1/24 , A61B6/03 , G01N23/04 , G01T1/29
摘要： There is provided a method for enabling estimation of an initial point of interaction of an x-ray photon in a photon-counting x-ray detector, which is based on a number of x- ray detector sub-modules or wafers, each of which comprises detector elements, wherein the x-ray detector sub-modules are oriented in edge-on geometry with the edge directed towards the x-ray source, assuming the x-rays enter through the edge. Each detector sub-module or wafer has a thickness with two opposite sides of different potentials to enable charge drift towards the side, where the detector elements, also referred to as pixels, are arranged. Basically, the method comprises: determining (S1) an estimate of charge diffusion originating from a Compton interaction or an interaction through photoeffect related to the x-ray photon in a detector sub-module or wafer of the x-ray detector; and estimating (S2) the initial point of interaction along the thickness of the detector sub-module based on the determined estimate of charge diffusion.

9. 发明申请

WO2020005132A1 X-RAY SENSOR, METHOD FOR CONSTRUCTING AN X-RAY SENSOR AND AN X-RAY IMAGING SYSTEM COMPRISING SUCH AN X-RAY SENSOR 审中-公开
公开(公告)号：WO2020005132A1
公开(公告)日：2020-01-02
申请号：PCT/SE2019/050484
申请日：2019-05-27
申请人： PRISMATIC SENSORS AB
发明人： BAKOWSKI HOLTRYD, Mietek , DANIELSSON, Mats , XU, Cheng
IPC分类号： G01T1/24 , A61B6/03 , G01N23/046 , H01L31/0224 , H01L31/115
摘要： Disclosed is an X-ray sensor (1) having an active detector region comprising a plurality of detector diodes (2) arranged on a surface region (3) of the X-ray sensor (1) the X- ray sensor (1) further comprising a junction termination (4) surrounding the surface area (3) comprising the plurality of detector diodes (2), the junction termination (4) comprising a guard (5) arranged closest to the end of the surface region (3), a field stop (6) arranged outside the guard (2) and a number Nof field limiting rings, FLRs(7) arranged between the guard (5) and the field stop (6), wherein each of the FLRs (7) are placed at positions selected so that distances between different FLRs (7) and between the guard and the first FLR lie within an effective area, the effective area being bounded by the lines α = (10 +1,3 x (n-1)) μm and β= (5+1,05 x (n-1)) μm, and selected so that the distance between successive FLRs (7) is either constant or increases with increasing n where n denotes the index of the FLRs (7), and 1≤ n ≤ N. Also disclosed is method for constructing such an X-ray sensor (1) and an X-ray imaging system (100) comprising such an X-ray sensor (1).

10. 发明申请

WO2018190760A1 THERMAL MANAGEMENT OF PHOTON-COUNTING DETECTORS 审中-公开
公开(公告)号：WO2018190760A1
公开(公告)日：2018-10-18
申请号：PCT/SE2018/050209
申请日：2018-03-06
申请人： PRISMATIC SENSORS AB
发明人： DANIELSSON, Mats , KARLSSON, Staffan , LIU, Xuejin
IPC分类号： G01T1/24 , A61B6/03 , G01N23/04 , G01N23/083 , G01T1/36
摘要： An X-ray detector system comprises a photon-counting detector (20) with multiple detector modules comprising a respective power-consuming circuitry (30). At least some of the detector modules comprises a temperature sensor to monitor a temperature on the detector module and generate a temperature representing signal. A detector controller selectively switches, for at least a subset of the detector modules, the detector modules between an idle mode in which at least a respective part of the detector modules is powered off and an operational mode in which the detector modules are powered on. The power-consuming circuitries (30) of the at least a subset of detector modules generate calibration data based on the temperature representing signals to correct for any temperature-induced changes to image data generated by the photon-counting detector (20).

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